JP2022539089A5 - - Google Patents
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- Publication number
- JP2022539089A5 JP2022539089A5 JP2021577003A JP2021577003A JP2022539089A5 JP 2022539089 A5 JP2022539089 A5 JP 2022539089A5 JP 2021577003 A JP2021577003 A JP 2021577003A JP 2021577003 A JP2021577003 A JP 2021577003A JP 2022539089 A5 JP2022539089 A5 JP 2022539089A5
- Authority
- JP
- Japan
- Prior art keywords
- mol
- alkyl
- present
- amount
- alkyl groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024002304A JP7667327B2 (ja) | 2019-06-29 | 2024-01-11 | 核酸送達のためのイオン化可能な脂質 |
| JP2025065109A JP7908452B2 (ja) | 2019-06-29 | 2025-04-10 | 核酸送達のためのイオン化可能な脂質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962868900P | 2019-06-29 | 2019-06-29 | |
| US62/868,900 | 2019-06-29 | ||
| US202063009042P | 2020-04-13 | 2020-04-13 | |
| US63/009,042 | 2020-04-13 | ||
| PCT/CA2020/050897 WO2021000041A1 (en) | 2019-06-29 | 2020-06-26 | Ionizable lipids for nucleic acid delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002304A Division JP7667327B2 (ja) | 2019-06-29 | 2024-01-11 | 核酸送達のためのイオン化可能な脂質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022539089A JP2022539089A (ja) | 2022-09-07 |
| JP2022539089A5 true JP2022539089A5 (enExample) | 2023-07-04 |
| JP7420841B2 JP7420841B2 (ja) | 2024-01-23 |
Family
ID=74100092
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577003A Active JP7420841B2 (ja) | 2019-06-29 | 2020-06-26 | 核酸送達のためのイオン化可能な脂質 |
| JP2024002304A Active JP7667327B2 (ja) | 2019-06-29 | 2024-01-11 | 核酸送達のためのイオン化可能な脂質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002304A Active JP7667327B2 (ja) | 2019-06-29 | 2024-01-11 | 核酸送達のためのイオン化可能な脂質 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12636368B2 (enExample) |
| EP (1) | EP3990441A4 (enExample) |
| JP (2) | JP7420841B2 (enExample) |
| KR (2) | KR102928289B1 (enExample) |
| CN (1) | CN115279743B (enExample) |
| CA (1) | CA3143578A1 (enExample) |
| WO (1) | WO2021000041A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3864163T3 (da) | 2018-10-09 | 2024-05-06 | Univ British Columbia | Sammensætninger og systemer omfattende transfektionskompetente vesikler fri for organiske opløsningsmidler og rengøringsmidler og fremgangsmåder forbundet dermed |
| CN112888451A (zh) * | 2018-10-19 | 2021-06-01 | 川斯勒佰尔公司 | 信使rna的无泵包封 |
| CZ310613B6 (cs) * | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
| CN112961065B (zh) * | 2021-02-05 | 2023-03-14 | 嘉晨西海(杭州)生物技术有限公司 | 一种可电离脂质分子及其制备方法及其在制备脂质纳米颗粒的应用 |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| JP7689238B2 (ja) | 2021-07-27 | 2025-06-05 | エスケー バイオサイエンス カンパニー リミテッド | タンパク質発現のためのｍＲＮＡ、及びそのためのテンプレート |
| WO2023044343A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| WO2023067121A1 (en) * | 2021-10-22 | 2023-04-27 | BioNTech SE | Oligosaccharide compounds and complexes |
| JP2024543721A (ja) * | 2021-10-22 | 2024-11-22 | ビオンテック・ソシエタス・エウロパエア | オリゴ糖複合体及び用途 |
| US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
| CA3143650A1 (en) * | 2021-12-22 | 2023-06-22 | Providence Therapeutics Holdings Inc. | Lipids and compositions thereof |
| WO2023230587A2 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| AU2023393613A1 (en) | 2022-12-12 | 2025-06-19 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticles lyophilization methods and compositions |
| IL321425A (en) | 2022-12-23 | 2025-08-01 | Biontech Delivery Tech Gmbh | compound |
| EP4719352A1 (en) | 2023-05-31 | 2026-04-08 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| KR20260030139A (ko) | 2023-06-28 | 2026-03-05 | 글로벌 라이프 사이언시즈 솔루션즈 캐나다 유엘씨 | 세포 요법을 위한 지질 나노입자 제형 및 관련 방법 |
| IL326522A (en) | 2023-08-21 | 2026-04-01 | Global Life Sciences Solutions Canada Ulc | Method and apparatus for ion flux lipid nanoparticle manufacture |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| CN119143714B (zh) * | 2023-12-11 | 2025-06-10 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
| WO2025224267A1 (en) | 2024-04-25 | 2025-10-30 | Global Life Sciences Solutions Canada Ulc | Method for producing a liquid composition including a nanoparticle, and formulation thereof |
