CN115279743B - 用于核酸递送的可离子化脂质 - Google Patents

用于核酸递送的可离子化脂质 Download PDF

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CN115279743B
CN115279743B CN202080047923.6A CN202080047923A CN115279743B CN 115279743 B CN115279743 B CN 115279743B CN 202080047923 A CN202080047923 A CN 202080047923A CN 115279743 B CN115279743 B CN 115279743B
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lipid
alkyl
mmol
pni
mol
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CN115279743A (zh
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A·托马斯
N·杰恩
A·W·布朗
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Global Life Sciences Solutions Canada ULC
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Precision Nanosystems ULC
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN202080047923.6A 2019-06-29 2020-06-26 用于核酸递送的可离子化脂质 Active CN115279743B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962868900P 2019-06-29 2019-06-29
US62/868,900 2019-06-29
US202063009042P 2020-04-13 2020-04-13
US63/009,042 2020-04-13
PCT/CA2020/050897 WO2021000041A1 (en) 2019-06-29 2020-06-26 Ionizable lipids for nucleic acid delivery

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CN115279743A CN115279743A (zh) 2022-11-01
CN115279743B true CN115279743B (zh) 2024-05-14

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US (1) US12636368B2 (enExample)
EP (1) EP3990441A4 (enExample)
JP (2) JP7420841B2 (enExample)
KR (2) KR102928289B1 (enExample)
CN (1) CN115279743B (enExample)
CA (1) CA3143578A1 (enExample)
WO (1) WO2021000041A1 (enExample)

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