JP2022548581A5 - - Google Patents
Info
- Publication number
- JP2022548581A5 JP2022548581A5 JP2022516098A JP2022516098A JP2022548581A5 JP 2022548581 A5 JP2022548581 A5 JP 2022548581A5 JP 2022516098 A JP2022516098 A JP 2022516098A JP 2022516098 A JP2022516098 A JP 2022516098A JP 2022548581 A5 JP2022548581 A5 JP 2022548581A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocycloalkyl
- compound according
- alkyl
- nrr
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962899912P | 2019-09-13 | 2019-09-13 | |
| US62/899,912 | 2019-09-13 | ||
| PCT/IB2020/000727 WO2021048618A1 (en) | 2019-09-13 | 2020-09-11 | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022548581A JP2022548581A (ja) | 2022-11-21 |
| JP2022548581A5 true JP2022548581A5 (https=) | 2023-09-19 |
Family
ID=72744787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022516098A Withdrawn JP2022548581A (ja) | 2019-09-13 | 2020-09-11 | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12384788B2 (https=) |
| EP (1) | EP4028016A1 (https=) |
| JP (1) | JP2022548581A (https=) |
| KR (1) | KR20220062567A (https=) |
| CN (1) | CN115103844A (https=) |
| AU (1) | AU2020345000A1 (https=) |
| CA (1) | CA3154131A1 (https=) |
| IL (1) | IL291338A (https=) |
| WO (1) | WO2021048618A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7796007B2 (ja) * | 2019-09-13 | 2026-01-08 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
| JP2023549294A (ja) * | 2020-10-26 | 2023-11-22 | ニューロン２３， インコーポレイテッド | 野生型ｌｒｒｋ２に関連するパーキンソン病の処置および診断方法 |
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| US20240228493A1 (en) * | 2022-11-18 | 2024-07-11 | Neuron23, Icn. | Lrrk2 inhibitors and uses thereof |
| WO2024108116A1 (en) * | 2022-11-18 | 2024-05-23 | Neuron23, Inc. | Lrrk2 inhibitors and uses thereof |
| CN121154824A (zh) * | 2025-11-19 | 2025-12-19 | 安徽省立医院(中国科学技术大学附属第一医院) | Nuak1作为生物标志物在骨质疏松临床诊断和预防中的应用及其试剂盒 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2350086B1 (en) * | 2008-09-23 | 2021-04-21 | The Johns Hopkins University | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
| AU2012244549B2 (en) * | 2011-04-21 | 2017-04-20 | Origenis Gmbh | Heterocyclic compounds as kinase inhibitors |
| KR102091895B1 (ko) | 2012-05-03 | 2020-04-14 | 제넨테크, 인크. | 파킨슨병의 치료에 사용하기 위한 lrrk2 조절제로서의 피라졸 아미노피리미딘 유도체 |
| AU2013322736A1 (en) | 2012-09-26 | 2015-02-26 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| RU2722149C1 (ru) * | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| CA3046809A1 (en) | 2016-12-12 | 2018-06-21 | The University Of Sydney | Non-peptide oxytocin receptor agonists |
| JP7796007B2 (ja) * | 2019-09-13 | 2026-01-08 | オリゲニス ゲーエムベーハー | 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物 |
-
2020
- 2020-09-11 JP JP2022516098A patent/JP2022548581A/ja not_active Withdrawn
- 2020-09-11 CA CA3154131A patent/CA3154131A1/en active Pending
- 2020-09-11 KR KR1020227011534A patent/KR20220062567A/ko active Pending
- 2020-09-11 WO PCT/IB2020/000727 patent/WO2021048618A1/en not_active Ceased
- 2020-09-11 US US17/642,136 patent/US12384788B2/en active Active
- 2020-09-11 AU AU2020345000A patent/AU2020345000A1/en active Pending
- 2020-09-11 CN CN202080079002.8A patent/CN115103844A/zh active Pending
- 2020-09-11 EP EP20786036.2A patent/EP4028016A1/en not_active Withdrawn
-
2022
- 2022-03-13 IL IL291338A patent/IL291338A/en unknown
-
2025
- 2025-08-05 US US19/290,905 patent/US20250361237A1/en active Pending
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