JP2022536043A - シトクロムｂｃ１阻害剤とクラリスロマイシン又はアジスロマイシン及びクロファジミンを組み合わせることを特徴とするマイコバクテリア感染症治療用医薬 - Google Patents

シトクロムｂｃ１阻害剤とクラリスロマイシン又はアジスロマイシン及びクロファジミンを組み合わせることを特徴とするマイコバクテリア感染症治療用医薬 Download PDF

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JP2022536043A
JP2022536043A JP2021570326A JP2021570326A JP2022536043A JP 2022536043 A JP2022536043 A JP 2022536043A JP 2021570326 A JP2021570326 A JP 2021570326A JP 2021570326 A JP2021570326 A JP 2021570326A JP 2022536043 A JP2022536043 A JP 2022536043A
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pharmaceutically acceptable
acceptable salt
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JPWO2020243224A5 (https=
JP2022536043A5 (https=
Inventor
賢三 西口
聡史 宮川
ディ クレイプール，ウィリアム
ジェイ ミラー，マービン
シー モラスキ，ギャレット
エス ショリー，ジェフリー
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Hsiri Therapeutics Inc
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Hsiri Therapeutics Inc
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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JP2021570326A 2019-05-28 2020-05-28 シトクロムｂｃ１阻害剤とクラリスロマイシン又はアジスロマイシン及びクロファジミンを組み合わせることを特徴とするマイコバクテリア感染症治療用医薬 Pending JP2022536043A (ja)

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US201962853273P 2019-05-28 2019-05-28
US62/853,273 2019-05-28
PCT/US2020/034794 WO2020243224A1 (en) 2019-05-28 2020-05-28 A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE

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JP2022536043A true JP2022536043A (ja) 2022-08-12
JPWO2020243224A5 JPWO2020243224A5 (https=) 2023-05-31
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EP (1) EP3976031A4 (https=)
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Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
TWI861208B (zh) * 2019-09-10 2024-11-11 日商鹽野義製藥股份有限公司 對分枝桿菌感染有用之含苄胺的 5,6-雜芳族化合物
TW202237116A (zh) * 2020-12-02 2022-10-01 日商塩野義製藥股份有限公司 以組合細胞色素bc1抑制劑與克拉黴素或阿奇黴素為特徵之用於治療分枝桿菌感染之藥物

Citations (2)

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WO2018158280A1 (en) * 2017-03-01 2018-09-07 Janssen Sciences Ireland Uc Combination therapy
JP2018532723A (ja) * 2015-09-17 2018-11-08 ジェー． ミラー，マーヴィン マイコバクテリア感染症に対して有用なベンジルアミン含有複素環化合物及び組成物

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UA125171C2 (uk) * 2015-07-02 2022-01-26 Янссен Саєнсиз Айрленд Юсі Антибактеріальні сполуки
EP3266454A1 (en) * 2016-07-07 2018-01-10 Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften Acc inhibitors for use in treating mycobacterial diseases

Patent Citations (2)

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JP2018532723A (ja) * 2015-09-17 2018-11-08 ジェー． ミラー，マーヴィン マイコバクテリア感染症に対して有用なベンジルアミン含有複素環化合物及び組成物
WO2018158280A1 (en) * 2017-03-01 2018-09-07 Janssen Sciences Ireland Uc Combination therapy

Non-Patent Citations (3)

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Title
BEATRIZ E. FERRO ET AL.: ""Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 60, no. 2, JPN6024020234, February 2016 (2016-02-01), pages 1097 - 1105, XP093050396, ISSN: 0005457519, DOI: 10.1128/AAC.02615-15 *
D M YAJKO ET AL.: ""In vitro activities of rifabutin, azithromycin, ciprofloxacin, clarithromycin, clofazimine, ethamb", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 40, no. 3, JPN6024020233, March 1996 (1996-03-01), pages 743 - 749, ISSN: 0005457520 *
DIRK A. LAMPRECHT ET AL.: ""Turning the respiratory flexibility of Mycobacterium tuberculosis against itself"", NATURE COMMUNICATIONS, vol. 7, no. 1, JPN6024020236, 10 August 2016 (2016-08-10), ISSN: 0005457518 *

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US20220235047A1 (en) 2022-07-28
EP3976031A4 (en) 2023-07-12
EP3976031A1 (en) 2022-04-06

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