JP2022543191A - 増強された生理活性を有する多量体オリゴヌクレオチドの皮下送達 - Google Patents

増強された生理活性を有する多量体オリゴヌクレオチドの皮下送達 Download PDF

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JP2022543191A
JP2022543191A JP2022502227A JP2022502227A JP2022543191A JP 2022543191 A JP2022543191 A JP 2022543191A JP 2022502227 A JP2022502227 A JP 2022502227A JP 2022502227 A JP2022502227 A JP 2022502227A JP 2022543191 A JP2022543191 A JP 2022543191A
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oligonucleotide
subunits
multimeric oligonucleotide
multimeric
subunit
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JP2022543191A5 (https=
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ジョナサン マイルズ ブラウン
クリスティン ケイ．エイチ． ニューマン
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エムペグ エルエイ リミテッド ライアビリティ カンパニー
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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JP2022502227A 2019-07-30 2020-07-29 増強された生理活性を有する多量体オリゴヌクレオチドの皮下送達 Withdrawn JP2022543191A (ja)

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US201962880591P 2019-07-30 2019-07-30
US62/880,591 2019-07-30
PCT/US2020/044110 WO2021021959A2 (en) 2019-07-30 2020-07-29 Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity

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JP2022543191A true JP2022543191A (ja) 2022-10-11
JP2022543191A5 JP2022543191A5 (https=) 2023-08-07
JPWO2021021959A5 JPWO2021021959A5 (https=) 2023-08-07

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US (1) US20230114023A1 (https=)
EP (1) EP4004205A4 (https=)
JP (1) JP2022543191A (https=)
CN (1) CN114466929A (https=)
AU (1) AU2020319911A1 (https=)
CA (1) CA3144467A1 (https=)
IL (1) IL289801A (https=)
WO (1) WO2021021959A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025100427A1 (ja) * 2023-11-06 2025-05-15 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防および／または治療用医薬

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101141544B1 (ko) 2009-03-13 2012-05-03 한국과학기술원 에스아이알엔에이 다중 접합체 및 이의 제조방법
IL316159A (en) 2015-06-15 2024-12-01 Mpeg La Llc Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
EP3576752A4 (en) 2017-02-06 2020-12-16 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE
US20230372508A1 (en) * 2022-05-19 2023-11-23 Olix Us, Inc. Linkers coupling functional ligands to macromolecules

Family Cites Families (7)

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US20060035815A1 (en) * 2004-05-04 2006-02-16 Nastech Pharmaceutical Company Inc. Pharmaceutical compositions for delivery of ribonucleic acid to a cell
DK2539451T3 (da) * 2010-02-24 2016-04-04 Arrowhead Res Corp Sammensætninger til målrettet tilførsel af siRNA
EP2895200B1 (en) * 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds
US10077443B2 (en) * 2012-11-15 2018-09-18 Roche Innovation Center Copenhagen A/S Oligonucleotide conjugates
CN104955952A (zh) * 2013-01-30 2015-09-30 弗·哈夫曼-拉罗切有限公司 Lna寡核苷酸碳水化合物缀合物
IL316159A (en) * 2015-06-15 2024-12-01 Mpeg La Llc Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
EP3576752A4 (en) * 2017-02-06 2020-12-16 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025100427A1 (ja) * 2023-11-06 2025-05-15 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防および／または治療用医薬

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EP4004205A4 (en) 2023-11-08
AU2020319911A1 (en) 2022-02-24
US20230114023A1 (en) 2023-04-13
WO2021021959A2 (en) 2021-02-04
CN114466929A (zh) 2022-05-10
CA3144467A1 (en) 2021-02-04
EP4004205A2 (en) 2022-06-01
WO2021021959A3 (en) 2021-03-04
IL289801A (en) 2022-03-01

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