JP2022513347A - 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法 - Google Patents

高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法 Download PDF

Info

Publication number
JP2022513347A
JP2022513347A JP2021544949A JP2021544949A JP2022513347A JP 2022513347 A JP2022513347 A JP 2022513347A JP 2021544949 A JP2021544949 A JP 2021544949A JP 2021544949 A JP2021544949 A JP 2021544949A JP 2022513347 A JP2022513347 A JP 2022513347A
Authority
JP
Japan
Prior art keywords
continuous
polynucleic acid
acid molecule
cassette
genome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021544949A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022513347A5 (cg-RX-API-DMAC7.html
Inventor
べネンソン，ヤコブ
アンジェリシ，バルトロメオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ETH Zurich
Original Assignee
ETH Zurich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ETH Zurich filed Critical ETH Zurich
Publication of JP2022513347A publication Critical patent/JP2022513347A/ja
Publication of JP2022513347A5 publication Critical patent/JP2022513347A5/ja
Priority to JP2024192576A priority Critical patent/JP2025049296A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/40—Vector systems having a special element relevant for transcription being an insulator

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2021544949A 2018-10-11 2019-10-10 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法 Pending JP2022513347A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024192576A JP2025049296A (ja) 2018-10-11 2024-11-01 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862744173P 2018-10-11 2018-10-11
US62/744,173 2018-10-11
PCT/IB2019/001100 WO2020074956A2 (en) 2018-10-11 2019-10-10 A method to treat disease using a nucleic acid vector encoding a highly compact multi-input logic gate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024192576A Division JP2025049296A (ja) 2018-10-11 2024-11-01 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法

Publications (2)

Publication Number Publication Date
JP2022513347A true JP2022513347A (ja) 2022-02-07
JP2022513347A5 JP2022513347A5 (cg-RX-API-DMAC7.html) 2022-10-14

Family

ID=68654816

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021544949A Pending JP2022513347A (ja) 2018-10-11 2019-10-10 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法
JP2024192576A Pending JP2025049296A (ja) 2018-10-11 2024-11-01 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024192576A Pending JP2025049296A (ja) 2018-10-11 2024-11-01 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法

Country Status (8)

Country Link
US (1) US20210381001A1 (cg-RX-API-DMAC7.html)
EP (1) EP3864158A2 (cg-RX-API-DMAC7.html)
JP (2) JP2022513347A (cg-RX-API-DMAC7.html)
KR (1) KR20210075126A (cg-RX-API-DMAC7.html)
CN (1) CN112823209A (cg-RX-API-DMAC7.html)
AU (2) AU2019359505B2 (cg-RX-API-DMAC7.html)
CA (1) CA3113325A1 (cg-RX-API-DMAC7.html)
WO (1) WO2020074956A2 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021256845A1 (en) * 2020-04-14 2022-11-24 Eidgenössische Technische Hochschule Zürich Cell classifier circuits and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008545406A (ja) * 2005-05-27 2008-12-18 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7527942B2 (en) 2002-02-08 2009-05-05 The Regents Of The University Of California Transcription amplification system for molecular imaging
WO2008070448A2 (en) 2006-11-22 2008-06-12 Board Of Regents, The University Of Texas System Cancer-specific promoters
US9458509B2 (en) 2010-07-22 2016-10-04 President And Fellows Of Harvard College Multiple input biologic classifier circuits for cells
JP6419082B2 (ja) 2012-12-13 2018-11-07 マサチューセッツ インスティテュート オブ テクノロジー リコンビナーゼに基づく論理／メモリシステム
KR20160097338A (ko) * 2013-12-12 2016-08-17 더 브로드 인스티튜트, 인코퍼레이티드 뉴클레오티드 반복 장애에서의 ｃｒｉｓｐｒ-ｃａｓ 시스템의 조성물 및 방법 및 용도
US11030531B2 (en) 2014-06-06 2021-06-08 Trustees Of Boston University DNA recombinase circuits for logical control of gene expression
AU2016337408B2 (en) * 2015-10-16 2022-11-03 Astrazeneca Ab Inducible modification of a cell genome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008545406A (ja) * 2005-05-27 2008-12-18 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Bartolomeo A., Design and Implementation of Transcription Factor Based Gene Classifier Circuits, [on", DOCTORAL THESIS, ETH ZURICH, vol. pp. 1-172, JPN6023039942, 2017, ISSN: 0005515876 *
BMC BIOTECHNOL, vol. 13, JPN6023039938, 22 January 2013 (2013-01-22), pages 5 - 1, ISSN: 0005515878 *
CELL REP, vol. 16, no. 9, JPN6023039936, 18 August 2016 (2016-08-18), pages 2525 - 2537, ISSN: 0005515877 *
MOL THER, vol. 15, no. 7, JPN6023039940, 1 May 2007 (2007-05-01), pages 1340 - 2347, ISSN: 0005515880 *
NUCLEIC ACIDS RES, vol. 46, no. 18, JPN7023003645, 7 September 2018 (2018-09-07), pages 9855 - 9863, ISSN: 0005515879 *

