JP2022533419A5 - - Google Patents
Info
- Publication number
- JP2022533419A5 JP2022533419A5 JP2021569112A JP2021569112A JP2022533419A5 JP 2022533419 A5 JP2022533419 A5 JP 2022533419A5 JP 2021569112 A JP2021569112 A JP 2021569112A JP 2021569112 A JP2021569112 A JP 2021569112A JP 2022533419 A5 JP2022533419 A5 JP 2022533419A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleotide sequence
- nucleotide
- group
- sirna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910430586.8 | 2019-05-22 | ||
| CN201910430586 | 2019-05-22 | ||
| PCT/CN2020/091485 WO2020233651A1 (zh) | 2019-05-22 | 2020-05-21 | 核酸、药物组合物与缀合物及制备方法和用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022533419A JP2022533419A (ja) | 2022-07-22 |
| JP2022533419A5 true JP2022533419A5 (enExample) | 2023-05-30 |
| JP7606758B2 JP7606758B2 (ja) | 2024-12-26 |
Family
ID=73458360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021569112A Active JP7606758B2 (ja) | 2019-05-22 | 2020-05-21 | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240200076A1 (enExample) |
| EP (1) | EP3974533A4 (enExample) |
| JP (1) | JP7606758B2 (enExample) |
| CN (2) | CN113614230B (enExample) |
| TW (1) | TWI863999B (enExample) |
| WO (1) | WO2020233651A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020135673A1 (zh) | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| KR20220011689A (ko) | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN114686482B (zh) * | 2020-12-29 | 2024-05-17 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途 |
| CN113073098B (zh) * | 2021-02-20 | 2024-08-20 | 北京理工大学 | 抑制BACE1基因表达的siRNA修饰物及其应用 |
| CN119343449A (zh) * | 2023-05-24 | 2025-01-21 | 云合智药（苏州）生物科技有限公司 | 用于抑制angptl3表达的rnai剂及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2429814C (en) * | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| EP2449106B1 (en) * | 2009-07-01 | 2015-04-08 | Protiva Biotherapeutics Inc. | Compositions and methods for silencing apolipoprotein b |
| JP2013523149A (ja) * | 2010-04-09 | 2013-06-17 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規な単一化学物質およびオリゴヌクレオチドの送達方法 |
| CN103380113B (zh) | 2010-11-15 | 2018-03-30 | 生命科技公司 | 含胺的转染试剂及其制备和使用方法 |
| BR112013025917A2 (pt) * | 2011-04-08 | 2016-12-20 | Omeros Corp | uso de um anticorpo masp-2 ou fragmento do mesmo que inibe ativação de complemento dependente de masp-2 |
| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3019595A4 (en) * | 2013-07-09 | 2016-11-30 | THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS | |
| WO2015006740A2 (en) | 2013-07-11 | 2015-01-15 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| ES2923942T3 (es) * | 2013-11-06 | 2022-10-03 | Us Health | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| DK3719128T3 (da) * | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719126B1 (en) * | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| WO2023284763A1 (zh) * | 2021-07-16 | 2023-01-19 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
-
2020
- 2020-05-21 JP JP2021569112A patent/JP7606758B2/ja active Active
- 2020-05-21 TW TW109116934A patent/TWI863999B/zh active
- 2020-05-21 WO PCT/CN2020/091485 patent/WO2020233651A1/zh not_active Ceased
- 2020-05-21 US US17/595,620 patent/US20240200076A1/en not_active Abandoned
- 2020-05-21 EP EP20810635.1A patent/EP3974533A4/en not_active Withdrawn
- 2020-05-21 CN CN202080007348.7A patent/CN113614230B/zh active Active
- 2020-05-21 CN CN202410318986.0A patent/CN118340793A/zh active Pending