JP2022546040A5 - - Google Patents

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Publication number
JP2022546040A5
JP2022546040A5 JP2022513127A JP2022513127A JP2022546040A5 JP 2022546040 A5 JP2022546040 A5 JP 2022546040A5 JP 2022513127 A JP2022513127 A JP 2022513127A JP 2022513127 A JP2022513127 A JP 2022513127A JP 2022546040 A5 JP2022546040 A5 JP 2022546040A5
Authority
JP
Japan
Prior art keywords
seq
dsrna
chain contains
optionally
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022513127A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022546040A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/073961 external-priority patent/WO2021037972A1/en
Publication of JP2022546040A publication Critical patent/JP2022546040A/ja
Publication of JP2022546040A5 publication Critical patent/JP2022546040A5/ja
Priority to JP2024180454A priority Critical patent/JP2025013845A/ja
Pending legal-status Critical Current

Links

JP2022513127A 2019-08-27 2020-08-27 Ｐｃｓｋ９を阻害するための組成物および方法 Pending JP2022546040A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024180454A JP2025013845A (ja) 2019-08-27 2024-10-16 Ｐｃｓｋ９を阻害するための組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19306036.5 2019-08-27
EP19306036 2019-08-27
PCT/EP2020/073961 WO2021037972A1 (en) 2019-08-27 2020-08-27 Compositions and methods for inhibiting pcsk9

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024180454A Division JP2025013845A (ja) 2019-08-27 2024-10-16 Ｐｃｓｋ９を阻害するための組成物および方法

Publications (2)

Publication Number Publication Date
JP2022546040A JP2022546040A (ja) 2022-11-02
JP2022546040A5 true JP2022546040A5 (enExample) 2023-09-04

Family

ID=67956661

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022513127A Pending JP2022546040A (ja) 2019-08-27 2020-08-27 Ｐｃｓｋ９を阻害するための組成物および方法
JP2024180454A Pending JP2025013845A (ja) 2019-08-27 2024-10-16 Ｐｃｓｋ９を阻害するための組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024180454A Pending JP2025013845A (ja) 2019-08-27 2024-10-16 Ｐｃｓｋ９を阻害するための組成物および方法

Country Status (5)

Country Link
US (1) US20220290156A1 (enExample)
EP (1) EP4022061A1 (enExample)
JP (2) JP2022546040A (enExample)
CN (1) CN115176011B (enExample)
WO (1) WO2021037972A1 (enExample)

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US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
CN113166760A (zh) 2018-11-23 2021-07-23 赛诺菲 用于抑制angptl8的新型rna组合物和方法
CN114728999A (zh) * 2019-09-05 2022-07-08 赛诺菲 含有核苷酸类似物的寡核苷酸
CN119451971A (zh) * 2022-06-27 2025-02-14 大睿生物医药科技(上海)有限公司 具有增强的稳定性的核苷酸替代物
WO2024073732A1 (en) 2022-09-30 2024-04-04 Alnylam Pharmaceuticals, Inc. Modified double-stranded rna agents
WO2024228030A2 (en) * 2023-05-04 2024-11-07 Argonaute RNA Limited Dual silencing
WO2024263915A2 (en) * 2023-06-21 2024-12-26 Sanegene Bio Usa Inc. Double stranded rna targeting proprotein convertase subtilisin kexin 9 (pcsk9) and methods of use thereof
WO2025077949A1 (zh) * 2023-11-06 2025-04-17 杭州天龙药业有限公司 提升双链寡核苷酸靶基因抑制效果的修饰模板及其组合与应用

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AR020078A1 (es) 1998-05-26 2002-04-10 Syngenta Participations Ag Metodo para alterar la expresion de un gen objetivo en una celula de planta
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JP5894913B2 (ja) * 2009-06-15 2016-03-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｐｃｓｋ９遺伝子を標的とする、脂質で製剤化されたｄｓｒｎａ
WO2013154766A1 (en) * 2012-04-13 2013-10-17 New York University Microrna control of ldl receptor pathway
IL292159B1 (en) * 2012-12-05 2026-04-01 Alnylam Pharmaceuticals Inc PCSK9 iRNA compositions and methods of using them
DK2992098T3 (da) 2013-05-01 2019-06-17 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
US11897911B2 (en) * 2018-03-07 2024-02-13 Sanofi Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
JP7357002B2 (ja) * 2018-04-18 2023-10-05 ディセルナ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症及び関連状態を治療するための、ｐｃｓｋ９を標的とするオリゴヌクレオチド

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