JP2022520083A - Ｊａｋ２阻害剤の結晶形態 - Google Patents

Ｊａｋ２阻害剤の結晶形態 Download PDF

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Publication number
JP2022520083A
JP2022520083A JP2021547092A JP2021547092A JP2022520083A JP 2022520083 A JP2022520083 A JP 2022520083A JP 2021547092 A JP2021547092 A JP 2021547092A JP 2021547092 A JP2021547092 A JP 2021547092A JP 2022520083 A JP2022520083 A JP 2022520083A
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JP
Japan
Prior art keywords
crystalline
compound
solvate
powder diffraction
ray powder
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JP2021547092A
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English (en)
Japanese (ja)
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JP2022520083A5 (https=
Inventor
ロベール，ブノワ
ビヨー，パスカル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Impact Biomedicines Inc
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Impact Biomedicines Inc
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Application filed by Impact Biomedicines Inc filed Critical Impact Biomedicines Inc
Publication of JP2022520083A publication Critical patent/JP2022520083A/ja
Publication of JP2022520083A5 publication Critical patent/JP2022520083A5/ja
Priority to JP2024212168A priority Critical patent/JP2025032217A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021547092A 2019-02-12 2020-02-11 Ｊａｋ２阻害剤の結晶形態 Pending JP2022520083A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024212168A JP2025032217A (ja) 2019-02-12 2024-12-05 Ｊａｋ２阻害剤の結晶形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1902018 2019-02-12
FR1902018A FR3092581A1 (fr) 2019-02-12 2019-02-12 Formes cristallines d'un inhibiteur de jak2
PCT/US2020/017764 WO2020167844A1 (en) 2019-02-12 2020-02-11 Crystalline forms of a jak2 inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024212168A Division JP2025032217A (ja) 2019-02-12 2024-12-05 Ｊａｋ２阻害剤の結晶形態

Publications (2)

Publication Number Publication Date
JP2022520083A true JP2022520083A (ja) 2022-03-28
JP2022520083A5 JP2022520083A5 (https=) 2023-02-20

Family

ID=68281482

Family Applications (2)

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JP2021547092A Pending JP2022520083A (ja) 2019-02-12 2020-02-11 Ｊａｋ２阻害剤の結晶形態
JP2024212168A Pending JP2025032217A (ja) 2019-02-12 2024-12-05 Ｊａｋ２阻害剤の結晶形態

Family Applications After (1)

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JP2024212168A Pending JP2025032217A (ja) 2019-02-12 2024-12-05 Ｊａｋ２阻害剤の結晶形態

Country Status (13)

Country Link
US (1) US20220332706A1 (https=)
EP (1) EP3927704A4 (https=)
JP (2) JP2022520083A (https=)
KR (1) KR20210148110A (https=)
CN (1) CN114026088A (https=)
AU (1) AU2020221796A1 (https=)
BR (1) BR112021015318A2 (https=)
EA (1) EA202192237A1 (https=)
FR (1) FR3092581A1 (https=)
IL (1) IL285427A (https=)
MX (1) MX2021009423A (https=)
SG (1) SG11202108607QA (https=)
WO (1) WO2020167844A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021005518A2 (pt) 2018-09-25 2021-06-29 Impact Biomedicines, Inc. métodos para tratar distúrbios mieloproliferativos
US12559463B2 (en) * 2019-02-12 2026-02-24 Impact Biomedicines Inc. Crystalline forms of a JAK2 inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513703A (ja) * 2005-11-01 2009-04-02 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
WO2013013195A1 (en) * 2011-07-21 2013-01-24 Sanofi Compositions and methods for treating polycythemia vera and essential thrombocythemia
JP2013541595A (ja) * 2010-11-07 2013-11-14 ターゲジェン インコーポレーティッド 骨髄線維症を処置するための組成物及び方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10040804B2 (en) * 2016-12-21 2018-08-07 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513703A (ja) * 2005-11-01 2009-04-02 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
JP2013541595A (ja) * 2010-11-07 2013-11-14 ターゲジェン インコーポレーティッド 骨髄線維症を処置するための組成物及び方法
WO2013013195A1 (en) * 2011-07-21 2013-01-24 Sanofi Compositions and methods for treating polycythemia vera and essential thrombocythemia

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PHARM TECH JAPAN, vol. 18, no. 10, JPN7014002019, 2002, pages 81 - 96, ISSN: 0005570793 *
芦澤一英, 医薬品の多形現象と晶析の化学, JPN6015027444, 2002, pages 273 - 278, ISSN: 0005570794 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0005570795 *

Also Published As

Publication number Publication date
CN114026088A (zh) 2022-02-08
SG11202108607QA (en) 2021-09-29
BR112021015318A2 (pt) 2021-10-05
WO2020167844A1 (en) 2020-08-20
JP2025032217A (ja) 2025-03-11
FR3092581A1 (fr) 2020-08-14
MX2021009423A (es) 2021-11-17
AU2020221796A1 (en) 2021-08-12
IL285427A (en) 2021-09-30
KR20210148110A (ko) 2021-12-07
EP3927704A4 (en) 2022-12-28
US20220332706A1 (en) 2022-10-20
EP3927704A1 (en) 2021-12-29
EA202192237A1 (ru) 2021-12-14

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