JP2022512735A - 肝疾患を治療するための組成物および方法 - Google Patents

肝疾患を治療するための組成物および方法 Download PDF

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JP2022512735A
JP2022512735A JP2021521144A JP2021521144A JP2022512735A JP 2022512735 A JP2022512735 A JP 2022512735A JP 2021521144 A JP2021521144 A JP 2021521144A JP 2021521144 A JP2021521144 A JP 2021521144A JP 2022512735 A JP2022512735 A JP 2022512735A
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wisp1
antibody
liver
liver disease
mir
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ユンソク チェ,マイケル
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ザ ジェネラル ホスピタル コーポレイション
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N5/067Hepatocytes
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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JP2021521144A 2018-10-19 2019-10-18 肝疾患を治療するための組成物および方法 Withdrawn JP2022512735A (ja)

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JP2024163238A JP2025011102A (ja) 2018-10-19 2024-09-20 肝疾患を治療するための組成物および方法

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US201862747903P 2018-10-19 2018-10-19
US62/747,903 2018-10-19
PCT/US2019/056910 WO2020081920A1 (en) 2018-10-19 2019-10-18 Compositions and methods for treatment of liver disease

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US (2) US20210388073A1 (https=)
EP (1) EP3866852A4 (https=)
JP (2) JP2022512735A (https=)
KR (1) KR20210081366A (https=)
CN (2) CN120305401A (https=)
AU (1) AU2019361120A1 (https=)
CA (1) CA3117098A1 (https=)
IL (1) IL282251A (https=)
WO (1) WO2020081920A1 (https=)

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Publication number Priority date Publication date Assignee Title
CA3154648A1 (en) 2019-09-16 2021-03-25 Opsidio, LLC Anti-stem cell factor antibodies and methods of use thereof
US20220378843A1 (en) * 2019-11-01 2022-12-01 Figene, Llc Fibroblast-based therapy for treatment of sclerosing cholangitis
CN117487010B (zh) * 2022-08-02 2025-02-14 东莞市朋志生物科技有限公司 抗四碘甲状腺素抗体或其功能性片段、检测四碘甲状腺素的试剂和试剂盒
AU2024232439A1 (en) * 2023-03-03 2025-08-28 Karydo Therapeutix, Inc. Antibody or antigen-binding fragment of same
CN117045680B (zh) * 2023-10-12 2023-12-08 北京国卫生物科技有限公司 促进肝脏再生的干细胞制剂及其制备方法
WO2025179048A2 (en) * 2024-02-20 2025-08-28 Ecogenome Llc Antibodies that bind dach1 and methods of use
CN119331100B (zh) * 2024-10-16 2025-07-25 天津大学 特异性结合25-羟基维生素d的单克隆抗体及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064478A1 (en) * 1999-04-27 2000-11-02 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
WO2003014345A1 (fr) * 2001-08-08 2003-02-20 Ajinomoto Co., Inc. Ensemble de genes participant a l'activation des astrocytes du foie
JP2013531487A (ja) * 2010-06-02 2013-08-08 アルナイラム ファーマシューティカルズ, インコーポレイテッド 肝線維症治療用組成物および肝線維症の治療法
JP2017513854A (ja) * 2014-04-15 2017-06-01 ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. Wisp1に結合する抗原結合タンパク質
WO2017201422A1 (en) * 2016-05-20 2017-11-23 The General Hospital Corporation Using micrornas to control activation status of hepatic stellate cells and to prevent fibrosis in progressive liver diseases

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EP2014770A3 (en) * 1997-10-29 2009-02-18 Genentech, Inc. WNT-1 Iinduced secreted polypeptide WISP-2
AU2015360502A1 (en) * 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000064478A1 (en) * 1999-04-27 2000-11-02 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
WO2003014345A1 (fr) * 2001-08-08 2003-02-20 Ajinomoto Co., Inc. Ensemble de genes participant a l'activation des astrocytes du foie
JP2013531487A (ja) * 2010-06-02 2013-08-08 アルナイラム ファーマシューティカルズ, インコーポレイテッド 肝線維症治療用組成物および肝線維症の治療法
JP2017513854A (ja) * 2014-04-15 2017-06-01 ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. Wisp1に結合する抗原結合タンパク質
WO2017201422A1 (en) * 2016-05-20 2017-11-23 The General Hospital Corporation Using micrornas to control activation status of hepatic stellate cells and to prevent fibrosis in progressive liver diseases

Non-Patent Citations (5)

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Title
ARCH. MED. SCI., vol. 11, no. 3, JPN6023038722, 2015, pages 647 - 653, ISSN: 0005327300 *
JOURNAL OF HEPATOLOGY, vol. 68, no. 1, JPN6023038723, April 2018 (2018-04-01), pages 614 - 615, ISSN: 0005158741 *
肝胆膵, vol. 53(3), JPN6024018745, 2006, pages 349 - 355, ISSN: 0005327303 *
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肝胆膵, vol. 60(6), JPN6024018744, 2010, pages 1033 - 1040, ISSN: 0005327302 *

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JP2025011102A (ja) 2025-01-23
US20210388073A1 (en) 2021-12-16
WO2020081920A1 (en) 2020-04-23
AU2019361120A1 (en) 2021-05-13
CN120305401A (zh) 2025-07-15
IL282251A (en) 2021-05-31
EP3866852A4 (en) 2022-07-06
EP3866852A1 (en) 2021-08-25
KR20210081366A (ko) 2021-07-01
US20250223344A1 (en) 2025-07-10
CA3117098A1 (en) 2020-04-23
CN113271971A (zh) 2021-08-17

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