CA3154131A1 - 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease - Google Patents

1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease Download PDF

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Publication number
CA3154131A1
CA3154131A1 CA3154131A CA3154131A CA3154131A1 CA 3154131 A1 CA3154131 A1 CA 3154131A1 CA 3154131 A CA3154131 A CA 3154131A CA 3154131 A CA3154131 A CA 3154131A CA 3154131 A1 CA3154131 A1 CA 3154131A1
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CA
Canada
Prior art keywords
compound
heterocycloalkyl
alkyl
nrr
hplc
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3154131A
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English (en)
French (fr)
Inventor
Roland Koestler
Jean TASSEL
Michael Thormann
Nasser YEHIA
Andreas Treml
Michael Almstetter
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Origenis GmbH
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Origenis GmbH
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Publication of CA3154131A1 publication Critical patent/CA3154131A1/en
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3154131A 2019-09-13 2020-09-11 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease Pending CA3154131A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962899912P 2019-09-13 2019-09-13
US62/899,912 2019-09-13
PCT/IB2020/000727 WO2021048618A1 (en) 2019-09-13 2020-09-11 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease

Publications (1)

Publication Number Publication Date
CA3154131A1 true CA3154131A1 (en) 2021-03-18

Family

ID=72744787

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3154131A Pending CA3154131A1 (en) 2019-09-13 2020-09-11 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease

Country Status (9)

Country Link
US (2) US12384788B2 (https=)
EP (1) EP4028016A1 (https=)
JP (1) JP2022548581A (https=)
KR (1) KR20220062567A (https=)
CN (1) CN115103844A (https=)
AU (1) AU2020345000A1 (https=)
CA (1) CA3154131A1 (https=)
IL (1) IL291338A (https=)
WO (1) WO2021048618A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7796007B2 (ja) * 2019-09-13 2026-01-08 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物
JP2023549294A (ja) * 2020-10-26 2023-11-22 ニューロン２３， インコーポレイテッド 野生型ｌｒｒｋ２に関連するパーキンソン病の処置および診断方法
EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
US20240228493A1 (en) * 2022-11-18 2024-07-11 Neuron23, Icn. Lrrk2 inhibitors and uses thereof
WO2024108116A1 (en) * 2022-11-18 2024-05-23 Neuron23, Inc. Lrrk2 inhibitors and uses thereof
CN121154824A (zh) * 2025-11-19 2025-12-19 安徽省立医院(中国科学技术大学附属第一医院) Nuak1作为生物标志物在骨质疏松临床诊断和预防中的应用及其试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350086B1 (en) * 2008-09-23 2021-04-21 The Johns Hopkins University Fused diimidazodiazepine compounds and methods of use and manufacture thereof
AU2012244549B2 (en) * 2011-04-21 2017-04-20 Origenis Gmbh Heterocyclic compounds as kinase inhibitors
KR102091895B1 (ko) 2012-05-03 2020-04-14 제넨테크, 인크. 파킨슨병의 치료에 사용하기 위한 lrrk2 조절제로서의 피라졸 아미노피리미딘 유도체
AU2013322736A1 (en) 2012-09-26 2015-02-26 F. Hoffmann-La Roche Ag Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
RU2722149C1 (ru) * 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2
CA3046809A1 (en) 2016-12-12 2018-06-21 The University Of Sydney Non-peptide oxytocin receptor agonists
JP7796007B2 (ja) * 2019-09-13 2026-01-08 オリゲニス ゲーエムベーハー 例えば自己免疫疾患の処置のための、ＬＲＲＫ２、ＮＵＡＫ１および／またはＴＹＫ２キナーゼモジュレータとしての１，４－ジヒドロベンゾ［ｄ］ピラゾロ［３，４－ｆ］［１，３］ジアゼピン誘導体および関連する化合物

Also Published As

Publication number Publication date
US12384788B2 (en) 2025-08-12
CN115103844A (zh) 2022-09-23
KR20220062567A (ko) 2022-05-17
US20220380373A1 (en) 2022-12-01
US20250361237A1 (en) 2025-11-27
JP2022548581A (ja) 2022-11-21
EP4028016A1 (en) 2022-07-20
IL291338A (en) 2022-05-01
WO2021048618A1 (en) 2021-03-18
AU2020345000A1 (en) 2022-03-31

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