JP2022501060A5 - - Google Patents
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- Publication number
- JP2022501060A5 JP2022501060A5 JP2021517702A JP2021517702A JP2022501060A5 JP 2022501060 A5 JP2022501060 A5 JP 2022501060A5 JP 2021517702 A JP2021517702 A JP 2021517702A JP 2021517702 A JP2021517702 A JP 2021517702A JP 2022501060 A5 JP2022501060 A5 JP 2022501060A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- nucleic acid
- sequence
- promoter
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738894P | 2018-09-28 | 2018-09-28 | |
| US62/738,894 | 2018-09-28 | ||
| PCT/US2019/053492 WO2020069339A1 (en) | 2018-09-28 | 2019-09-27 | Mutant reverse tetracycline transactivators for expression of genes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501060A JP2022501060A (ja) | 2022-01-06 |
| JP2022501060A5 true JP2022501060A5 (enExample) | 2022-10-05 |
| JP7589997B2 JP7589997B2 (ja) | 2024-11-26 |
Family
ID=68242854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517702A Active JP7589997B2 (ja) | 2018-09-28 | 2019-09-27 | 遺伝子の発現のための変異体リバーステトラサイクリントランスアクチベーター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20210403923A1 (enExample) |
| EP (1) | EP3856260A1 (enExample) |
| JP (1) | JP7589997B2 (enExample) |
| CN (1) | CN113164625B (enExample) |
| CA (1) | CA3113470A1 (enExample) |
| WO (1) | WO2020069339A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL281470B2 (en) | 2018-09-28 | 2025-08-01 | Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| US12274733B2 (en) | 2018-09-28 | 2025-04-15 | President And Fellows Of Harvard College | Cellular reprogramming to reverse aging and promote organ and tissue regeneration |
| CA3159557A1 (en) * | 2019-11-05 | 2021-05-14 | Lonza Walkersville, Inc. | Allogeneic t-cells and methods for production thereof |
| GB202103327D0 (en) * | 2021-03-10 | 2021-04-21 | Babraham Inst | Novel method |
| US12467917B2 (en) | 2021-03-16 | 2025-11-11 | California Institute Of Technology | Reconstructing human early embryogenesis in vitro with pluripotent stem cells |
| EP4355882A2 (en) * | 2021-06-15 | 2024-04-24 | Modernatx, Inc. | Engineered polynucleotides for cell-type or microenvironment-specific expression |
| WO2023196851A1 (en) * | 2022-04-06 | 2023-10-12 | President And Fellows Of Harvard College | Reversing aging of the central nervous system |
| WO2024012504A1 (zh) * | 2022-07-12 | 2024-01-18 | 南京瑞初医药有限公司 | 组合物及其使用方法 |
| WO2024026254A1 (en) * | 2022-07-26 | 2024-02-01 | Modernatx, Inc. | Engineered polynucleotides for temporal control of expression |
| CN116004789B (zh) * | 2022-08-01 | 2024-06-04 | 湖南家辉生物技术有限公司 | 一种Seckel综合征致病基因CEP152突变位点的应用及其诊断试剂 |
| US12252518B2 (en) | 2023-01-06 | 2025-03-18 | Life Biosciences, Inc. | Methods of treating non-arteritic anterior ischemic optic neuropathy |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
| JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| AU746850B2 (en) * | 1994-07-01 | 2002-05-02 | Tet Systems Holding Gmbh & Co. Kg | Tetracycline-regulated transcriptional modulaters |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| DE19851415B4 (de) * | 1998-11-07 | 2010-11-04 | Wolfgang Hillen | Mutanter Transaktivator |
| MX359371B (es) | 2001-11-13 | 2018-09-25 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| US20030186281A1 (en) * | 2001-12-21 | 2003-10-02 | Wolfgang Hillen | Modified tetracycline repressor protein compositions and methods of use |
| GB0327384D0 (en) * | 2003-11-25 | 2003-12-31 | Queen Mary & Westfield College | Gene therapy |
| ATE512228T1 (de) * | 2005-11-17 | 2011-06-15 | Tet Systems Gmbh & Co Kg | Induzierbare expressionssysteme |
| US9388425B2 (en) * | 2006-10-20 | 2016-07-12 | Trustees Of Boston University | Tunable genetic switch for regulating gene expression |
| US8080647B2 (en) * | 2006-11-22 | 2011-12-20 | Pioneer Hi Bred International Inc | Tetracycline repressor and uses thereof |
| CN101302553A (zh) * | 2008-05-30 | 2008-11-12 | 广州华峰生物科技有限公司 | 基于环介导等温扩增技术的结核分歧杆菌基因快速诊断试剂盒及其检测方法 |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| WO2012071549A2 (en) * | 2010-11-24 | 2012-05-31 | Clontech Laboratories, Inc. | Inducible expression system transcription modulators comprising a distributed protein transduction domain and methods for using the same |
| EP2710130B1 (en) * | 2011-05-19 | 2022-06-29 | Fundación Pública Andaluza Progreso Y Salud | Highly inducible dual-promoter lentiviral tet-on system |
| CN102816793B (zh) * | 2012-08-22 | 2014-09-10 | 陕西师范大学 | 单载体双向启动的Tet-on诱导表达系统及其构建方法和应用 |
| DK2898076T3 (en) * | 2012-09-19 | 2018-06-14 | Dsm Ip Assets Bv | METHOD OF CELL MODIFICATION USING ESSENTIAL GENES AS MARKERS AND EVEN RECYCLING THESE |
| KR20150087321A (ko) * | 2012-11-21 | 2015-07-29 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 신경독소 생물학적 활성의 결정을 위한 수단 및 방법 |
| US10004765B2 (en) * | 2013-03-14 | 2018-06-26 | University Of Massachusetts | Dosage compensating transgenes and cells |
| US11219636B2 (en) * | 2015-05-17 | 2022-01-11 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Compositions and methods for treating cancer |
| AU2016315703A1 (en) * | 2015-08-31 | 2018-03-08 | The Trustees Of The University Of Pennsylvania | Chimeric AAV-anti-VEGF for treating cancer in canines |
| CN111801345A (zh) * | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019099552A1 (en) * | 2017-11-14 | 2019-05-23 | The J. David Gladstone Institutes | Methods of generating retinal pigment epithelium (rpe) |
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2019
- 2019-09-27 EP EP19787521.4A patent/EP3856260A1/en active Pending
- 2019-09-27 JP JP2021517702A patent/JP7589997B2/ja active Active
- 2019-09-27 CA CA3113470A patent/CA3113470A1/en active Pending
- 2019-09-27 US US17/280,294 patent/US20210403923A1/en active Pending
- 2019-09-27 CN CN201980076921.7A patent/CN113164625B/zh active Active
- 2019-09-27 WO PCT/US2019/053492 patent/WO2020069339A1/en not_active Ceased