| WO2026043843A1 (en) * | 2024-08-19 | 2026-02-26 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, | Tetrahydropyrimidine (thp) ionizable lipids for efficient mrna delivery |
| WO2026052844A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
| WO2026052854A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
| WO2026109722A1 (en) | 2024-11-21 | 2026-05-28 | Aldexchem Kft. | Advanced silicon-containing lipid nanoparticles for efficient human t cell transfection |
| WO2026122996A1 (en) * | 2024-12-06 | 2026-06-11 | Tessera Therapeutics, Inc. | Lipid nanoparticles for delivery of therapeutic payloads to cells |
| WO2026146172A1 (en) | 2024-12-31 | 2026-07-09 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations and methods of preparing thereof |
| WO2026149959A1 (en) | 2025-01-08 | 2026-07-16 | Global Life Sciences Solutions Canada Ulc | MODIFIED sgRNAs, LIPID NANOPARTICLES WITH MODIFIED sgRNAs, AND USES THEREOF |
| WO2026153956A1 (en) | 2025-01-14 | 2026-07-23 | Global Life Sciences Solutions Canada Ulc | Stabilizing agents, compositions, and uses thereof |
| WO2026159142A1 (en) | 2025-01-22 | 2026-07-30 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticles comprising sugar-based stabilizing agents for nucleic acid delivery and method of preparation thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0854716A (ja) | 1994-08-12 | 1996-02-27 | Konica Corp | ハロゲン化銀写真感光材料およびその処理方法 |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US6734171B1 (en) | 1997-10-10 | 2004-05-11 | Inex Pharmaceuticals Corp. | Methods for encapsulating nucleic acids in lipid bilayers |
| EP1412065A2 (en) | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| JP5300119B2 (ja) | 2007-08-28 | 2013-09-25 | Ｊｆｅスチール株式会社 | シームレス缶用表面処理鋼板、樹脂被覆鋼板及びシームレス缶 |
| EP3100718B1 (en) * | 2008-01-02 | 2019-11-27 | Arbutus Biopharma Corporation | Improved compositions and methods for the delivery of nucleic acids |
| EP3699172A3 (en) * | 2008-11-10 | 2020-11-18 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| KR20220038506A (ko) | 2009-06-10 | 2022-03-28 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| RU2573409C2 (ru) | 2009-11-04 | 2016-01-20 | Дзе Юниверсити Оф Бритиш Коламбиа | Содержащие нуклеиновые кислоты липидные частицы и относящиеся к ним способы |
| US9999673B2 (en) * | 2011-01-11 | 2018-06-19 | Alnylam Pharmaceuticals, Inc. | PEGylated lipids and their use for drug delivery |
| TW201309621A (zh) | 2011-02-08 | 2013-03-01 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| US20140328759A1 (en) | 2011-10-25 | 2014-11-06 | The University Of British Columbia | Limit size lipid nanoparticles and related methods |
| US9352042B2 (en) | 2012-02-24 | 2016-05-31 | Protiva Biotherapeutics, Inc. | Trialkyl cationic lipids and methods of use thereof |
| CN105143456A (zh) | 2013-03-15 | 2015-12-09 | 不列颠哥伦比亚大学 | 用于转染的脂质纳米粒子和相关方法 |
| US9920003B2 (en) * | 2014-08-19 | 2018-03-20 | Archer Daniels Midland Company | Non-ionic amphiphiles and methods of making the same |
| WO2017117647A1 (en) | 2016-01-06 | 2017-07-13 | The University Of British Columbia | Bifurcating mixers and methods of their use and manufacture |
| US11059039B2 (en) | 2016-07-06 | 2021-07-13 | Precision Nanosystems Inc. | Smart microfluidic mixing instrument and cartridges |
| WO2018062413A1 (ja) * | 2016-09-28 | 2018-04-05 | 協和発酵キリン株式会社 | 核酸含有脂質ナノ粒子 |
-
2020
- 2020-06-26 KR KR1020227003336A patent/KR102928289B1/ko active Active
- 2020-06-26 KR KR1020267004502A patent/KR20260033101A/ko active Pending
- 2020-06-26 CA CA3143578A patent/CA3143578A1/en active Pending
- 2020-06-26 CN CN202080047923.6A patent/CN115279743B/zh active Active
- 2020-06-26 US US17/622,096 patent/US12636368B2/en active Active
- 2020-06-26 WO PCT/CA2020/050897 patent/WO2021000041A1/en not_active Ceased
- 2020-06-26 JP JP2021577003A patent/JP7420841B2/ja active Active
- 2020-06-26 EP EP20835492.8A patent/EP3990441A4/en active Pending
-
2024
- 2024-01-11 JP JP2024002304A patent/JP7667327B2/ja active Active