CN114466929A - 具有增强的生物活性的多聚体寡核苷酸的皮下递送 - Google Patents

具有增强的生物活性的多聚体寡核苷酸的皮下递送 Download PDF

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Publication number
CN114466929A
CN114466929A CN202080068000.9A CN202080068000A CN114466929A CN 114466929 A CN114466929 A CN 114466929A CN 202080068000 A CN202080068000 A CN 202080068000A CN 114466929 A CN114466929 A CN 114466929A
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oligonucleotide
multimeric oligonucleotide
subunits
multimeric
subunit
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CN202080068000.9A
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Chinese (zh)
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J·M·布朗
K·K·H·纽曼
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MPEG LA LLC
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MPEG LA LLC
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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CN202080068000.9A 2019-07-30 2020-07-29 具有增强的生物活性的多聚体寡核苷酸的皮下递送 Pending CN114466929A (zh)

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US201962880591P 2019-07-30 2019-07-30
US62/880,591 2019-07-30
PCT/US2020/044110 WO2021021959A2 (en) 2019-07-30 2020-07-29 Subcutaneous delivery of multimeric oligonucleotides with enhanced bioactivity

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US (1) US20230114023A1 (https=)
EP (1) EP4004205A4 (https=)
JP (1) JP2022543191A (https=)
CN (1) CN114466929A (https=)
AU (1) AU2020319911A1 (https=)
CA (1) CA3144467A1 (https=)
IL (1) IL289801A (https=)
WO (1) WO2021021959A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11859184B2 (en) 2009-03-13 2024-01-02 Kip Co., Ltd. Multi-conjugate of siRNA and preparing method thereof

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Publication number Priority date Publication date Assignee Title
IL316159A (en) 2015-06-15 2024-12-01 Mpeg La Llc Defined Oligonucleotide Multimers and Methods for Manufacture Thereof
EP3576752A4 (en) 2017-02-06 2020-12-16 Mpeg La, LLC MULTIMERIC OLIGONUCLEOTIDES WITH REDUCED RENAL CLEARANCE
US20230372508A1 (en) * 2022-05-19 2023-11-23 Olix Us, Inc. Linkers coupling functional ligands to macromolecules
WO2025100427A1 (ja) * 2023-11-06 2025-05-15 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防および／または治療用医薬

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CN101263230A (zh) * 2005-09-08 2008-09-10 纳斯泰克制药公司 递送核糖核酸至细胞的药物组合物
CN104837996A (zh) * 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 抗apob反义缀合物化合物
CN104955952A (zh) * 2013-01-30 2015-09-30 弗·哈夫曼-拉罗切有限公司 Lna寡核苷酸碳水化合物缀合物
CN108026527A (zh) * 2015-06-15 2018-05-11 Mpeg La有限责任公司 确定的多偶联寡核苷酸
WO2018145086A1 (en) * 2017-02-06 2018-08-09 Mpeg La, Llc Multimeric oligonucleotides having decreased kidney clearance

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EP2895200B1 (en) * 2012-09-14 2019-11-06 Translate Bio MA, Inc. Multimeric oligonucleotide compounds

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CN104837996A (zh) * 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 抗apob反义缀合物化合物
CN104884618A (zh) * 2012-11-15 2015-09-02 罗氏创新中心哥本哈根有限公司 寡核苷酸缀合物
CN104955952A (zh) * 2013-01-30 2015-09-30 弗·哈夫曼-拉罗切有限公司 Lna寡核苷酸碳水化合物缀合物
CN108026527A (zh) * 2015-06-15 2018-05-11 Mpeg La有限责任公司 确定的多偶联寡核苷酸
WO2018145086A1 (en) * 2017-02-06 2018-08-09 Mpeg La, Llc Multimeric oligonucleotides having decreased kidney clearance

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SERGEY NECHAEV等: "Intracellular processing of immunostimulatory CpG-siRNA: Tolllike receptor 9 facilitates siRNA dicing and endosomal escape", J CONTROL RELEASE, vol. 170, no. 3, 28 September 2013 (2013-09-28), pages 307 - 315, XP093087392, DOI: 10.1016/j.jconrel.2013.06.007 *
TAMAKI ENDOH等: "Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape", ADVANCED DRUG DELIVERY REVIEWS, vol. 61, 19 April 2009 (2009-04-19), pages 704 - 709, XP026142659, DOI: 10.1016/j.addr.2009.04.005 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11859184B2 (en) 2009-03-13 2024-01-02 Kip Co., Ltd. Multi-conjugate of siRNA and preparing method thereof

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EP4004205A4 (en) 2023-11-08
AU2020319911A1 (en) 2022-02-24
JP2022543191A (ja) 2022-10-11
US20230114023A1 (en) 2023-04-13
WO2021021959A2 (en) 2021-02-04
CA3144467A1 (en) 2021-02-04
EP4004205A2 (en) 2022-06-01
WO2021021959A3 (en) 2021-03-04
IL289801A (en) 2022-03-01

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