JP2022512941A - 核酸送達のためのハイブリッド犠牲細胞透過性複合体 - Google Patents
核酸送達のためのハイブリッド犠牲細胞透過性複合体 Download PDFInfo
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- JP2022512941A JP2022512941A JP2021524356A JP2021524356A JP2022512941A JP 2022512941 A JP2022512941 A JP 2022512941A JP 2021524356 A JP2021524356 A JP 2021524356A JP 2021524356 A JP2021524356 A JP 2021524356A JP 2022512941 A JP2022512941 A JP 2022512941A
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- 0 CCC(C)(C(C)(C)NC(C)(C)C(C)(**)**)*=N Chemical compound CCC(C)(C(C)(C)NC(C)(C)C(C)(**)**)*=N 0.000 description 12
- UXXIFJBQPUDTNK-UHFFFAOYSA-N COCC1CCCCC1 Chemical compound COCC1CCCCC1 UXXIFJBQPUDTNK-UHFFFAOYSA-N 0.000 description 1
- GQKZBCPTCWJTAS-UHFFFAOYSA-N COCc1ccccc1 Chemical compound COCc1ccccc1 GQKZBCPTCWJTAS-UHFFFAOYSA-N 0.000 description 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G64/02—Aliphatic polycarbonates
- C08G64/0291—Aliphatic polycarbonates unsaturated
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Zoology (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
- Nanotechnology (AREA)
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- Physics & Mathematics (AREA)
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- General Chemical & Material Sciences (AREA)
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- Oncology (AREA)
- Cell Biology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862758487P | 2018-11-09 | 2018-11-09 | |
| US62/758,487 | 2018-11-09 | ||
| PCT/US2019/060807 WO2020097614A2 (en) | 2018-11-09 | 2019-11-11 | Hybrid immolative cell-penetrating complexes for nucleic acid delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022512941A true JP2022512941A (ja) | 2022-02-07 |
| JP2022512941A5 JP2022512941A5 (enExample) | 2022-11-17 |
Family
ID=70612292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524356A Pending JP2022512941A (ja) | 2018-11-09 | 2019-11-11 | 核酸送達のためのハイブリッド犠牲細胞透過性複合体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12215341B2 (enExample) |
| EP (1) | EP3877002A4 (enExample) |
| JP (1) | JP2022512941A (enExample) |
| KR (1) | KR20210125979A (enExample) |
| CN (1) | CN113573740A (enExample) |
| AU (1) | AU2019377137B2 (enExample) |
| CA (1) | CA3119288A1 (enExample) |
| IL (1) | IL283037A (enExample) |
| WO (1) | WO2020097614A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4185331A4 (en) * | 2020-07-24 | 2025-02-26 | The Board of Trustees of the Leland Stanford Junior University | THREE-COMPONENT VACCINE FOR COVID-19 |
| US20250177559A1 (en) | 2022-03-09 | 2025-06-05 | The Board Of Trustees Of The Leland Stanford Junior University | Branched lipid charge-altering releasable transporters for nucleic acid delivery |
| US20260103709A1 (en) | 2022-09-29 | 2026-04-16 | The Board Of Trustees Of The Leland Stanford Junior University | C-myc-targeting charge-altering releasable transporters as anti-tumor agents for breast cancer therapy |
| EP4615508A1 (en) | 2022-11-08 | 2025-09-17 | The Board Of Trustees Of The Leland Stanford Junior University | Charge-altering nucleic acid transporters with beta-amido carbonate backbones |
| WO2025034780A1 (en) * | 2023-08-08 | 2025-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Statistical charge-altering releasable transporters for nucleic acid delivery |
| WO2025034782A1 (en) * | 2023-08-08 | 2025-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Charge-altering releasable transporters from amino alcohol initiators |
| US20250302763A1 (en) * | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2026026972A1 (zh) * | 2024-08-01 | 2026-02-05 | 苏州百递博远生物科技有限公司 | 核酸递送载体及其制备与应用 |
| WO2026026974A1 (zh) * | 2024-08-01 | 2026-02-05 | 苏州百递博远生物科技有限公司 | 功能性聚碳酸酯及其制备方法与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018022930A1 (en) * | 2016-07-27 | 2018-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Immolative cell-penetrating complexes for nucleic acid delivery |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| JP2004535388A (ja) | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
| WO2003106636A2 (en) * | 2002-06-14 | 2003-12-24 | Mirus Corporation | Novel methods for the delivery of polynucleotides to cells |
| US9902957B2 (en) | 2011-09-06 | 2018-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Amphipathic co-oligomers for the delivery of siRNA |
| US20150329640A1 (en) * | 2012-12-20 | 2015-11-19 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| AU2016243583B2 (en) * | 2015-03-27 | 2022-03-10 | President And Fellows Of Harvard College | Modified T cells and methods of making and using the same |
| US10654875B2 (en) | 2015-11-12 | 2020-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
-
2019
- 2019-11-11 KR KR1020217017692A patent/KR20210125979A/ko not_active Abandoned
- 2019-11-11 US US17/292,370 patent/US12215341B2/en active Active
- 2019-11-11 CN CN201980085871.9A patent/CN113573740A/zh active Pending
- 2019-11-11 EP EP19883021.8A patent/EP3877002A4/en active Pending
- 2019-11-11 AU AU2019377137A patent/AU2019377137B2/en active Active
- 2019-11-11 CA CA3119288A patent/CA3119288A1/en active Pending
- 2019-11-11 WO PCT/US2019/060807 patent/WO2020097614A2/en not_active Ceased
- 2019-11-11 JP JP2021524356A patent/JP2022512941A/ja active Pending
-
2021
- 2021-05-09 IL IL283037A patent/IL283037A/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018022930A1 (en) * | 2016-07-27 | 2018-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Immolative cell-penetrating complexes for nucleic acid delivery |
Non-Patent Citations (1)
| Title |
|---|
| COLIN J. MCKINLAY ET AL.: ""Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering relea", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 115, no. 26, JPN6023044455, 11 June 2018 (2018-06-11), pages 5859 - 5866, ISSN: 0005304822 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220088163A1 (en) | 2022-03-24 |
| CN113573740A (zh) | 2021-10-29 |
| EP3877002A4 (en) | 2022-11-02 |
| AU2019377137A1 (en) | 2021-05-27 |
| US12215341B2 (en) | 2025-02-04 |
| EP3877002A2 (en) | 2021-09-15 |
| CA3119288A1 (en) | 2020-05-14 |
| IL283037A (en) | 2021-06-30 |
| KR20210125979A (ko) | 2021-10-19 |
| WO2020097614A2 (en) | 2020-05-14 |
| AU2019377137B2 (en) | 2025-12-11 |
| WO2020097614A3 (en) | 2020-06-11 |
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| JP2022512941A (ja) | 核酸送達のためのハイブリッド犠牲細胞透過性複合体 | |
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