JP2022548568A5 - - Google Patents
Info
- Publication number
- JP2022548568A5 JP2022548568A5 JP2022515905A JP2022515905A JP2022548568A5 JP 2022548568 A5 JP2022548568 A5 JP 2022548568A5 JP 2022515905 A JP2022515905 A JP 2022515905A JP 2022515905 A JP2022515905 A JP 2022515905A JP 2022548568 A5 JP2022548568 A5 JP 2022548568A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carboxamide
- fluoro
- cycloalkyl
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962898839P | 2019-09-11 | 2019-09-11 | |
| US62/898,839 | 2019-09-11 | ||
| US202063005577P | 2020-04-06 | 2020-04-06 | |
| US63/005,577 | 2020-04-06 | ||
| PCT/US2020/050326 WO2021050824A1 (en) | 2019-09-11 | 2020-09-11 | Cdk inhibitors and their use as pharmaceuticals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022548568A JP2022548568A (ja) | 2022-11-21 |
| JP2022548568A5 true JP2022548568A5 (https=) | 2023-09-15 |
| JP7763489B2 JP7763489B2 (ja) | 2025-11-04 |
Family
ID=74850746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022515905A Active JP7763489B2 (ja) | 2019-09-11 | 2020-09-11 | Ｃｄｋ阻害剤及び医薬品としてのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20220324830A1 (https=) |
| EP (1) | EP4028005A4 (https=) |
| JP (1) | JP7763489B2 (https=) |
| KR (1) | KR20220079851A (https=) |
| CN (1) | CN114786673A (https=) |
| AU (1) | AU2020345950A1 (https=) |
| BR (1) | BR112022004327A2 (https=) |
| CA (1) | CA3153531A1 (https=) |
| IL (1) | IL291191A (https=) |
| MX (1) | MX2022002946A (https=) |
| WO (1) | WO2021050824A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220079851A (ko) * | 2019-09-11 | 2022-06-14 | 프렐루드 테라퓨틱스, 인코포레이티드 | Cdk 억제제 및 약제로서의 이의 용도 |
| US12570607B2 (en) | 2019-12-09 | 2026-03-10 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Compound as cyclin-dependent kinase 9 inhibitor and use thereof |
| CN114605390B (zh) * | 2020-12-04 | 2024-08-16 | 上海凌达生物医药有限公司 | 具有cdk激酶抑制活性的化合物、其药物组合物和用途 |
| WO2022247785A1 (zh) * | 2021-05-24 | 2022-12-01 | 石药集团中奇制药技术（石家庄）有限公司 | 一种周期蛋白依赖性激酶9抑制剂的用途 |
| WO2022247796A1 (zh) * | 2021-05-24 | 2022-12-01 | 石药集团中奇制药技术（石家庄）有限公司 | 周期蛋白依赖性激酶9抑制剂的用途 |
| US20230144528A1 (en) * | 2021-09-30 | 2023-05-11 | Prelude Therapeutics Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
| KR20240115816A (ko) | 2021-10-14 | 2024-07-26 | 프렐루드 테라퓨틱스, 인코포레이티드 | Cdk9 억제제로서 작용하는 치환된 벤즈이미다졸의 결정질 형태 및 이의 용도 |
| WO2025076115A1 (en) * | 2023-10-02 | 2025-04-10 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| WO2025189114A1 (en) | 2024-03-08 | 2025-09-12 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| WO2026024933A1 (en) * | 2024-07-24 | 2026-01-29 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| CN119638640A (zh) * | 2024-12-10 | 2025-03-18 | 杭州亦宁医药技术有限公司 | 一种5-溴-2-甲基-3-异丙基-吲唑的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010508301A (ja) | 2006-10-31 | 2010-03-18 | スミスクライン ビーチャム コーポレーション | ５−置換及び６−置換ベンゾイミダゾールチオフェン化合物 |
| CN103083643B (zh) | 2008-03-27 | 2015-01-07 | 雀巢产品技术援助有限公司 | 增加肽、肽模拟物和其他胃肠道转运蛋白底物吸收的方法 |
| CN102471339A (zh) * | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
