JP2022514569A - 非晶質スパルセンタン組成物 - Google Patents

非晶質スパルセンタン組成物 Download PDF

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Publication number
JP2022514569A
JP2022514569A JP2021535041A JP2021535041A JP2022514569A JP 2022514569 A JP2022514569 A JP 2022514569A JP 2021535041 A JP2021535041 A JP 2021535041A JP 2021535041 A JP2021535041 A JP 2021535041A JP 2022514569 A JP2022514569 A JP 2022514569A
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JP
Japan
Prior art keywords
compound
pharmaceutical composition
pharmaceutically acceptable
amorphous
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021535041A
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English (en)
Japanese (ja)
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JP2022514569A5 (https=
Inventor
ダイニュス マシケナス，
ケール ルビー，
ジェイムズ フランシス ハルヴァト，
シャンミン ウー，
Original Assignee
トラビア セラピューティクス， インコーポレイテッド
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Application filed by トラビア セラピューティクス， インコーポレイテッド filed Critical トラビア セラピューティクス， インコーポレイテッド
Publication of JP2022514569A publication Critical patent/JP2022514569A/ja
Publication of JP2022514569A5 publication Critical patent/JP2022514569A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021535041A 2018-12-21 2019-12-20 非晶質スパルセンタン組成物 Pending JP2022514569A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862783947P 2018-12-21 2018-12-21
US62/783,947 2018-12-21
PCT/US2019/068094 WO2020132594A1 (en) 2018-12-21 2019-12-20 Amorphous sparsentan compositions

Publications (2)

Publication Number Publication Date
JP2022514569A true JP2022514569A (ja) 2022-02-14
JP2022514569A5 JP2022514569A5 (https=) 2022-11-29

Family

ID=69187971

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021535041A Pending JP2022514569A (ja) 2018-12-21 2019-12-20 非晶質スパルセンタン組成物

Country Status (12)

Country Link
US (1) US20220048900A1 (https=)
EP (1) EP3897834A1 (https=)
JP (1) JP2022514569A (https=)
KR (1) KR20210125994A (https=)
CN (1) CN114126712A (https=)
AU (1) AU2019404552A1 (https=)
BR (1) BR112021012226A2 (https=)
CA (1) CA3124127A1 (https=)
IL (1) IL284186A (https=)
MA (1) MA54542A (https=)
MX (1) MX2021007258A (https=)
WO (1) WO2020132594A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024101440A1 (ja) * 2022-11-11 2024-05-16 株式会社アークメディスン 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53817A (fr) 2018-10-04 2021-08-11 Travere Therapeutics Inc Composés biphényl-sulfonamide destinés au traitement de maladies du collagène de type iv
WO2022266370A1 (en) 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan for treating idiopathic pulmonary fibrosis
EP4458826A4 (en) * 2021-12-28 2025-12-24 Alchemedicine Inc COMPOUND, ANGIOTENSIN II TYPE 1 RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION
KR20250151548A (ko) * 2023-02-24 2025-10-21 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 방향족 고리계 함유 유도체 길항제의 염, 이의 제조 방법과 응용
CN118666826A (zh) * 2024-08-23 2024-09-20 成都臻拓医药科技有限公司 一种司帕生坦原料药的重结晶纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003520785A (ja) * 1999-12-15 2003-07-08 ブリストル−マイヤーズ スクイブ カンパニー アンジオテンシン・エンドセリン受容体二重拮抗薬としてのビフェニルスルホンアミド類
WO2010135350A2 (en) * 2009-05-20 2010-11-25 Pharmacopeia, Llc Biphenyl intermediate compounds and methods for the preparation of a dual angiotensin ii and endothelin a receptor antagonist
JP2012522058A (ja) * 2009-03-31 2012-09-20 リガンド・ファーマシューティカルズ・インコーポレイテッド 血圧上昇および糖尿病性腎症を処置するための、ジフェニルスルホンアミドエンドセリンおよびアンジオテンシンｉｉ受容体アゴニストの経口製剤
WO2018071784A1 (en) * 2016-10-13 2018-04-19 Retrophin, Inc. Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003520785A (ja) * 1999-12-15 2003-07-08 ブリストル−マイヤーズ スクイブ カンパニー アンジオテンシン・エンドセリン受容体二重拮抗薬としてのビフェニルスルホンアミド類
JP2012522058A (ja) * 2009-03-31 2012-09-20 リガンド・ファーマシューティカルズ・インコーポレイテッド 血圧上昇および糖尿病性腎症を処置するための、ジフェニルスルホンアミドエンドセリンおよびアンジオテンシンｉｉ受容体アゴニストの経口製剤
WO2010135350A2 (en) * 2009-05-20 2010-11-25 Pharmacopeia, Llc Biphenyl intermediate compounds and methods for the preparation of a dual angiotensin ii and endothelin a receptor antagonist
WO2018071784A1 (en) * 2016-10-13 2018-04-19 Retrophin, Inc. Biphenyl sulfonamide compounds for the treatment of kidney diseases or disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIAN YU: ""Amorphous pharmaceutical solids: preparation, characterization and stabilization"", ADVANCED DRUG DELIVERY REVIEWS, vol. 48, JPN5022003300, 2001, pages 27 - 42, ISSN: 0005208984 *
NATESAN MURUGESAN ET AL.: ""Dual Angiotensin II and Endothelin A Receptor Antagonists: Synthesis of 2'-Substituted N-3-Isoxazol", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 1, JPN6023049608, 2005, pages 171 - 179, ISSN: 0005208985 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024101440A1 (ja) * 2022-11-11 2024-05-16 株式会社アークメディスン 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物

Also Published As

Publication number Publication date
CA3124127A1 (en) 2020-06-25
MX2021007258A (es) 2021-08-16
US20220048900A1 (en) 2022-02-17
EP3897834A1 (en) 2021-10-27
BR112021012226A2 (pt) 2021-09-08
KR20210125994A (ko) 2021-10-19
AU2019404552A1 (en) 2021-07-15
IL284186A (en) 2021-08-31
WO2020132594A1 (en) 2020-06-25
CN114126712A (zh) 2022-03-01
MA54542A (fr) 2021-10-27

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