JP2022547888A5 - - Google Patents

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Publication number
JP2022547888A5
JP2022547888A5 JP2022514677A JP2022514677A JP2022547888A5 JP 2022547888 A5 JP2022547888 A5 JP 2022547888A5 JP 2022514677 A JP2022514677 A JP 2022514677A JP 2022514677 A JP2022514677 A JP 2022514677A JP 2022547888 A5 JP2022547888 A5 JP 2022547888A5
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JP
Japan
Prior art keywords
formula
nucleotide
group
double
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022514677A
Other languages
English (en)
Japanese (ja)
Other versions
JP7667775B2 (ja
JP2022547888A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/074800 external-priority patent/WO2021044004A1/en
Publication of JP2022547888A publication Critical patent/JP2022547888A/ja
Publication of JP2022547888A5 publication Critical patent/JP2022547888A5/ja
Application granted granted Critical
Publication of JP7667775B2 publication Critical patent/JP7667775B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022514677A 2019-09-05 2020-09-04 ヌクレオチド類似体を含有するオリゴヌクレオチド Active JP7667775B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19195696 2019-09-05
EP19195696.0 2019-09-05
PCT/EP2020/074800 WO2021044004A1 (en) 2019-09-05 2020-09-04 Oligonucleotides containing nucleotide analogs

Publications (3)

Publication Number Publication Date
JP2022547888A JP2022547888A (ja) 2022-11-16
JP2022547888A5 true JP2022547888A5 (https=) 2025-01-08
JP7667775B2 JP7667775B2 (ja) 2025-04-23

Family

ID=67874384

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022514677A Active JP7667775B2 (ja) 2019-09-05 2020-09-04 ヌクレオチド類似体を含有するオリゴヌクレオチド

Country Status (5)

Country Link
US (1) US20220372063A1 (https=)
EP (1) EP4025582A1 (https=)
JP (1) JP7667775B2 (https=)
CN (1) CN114728999A (https=)
WO (1) WO2021044004A1 (https=)

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US11897911B2 (en) 2018-03-07 2024-02-13 Sanofi Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
CN113166760A (zh) 2018-11-23 2021-07-23 赛诺菲 用于抑制angptl8的新型rna组合物和方法
CA3226457A1 (en) * 2021-07-30 2023-02-02 Amy WALKER Nanoparticles and peptides for the delivery of cargos to muscle cells
CN119451971A (zh) * 2022-06-27 2025-02-14 大睿生物医药科技(上海)有限公司 具有增强的稳定性的核苷酸替代物
WO2024073732A1 (en) 2022-09-30 2024-04-04 Alnylam Pharmaceuticals, Inc. Modified double-stranded rna agents
CN121729422A (zh) * 2023-08-10 2026-03-24 大睿生物医药科技(上海)有限公司 含有核苷酸类似物的双链rna
WO2025077949A1 (zh) * 2023-11-06 2025-04-17 杭州天龙药业有限公司 提升双链寡核苷酸靶基因抑制效果的修饰模板及其组合与应用
CN118994133A (zh) * 2023-12-08 2024-11-22 浙江大学 基于无保护扩环策略的吗啉代核苷单体全流程合成工艺
WO2025240414A1 (en) * 2024-05-14 2025-11-20 Sri International Cardiomyocyte-specific molecular guidance system peptides and uses thereof
WO2026002117A1 (zh) * 2024-06-26 2026-01-02 上海拓界生物医药科技有限公司 双环结构及包含其的寡核苷酸
WO2026064467A1 (en) * 2024-09-18 2026-03-26 Eli Lilly And Company Improved chemical methods for manufacturing a phosphoramidite used in rna synthesis

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US11897911B2 (en) 2018-03-07 2024-02-13 Sanofi Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
CN113166760A (zh) 2018-11-23 2021-07-23 赛诺菲 用于抑制angptl8的新型rna组合物和方法
CN115176011B (zh) 2019-08-27 2025-11-11 赛诺菲 用于抑制pcsk9的组合物和方法

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