JP2022526025A5 - - Google Patents

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Publication number
JP2022526025A5
JP2022526025A5 JP2021559950A JP2021559950A JP2022526025A5 JP 2022526025 A5 JP2022526025 A5 JP 2022526025A5 JP 2021559950 A JP2021559950 A JP 2021559950A JP 2021559950 A JP2021559950 A JP 2021559950A JP 2022526025 A5 JP2022526025 A5 JP 2022526025A5
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JP2021559950A
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JP2022526025A (ja
JP7580393B2 (ja
JPWO2020210508A5 (https=
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JP2021559950A 2019-04-09 2020-04-09 Cbl-b阻害のための3-置換ピペリジン化合物、並びに癌ワクチン及び/又は腫瘍溶解性ウイルスと組み合わせたCbl-b阻害剤の使用 Active JP7580393B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962831392P 2019-04-09 2019-04-09
US62/831,392 2019-04-09
US201962866909P 2019-06-26 2019-06-26
US62/866,909 2019-06-26
US201962880267P 2019-07-30 2019-07-30
US62/880,267 2019-07-30
US201962888870P 2019-08-19 2019-08-19
US201962888845P 2019-08-19 2019-08-19
US62/888,870 2019-08-19
US62/888,845 2019-08-19
PCT/US2020/027492 WO2020210508A1 (en) 2019-04-09 2020-04-09 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus

Publications (4)

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JP2022526025A JP2022526025A (ja) 2022-05-20
JP2022526025A5 true JP2022526025A5 (https=) 2023-04-17
JPWO2020210508A5 JPWO2020210508A5 (https=) 2023-04-17
JP7580393B2 JP7580393B2 (ja) 2024-11-11

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JP2021559950A Active JP7580393B2 (ja) 2019-04-09 2020-04-09 Cbl-b阻害のための3-置換ピペリジン化合物、並びに癌ワクチン及び/又は腫瘍溶解性ウイルスと組み合わせたCbl-b阻害剤の使用

