JP2022544564A5 - - Google Patents
Info
- Publication number
- JP2022544564A5 JP2022544564A5 JP2022509137A JP2022509137A JP2022544564A5 JP 2022544564 A5 JP2022544564 A5 JP 2022544564A5 JP 2022509137 A JP2022509137 A JP 2022509137A JP 2022509137 A JP2022509137 A JP 2022509137A JP 2022544564 A5 JP2022544564 A5 JP 2022544564A5
- Authority
- JP
- Japan
- Prior art keywords
- opioid
- hexadienoneate
- methylhexadienoneate
- composition according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962885311P | 2019-08-11 | 2019-08-11 | |
| US62/885,311 | 2019-08-11 | ||
| US16/540,058 | 2019-08-14 | ||
| US16/540,058 US11186585B2 (en) | 2018-08-17 | 2019-08-14 | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
| PCT/US2020/021599 WO2021029914A1 (en) | 2019-08-11 | 2020-03-07 | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022544564A JP2022544564A (ja) | 2022-10-19 |
| JP2022544564A5 true JP2022544564A5 (https=) | 2023-03-15 |
| JP7535569B2 JP7535569B2 (ja) | 2024-08-16 |
Family
ID=74571142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022509137A Active JP7535569B2 (ja) | 2019-08-11 | 2020-03-07 | オピオイドヘキサジエノエート及び選択的に置換されたヘキサジエノエートによってオピオイド受容体の結合を改善する組成物並びに方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4010078A4 (https=) |
| JP (1) | JP7535569B2 (https=) |
| CN (1) | CN114828961B (https=) |
| CA (1) | CA3149152A1 (https=) |
| MX (1) | MX2022001520A (https=) |
| WO (1) | WO2021029914A1 (https=) |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| EP0615756B1 (en) * | 1993-03-15 | 2001-06-27 | National Science Council | Nalbuphine esters and long-acting pharmaceutical compositions containing them |
| CN1050130C (zh) | 1997-07-04 | 2000-03-08 | 卢正堂 | 纳洛酮酸脂和纳屈酮酸脂及系列物和制备方法 |
| DE60001487T2 (de) | 2000-04-27 | 2003-12-24 | Oliver Yoa-Pu Hu | Polynalbuphinderivat |
| TWI226239B (en) | 2000-05-15 | 2005-01-11 | You-Pu Hu | Novel oral pharmaceutical composition containing nalbuphine ester prodrug |
| EP1309354A2 (en) | 2000-07-27 | 2003-05-14 | Rutgers, The State University | Therapeutic polyesters and polyamides |
| US6569449B1 (en) * | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| WO2005009377A2 (en) | 2003-07-23 | 2005-02-03 | University Of Kentucky Research Foundation | Novel oral bioavailable prodrugs |
| US20050137141A1 (en) | 2003-10-24 | 2005-06-23 | John Hilfinger | Prodrug composition |
| US8163701B2 (en) | 2005-08-19 | 2012-04-24 | Signature Therapeutics, Inc. | Prodrugs of active agents |
| US20090192095A1 (en) | 2008-01-18 | 2009-07-30 | Shire Llc | Amino acid and peptide prodrugs of opioid analgesics with reduced gi side-effects |
| BRPI1015108A2 (pt) | 2009-04-02 | 2016-04-26 | Shire Llc | pró-fármacos de aminoácidos e peptídios ligados a ácido dicarboxílico de opiáceos e seus usos |
| WO2011007247A1 (en) | 2009-07-17 | 2011-01-20 | Llc Shire | Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof |
| MX2012000980A (es) | 2009-07-21 | 2012-06-12 | Nektar Therapeutics | Conjugados de agonistas de oligómeros-opioides. |
| US20110190267A1 (en) * | 2010-01-05 | 2011-08-04 | Shire Pharmaceuticals, Inc. | Prodrugs of opioids and uses thereof |
| US8461171B2 (en) | 2010-02-09 | 2013-06-11 | QRxPharma Ltd. | Hybrid opioid compounds and compositions |
| CA2795156C (en) * | 2010-04-02 | 2019-05-14 | Alltranz Inc. | Transdermally deliverable opioid prodrugs, abuse-resistant compositions and methods of using opioid prodrugs |
| EP2658523A1 (en) | 2010-12-28 | 2013-11-06 | Euro-Celtique S.A. | A combination of an opioid agonist and an opioid antagonist in the treatment of parkinson's disease |
| US10017519B2 (en) * | 2015-04-27 | 2018-07-10 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof |
| US10449190B2 (en) | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
| US9987269B2 (en) | 2015-04-27 | 2018-06-05 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of oxymorphone and uses thereof |
| CN107427509B (zh) * | 2015-08-29 | 2021-06-15 | 美德阿利克斯株式会社 | 含有碱性药物和山梨酸的经皮吸收组成物 |
| US12590065B2 (en) | 2017-04-14 | 2026-03-31 | Zevra Therapeutics, Inc. | Levorphanol prodrugs and processes for making and using them |
| US11186585B2 (en) * | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
-
2020
- 2020-03-07 CA CA3149152A patent/CA3149152A1/en active Pending
- 2020-03-07 JP JP2022509137A patent/JP7535569B2/ja active Active
- 2020-03-07 EP EP20852037.9A patent/EP4010078A4/en active Pending
- 2020-03-07 WO PCT/US2020/021599 patent/WO2021029914A1/en not_active Ceased
- 2020-03-07 MX MX2022001520A patent/MX2022001520A/es unknown
- 2020-03-07 CN CN202080071185.9A patent/CN114828961B/zh active Active
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