JP2022546557A5 - - Google Patents
Info
- Publication number
- JP2022546557A5 JP2022546557A5 JP2022514209A JP2022514209A JP2022546557A5 JP 2022546557 A5 JP2022546557 A5 JP 2022546557A5 JP 2022514209 A JP2022514209 A JP 2022514209A JP 2022514209 A JP2022514209 A JP 2022514209A JP 2022546557 A5 JP2022546557 A5 JP 2022546557A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- phosphate
- group
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962895417P | 2019-09-03 | 2019-09-03 | |
| US62/895,417 | 2019-09-03 | ||
| PCT/US2020/049261 WO2021046260A1 (en) | 2019-09-03 | 2020-09-03 | Asialoglycoprotein receptor mediated delivery of therapeutically active conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022546557A JP2022546557A (ja) | 2022-11-04 |
| JP2022546557A5 true JP2022546557A5 (https=) | 2023-09-13 |
| JP7672394B2 JP7672394B2 (ja) | 2025-05-07 |
Family
ID=74680487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022514209A Active JP7672394B2 (ja) | 2019-09-03 | 2020-09-03 | 治療的に活性な複合体のアシアロ糖タンパク質受容体媒介送達 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12290567B2 (https=) |
| EP (1) | EP4025252A4 (https=) |
| JP (1) | JP7672394B2 (https=) |
| KR (1) | KR20220058578A (https=) |
| CN (1) | CN114929282B (https=) |
| AU (1) | AU2020340987B2 (https=) |
| CA (1) | CA3152529A1 (https=) |
| IL (1) | IL290766B2 (https=) |
| WO (1) | WO2021046260A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021257916A1 (en) * | 2020-06-18 | 2021-12-23 | Arcturus Therapeutics, Inc. | Una oligomers for the treatment of polyglutamine diseases |
| US20230227826A1 (en) * | 2020-06-18 | 2023-07-20 | Arcturus Therapeutics, Inc. | Una oligomers for the treatment of polyglutamine diseases |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| WO2024104386A1 (zh) * | 2022-11-16 | 2024-05-23 | 南京明德新药研发有限公司 | 一类含七元杂环的三齿缀合基团 |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2025049634A1 (en) * | 2023-08-29 | 2025-03-06 | Ganna Bio, Inc. | Glycan conjugate compositions and methods |
| CN117466959A (zh) * | 2023-10-30 | 2024-01-30 | 烟台药物研究所 | 一种肝靶向化合物、缀合物及应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| CA2721183C (en) * | 2008-04-11 | 2019-07-16 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| WO2013033230A1 (en) | 2011-08-29 | 2013-03-07 | Isis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| AU2013299717B2 (en) * | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3564374A1 (en) | 2013-06-21 | 2019-11-06 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
| WO2015042447A1 (en) * | 2013-09-20 | 2015-03-26 | Isis Pharmaceuticals, Inc. | Targeted therapeutic nucleosides and their use |
| CA2935426C (en) | 2014-01-30 | 2023-07-25 | F. Hoffmann-La Roche Ag | Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target |
| US10513710B2 (en) | 2014-04-18 | 2019-12-24 | University Of Massachusetts | Exosomal loading using hydrophobically modified oligonucleotides |
| US10098959B2 (en) | 2014-05-01 | 2018-10-16 | Ionis Pharmaceuticals, Inc. | Method for synthesis of reactive conjugate clusters |
| EA036496B1 (ru) | 2014-05-01 | 2020-11-17 | Ионис Фармасьютикалз, Инк. | Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b |
| BR112016022742B1 (pt) | 2014-05-01 | 2022-06-14 | Ionis Pharmaceuticals, Inc | Composto químico, composição compreendendo o composto e uso dos mesmos |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| DK3569711T3 (da) | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| US9834510B2 (en) | 2015-12-30 | 2017-12-05 | Arcturus Therapeutics, Inc. | Aromatic ionizable cationic lipid |
| CA3011946A1 (en) | 2016-03-07 | 2017-09-14 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
| EP3228326A1 (en) | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
| WO2018013525A1 (en) * | 2016-07-11 | 2018-01-18 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| SG11201901841TA (en) * | 2016-09-02 | 2019-03-28 | Arrowhead Pharmaceuticals Inc | Targeting ligands |
| US11400161B2 (en) | 2016-10-06 | 2022-08-02 | Ionis Pharmaceuticals, Inc. | Method of conjugating oligomeric compounds |
| US10383952B2 (en) | 2016-12-21 | 2019-08-20 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| JP7420727B2 (ja) | 2018-02-17 | 2024-01-23 | アローヘッド ファーマシューティカルズ インコーポレイテッド | トリアルキン結合剤及び使用方法 |
| US20230227826A1 (en) * | 2020-06-18 | 2023-07-20 | Arcturus Therapeutics, Inc. | Una oligomers for the treatment of polyglutamine diseases |
| WO2021257916A1 (en) * | 2020-06-18 | 2021-12-23 | Arcturus Therapeutics, Inc. | Una oligomers for the treatment of polyglutamine diseases |
-
2020
- 2020-09-03 JP JP2022514209A patent/JP7672394B2/ja active Active
- 2020-09-03 US US17/011,880 patent/US12290567B2/en active Active
- 2020-09-03 CA CA3152529A patent/CA3152529A1/en active Pending
- 2020-09-03 KR KR1020227010731A patent/KR20220058578A/ko active Pending
- 2020-09-03 IL IL290766A patent/IL290766B2/en unknown
- 2020-09-03 AU AU2020340987A patent/AU2020340987B2/en active Active
- 2020-09-03 WO PCT/US2020/049261 patent/WO2021046260A1/en not_active Ceased
- 2020-09-03 CN CN202080074997.9A patent/CN114929282B/zh active Active
- 2020-09-03 EP EP20860366.2A patent/EP4025252A4/en active Pending
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