| WO2014137728A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| EP2970200A1 (en) * | 2013-03-13 | 2016-01-20 | Abbvie Inc. | Pyridine cdk9 kinase inhibitors |
| WO2015108861A1 (en) * | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| JP2017523214A (ja) * | 2014-08-05 | 2017-08-17 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロ環キナーゼ阻害剤 |
| WO2016197078A1 (en) * | 2015-06-05 | 2016-12-08 | Syros Pharmaceuticals, Inc. | Compounds for the modulation of myc activity |
| ES2728356T3 (es) * | 2015-06-29 | 2019-10-23 | Astrazeneca Ab | Derivados de amidas policíclicas como inhibidores de CDK9 |
| WO2017051262A1 (en) | 2015-09-22 | 2017-03-30 | Hindustan Petroleum Corporation Limited | An additive and a catalyst composition comprising the additive for fcc process |
| FR3041639B1 (fr) * | 2015-09-30 | 2019-01-25 | Les Laboratoires Servier | NOUVEAUX DERIVES D'IMIDAZO[4,5-b]PYRIDINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
| CN107641118B (zh) * | 2016-07-22 | 2020-11-06 | 爱科诺生物医药股份有限公司 | 具有细胞坏死抑制活性的化合物及其组合物和应用 |
| KR20220079851A (ko) * | 2019-09-11 | 2022-06-14 | 프렐루드 테라퓨틱스, 인코포레이티드 | Cdk 억제제 및 약제로서의 이의 용도 |
| US12570607B2 (en) * | 2019-12-09 | 2026-03-10 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Compound as cyclin-dependent kinase 9 inhibitor and use thereof |
| WO2022035799A1 (en) * | 2020-08-10 | 2022-02-17 | Prelude Therapeutics Incorporated | Heterocycle cdk inhibitors and their use thereof |
| US11685744B2 (en) * | 2020-09-21 | 2023-06-27 | Prelude Therapeutics Incorporated | CDK inhibitors and their use as pharmaceuticals |
| CA3205652A1 (en) * | 2020-12-18 | 2022-06-23 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
| US20230144528A1 (en) * | 2021-09-30 | 2023-05-11 | Prelude Therapeutics Incorporated | CDK Inhibitors And Their Use As Pharmaceuticals |
| KR20240115816A (ko) * | 2021-10-14 | 2024-07-26 | 프렐루드 테라퓨틱스, 인코포레이티드 | Cdk9 억제제로서 작용하는 치환된 벤즈이미다졸의 결정질 형태 및 이의 용도 |
| WO2025076115A1 (en) * | 2023-10-02 | 2025-04-10 | Prelude Therapeutics Incorporated | Cdk inhibitors and their use as pharmaceuticals |
-
2020
- 2020-09-11 KR KR1020227011706A patent/KR20220079851A/ko not_active Ceased
- 2020-09-11 US US17/642,482 patent/US20220324830A1/en not_active Abandoned
- 2020-09-11 BR BR112022004327A patent/BR112022004327A2/pt unknown
- 2020-09-11 AU AU2020345950A patent/AU2020345950A1/en active Pending
- 2020-09-11 US US17/018,005 patent/US11673893B2/en active Active
- 2020-09-11 JP JP2022515905A patent/JP7763489B2/ja active Active
- 2020-09-11 EP EP20864098.7A patent/EP4028005A4/en not_active Withdrawn
- 2020-09-11 MX MX2022002946A patent/MX2022002946A/es unknown
- 2020-09-11 CN CN202080078041.6A patent/CN114786673A/zh active Pending
- 2020-09-11 CA CA3153531A patent/CA3153531A1/en active Pending
- 2020-09-11 WO PCT/US2020/050326 patent/WO2021050824A1/en not_active Ceased
-
2022
- 2022-03-08 IL IL291191A patent/IL291191A/en unknown
-
2023
- 2023-04-04 US US18/295,394 patent/US12486277B2/en active Active
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