JP2022501381A - 筋萎縮性側索硬化症の治療方法 - Google Patents

筋萎縮性側索硬化症の治療方法 Download PDF

Info

Publication number
JP2022501381A
JP2022501381A JP2021515595A JP2021515595A JP2022501381A JP 2022501381 A JP2022501381 A JP 2022501381A JP 2021515595 A JP2021515595 A JP 2021515595A JP 2021515595 A JP2021515595 A JP 2021515595A JP 2022501381 A JP2022501381 A JP 2022501381A
Authority
JP
Japan
Prior art keywords
als
sulfate
palmitoyl
mice
sod1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021515595A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020058979A5 (zh
Inventor
エラン エリナヴ,
エラン セガル,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL261908A external-priority patent/IL261908A/en
Priority claimed from IL26775219A external-priority patent/IL267752A/en
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of JP2022501381A publication Critical patent/JP2022501381A/ja
Publication of JPWO2020058979A5 publication Critical patent/JPWO2020058979A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021515595A 2018-09-20 2019-09-19 筋萎縮性側索硬化症の治療方法 Pending JP2022501381A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL261908A IL261908A (en) 2018-09-20 2018-09-20 Methods of treating amyotrophic lateral sclerosis
IL261908 2018-09-20
IL267752 2019-06-27
IL26775219A IL267752A (en) 2019-06-27 2019-06-27 Methods of treating amyotrophic lateral sclerosis
PCT/IL2019/051041 WO2020058979A2 (en) 2018-09-20 2019-09-19 Methods of treating amyotrophic lateral sclerosis

Publications (2)

Publication Number Publication Date
JP2022501381A true JP2022501381A (ja) 2022-01-06
JPWO2020058979A5 JPWO2020058979A5 (zh) 2022-09-27

Family

ID=69886990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021515595A Pending JP2022501381A (ja) 2018-09-20 2019-09-19 筋萎縮性側索硬化症の治療方法

Country Status (6)

Country Link
US (1) US20210353611A1 (zh)
EP (1) EP3852759A2 (zh)
JP (1) JP2022501381A (zh)
CN (1) CN113038951B (zh)
CA (1) CA3112135A1 (zh)
WO (1) WO2020058979A2 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440884B (zh) * 2020-04-22 2021-03-16 中国医学科学院北京协和医院 源于肠道的诊断肌少症的菌群及其用途
WO2022236131A1 (en) * 2021-05-07 2022-11-10 Board Of Regents, The University Of Texas System Serum metabolomics related to chimeric antigen receptor (car) t-cell therapy
WO2023156983A1 (en) * 2022-02-21 2023-08-24 Universidade Nova De Lisboa Compounds and compositions for neurodegenerative diseases
CN114642684A (zh) * 2022-03-21 2022-06-21 北京航空航天大学 用于防治焦虑抑郁症的直肠真杆菌(Eubacterium rectale)
WO2024015955A2 (en) * 2022-07-15 2024-01-18 President And Fellows Of Harvard College Mucispirillum compositions and cancer treatment methods thereof
CN117805249A (zh) * 2022-09-23 2024-04-02 合肥瀚微生物科技有限公司 一种抑郁症诊断的生物标记物及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
AU744156B2 (en) 1996-10-28 2002-02-14 General Mills Inc. Embedding and encapsulation of controlled release particles
GB9715584D0 (en) 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
EE200300360A (et) 2001-01-31 2003-12-15 Pfizer Products Inc. PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid
AU2003201745A1 (en) 2002-02-11 2003-09-04 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken INDUCTION / DIFFERENTIATION METHOD IN PHOTORECEPTOR CELL
EP3263127B1 (en) 2011-05-23 2019-08-21 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
US20140303228A1 (en) * 2011-10-18 2014-10-09 Metabolon, Inc. Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same
WO2016079731A2 (en) 2014-11-17 2016-05-26 Yeda Research And Development Co. Ltd. Method of analyzing microbiome
EP3483256A4 (en) * 2016-07-11 2019-12-04 Korea Research Institute of Bioscience and Biotechnology AKKERMANSIA MUCINIPHILA TRIBE WITH EFFECT FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASES OR METABOLIC DISEASES AND USE THEREOF
CA3045026A1 (en) * 2016-12-06 2018-06-14 Whole Biome Inc. Methods and compositions relating to isolated and purified microbes

Also Published As

Publication number Publication date
CN113038951B (zh) 2024-04-30
CN113038951A (zh) 2021-06-25
CA3112135A1 (en) 2020-03-26
WO2020058979A9 (en) 2020-05-28
EP3852759A2 (en) 2021-07-28
WO2020058979A3 (en) 2020-04-16
WO2020058979A2 (en) 2020-03-26
US20210353611A1 (en) 2021-11-18

Similar Documents

Publication Publication Date Title
JP2022501381A (ja) 筋萎縮性側索硬化症の治療方法
US20210386798A1 (en) Methods and compositions relating to microbial treatment and diagnosis of disorders
US20210254171A1 (en) Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
US10092596B2 (en) Tungstate treatment of the dysbiosis associated with gastrointestinal inflammation
JP2021501130A (ja) DUX4の発現を低減するためのp38阻害剤の使用
US20210085744A1 (en) Edible plant-derived nanoparticles for regulation of gut microbiota
US20200268813A1 (en) Modulation of host immune cell populations using gut microbiota
Plaeke et al. Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)‐induced mouse model for sepsis
Du et al. The role and mechanisms of the two‐component system EnvZ/OmpR on the intracellular survival of Aeromonas hydrophila
US20220047538A1 (en) Tuft cell specification in inflammatory ileitis
AU2016361499B2 (en) Methods and compositions for identifying and treating subjects at risk for checkpoint blockade therapy associated colitis
WO2020176461A2 (en) Methods and compositions for treating neuroendocrine prostate cancer
US20190343782A1 (en) Methods of treating liver toxicity and disorders
Bai et al. frontiers ORIGINAL RESEARCH in Microbiology published: 02 November 2021
Villani Establishing the Gut-Joint Axis: The Role of the Gut Microbiome, Colonic Inflammation, and Immune Cell Migration in Osteoarthritis
Uttarwar Metatranscriptomics Analysis of Ileum Microbial Communities in Necrotic Enteritis Chickens
WO2018070524A1 (ja) 血中のIgAの産生抑制剤又は血中の過剰IgAに起因する疾患の予防又は治療剤をスクリーニングする方法
Peña-Cearra et al. Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation
CN106999607A (zh) 非编码rna malat‑1是调控学习和记忆的靶标
TW202216169A (zh) 低醯化脂多醣用於抗氧化及預防/治療疾病的用途
CN118226036A (zh) 一种cGAS的应用
US20180214519A1 (en) Combination therapies for modulation of histone methyl modifying enzymes
Shank The Roles of Calprotectin and Calgranulin C in Campylobacter jejuni Infection

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220914

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220914

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240405

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240611