JP2022541435A - クローディン１８抗体及びがんを処置する方法 - Google Patents

クローディン１８抗体及びがんを処置する方法 Download PDF

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JP2022541435A
JP2022541435A JP2022502205A JP2022502205A JP2022541435A JP 2022541435 A JP2022541435 A JP 2022541435A JP 2022502205 A JP2022502205 A JP 2022502205A JP 2022502205 A JP2022502205 A JP 2022502205A JP 2022541435 A JP2022541435 A JP 2022541435A
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seq
antigen binding
nos
binding protein
amino acid
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JP2022541435A5 (enExample
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コンクリン，ディラン
マクダーモット，マルティナ，エス．
オブライエン，ニール，エー．
パラッツォーロ，マイケル，ジェイ．
スレイモン，デニス
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University of California, San Diego
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University of California, San Diego
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C07K—PEPTIDES
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    • C07K—PEPTIDES
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2022502205A 2019-07-17 2020-07-17 クローディン１８抗体及びがんを処置する方法 Pending JP2022541435A (ja)

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US201962875416P 2019-07-17 2019-07-17
US62/875,416 2019-07-17
PCT/US2020/042573 WO2021011885A1 (en) 2019-07-17 2020-07-17 Claudin18 antibodies and methods of treating cancer

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CN (1) CN114364701A (enExample)
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Cited By (1)

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WO2025206223A1 (ja) * 2024-03-28 2025-10-02 早智子 月田 抗ヒトクローディン１８．２抗体及びその使用

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JP7840511B2 (ja) 2019-02-01 2026-04-06 石▲薬▼集▲団▼巨石生物制▲薬▼有限公司 抗クローディン１８抗体及びそれらの使用の方法
CN114364701A (zh) 2019-07-17 2022-04-15 加利福尼亚大学董事会 密封蛋白18抗体和治疗癌症的方法
AU2021354827A1 (en) * 2020-09-30 2023-06-01 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition
EP4305067A1 (en) 2021-03-09 2024-01-17 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
EP4335873A4 (en) * 2021-05-08 2025-03-19 RemeGen Co., Ltd. ANTI-CLAUDIN 18.2 ANTIBODY AND ANTIBODY-DRUG CONJUGATE THEREOF
JP7901102B2 (ja) * 2021-06-15 2026-08-05 ゼンコア インコーポレイテッド クローディン１８．２及びｃｄ３に結合するヘテロ二量体抗体
WO2022268200A1 (zh) * 2021-06-25 2022-12-29 信达生物制药(苏州)有限公司 针对密蛋白18.2的抗体及其用途
KR20240044467A (ko) * 2021-08-09 2024-04-04 하버 바이오메드 (상하이) 컴퍼니 리미티드 Cldn18.2-표적화 항체, 이중특이적 항체, 및 이들의 용도
WO2023078386A1 (zh) * 2021-11-05 2023-05-11 正大天晴药业集团股份有限公司 抗cldn18.2抗体及其用途
WO2023196742A1 (en) * 2022-04-08 2023-10-12 Fred Hutchinson Cancer Center Anti-cd90 antibodies, binding fragments, and uses thereof
KR20250069817A (ko) * 2022-06-03 2025-05-20 라노바 메디신즈 리미티드 Pd-1 또는 pd-l1 억제제 및 클라우딘 18.2를 표적화하는 항체-약물 콘쥬게이트를 사용한 암 치료
IL321037A (en) * 2022-11-30 2025-07-01 Shanghai Chia Tai Tianqing Pharmaceutical Tech Development Co Ltd Anti-cldn18.2 antibody-drug conjugate, and pharmaceutical composition thereof and use thereof
JP2026501506A (ja) * 2022-12-14 2026-01-16 アステラス・ファーマ・ヨーロッパ・ベスローデン・フェンノートシャップ Ｃｌｄｎ１８．２及びｃｄ３に結合する二重特異性結合剤並びに免疫チェックポイント阻害剤を含む併用療法
WO2024226646A2 (en) * 2023-04-25 2024-10-31 Memorial Sloan-Kettering Cancer Center Dlk1 -targeting antibodies and uses thereof
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025078686A1 (en) 2023-10-12 2025-04-17 Sotio Biotech A.S. Combination therapy involving antibody-drug conjugates against claudin18.2 and pd1/pd-l axis inhibitors for treatment of cancer
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
KR20250154059A (ko) 2024-04-19 2025-10-28 강원대학교산학협력단 Cldn18 단백질 또는 이를 코딩하는 유전자, 또는 프로모터 부위가 메틸화된 cldn18을 유효성분으로 포함하는 폐포 내 미세먼지 노출 진단용 바이오마커 조성물
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
WO2026090116A2 (en) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Ras inhibitors
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090245A1 (en) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Use of ras inhibitors for treating cancer
WO2026106912A1 (en) 2024-11-12 2026-05-21 Revolution Medicines, Inc. Ras inhibitors
WO2026112260A1 (en) 2024-11-21 2026-05-28 Revolution Medicines, Inc. Ras inhibitors
WO2026122764A2 (en) 2024-12-06 2026-06-11 Revolution Medicines, Inc. Ras inhibitors
WO2026128688A2 (en) 2024-12-13 2026-06-18 Revolution Medicines, Inc. Ras inhibitors
WO2026161839A1 (en) 2025-01-27 2026-07-30 Revolution Medicines, Inc. Ras inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010528075A (ja) * 2007-05-29 2010-08-19 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン１８に対するモノクローナル抗体
JP2016517447A (ja) * 2013-03-18 2016-06-16 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン１８．２に対する抗体を含む治療法
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
WO2018054484A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
KR20190038564A (ko) * 2016-07-08 2019-04-08 카르스젠 테라퓨틱스 컴퍼니, 리미티드 항클라우딘 18a2의 항체 및 이의 응용
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020009326A (es) * 2018-03-08 2020-10-08 Phanes Therapeutics Inc Anticuerpos anti-claudina 18.2 y usos de los mismos.
BR112021002032A2 (pt) * 2018-08-03 2021-07-20 Amgen Research (Munich) Gmbh construtos de anticorpos para cldn18.2 e cd3
CN114364701A (zh) 2019-07-17 2022-04-15 加利福尼亚大学董事会 密封蛋白18抗体和治疗癌症的方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010528075A (ja) * 2007-05-29 2010-08-19 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン１８に対するモノクローナル抗体
JP2016517447A (ja) * 2013-03-18 2016-06-16 ガニメド ファーマシューティカルズ アーゲー 癌の治療のためのクローディン１８．２に対する抗体を含む治療法
WO2016165762A1 (en) * 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Drug conjugates comprising antibodies against claudin 18.2
KR20190038564A (ko) * 2016-07-08 2019-04-08 카르스젠 테라퓨틱스 컴퍼니, 리미티드 항클라우딘 18a2의 항체 및 이의 응용
WO2018054484A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
WO2018054973A1 (en) * 2016-09-23 2018-03-29 Biontech Ag Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
CN109762067A (zh) * 2019-01-17 2019-05-17 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF HEMATOLOGY AND ONCOLOGY, vol. 10, no. 105, JPN6023039208, 2017, pages 1 - 5, ISSN: 0005361203 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025206223A1 (ja) * 2024-03-28 2025-10-02 早智子 月田 抗ヒトクローディン１８．２抗体及びその使用

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