JP2022549222A5 - - Google Patents
Info
- Publication number
- JP2022549222A5 JP2022549222A5 JP2022517875A JP2022517875A JP2022549222A5 JP 2022549222 A5 JP2022549222 A5 JP 2022549222A5 JP 2022517875 A JP2022517875 A JP 2022517875A JP 2022517875 A JP2022517875 A JP 2022517875A JP 2022549222 A5 JP2022549222 A5 JP 2022549222A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- dioxopiperidine
- carboxamide
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962903997P | 2019-09-23 | 2019-09-23 | |
| US62/903,997 | 2019-09-23 | ||
| PCT/US2020/051997 WO2021061642A1 (en) | 2019-09-23 | 2020-09-22 | Novel ureas having androgen receptor degradation activity and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022549222A JP2022549222A (ja) | 2022-11-24 |
| JP2022549222A5 true JP2022549222A5 (https=) | 2023-09-28 |
Family
ID=74879893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022517875A Pending JP2022549222A (ja) | 2019-09-23 | 2020-09-22 | アンドロゲン受容体分解活性を有する新規尿素およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11420956B2 (https=) |
| EP (1) | EP4034114A4 (https=) |
| JP (1) | JP2022549222A (https=) |
| CN (1) | CN114761003B (https=) |
| WO (1) | WO2021061642A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110506039A (zh) * | 2016-10-11 | 2019-11-26 | 阿尔维纳斯股份有限公司 | 用于雄激素受体靶向降解的化合物和方法 |
| EP3917916A4 (en) | 2019-01-30 | 2022-12-14 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
| EP4034114A4 (en) * | 2019-09-23 | 2023-07-26 | Accutar Biotechnology Inc. | NEW UREAES HAVING ANDROGEN RECEPTOR DEGRADING ACTIVITY AND THEIR USES |
| AU2020405129A1 (en) | 2019-12-19 | 2022-06-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CR20220630A (es) | 2020-05-09 | 2023-01-23 | Arvinas Operations Inc | Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo |
| AU2021311245A1 (en) * | 2020-07-21 | 2023-03-09 | Ubix Therapeutics, Inc. | Compound for androgen receptor degradation, and pharmaceutical use thereof |
| WO2023039604A1 (en) * | 2021-09-13 | 2023-03-16 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
| KR20230112501A (ko) | 2022-01-20 | 2023-07-27 | 주식회사 유빅스테라퓨틱스 | 안드로겐 수용체 분해활성을 갖는 화합물 및 이들의 의약 용도 |
| US20240190842A1 (en) * | 2022-11-09 | 2024-06-13 | Accutar Biotechnology Inc. | Substituted quinolinone-8-carbonitrile derivatives having androgen degradation activity and uses thereof |
| TW202535392A (zh) | 2023-12-08 | 2025-09-16 | 美商亞文納營運公司 | 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122007000079I2 (de) * | 1996-07-24 | 2010-08-12 | Celgene Corp | Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels |
| CN1129581C (zh) * | 1998-09-22 | 2003-12-03 | 山之内制药株式会社 | 氰基苯基衍生物 |
| US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| AU2003248052A1 (en) * | 2002-07-12 | 2004-02-02 | Yamanouchi Pharmaceutical Co., Ltd. | N-phenyl-(2r,5s)dimethylpiperadine derivative |
| WO2005011011A1 (en) * | 2003-07-21 | 2005-02-03 | Unaxis Usa Inc. | Etching method for making chalcogenide memory elements |
| US20050124625A1 (en) * | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
| EA201390598A1 (ru) * | 2010-10-22 | 2013-08-30 | Астеллас Фарма Инк. | Антагонист мутантного андрогенного рецептора |
| SMT201900735T1 (it) * | 2012-07-27 | 2020-03-13 | Aragon Pharmaceuticals Inc | Metodi e composizioni per determinare la resistenza a una terapia verso recettore degli androgeni |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| RU2738833C9 (ru) * | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| KR101597327B1 (ko) * | 2014-04-24 | 2016-02-24 | 동아에스티 주식회사 | 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
| CN110506039A (zh) * | 2016-10-11 | 2019-11-26 | 阿尔维纳斯股份有限公司 | 用于雄激素受体靶向降解的化合物和方法 |
| KR20250117470A (ko) | 2016-12-23 | 2025-08-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
| EP4034114A4 (en) * | 2019-09-23 | 2023-07-26 | Accutar Biotechnology Inc. | NEW UREAES HAVING ANDROGEN RECEPTOR DEGRADING ACTIVITY AND THEIR USES |
-
2020
- 2020-09-22 EP EP20868648.5A patent/EP4034114A4/en active Pending
- 2020-09-22 JP JP2022517875A patent/JP2022549222A/ja active Pending
- 2020-09-22 CN CN202080079154.8A patent/CN114761003B/zh not_active Expired - Fee Related
- 2020-09-22 WO PCT/US2020/051997 patent/WO2021061642A1/en not_active Ceased
- 2020-09-22 US US17/028,612 patent/US11420956B2/en active Active
-
2021
- 2021-05-26 US US17/331,015 patent/US11220490B2/en not_active Expired - Fee Related
-
2022
- 2022-06-27 US US17/850,289 patent/US20230150973A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022549222A5 (https=) | ||
| IL291590B2 (en) | Novel substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof | |
| US12083118B2 (en) | Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same | |
| KR102271574B1 (ko) | 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도 | |
| JP2020503297A5 (https=) | ||
| JP2022185107A5 (https=) | ||
| RU2704129C2 (ru) | Соединение 2-аминопиримидина и фармацевтическая композиция и применение данного соединения | |
| RU2606497C2 (ru) | Тиазолилфенилбензолсульфонамидопроизводные в качестве ингибиторов киназ | |
| JP2019517487A5 (https=) | ||
| CN114430740A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| JP2014527082A5 (https=) | ||
| JP2022520448A5 (https=) | ||
| JP2023536164A5 (https=) | ||
| JP2016513660A5 (https=) | ||
| RU2010150786A (ru) | Пирролопиридины как ингибиторы киназы | |
| US20210261542A1 (en) | Compounds which inhibit rna polymerase, compositions including such compounds, and their use | |
| JP2016525078A5 (https=) | ||
| JP2008528467A5 (https=) | ||
| JP2015517574A5 (https=) | ||
| JP2016522246A5 (https=) | ||
| JP6896701B2 (ja) | イミダゾリルアミド誘導体 | |
| RU2009144191A (ru) | Имидазопиридиновые ингибиторы киназ | |
| JP2007504160A5 (https=) | ||
| RU2015111133A (ru) | Ингибиторы тирозинкиназы брутона | |
| JP2014520108A5 (https=) |