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US (3) US11464802B2 (https=)
EP (1) EP3953346A1 (https=)
JP (1) JP7580393B2 (https=)
KR (1) KR102922115B1 (https=)
CN (1) CN114364667B (https=)
AU (1) AU2020272937B2 (https=)
BR (1) BR112021019722A2 (https=)
CA (1) CA3136348A1 (https=)
IL (1) IL287049B2 (https=)
MX (3) MX2021012285A (https=)
WO (1) WO2020210508A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110790758A (zh) * 2018-08-01 2020-02-14 上海轶诺药业有限公司 一类具有免疫调节功能的含n杂环化合物的制备和应用
JP7600123B2 (ja) 2018-10-15 2024-12-16 ニューリックス セラピューティクス,インコーポレイテッド ユビキチンプロテオソーム経路を介してbtkを分解するための二官能性化合物
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
EP3953346A1 (en) 2019-04-09 2022-02-16 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
EP4034141A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for expansion of immune cells
US11820781B2 (en) 2019-12-04 2023-11-21 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CA3191387A1 (en) 2020-09-30 2022-04-07 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
AR124800A1 (es) * 2021-02-03 2023-05-03 Genentech Inc Lactamas como inhibidores cbl-b
WO2022169998A1 (en) * 2021-02-03 2022-08-11 Genentech, Inc. Amides as cbl-b inhibitors
US12016860B2 (en) 2021-04-08 2024-06-25 Nurix Therapeutics, Inc. Combination therapies with Cbl-b inhibitor compounds
AU2022256074A1 (en) * 2021-04-09 2023-11-02 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
BR112023021068A2 (pt) * 2021-04-16 2024-01-23 Hotspot Therapeutics Inc Compostos, composições e métodos para tratar câncer
WO2022272248A1 (en) * 2021-06-21 2022-12-29 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
AU2022379494A1 (en) 2021-10-26 2024-05-30 Nurix Therapeutics, Inc. Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk
WO2023072273A1 (zh) * 2021-10-29 2023-05-04 先声再明医药有限公司 作为cbl-b抑制剂的并环化合物
JP2024542117A (ja) 2021-11-05 2024-11-13 ジェネンテック, インコーポレイテッド C-cblに対して選択的なcbl-b阻害剤としてのラクタム
TW202342013A (zh) * 2022-02-10 2023-11-01 英屬開曼群島商百濟神州有限公司 雜環化合物、其組成物及用其進行治療之方法
WO2023170608A1 (en) * 2022-03-09 2023-09-14 Orum Therapeutics, Inc. Activators of effector t cells
WO2023205180A1 (en) 2022-04-19 2023-10-26 Nurix Therapeutics, Inc. Biomarkers for cbl, and compositions and methods for their use
CN119212724A (zh) * 2022-05-09 2024-12-27 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
WO2023250097A1 (en) 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents
AR129946A1 (es) * 2022-07-18 2024-10-16 Insilico Medicine Ip Ltd Inhibidores de cbl-b y métodos de uso de los mismos
US20260028336A1 (en) * 2022-07-20 2026-01-29 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024017362A1 (zh) * 2022-07-22 2024-01-25 上海先博生物科技有限公司 靶向gprc5d和/或bcma的嵌合抗原受体及其应用
JP2025525947A (ja) 2022-08-16 2025-08-07 グレンマーク ファーマシューティカルズ エルティーディー Cbl-b阻害剤としての置換ピリジノン化合物
WO2024074977A1 (en) * 2022-10-04 2024-04-11 Pfizer Inc. Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds
WO2024112692A1 (en) * 2022-11-21 2024-05-30 Arvinas Operations, Inc. Casitas b-lineage lymphoma protooncogene b (cbl-b) degrading compounds and associated methods of use
WO2024153246A1 (zh) * 2023-01-20 2024-07-25 海南先声再明医药股份有限公司 取代的三环化合物及其应用
TW202435863A (zh) 2023-01-28 2024-09-16 芬蘭商奧利安公司 Cbl-b抑制劑
WO2024245264A1 (zh) * 2023-05-29 2024-12-05 海南先声再明医药股份有限公司 Cbl-b抑制剂及其应用
CN121816192A (zh) 2023-09-14 2026-04-07 因斯布鲁克医科大学 通过抑制NR2f6增强CAR-T细胞疗效
WO2025214476A1 (zh) * 2024-04-11 2025-10-16 北京诺诚健华医药科技有限公司 Cbl-b抑制剂
WO2025223343A1 (zh) * 2024-04-22 2025-10-30 杭州中美华东制药有限公司 作为Cbl-b抑制剂的化合物
WO2026022749A2 (en) 2024-07-26 2026-01-29 Aurigene Oncology Limited Cbl-b inhibitors
WO2026040995A1 (zh) * 2024-08-19 2026-02-26 北京望实智慧科技有限公司 用作Cbl-b抑制剂的化合物

