JP2022531474A - T細胞製造組成物および方法 - Google Patents

T細胞製造組成物および方法 Download PDF

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JP2022531474A
JP2022531474A JP2021566008A JP2021566008A JP2022531474A JP 2022531474 A JP2022531474 A JP 2022531474A JP 2021566008 A JP2021566008 A JP 2021566008A JP 2021566008 A JP2021566008 A JP 2021566008A JP 2022531474 A JP2022531474 A JP 2022531474A
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cells
population
specific
cell
tumor antigen
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JPWO2020227546A5 (de
Inventor
ビューレン, マリト エム. ファン
ディヴィヤ レディ レンカラ,
ジェシカ コーラー,
フラヴィアン デュヴァル ブラウン,
クリスティーナ マーフィー ククシン,
デン ベルフ, ヨースト ヘイベルト ファン
ブール, レナーテ デ
ノール バッケル,
トン シューマッハー,
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Stichting Het Nederlands Kanker Instituut
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Stichting Het Nederlands Kanker Instituut
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Publication of JP2022531474A publication Critical patent/JP2022531474A/ja
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Priority to JP2024011014A priority Critical patent/JP2024038503A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
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    • A61K39/4612B-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4643Vertebrate antigens
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081Purging biological preparations of unwanted cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0638Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/876Skin, melanoma

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  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2021566008A 2019-05-08 2020-05-07 T細胞製造組成物および方法 Pending JP2022531474A (ja)

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JP2024011014A JP2024038503A (ja) 2019-05-08 2024-01-29 T細胞製造組成物および方法

Applications Claiming Priority (3)

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US201962845251P 2019-05-08 2019-05-08
US62/845,251 2019-05-08
PCT/US2020/031898 WO2020227546A1 (en) 2019-05-08 2020-05-07 T cell manufacturing compositions and methods

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JP2022531474A true JP2022531474A (ja) 2022-07-06
JPWO2020227546A5 JPWO2020227546A5 (de) 2023-05-16

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US (1) US20220280621A1 (de)
EP (1) EP3965784A4 (de)
JP (2) JP2022531474A (de)
KR (1) KR20220044242A (de)
CN (1) CN114096261A (de)
AR (1) AR118859A1 (de)
AU (1) AU2020268397A1 (de)
BR (1) BR112021022363A2 (de)
CA (1) CA3137037A1 (de)
IL (1) IL287874A (de)
MX (1) MX2021013608A (de)
SG (1) SG11202112346WA (de)
TW (2) TWI777160B (de)
WO (1) WO2020227546A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
HRP20221303T1 (hr) 2012-02-09 2022-12-23 Baylor College Of Medicine SMJESE PEPTIDA ZA NASTAJANJE MULTIVIRUSNIH CITOTOKSIČNIH T-LIMFOCITA(CTLs) ŠIROKE SPECIFIČNOSTI
IL298359A (en) 2015-09-18 2023-01-01 Baylor College Medicine Immunogenic detection of antigen from a pathogen and adjustment of effective clinical treatment
BR112023002733A2 (pt) * 2020-08-13 2023-05-02 Biontech Us Inc Composições e métodos de fabricação de células t
US11948694B2 (en) * 2021-05-12 2024-04-02 Merative Us L.P. Controlling compartmental flows in epidemiological modeling based on mobility data
US12062456B2 (en) 2021-05-27 2024-08-13 Merative Us L.P. Hypothetical scenario evaluation in infectious disease dynamics based on similar regions
EP4415728A1 (de) * 2021-10-15 2024-08-21 BioNTech US Inc. Zusammensetzungen und verfahren zur herstellung von t-zellen
WO2023159088A1 (en) * 2022-02-15 2023-08-24 Marker Therapeutics, Inc. Compositions and methods for antigen-specific t cell expansion
WO2024124222A1 (en) * 2022-12-09 2024-06-13 Biontech Us Inc. T cell manufacturing compositions and methods
WO2024151124A1 (ko) * 2023-01-12 2024-07-18 주식회사 이뮤노맥스 항암능이 우수한 기억 t 세포 유래 면역세포치료제의 제조방법
CN117417886B (zh) * 2023-10-20 2024-05-14 广东壹加再生医学研究院有限公司 一种负载肿瘤抗原的树突状细胞激活的t淋巴细胞的培养方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100330056A1 (en) * 2007-10-03 2010-12-30 Cassian Yee Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression
WO2013118899A1 (ja) * 2012-02-10 2013-08-15 医療法人社団博心厚生会 単球増殖剤、単球増殖用培地、単球の製造方法、樹状細胞の製造方法、及び樹状細胞ワクチンの製造方法
WO2017026389A1 (ja) * 2015-08-10 2017-02-16 東レ株式会社 免疫誘導剤
JP2018526034A (ja) * 2015-09-10 2018-09-13 アフィジェン・インコーポレイテッド 腫瘍治療薬の配列決定により導かれる選択

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007506789A (ja) * 2003-09-25 2007-03-22 ザイモジェネティクス, インコーポレイテッド Il−21を用いた自己免疫疾患の治療方法
WO2006110582A1 (en) * 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
WO2017059557A1 (en) * 2015-10-09 2017-04-13 Peking University Methods for enhancing in vivo persistence and efficacy of exogenously administered t cells, genetically modified t cells and method and method of use
AU2018337960A1 (en) * 2017-09-20 2020-04-30 Neximmune, Inc. Cell compositions comprising antigen-specific T cells for adoptive therapy
CA3081840A1 (en) * 2017-11-08 2019-05-16 Neon Therapeutics, Inc. T cell manufacturing compositions and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100330056A1 (en) * 2007-10-03 2010-12-30 Cassian Yee Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression
WO2013118899A1 (ja) * 2012-02-10 2013-08-15 医療法人社団博心厚生会 単球増殖剤、単球増殖用培地、単球の製造方法、樹状細胞の製造方法、及び樹状細胞ワクチンの製造方法
WO2017026389A1 (ja) * 2015-08-10 2017-02-16 東レ株式会社 免疫誘導剤
JP2018526034A (ja) * 2015-09-10 2018-09-13 アフィジェン・インコーポレイテッド 腫瘍治療薬の配列決定により導かれる選択

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 112, no. 11, JPN6023021624, 2008, pages 2311, ISSN: 0005069175 *

Also Published As

Publication number Publication date
EP3965784A1 (de) 2022-03-16
TW202248419A (zh) 2022-12-16
WO2020227546A1 (en) 2020-11-12
CN114096261A (zh) 2022-02-25
TW202108761A (zh) 2021-03-01
MX2021013608A (es) 2022-01-31
TWI777160B (zh) 2022-09-11
SG11202112346WA (en) 2021-12-30
US20220280621A1 (en) 2022-09-08
AR118859A1 (es) 2021-11-03
CA3137037A1 (en) 2020-11-12
KR20220044242A (ko) 2022-04-07
JP2024038503A (ja) 2024-03-19
BR112021022363A2 (pt) 2022-03-22
AU2020268397A1 (en) 2022-01-06
EP3965784A4 (de) 2023-06-21
IL287874A (en) 2022-01-01

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