JP2022539089A5 - - Google Patents

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Publication number
JP2022539089A5
JP2022539089A5 JP2021577003A JP2021577003A JP2022539089A5 JP 2022539089 A5 JP2022539089 A5 JP 2022539089A5 JP 2021577003 A JP2021577003 A JP 2021577003A JP 2021577003 A JP2021577003 A JP 2021577003A JP 2022539089 A5 JP2022539089 A5 JP 2022539089A5
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JP
Japan
Prior art keywords
mol
alkyl
present
amount
alkyl groups
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2021577003A
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English (en)
Japanese (ja)
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JP2022539089A (ja
JP7420841B2 (ja
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Application filed filed Critical
Priority claimed from PCT/CA2020/050897 external-priority patent/WO2021000041A1/en
Publication of JP2022539089A publication Critical patent/JP2022539089A/ja
Publication of JP2022539089A5 publication Critical patent/JP2022539089A5/ja
Priority to JP2024002304A priority Critical patent/JP7667327B2/ja
Application granted granted Critical
Publication of JP7420841B2 publication Critical patent/JP7420841B2/ja
Priority to JP2025065109A priority patent/JP2025105627A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2021577003A 2019-06-29 2020-06-26 核酸送達のためのイオン化可能な脂質 Active JP7420841B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024002304A JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質
JP2025065109A JP2025105627A (ja) 2019-06-29 2025-04-10 核酸送達のためのイオン化可能な脂質

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962868900P 2019-06-29 2019-06-29
US62/868,900 2019-06-29
US202063009042P 2020-04-13 2020-04-13
US63/009,042 2020-04-13
PCT/CA2020/050897 WO2021000041A1 (en) 2019-06-29 2020-06-26 Ionizable lipids for nucleic acid delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024002304A Division JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質

Publications (3)

Publication Number Publication Date
JP2022539089A JP2022539089A (ja) 2022-09-07
JP2022539089A5 true JP2022539089A5 (enExample) 2023-07-04
JP7420841B2 JP7420841B2 (ja) 2024-01-23

Family

ID=74100092

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021577003A Active JP7420841B2 (ja) 2019-06-29 2020-06-26 核酸送達のためのイオン化可能な脂質
JP2024002304A Active JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質
JP2025065109A Pending JP2025105627A (ja) 2019-06-29 2025-04-10 核酸送達のためのイオン化可能な脂質

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2024002304A Active JP7667327B2 (ja) 2019-06-29 2024-01-11 核酸送達のためのイオン化可能な脂質
JP2025065109A Pending JP2025105627A (ja) 2019-06-29 2025-04-10 核酸送達のためのイオン化可能な脂質

Country Status (7)

Country Link
US (1) US20220378917A1 (enExample)
EP (1) EP3990441A4 (enExample)
JP (3) JP7420841B2 (enExample)
KR (2) KR102928289B1 (enExample)
CN (1) CN115279743B (enExample)
CA (1) CA3143578A1 (enExample)
WO (1) WO2021000041A1 (enExample)

