JP2022543419A5 - - Google Patents

Info

Publication number
JP2022543419A5
JP2022543419A5 JP2022506947A JP2022506947A JP2022543419A5 JP 2022543419 A5 JP2022543419 A5 JP 2022543419A5 JP 2022506947 A JP2022506947 A JP 2022506947A JP 2022506947 A JP2022506947 A JP 2022506947A JP 2022543419 A5 JP2022543419 A5 JP 2022543419A5
Authority
JP
Japan
Prior art keywords
compound
salt
acid
solvent
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022506947A
Other languages
English (en)
Japanese (ja)
Other versions
JP7626751B2 (ja
JP2022543419A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/044921 external-priority patent/WO2021026182A1/en
Publication of JP2022543419A publication Critical patent/JP2022543419A/ja
Publication of JP2022543419A5 publication Critical patent/JP2022543419A5/ja
Application granted granted Critical
Publication of JP7626751B2 publication Critical patent/JP7626751B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022506947A 2019-08-06 2020-08-05 血漿カリクレイン阻害剤のプロセス規模合成 Active JP7626751B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962883396P 2019-08-06 2019-08-06
US62/883,396 2019-08-06
PCT/US2020/044921 WO2021026182A1 (en) 2019-08-06 2020-08-05 Process-scale synthesis of a plasma kallikrein inhibitor

Publications (3)

Publication Number Publication Date
JP2022543419A JP2022543419A (ja) 2022-10-12
JP2022543419A5 true JP2022543419A5 (https=) 2023-08-08
JP7626751B2 JP7626751B2 (ja) 2025-02-04

Family

ID=74504082

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022506947A Active JP7626751B2 (ja) 2019-08-06 2020-08-05 血漿カリクレイン阻害剤のプロセス規模合成

Country Status (26)

Country Link
US (1) US12503443B2 (https=)
EP (1) EP4010320A4 (https=)
JP (1) JP7626751B2 (https=)
KR (1) KR102928815B1 (https=)
CN (1) CN114206839B (https=)
AR (1) AR119617A1 (https=)
AU (1) AU2020324422B2 (https=)
BR (1) BR112022002060A2 (https=)
CA (1) CA3149176A1 (https=)
CL (2) CL2022000264A1 (https=)
CO (1) CO2022002392A2 (https=)
CR (1) CR20220092A (https=)
DO (1) DOP2022000027A (https=)
EC (1) ECSP22016209A (https=)
GE (2) GEAP202515893A (https=)
IL (1) IL290113B2 (https=)
JO (1) JOP20220021A1 (https=)
MX (1) MX2022001608A (https=)
PE (1) PE20221009A1 (https=)
PH (1) PH12022550221A1 (https=)
PY (1) PY2042865A (https=)
TN (1) TN2022000028A1 (https=)
TW (1) TWI881995B (https=)
UA (1) UA130182C2 (https=)
UY (1) UY38826A (https=)
WO (1) WO2021026182A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102736869B1 (ko) 2014-03-07 2024-12-02 바이오크리스트파마슈티컬즈,인코포레이티드 인간 혈장 칼리크레인 저해제
UY38438A (es) 2018-11-02 2020-05-29 Biocryst Pharm Inc Sales cristalinas de un inhibidor de calicreína plasmática
CN114206839B (zh) 2019-08-06 2025-03-07 拜奥克里斯特制药公司 血浆激肽释放酶抑制剂的生产规模合成
CN116375648A (zh) * 2023-03-22 2023-07-04 苏州农平科技发展有限公司 贝罗司他中间体的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
LU86084A1 (fr) 1985-09-20 1987-04-02 Faco Sa Apparei de massage electrique
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO1990013332A1 (en) 1989-05-11 1990-11-15 Cedars-Sinai Medical Center Stent with sustained drug delivery
DE69110787T2 (de) 1990-02-28 1996-04-04 Medtronic, Inc., Minneapolis, Minn. Intraluminale prothese mit wirkstoffeluierung.
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
DE60034447T2 (de) 2000-08-11 2008-02-14 Wilex Ag Nicht-kovalente Urokinase-und Angiogenese-Inhibitoren
US7038057B2 (en) * 2001-08-13 2006-05-02 E.I. Du Pont De Nemours And Company Substituted 1H-dihydropyrazoles, their preparation and use
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
MX2011006319A (es) * 2008-12-18 2011-06-24 Bayer Cropscience Ag Amidas del acido antranilico sustituidas con tetrazol como plaguicidas.
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
EP2909181B1 (en) 2012-10-16 2017-08-09 Tolero Pharmaceuticals, Inc. Pkm2 modulators and methods for their use
KR102736869B1 (ko) 2014-03-07 2024-12-02 바이오크리스트파마슈티컬즈,인코포레이티드 인간 혈장 칼리크레인 저해제
CN114206839B (zh) 2019-08-06 2025-03-07 拜奥克里斯特制药公司 血浆激肽释放酶抑制剂的生产规模合成

Similar Documents

Publication Publication Date Title
JP2022543419A5 (https=)
EP2128130B1 (en) Process for production of precursor compound for radioactive halogen-labeled organic compound
US9447141B2 (en) Process for the preparation of sterol derivatives
RU2012150753A (ru) Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP2023537397A5 (https=)
US7714115B2 (en) Method of deprotection
Kaźmierczak et al. Diethylaminosulfur trifluoride (DAST) mediated transformations leading to valuable building blocks and bioactive compounds
US20050261211A1 (en) Process for preparing substituted benzimidazole compounds
JP2024524215A5 (https=)
JP2002114801A (ja) 多糖類誘導体の製造法
US11339129B2 (en) Triazabutadienes as cleavable cross-linkers
EP2450343A1 (en) Method for producing threo-3-(3,4-dihydroxyphenyl)-l-serine
FONG et al. Synthesis and α-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives
TH2201000659A (th) การสังเคราะห์ระดับกระบวนการของสารยับยั้งพลาสมาคัลลิครีอิน
US20210300896A1 (en) Method for producing optically active pyrrolidine compounds
CA2641542A1 (en) Improved process for producing nitroisourea derivatives
ES2425477T3 (es) Compuesto para preparar tiazol mediante aminometilación
JP2002514654A5 (https=)
JPH05148288A (ja) 新規ベタイン化糖化合物
EP3819285B1 (en) 4-alkoxy-3-(trifluoromethyl)benzyl alcohol production method
CN113024405A (zh) 一种新的拉考沙胺杂质及其制备方法和用途
SG194544A1 (en) Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
WO2013008091A1 (en) Manufacturing of epothilone derivatives and the use thereof
ES2165047T3 (es) Procedimiento quimico mejorado para preparar derivados de amida del antibiotico a 40926.
US20220185794A1 (en) Process for preparing osimertinib or a salt thereof