JP2022548866A - 融合タンパク質を用いたｔｃｒリプログラミングのための組成物及び方法 - Google Patents

融合タンパク質を用いたｔｃｒリプログラミングのための組成物及び方法 Download PDF

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JP2022548866A
JP2022548866A JP2022516320A JP2022516320A JP2022548866A JP 2022548866 A JP2022548866 A JP 2022548866A JP 2022516320 A JP2022516320 A JP 2022516320A JP 2022516320 A JP2022516320 A JP 2022516320A JP 2022548866 A JP2022548866 A JP 2022548866A
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nucleic acid
domain
sequence
recombinant nucleic
tcr
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JP2022548866A5 (enExample
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バユエルレ，パトリック
ホフマイスター，ロバート
ゲッツ，ダニエル
グティエレス，ダリオ
キーファー－クォン，フィリップ
ドナゲイ，ジュリー
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ティーシーアール２ セラピューティクス インク．
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector

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JP2022516320A 2019-09-12 2020-09-11 融合タンパク質を用いたｔｃｒリプログラミングのための組成物及び方法 Pending JP2022548866A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962899563P 2019-09-12 2019-09-12
US62/899,563 2019-09-12
US202062971682P 2020-02-07 2020-02-07
US62/971,682 2020-02-07
PCT/US2020/050503 WO2021050948A1 (en) 2019-09-12 2020-09-11 Compositions and methods for tcr reprogramming using fusion proteins

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JP2022548866A true JP2022548866A (ja) 2022-11-22
JP2022548866A5 JP2022548866A5 (enExample) 2023-09-20

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EP (1) EP4028033A4 (enExample)
JP (1) JP2022548866A (enExample)
KR (1) KR20220078607A (enExample)
CN (1) CN114828862A (enExample)
AU (1) AU2020344628A1 (enExample)
BR (1) BR112022004458A2 (enExample)
CA (1) CA3154287A1 (enExample)
IL (1) IL291236A (enExample)
MX (1) MX2022002984A (enExample)
WO (1) WO2021050948A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2020123938A1 (en) 2018-12-14 2020-06-18 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
EP4217377A4 (en) * 2020-09-23 2024-11-27 Myeloid Therapeutics, Inc. Improved methods and compositions for expression of nucleic acids in cells
WO2023091420A2 (en) * 2021-11-16 2023-05-25 TCR2 Therapeutics Inc. Compositions and methods for t cell engineering
US20260007747A1 (en) * 2022-01-07 2026-01-08 Vivasor, Inc. Engineered PD-L1-Targeting Gamma Delta T Cell Receptors
EP4573114A4 (en) * 2022-08-19 2026-07-29 Memorial Sloan Kettering Cancer Center T-LYMPHOCYTE RECEPTORS TARGETTING RAS MUTATIONS AND ASSOCIATED USES
WO2025217063A1 (en) * 2024-04-08 2025-10-16 Baylor College Of Medicine Dual stimulatory receptors for immunotherapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02174681A (ja) * 1988-05-04 1990-07-06 Yeda Res & Dev Co Ltd 組換え体遺伝子対
JP2017529841A (ja) * 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キメラ抗原受容体
WO2018102795A2 (en) * 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof
JP2019500848A (ja) * 2015-10-23 2019-01-17 ユーリカ セラピューティックス， インコーポレイテッド 抗体／ｔ細胞受容体キメラ構築物およびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011059836A2 (en) * 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
RS61455B1 (sr) * 2011-10-28 2021-03-31 Regeneron Pharma Genetski modifikovani miševi t ćelijskog receptora
GB201604494D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
BR112019007100A2 (pt) * 2016-10-07 2019-06-25 Tcr2 Therapeutics Inc composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão
CN110177803A (zh) * 2016-11-22 2019-08-27 T细胞受体治疗公司 用于使用融合蛋白进行tcr重新编程的组合物和方法
CA3047999A1 (en) * 2016-12-21 2018-06-28 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
WO2018232020A1 (en) * 2017-06-13 2018-12-20 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US11738047B2 (en) * 2017-12-12 2023-08-29 The Trustees Of The University Of Pennsylvania Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
WO2019133443A1 (en) * 2017-12-28 2019-07-04 Janux Therapeutics, Inc. Modified t cell receptors
CA3093449A1 (en) * 2018-03-09 2019-09-12 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02174681A (ja) * 1988-05-04 1990-07-06 Yeda Res & Dev Co Ltd 組換え体遺伝子対
JP2017529841A (ja) * 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キメラ抗原受容体
JP2019500848A (ja) * 2015-10-23 2019-01-17 ユーリカ セラピューティックス， インコーポレイテッド 抗体／ｔ細胞受容体キメラ構築物およびその使用
WO2018102795A2 (en) * 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof

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BR112022004458A2 (pt) 2022-05-31
MX2022002984A (es) 2022-06-16
IL291236A (en) 2022-05-01
WO2021050948A1 (en) 2021-03-18
CA3154287A1 (en) 2021-03-18
KR20220078607A (ko) 2022-06-10
CN114828862A (zh) 2022-07-29
EP4028033A4 (en) 2023-10-04
AU2020344628A1 (en) 2022-04-07
EP4028033A1 (en) 2022-07-20

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