JP2022541435A - クローディン18抗体及びがんを処置する方法 - Google Patents

クローディン18抗体及びがんを処置する方法 Download PDF

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JP2022541435A
JP2022541435A JP2022502205A JP2022502205A JP2022541435A JP 2022541435 A JP2022541435 A JP 2022541435A JP 2022502205 A JP2022502205 A JP 2022502205A JP 2022502205 A JP2022502205 A JP 2022502205A JP 2022541435 A JP2022541435 A JP 2022541435A
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seq
antigen binding
nos
binding protein
amino acid
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JP2022541435A5 (enExample
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コンクリン,ディラン
マクダーモット,マルティナ,エス.
オブライエン,ニール,エー.
パラッツォーロ,マイケル,ジェイ.
スレイモン,デニス
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • GPHYSICS
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    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
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    • C07K16/2809Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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JP2022502205A 2019-07-17 2020-07-17 クローディン18抗体及びがんを処置する方法 Pending JP2022541435A (ja)

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US201962875416P 2019-07-17 2019-07-17
US62/875,416 2019-07-17
PCT/US2020/042573 WO2021011885A1 (en) 2019-07-17 2020-07-17 Claudin18 antibodies and methods of treating cancer

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AU (2) AU2020313978B2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025206223A1 (ja) * 2024-03-28 2025-10-02 早智子 月田 抗ヒトクローディン18.2抗体及びその使用

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202108398YA (en) 2019-02-01 2021-08-30 Novarock Biotherapeutics Ltd Anti-claudin 18 antibodies and methods of use thereof
KR102777693B1 (ko) 2019-07-17 2025-03-07 더 리전트 오브 더 유니버시티 오브 캘리포니아 Claudin18 항체 및 암 치료 방법
AU2021354827A1 (en) * 2020-09-30 2023-06-01 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition
US11739144B2 (en) 2021-03-09 2023-08-29 Xencor, Inc. Heterodimeric antibodies that bind CD3 and CLDN6
AU2022275043B2 (en) 2021-05-08 2025-11-20 Remegen Co., Ltd. Anti-Claudin 18.2 antibody and antibody-drug conjugate thereof
WO2022266219A1 (en) * 2021-06-15 2022-12-22 Xencor, Inc. Heterodimeric antibodies that bind claudin18.2 and cd3
WO2022268200A1 (zh) * 2021-06-25 2022-12-29 信达生物制药(苏州)有限公司 针对密蛋白18.2的抗体及其用途
IL310578A (en) * 2021-08-09 2024-03-01 Harbour Biomed Shanghai Co Ltd Cldn18.2-targeting antibody, bispecific antibody and use thereof
JP2024540062A (ja) * 2021-11-05 2024-10-31 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 抗cldn18.2抗体及びその用途
WO2023196742A1 (en) * 2022-04-08 2023-10-12 Fred Hutchinson Cancer Center Anti-cd90 antibodies, binding fragments, and uses thereof
CN119894929A (zh) * 2022-06-03 2025-04-25 礼新医药科技(上海)有限公司 使用PD-1或PD-L1抑制剂和靶向Claudin 18.2的抗体药物偶联物的癌症治疗
WO2024114667A1 (zh) * 2022-11-30 2024-06-06 正大天晴药业集团股份有限公司 抗cldn18.2抗体药物偶联物及其药物组合物和用途
JP2026501506A (ja) * 2022-12-14 2026-01-16 アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ Cldn18.2及びcd3に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法
WO2024226646A2 (en) * 2023-04-25 2024-10-31 Memorial Sloan-Kettering Cancer Center Dlk1 -targeting antibodies and uses thereof
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025078686A1 (en) 2023-10-12 2025-04-17 Sotio Biotech A.S. Combination therapy involving antibody-drug conjugates against claudin18.2 and pd1/pd-l axis inhibitors for treatment of cancer
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
KR20250154059A (ko) 2024-04-19 2025-10-28 강원대학교산학협력단 Cldn18 단백질 또는 이를 코딩하는 유전자, 또는 프로모터 부위가 메틸화된 cldn18을 유효성분으로 포함하는 폐포 내 미세먼지 노출 진단용 바이오마커 조성물
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ras抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010528075A (ja) * 2007-05-29 2010-08-19 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン18に対するモノクローナル抗体
JP2016517447A (ja) * 2013-03-18 2016-06-16 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン18.2に対する抗体を含む治療法
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
WO2018054484A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
KR20190038564A (ko) * 2016-07-08 2019-04-08 카르스젠 테라퓨틱스 컴퍼니, 리미티드 항클라우딘 18a2의 항체 및 이의 응용
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202007055QA (en) * 2018-03-08 2020-09-29 Phanes Therapeutics Inc Anti-claudin 18.2 antibodies and uses thereof
WO2020025792A1 (en) * 2018-08-03 2020-02-06 Amgen Research (Munich) Gmbh Antibody constructs for cldn18.2 and cd3
KR102777693B1 (ko) 2019-07-17 2025-03-07 더 리전트 오브 더 유니버시티 오브 캘리포니아 Claudin18 항체 및 암 치료 방법

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010528075A (ja) * 2007-05-29 2010-08-19 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン18に対するモノクローナル抗体
JP2016517447A (ja) * 2013-03-18 2016-06-16 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン18.2に対する抗体を含む治療法
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
KR20190038564A (ko) * 2016-07-08 2019-04-08 카르스젠 테라퓨틱스 컴퍼니, 리미티드 항클라우딘 18a2의 항체 및 이의 응용
WO2018054484A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
WO2018054973A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF HEMATOLOGY AND ONCOLOGY, vol. 10, no. 105, JPN6023039208, 2017, pages 1 - 5, ISSN: 0005361203 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025206223A1 (ja) * 2024-03-28 2025-10-02 早智子 月田 抗ヒトクローディン18.2抗体及びその使用

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