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005779A1 (en) 1985-04-03 1986-10-09 Yamanouchi Pharmaceutical Co., Ltd. Phenylene derivatives
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5273986A (en) 1992-07-02 1993-12-28 Hoffmann-La Roche Inc. Cycloalkylthiazoles
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6143780A (en) 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
EP1227321A1 (en) * 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
CA2437248A1 (en) 2001-02-02 2002-08-15 Takeda Chemical Industries, Ltd. Jnk inhibitor
US20060063782A1 (en) 2002-07-03 2006-03-23 Murray Christopher W 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors
WO2004099388A2 (en) 2003-03-05 2004-11-18 Proteologics, Inc. Cbl-b polypeptides, complexes and related methods
US7320992B2 (en) 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
WO2005080367A1 (en) 2004-02-12 2005-09-01 Pharmagene Laboratories Limited Ep2 receptor agonists
CN101365806B (zh) 2005-12-01 2016-11-16 医学预后研究所 用于鉴定治疗反应的生物标记的方法和装置及其预测疗效的用途
JP5113348B2 (ja) * 2006-05-25 2013-01-09 国立大学法人徳島大学 ユビキチンリガーゼ阻害剤
ES2566502T3 (es) 2006-09-13 2016-04-13 The Trustees Of Columbia University In The City Of New York Agentes y métodos para provocar una respuesta inmune antitumoral
CA2704266A1 (en) * 2007-11-02 2009-06-11 Vertex Pharmaceuticals Incorporated [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta
AT506041A1 (de) 2007-12-10 2009-05-15 Univ Innsbruck Verfahren zur erhöhung der immunreaktivität
CA2710462C (en) 2008-02-05 2015-11-24 F. Hoffmann-La Roche Ag Pyridinones and pyridazinones
AR079545A1 (es) 2009-12-21 2012-02-01 Bayer Cropscience Ag Tienilpiri(mi)dinilazol
KR101862327B1 (ko) 2010-05-07 2018-05-29 질레드 코네티컷 인코포레이티드 피리돈 및 아자-피리돈 화합물 및 사용 방법
MX342995B (es) 2010-07-13 2016-10-21 Anthrogenesis Corp Métodos de generar células asesinas naturales.
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
EP2471548A1 (de) * 2010-12-28 2012-07-04 Apeiron Biologics AG siRNA gegen Cbl-b und optional IL2 und IL12 zur Verwendung in der Behandlung von Krebs
WO2012175513A1 (en) 2011-06-20 2012-12-27 Bayer Intellectual Property Gmbh Thienylpyri(mi)dinylpyrazole
WO2013067264A1 (en) 2011-11-03 2013-05-10 Genentech, Inc. 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
CA2861066C (en) 2012-01-12 2024-01-02 Yale University Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
KR20150054994A (ko) 2012-09-13 2015-05-20 에프. 호프만-라 로슈 아게 브루톤 티로신 키나아제의 억제제
EP3008052A1 (en) 2013-06-13 2016-04-20 Bristol-Myers Squibb Company Macrocyclic factor viia inhibitors
CA2921199A1 (en) 2013-08-27 2015-03-05 Bristol-Myers Squibb Company Ido inhibitors
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
AU2014360446A1 (en) 2013-12-05 2016-06-09 Pharmacyclics, Llc Inhibitors of Bruton's tyrosine kinase
RU2763795C2 (ru) 2014-04-23 2022-01-11 Джуно Терапьютикс, Инк. Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
AU2015289644A1 (en) * 2014-07-15 2017-02-02 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
BR112017025986A2 (pt) 2015-06-02 2018-08-14 Pharmacyclics Llc inibidores de tirosina quinase de bruton.
EP3325475B1 (en) 2015-07-17 2020-03-18 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as hdac inhibitors
EP3138905A1 (en) 2015-09-04 2017-03-08 Miltenyi Biotec GmbH Method for natural killer cell expansion
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
WO2017107907A1 (zh) 2015-12-25 2017-06-29 四川海思科制药有限公司 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用
EP3254701A1 (en) 2016-06-09 2017-12-13 IMBA-Institut für Molekulare Biotechnologie GmbH Cbl-b inhibitor comprising a cbl-b binding peptide for the prevention or treatment of fungal infections
US10842878B2 (en) 2016-11-22 2020-11-24 Dana-Farber Cancer Institute, Inc. Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
EP3630291B9 (en) * 2017-05-26 2024-05-29 Cancer Research Technology Limited Benzimidazolone derived inhibitors of bcl6
WO2019063748A1 (en) 2017-09-30 2019-04-04 Glaxosmithkline Intellectual Property Development Limited INHIBITORS OF ROR-GAMMA
WO2019148005A1 (en) 2018-01-26 2019-08-01 Nurix Therapeutics, Inc. Inhibitors of cbl-b and methods of use thereof
JP7600123B2 (ja) 2018-10-15 2024-12-16 ニューリックス セラピューティクス,インコーポレイテッド ユビキチンプロテオソーム経路を介してbtkを分解するための二官能性化合物
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
EP3953346A1 (en) 2019-04-09 2022-02-16 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
WO2021021761A1 (en) 2019-07-30 2021-02-04 Nurix Therapeutics, Inc. Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition
EP4034141A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for expansion of immune cells
US20230024442A1 (en) 2019-11-08 2023-01-26 Nurix Therapeutics, Inc. Bifunctional compounds for grading btk via ubiquitin proteosome pathway
US11820781B2 (en) 2019-12-04 2023-11-21 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
US12016860B2 (en) 2021-04-08 2024-06-25 Nurix Therapeutics, Inc. Combination therapies with Cbl-b inhibitor compounds
IL310717A (en) 2021-08-20 2024-04-01 Biomea Fusion Inc Crystalline form of N-[4-[4-(4-morpholinyl)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO ] -2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE, IRREVERSIBLE MENIN-MLL INHIBITOR FOR CANCER TREATMENT
WO2023205180A1 (en) 2022-04-19 2023-10-26 Nurix Therapeutics, Inc. Biomarkers for cbl, and compositions and methods for their use
WO2023250097A1 (en) 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents

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