JP2022544946A5 - - Google Patents

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Publication number
JP2022544946A5
JP2022544946A5 JP2022509034A JP2022509034A JP2022544946A5 JP 2022544946 A5 JP2022544946 A5 JP 2022544946A5 JP 2022509034 A JP2022509034 A JP 2022509034A JP 2022509034 A JP2022509034 A JP 2022509034A JP 2022544946 A5 JP2022544946 A5 JP 2022544946A5
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JP
Japan
Prior art keywords
alkyl
halo
enantiomer
pharmaceutically acceptable
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022509034A
Other languages
English (en)
Japanese (ja)
Other versions
JP7638960B2 (ja
JP2022544946A (ja
Filing date
Publication date
Priority claimed from PCT/CN2019/100542 external-priority patent/WO2021026803A1/en
Application filed filed Critical
Publication of JP2022544946A publication Critical patent/JP2022544946A/ja
Publication of JP2022544946A5 publication Critical patent/JP2022544946A5/ja
Priority to JP2025024756A priority Critical patent/JP2025081505A/ja
Application granted granted Critical
Publication of JP7638960B2 publication Critical patent/JP7638960B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2022509034A 2019-08-14 2020-08-12 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン Active JP7638960B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025024756A JP2025081505A (ja) 2019-08-14 2025-02-19 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2019/100542 WO2021026803A1 (en) 2019-08-14 2019-08-14 Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents
CNPCT/CN2019/100542 2019-08-14
PCT/IB2020/057602 WO2021028854A1 (en) 2019-08-14 2020-08-12 Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025024756A Division JP2025081505A (ja) 2019-08-14 2025-02-19 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン

Publications (3)

Publication Number Publication Date
JP2022544946A JP2022544946A (ja) 2022-10-24
JP2022544946A5 true JP2022544946A5 (enExample) 2023-08-21
JP7638960B2 JP7638960B2 (ja) 2025-03-04

Family

ID=72145436

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022509034A Active JP7638960B2 (ja) 2019-08-14 2020-08-12 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン
JP2025024756A Pending JP2025081505A (ja) 2019-08-14 2025-02-19 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025024756A Pending JP2025081505A (ja) 2019-08-14 2025-02-19 Ｎｓｄ２阻害剤及び抗がん剤としてのピペリジニル－メチル－プリンアミン

Country Status (20)

