JP2022531325A - 操作されたキメラ融合タンパク質組成物およびそれらの使用の方法 - Google Patents

操作されたキメラ融合タンパク質組成物およびそれらの使用の方法 Download PDF

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JP2022531325A
JP2022531325A JP2021564784A JP2021564784A JP2022531325A JP 2022531325 A JP2022531325 A JP 2022531325A JP 2021564784 A JP2021564784 A JP 2021564784A JP 2021564784 A JP2021564784 A JP 2021564784A JP 2022531325 A JP2022531325 A JP 2022531325A
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cells
cfp
composition according
intracellular
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JPWO2020223550A5 (fr
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ゲッツ,ダニエル
ワーン,ユーシャオ
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マイエロイド・セラピューティクス,インコーポレーテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46Cellular immunotherapy
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    • A61K39/4633Antibodies or T cell engagers
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/4622Antigen presenting cells
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    • A61K39/4631Chimeric Antigen Receptors [CAR]
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    • A61K39/4643Vertebrate antigens
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    • A61K39/464403Receptors for growth factors
    • A61K39/464406Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464454Enzymes
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    • A61K39/4643Vertebrate antigens
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    • A61K39/464466Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • A61K39/4643Vertebrate antigens
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    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biotechnology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2021564784A 2019-04-30 2020-04-30 操作されたキメラ融合タンパク質組成物およびそれらの使用の方法 Pending JP2022531325A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962841183P 2019-04-30 2019-04-30
US201962841190P 2019-04-30 2019-04-30
US62/841,183 2019-04-30
US62/841,190 2019-04-30
US16/827,302 US11013764B2 (en) 2019-04-30 2020-03-23 Engineered phagocytic receptor compositions and methods of use thereof
US16/827,381 US11026973B2 (en) 2019-04-30 2020-03-23 Engineered phagocytic receptor compositions and methods of use thereof
US16/827,381 2020-03-23
US16/827,302 2020-03-23
PCT/US2020/030837 WO2020223550A1 (fr) 2019-04-30 2020-04-30 Compositions de protéines de fusion chimériques modifiées et leurs procédés d'utilisation

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JP2022531325A true JP2022531325A (ja) 2022-07-06
JPWO2020223550A5 JPWO2020223550A5 (fr) 2023-05-10

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EP (1) EP3962497A4 (fr)
JP (1) JP2022531325A (fr)
KR (1) KR20220045930A (fr)
CN (1) CN114072157A (fr)
AU (1) AU2020266595A1 (fr)
BR (1) BR112021021843A8 (fr)
CA (1) CA3135531A1 (fr)
GB (2) GB2626698B (fr)
IL (1) IL287650A (fr)
MX (1) MX2021013355A (fr)
SG (1) SG11202111985XA (fr)
WO (1) WO2020223550A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
WO2019067328A1 (fr) 2017-09-26 2019-04-04 Cero Therapeutics, Inc. Molécules de récepteur d'engloutissement chimérique et méthodes d'utilisation
CN112135904A (zh) 2018-01-03 2020-12-25 帕利昂制药有限公司 重组人唾液酸酶、唾液酸酶融合蛋白及其使用方法
JP2022546592A (ja) 2019-09-03 2022-11-04 マイエロイド・セラピューティクス,インコーポレーテッド ゲノム組込みのための方法および組成物
JP2023549140A (ja) 2020-11-04 2023-11-22 マイエロイド・セラピューティクス,インコーポレーテッド 操作されたキメラ融合タンパク質組成物およびその使用方法
WO2022150516A1 (fr) * 2021-01-06 2022-07-14 Palleon Pharmaceuticals Inc. Protéines de fusion d'anticorps her2-sialidase et procédés d'utilisation associés
WO2022197949A2 (fr) 2021-03-17 2022-09-22 Myeloid Therapeutics, Inc. Compositions de protéines de fusion chimériques modifiées et leurs méthodes d'utilisation
KR20240022465A (ko) 2021-04-28 2024-02-20 산퀸 아이피 비.브이. 키메라 Fc-알파 수용체 및 그것의 용도
CN113214408B (zh) * 2021-04-30 2022-12-27 清华大学深圳国际研究生院 一种嵌合抗原受体巨噬细胞及其制备方法和用途
GB202108366D0 (en) * 2021-06-11 2021-07-28 Quell Therapeutics Ltd Multichain chimeric antigen receptor
CN113817677B (zh) * 2021-09-29 2023-08-18 四川大学 泛酸或其衍生物与α-D-葡萄糖-1,6-二磷酸或其衍生物在促进DC迁移中的用途
WO2023194608A1 (fr) * 2022-04-07 2023-10-12 Institut Curie Cellules myéloïdes modifiées par un récepteur antigénique chimérique et leurs utilisations pour une thérapie anticancéreuse
WO2023194607A1 (fr) * 2022-04-07 2023-10-12 Institut Curie Cellules myéloïdes modifiées par un récepteur antigénique chimérique avec cd40 et leurs utilisations pour une thérapie anticancéreuse
KR20230162310A (ko) * 2022-05-20 2023-11-28 주식회사 카나프테라퓨틱스 Light 단백질 및 항-fap 항체를 포함하는 융합단백질 및 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108064283B (zh) * 2015-02-24 2024-01-09 加利福尼亚大学董事会 结合触发的转录开关及其使用方法
EP3286225B1 (fr) * 2015-04-23 2020-07-01 Baylor College of Medicine Récepteur antigénique chimérique ciblant le cd5 pour une thérapie adoptive à base de cellules t
MX2018001182A (es) * 2015-07-28 2018-04-20 Univ Pennsylvania Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos.
WO2017025944A2 (fr) * 2015-08-13 2017-02-16 Brigham Young University Car macrophage (moto-car) en immunothérapie
US20180186855A1 (en) * 2016-03-23 2018-07-05 Alector Llc Chimeric receptors and methods of use thereof
KR20230148844A (ko) * 2016-03-29 2023-10-25 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
CN110036033B (zh) * 2016-09-27 2023-12-08 森罗治疗公司 嵌合吞噬受体分子
WO2018073394A1 (fr) * 2016-10-19 2018-04-26 Cellectis Récepteurs d'antigènes chimériques induisant la mort cellulaire
CN110461868A (zh) * 2016-11-01 2019-11-15 根马布私人有限公司 多肽变体及其用途
CA3049791A1 (fr) * 2017-01-27 2018-08-02 Silverback Therapeutics, Inc. Conjugues ciblant les tumeurs et leurs methodes d'utilisation
EP3735460A4 (fr) * 2017-09-18 2021-08-11 Exuma Biotech Corp. Méthodes et compositions pour la modification génétique et l'expansion de lymphocytes et la régulation de l'activité de ces derniers

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GB202406391D0 (en) 2024-06-19
MX2021013355A (es) 2022-02-21
GB2626698B (en) 2024-10-23
BR112021021843A8 (pt) 2022-06-21
WO2020223550A1 (fr) 2020-11-05
CA3135531A1 (fr) 2020-11-05
GB2600834A (en) 2022-05-11
BR112021021843A2 (pt) 2022-02-15
KR20220045930A (ko) 2022-04-13
SG11202111985XA (en) 2021-11-29
GB2600834B (en) 2024-07-17
EP3962497A1 (fr) 2022-03-09
AU2020266595A1 (en) 2021-11-25
IL287650A (en) 2021-12-01
GB2626698A (en) 2024-07-31
EP3962497A4 (fr) 2023-01-18
CN114072157A (zh) 2022-02-18

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