Also Published As

Publication number Publication date
US20210381001A1 (en) 2021-12-09
JP2025049296A (ja) 2025-04-03
AU2019359505B2 (en) 2026-03-19
AU2026201687A1 (en) 2026-03-26
CN112823209A (zh) 2021-05-18
WO2020074956A3 (en) 2020-05-22
WO2020074956A2 (en) 2020-04-16
KR20210075126A (ko) 2021-06-22
EP3864158A2 (en) 2021-08-18
AU2019359505A1 (en) 2021-04-29
CA3113325A1 (en) 2020-04-16

Similar Documents

Publication Publication Date Title
KR102409077B1 (ko) 프로그램 가능한 항암 바이러스 백신 시스템 및 이의 적용
JP2021518161A5 (cg-RX-API-DMAC7.html)
JP2021518160A5 (cg-RX-API-DMAC7.html)
JP2008545406A5 (cg-RX-API-DMAC7.html)
CN104212802B (zh) 一种肿瘤细胞广谱高活性启动子及其用途
CN111989108A (zh) 利用rna去稳定元件协调基因表达
JP2021522188A (ja) 内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法
CN110073000A (zh) 遗传擦除子
CN103981155B (zh) 靶向肝癌溶瘤腺病毒的构建法和应用
AU2026201687A1 (en) A method to treat disease using a nucleic acid vector encoding a highly compact multi-input logic gate
KR101478869B1 (ko) 마이크로ｒｎａ를 이용한 조절을 통한 암 특이적 유전자 치료제
WO2021037232A1 (zh) 编辑造血干/祖细胞中bcl11a基因的方法
Isaeva et al. Shaping viral immunotherapy towards cancer-targeted immunological cell death
CN103667347A (zh) 一种高效表达抗癌基因的受特定miRNA调控的在胶质瘤细胞中特异增殖的腺病毒及其用途
JP7854941B2 (ja) 細胞分類指標回路およびその使用の方法
EP4048796B1 (en) Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy
HK40053066A (en) A method to treat disease using a nucleic acid vector encoding a highly compact multi-input logic gate
Yu et al. Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies
CN103981185A (zh) 肝癌特异性gp73核心启动子及其筛选构建方法
Ito et al. Cytotoxic effect of Drosophila deoxynucleoside kinase gene on replicating plasmid in HeLa cells
Valerie et al. Strategies of Gene Transfer and Silencing, and Technical Considerations
HK1253377B (en) Programmable vaccine system for oncolytic viruses and application of the same
HK40012408A (en) Spatiotemporal regulators
Somiari Methods and Application

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210412

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221005

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221005

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230913

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230928

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240227

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240327

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240701

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241101

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20241217