JP2022553329A - アルツハイマー病を治療するための抗ベータ－アミロイド抗体 - Google Patents

アルツハイマー病を治療するための抗ベータ－アミロイド抗体 Download PDF

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JP2022553329A
JP2022553329A JP2022523595A JP2022523595A JP2022553329A JP 2022553329 A JP2022553329 A JP 2022553329A JP 2022523595 A JP2022523595 A JP 2022523595A JP 2022523595 A JP2022523595 A JP 2022523595A JP 2022553329 A JP2022553329 A JP 2022553329A
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antibody
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tau
disease
seq
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Japanese (ja)
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JP2022553329A5 (cg-RX-API-DMAC10.html
Inventor
ヘーベルライン， サマンサ バッド
イン ティアン，
ローラ ニセンバウム，
ラジ ラジャゴビンダン，
ガーシャム デント，
ジョン ビーバー，
エドワード プロウェイ，
ティエリー ビュシエール，
ロジャー ニッチュ，
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Biogen MA Inc
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Biogen MA Inc
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Publication of JP2022553329A publication Critical patent/JP2022553329A/ja
Publication of JP2022553329A5 publication Critical patent/JP2022553329A5/ja
Priority to JP2025181171A priority Critical patent/JP2026012271A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2022523595A 2019-10-22 2020-10-21 アルツハイマー病を治療するための抗ベータ－アミロイド抗体 Pending JP2022553329A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025181171A JP2026012271A (ja) 2019-10-22 2025-10-27 アルツハイマー病を治療するための抗ベータ－アミロイド抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962924633P 2019-10-22 2019-10-22
US62/924,633 2019-10-22
PCT/US2020/056676 WO2021081101A1 (en) 2019-10-22 2020-10-21 Anti-beta-amyloid antibody for treating alzheimer's disease

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JP2025181171A Division JP2026012271A (ja) 2019-10-22 2025-10-27 アルツハイマー病を治療するための抗ベータ－アミロイド抗体

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JP2022553329A true JP2022553329A (ja) 2022-12-22
JP2022553329A5 JP2022553329A5 (cg-RX-API-DMAC10.html) 2023-10-30

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JP2022523595A Pending JP2022553329A (ja) 2019-10-22 2020-10-21 アルツハイマー病を治療するための抗ベータ－アミロイド抗体
JP2025181171A Pending JP2026012271A (ja) 2019-10-22 2025-10-27 アルツハイマー病を治療するための抗ベータ－アミロイド抗体

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Country Link
US (1) US20220372123A1 (cg-RX-API-DMAC10.html)
EP (1) EP4048695A1 (cg-RX-API-DMAC10.html)
JP (2) JP2022553329A (cg-RX-API-DMAC10.html)
KR (1) KR20220084095A (cg-RX-API-DMAC10.html)
CN (1) CN114599393A (cg-RX-API-DMAC10.html)
AU (1) AU2020371612A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022007595A2 (cg-RX-API-DMAC10.html)
CA (1) CA3158513A1 (cg-RX-API-DMAC10.html)
CO (1) CO2022004902A2 (cg-RX-API-DMAC10.html)
IL (1) IL292363A (cg-RX-API-DMAC10.html)
JO (1) JOP20220092A1 (cg-RX-API-DMAC10.html)
MX (1) MX2022004678A (cg-RX-API-DMAC10.html)
WO (1) WO2021081101A1 (cg-RX-API-DMAC10.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
EP3746476A1 (en) 2018-01-31 2020-12-09 Alector LLC Anti-ms4a4a antibodies and methods of use thereof
EP3746484A4 (en) 2018-01-31 2021-11-17 Alector LLC ANTI-MS4A6A ANTIBODY AND METHOD OF USING THEREOF
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
TW202300517A (zh) * 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
TW202300518A (zh) * 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
WO2023081194A2 (en) * 2021-11-03 2023-05-11 Biogen Ma Inc. Methods for treating alzheimer's disease
KR20240142535A (ko) * 2022-02-02 2024-09-30 에자이 알앤드디 매니지먼트 가부시키가이샤 P-tau181 수준을 사용한 치료 방법
WO2024086796A1 (en) * 2022-10-20 2024-04-25 Alector Llc Anti-ms4a4a antibodies with amyloid-beta therapies
EP4608432A4 (en) * 2022-10-25 2026-08-12 Inst For Basic Science Ibs EXTRACTION METHODS TO ENABLE CEREBRAL-SPINAL FLUID DRAINAGE
EP4455161A1 (en) 2023-04-24 2024-10-30 ONO Pharmaceutical Co., Ltd. Human-derived anti-collapsin response mediator protein 2 (crmp2) antibodies
WO2025059487A2 (en) 2023-09-15 2025-03-20 Othair Prothena Limited Cell penetrating agents and uses thereof
WO2025117721A1 (en) * 2023-11-27 2025-06-05 Massachusetts Institute Of Technology Reconstituted lipoprotein particles to rescue lipid defects in the alzheimer's brain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011501945A (ja) * 2007-10-17 2011-01-20 ヤンセン アルツハイマー イミュノセラピー ＡｐｏＥ状態に依存する免疫療法レジメ
JP2016501247A (ja) * 2012-12-07 2016-01-18 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー 抗Ａβ抗体を使用して脳アミロイド斑を減少させる方法
JP2019517540A (ja) * 2016-06-07 2019-06-24 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー アルツハイマー病を治療する方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033325T2 (en) 2007-01-05 2017-11-28 Univ Zuerich Anti-beta-amyloid binder antibodies and their use
US9040045B2 (en) * 2007-05-14 2015-05-26 Medtronic, Inc. Methods and device to neutralize soluble toxic agents in the brain
US9221900B2 (en) * 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
EP3275461A1 (en) * 2011-09-19 2018-01-31 Axon Neuroscience SE Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease field
MA41115A (fr) * 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011501945A (ja) * 2007-10-17 2011-01-20 ヤンセン アルツハイマー イミュノセラピー ＡｐｏＥ状態に依存する免疫療法レジメ
JP2016501247A (ja) * 2012-12-07 2016-01-18 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー 抗Ａβ抗体を使用して脳アミロイド斑を減少させる方法
JP2019517540A (ja) * 2016-06-07 2019-06-24 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー アルツハイマー病を治療する方法

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Publication number Publication date
CO2022004902A2 (es) 2022-07-08
EP4048695A1 (en) 2022-08-31
CN114599393A (zh) 2022-06-07
BR112022007595A2 (pt) 2022-08-23
US20220372123A1 (en) 2022-11-24
AU2020371612A1 (en) 2022-05-19
CA3158513A1 (en) 2021-04-29
IL292363A (en) 2022-06-01
JOP20220092A1 (ar) 2023-01-30
KR20220084095A (ko) 2022-06-21
MX2022004678A (es) 2022-08-15
WO2021081101A1 (en) 2021-04-29
JP2026012271A (ja) 2026-01-23

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