Country Link
US (3) US11420970B1 (enExample)
EP (2) EP4559915A1 (enExample)
JP (2) JP7638960B2 (enExample)
KR (1) KR102946008B1 (enExample)
CN (1) CN114585622B (enExample)
AU (1) AU2020328919A1 (enExample)
BR (1) BR112022002520A2 (enExample)
CO (1) CO2022002804A2 (enExample)
DK (1) DK4013755T3 (enExample)
EC (1) ECSP22019360A (enExample)
ES (1) ES3023540T3 (enExample)
FI (1) FI4013755T3 (enExample)
IL (2) IL289754B2 (enExample)
MX (1) MX2022001784A (enExample)
MY (1) MY209614A (enExample)
PH (1) PH12022550343A1 (enExample)
PL (1) PL4013755T3 (enExample)
PT (1) PT4013755T (enExample)
WO (2) WO2021026803A1 (enExample)
ZA (1) ZA202200519B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021026803A1 (en) * 2019-08-14 2021-02-18 Novartis Ag Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents
ES2987269T3 (es) * 2019-09-20 2024-11-14 Novartis Ag Inhibidores de MLL1 y agentes anticancerígenos
KR20240158230A (ko) * 2022-01-05 2024-11-04 케이36 테라퓨틱스, 인크. 중수소-풍부 피페리디닐-메틸-퓨린 아민 및 관련 화합물 및 질환 및 병태 치료에 있어서 이것들의 용도
IL314895A (en) * 2022-02-16 2024-10-01 Duke Street Bio Ltd Pharmaceutical compound
IL316882A (en) * 2022-05-18 2025-01-01 K36 Therapeutics Inc Piperidinyl-methyl-purine amine D-tartaric acid salts, crystalline forms, and their use in the treatment of diseases and medical conditions
WO2023225150A1 (en) * 2022-05-18 2023-11-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine fumaric acid salts, crystalline forms, and their use in treating medical diseases and conditions
WO2023225144A1 (en) * 2022-05-18 2023-11-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine salts, crystalline forms, and their use in treating medical diseases and conditions
US20250326752A1 (en) * 2022-05-18 2025-10-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine salts, crystalline forms, and their use in treating medical diseases and conditions
WO2023230026A1 (en) * 2022-05-23 2023-11-30 K36 Therapeutics, Inc. Piperidinyl-methylpurine benzenes and related compounds and their use in treating diseases and conditions
WO2023230038A1 (en) * 2022-05-23 2023-11-30 K36 Therapeutics, Inc. Piperidinyl-methylpurine pyrimidines and related compounds and their use in treating diseases and conditions
WO2024073282A2 (en) * 2022-09-26 2024-04-04 Board Of Regents, The University Of Texas System Heterocycles as modulators of nsd activity
WO2024073283A1 (en) * 2022-09-26 2024-04-04 Board Of Regents, The University Of Texas System Heterocycles as modulators of nsd activity
WO2024129670A1 (en) * 2022-12-12 2024-06-20 K36 Therapeutics, Inc. Pharmaceutical compositions containing a piperidinyl-methyl-purine amine and their use in treating diseases and conditions
US20250171445A1 (en) * 2023-11-17 2025-05-29 K36 Therapeutics, Inc. Deuterium-enriched piperidinyl-methyl-purine amine salts, crystalline forms, and their use in treating medical diseases and conditions
CN117720550A (zh) * 2023-12-14 2024-03-19 深圳市华先医药科技有限公司 (s)-3-甲基-4-氧代-2-氧杂-8-氮杂螺[4.5]癸烷-8-甲酸叔丁酯合成方法
CN117843641B (zh) * 2023-12-28 2025-04-25 和径医药科技（上海）有限公司 Nsd3抑制剂及其制备方法和应用
WO2025147514A1 (en) * 2024-01-02 2025-07-10 K36 Therapeutics, Inc. Piperidinyl-methyl-purineamine nsd2 inhibitor therapeutic methods and compositions for treating cancer
CN118459395A (zh) * 2024-05-10 2024-08-09 南通大学 一种5-(叔丁氧羰基氨基)哌啶-3-羧酸甲酯的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4331944B2 (ja) * 2001-04-17 2009-09-16 大日本住友製薬株式会社 新規アデニン誘導体
US7332486B2 (en) * 2002-08-08 2008-02-19 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
KR101111085B1 (ko) * 2002-09-27 2012-04-12 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 아데닌 화합물 및 그 용도
JP2004137157A (ja) * 2002-10-16 2004-05-13 Sumitomo Pharmaceut Co Ltd 新規アデニン誘導体を有効成分として含有する医薬
JP2007269629A (ja) 2004-06-21 2007-10-18 Astellas Pharma Inc キナゾリン誘導体
AR065784A1 (es) 2007-03-20 2009-07-01 Dainippon Sumitomo Pharma Co Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
MX2012004706A (es) * 2009-10-22 2012-06-08 Gilead Sciences Inc Derivados de purina o deazapurina utiles para el tratamiento de (inter alia) infecciones virales.
GB201204985D0 (en) 2012-03-21 2012-05-02 Genentech Inc Compounds
WO2019196918A1 (zh) 2018-04-13 2019-10-17 罗欣药业(上海)有限公司 五元杂环并嘧啶类化合物、药物组合物及用途
CN109223794B (zh) * 2018-08-24 2020-07-28 江苏理工学院 一种化合物c6作为组蛋白甲基转移酶nsd3活性抑制剂及其应用
CN108853110B (zh) * 2018-08-24 2020-07-28 江苏理工学院 一种化合物a8作为组蛋白甲基转移酶nsd3活性抑制剂及其应用
WO2021026803A1 (en) * 2019-08-14 2021-02-18 Novartis Ag Piperidinyl-methyl-purineamines as nsd2 inhibitors and anti-cancer agents
KR20240158230A (ko) 2022-01-05 2024-11-04 케이36 테라퓨틱스, 인크. 중수소-풍부 피페리디닐-메틸-퓨린 아민 및 관련 화합물 및 질환 및 병태 치료에 있어서 이것들의 용도
WO2023225150A1 (en) 2022-05-18 2023-11-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine fumaric acid salts, crystalline forms, and their use in treating medical diseases and conditions
IL316882A (en) 2022-05-18 2025-01-01 K36 Therapeutics Inc Piperidinyl-methyl-purine amine D-tartaric acid salts, crystalline forms, and their use in the treatment of diseases and medical conditions
WO2023225144A1 (en) 2022-05-18 2023-11-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine salts, crystalline forms, and their use in treating medical diseases and conditions
US20250326752A1 (en) 2022-05-18 2025-10-23 K36 Therapeutics, Inc. Piperidinyl-methyl-purine amine salts, crystalline forms, and their use in treating medical diseases and conditions

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