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HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
CA3112837A1 (en) * 2018-10-19 2020-04-23 Translate Bio, Inc. Pumpless encapsulation of messenger rna
CZ310613B6 (cs) * 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
WO2022115645A1 (en) 2020-11-25 2022-06-02 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
CN112961065B (zh) * 2021-02-05 2023-03-14 嘉晨西海(杭州)生物技术有限公司 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用
CN113993839B (zh) * 2021-02-05 2024-02-09 嘉晨西海(杭州)生物技术有限公司 一种可离子化脂质分子、其制备方法及其在制备脂质纳米颗粒中的应用
CN114149337B (zh) * 2021-07-07 2022-04-29 天津键凯科技有限公司 一种用于核酸递送的新型可电离脂质及其lnp组合物
EP4379055A4 (en) 2021-07-27 2025-08-06 Sk Bioscience Co Ltd MRNA FOR PROTEIN EXPRESSION AND TEMPLATE FOR IT
CN118317944A (zh) 2021-09-14 2024-07-09 雷纳嘉德医疗管理公司 非环状脂质及其使用方法
TW202328067A (zh) 2021-09-14 2023-07-16 美商雷納嘉德醫療管理公司 環狀脂質及其使用方法
US11510975B1 (en) 2021-11-29 2022-11-29 Replicate Bioscience, Inc. Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses
CA3143650A1 (en) * 2021-12-22 2023-06-22 Providence Therapeutics Holdings Inc. Lipids and compositions thereof
CA3256897A1 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for the administration of nucleic acids and their methods of use
WO2024006863A1 (en) 2022-06-30 2024-01-04 Precision NanoSystems ULC Lipid nanoparticle formulations for vaccines
JP2026500252A (ja) 2022-12-12 2026-01-06 グローバル・ライフ・サイエンシズ・ソリューションズ・カナダ・ユーエルシー 脂質ナノ粒子の凍結乾燥方法及び組成物
AU2023413766A1 (en) 2022-12-23 2025-05-29 Biontech Delivery Technologies Gmbh Composition
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
CN121443279A (zh) 2023-06-28 2026-01-30 环球生命科学解决方案加拿大有限公司 用于细胞疗法的脂质纳米颗粒制剂和相关方法
IL326522A (en) 2023-08-21 2026-04-01 Global Life Sciences Solutions Canada Ulc Method and device for producing lipid nanoparticles in an ion stream
CN121752251A (zh) 2023-08-31 2026-03-27 环球生命科学解决方案加拿大有限公司 用于肺部递送纳米颗粒的鼻内制剂、组合物、用途及其制造方法
CN119143714B (zh) * 2023-12-11 2025-06-10 仁景(苏州)生物科技有限公司 用于递送的脂质化合物和脂质纳米颗粒
WO2025219528A1 (en) 2024-04-17 2025-10-23 Global Life Sciences Solutions Canada Ulc Non-destructive plasmid delivery to immune cells
WO2025219491A1 (en) 2024-04-17 2025-10-23 Global Life Sciences Solutions Canada Ulc Method and composition for hdr template dna delivery
WO2025224267A1 (en) 2024-04-25 2025-10-30 Global Life Sciences Solutions Canada Ulc Method for producing a liquid composition including a nanoparticle, and formulation thereof
WO2026052854A1 (en) 2024-09-09 2026-03-12 Global Life Sciences Solutions Canada Ulc 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof
WO2026052844A1 (en) 2024-09-09 2026-03-12 Global Life Sciences Solutions Canada Ulc 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof

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Publication number Priority date Publication date Assignee Title
JPH0854716A (ja) * 1994-08-12 1996-02-27 Konica Corp ハロゲン化銀写真感光材料およびその処理方法
JP5300119B2 (ja) 2007-08-28 2013-09-25 Ｊｆｅスチール株式会社 シームレス缶用表面処理鋼板、樹脂被覆鋼板及びシームレス缶
WO2009086558A1 (en) * 2008-01-02 2009-07-09 Tekmira Pharmaceuticals Corporation Improved compositions and methods for the delivery of nucleic acids
CN111808084A (zh) * 2008-11-10 2020-10-23 阿布特斯生物制药公司 用于递送治疗剂的新型脂质和组合物
CA2824526C (en) * 2011-01-11 2020-07-07 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
WO2012108397A1 (ja) 2011-02-08 2012-08-16 第一三共株式会社 新規脂質
EP2817287B1 (en) * 2012-02-24 2018-10-03 Arbutus Biopharma Corporation Trialkyl cationic lipids and methods of use thereof
US9920003B2 (en) * 2014-08-19 2018-03-20 Archer Daniels Midland Company Non-ionic amphiphiles and methods of making the same
WO2018062413A1 (ja) * 2016-09-28 2018-04-05 協和発酵キリン株式会社 核酸含有脂質ナノ粒子

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