JP2022180348A5 - - Google Patents
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- Publication number
- JP2022180348A5 JP2022180348A5 JP2022128528A JP2022128528A JP2022180348A5 JP 2022180348 A5 JP2022180348 A5 JP 2022180348A5 JP 2022128528 A JP2022128528 A JP 2022128528A JP 2022128528 A JP2022128528 A JP 2022128528A JP 2022180348 A5 JP2022180348 A5 JP 2022180348A5
- Authority
- JP
- Japan
- Prior art keywords
- small
- tag
- library
- encoded
- linked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003384 small molecules Chemical class 0.000 claims 27
- 150000002605 large molecules Chemical class 0.000 claims 26
- 229920002521 macromolecule Polymers 0.000 claims 26
- 238000000034 method Methods 0.000 claims 17
- 238000003556 assay Methods 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 230000000269 nucleophilic effect Effects 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000003786 synthesis reaction Methods 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201618820 | 2016-11-08 | ||
| GB1618820.3 | 2016-11-08 | ||
| GBGB1709718.9A GB201709718D0 (en) | 2017-06-19 | 2017-06-19 | Tagless encoded chemical library |
| GB1709718.9 | 2017-06-19 | ||
| JP2019523655A JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
| PCT/GB2017/053360 WO2018087539A1 (en) | 2016-11-08 | 2017-11-08 | Tagless encoded chemical library |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Division JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022180348A JP2022180348A (ja) | 2022-12-06 |
| JP2022180348A5 true JP2022180348A5 (https=) | 2023-05-11 |
Family
ID=60702823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Pending JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
| JP2022128528A Pending JP2022180348A (ja) | 2016-11-08 | 2022-08-10 | タグなしコード化化学ライブラリ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523655A Pending JP2020503846A (ja) | 2016-11-08 | 2017-11-08 | タグなしコード化化学ライブラリ |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190264199A1 (https=) |
| EP (1) | EP3538653B1 (https=) |
| JP (2) | JP2020503846A (https=) |
| KR (1) | KR102355956B1 (https=) |
| CN (1) | CN110249050B (https=) |
| AU (1) | AU2017357638B2 (https=) |
| CA (1) | CA3042974A1 (https=) |
| IL (1) | IL266318B2 (https=) |
| WO (1) | WO2018087539A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019060830A1 (en) * | 2017-09-25 | 2019-03-28 | Plexium, Inc. | CHEMICAL LIBRARIES CODED BY OLIGONUCLEOTIDES |
| WO2020001560A1 (zh) * | 2018-06-29 | 2020-01-02 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
| GB201817321D0 (en) * | 2018-10-24 | 2018-12-05 | Nanna Therapeutics Ltd | Microbeads for tagless encoded chemical library screening |
| US20220010373A1 (en) * | 2018-11-07 | 2022-01-13 | The University Of Tokyo | Method for detecting genome-related information of cell coexisting with at least one type of test substance |
| WO2020206114A1 (en) * | 2019-04-02 | 2020-10-08 | The Trustees Of Columbia University In The City Of New York | Sequencing by synthesis with energy transfer dye pairs |
| EP3956467A1 (en) | 2019-04-16 | 2022-02-23 | F. Hoffmann-La Roche AG | Small molecule screening cellular assay using modified beads |
| WO2020259689A1 (zh) * | 2019-06-27 | 2020-12-30 | 成都先导药物开发股份有限公司 | 一种可识别混合物对复杂生物体系的鉴别方法 |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US11643649B2 (en) * | 2020-01-10 | 2023-05-09 | Thinkcyte, Inc. | Cellular phenotype screening method |
| CN111304753B (zh) * | 2020-03-24 | 2020-12-01 | 深圳奇点药物科技有限公司 | Dna编码分子库的筛选方法和试剂盒 |
| US11628382B2 (en) * | 2020-08-26 | 2023-04-18 | Duke University | Methods and apparatuses for purification of gel droplets supporting biological tissue |
| JP2023548062A (ja) * | 2020-10-23 | 2023-11-15 | イーティーエイチ チューリッヒ | 自己精製された核酸コードライブラリー |
| KR20230165231A (ko) * | 2021-03-04 | 2023-12-05 | 오레곤 헬스 앤드 사이언스 유니버시티 | 분자 바코드 및 관련 방법 및 시스템 |
| US20250197937A1 (en) * | 2022-03-13 | 2025-06-19 | Eleven Therapeutics Ltd | System and method for high throughput evaluation of chemical modifications of nucleic acid molecules |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0307428D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| EP1718667B1 (en) * | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| ATE540750T1 (de) * | 2006-05-11 | 2012-01-15 | Raindance Technologies Inc | Mikrofluidische vorrichtung und verfahren |
| DK2396459T3 (en) * | 2009-02-13 | 2017-08-28 | X-Chem Inc | Method for preparing and screening DNA-encoded libraries |
| WO2012019765A1 (en) * | 2010-08-10 | 2012-02-16 | European Molecular Biology Laboratory (Embl) | Methods and systems for tracking samples and sample combinations |
| NZ734644A (en) * | 2015-02-24 | 2023-02-24 | Hope City | Chemically encoded spatially addressed library screening platforms |
| EP3268462B1 (en) * | 2015-03-11 | 2021-08-11 | The Broad Institute, Inc. | Genotype and phenotype coupling |
-
2017
- 2017-11-08 AU AU2017357638A patent/AU2017357638B2/en not_active Ceased
- 2017-11-08 KR KR1020197016158A patent/KR102355956B1/ko not_active Expired - Fee Related
- 2017-11-08 CA CA3042974A patent/CA3042974A1/en active Pending
- 2017-11-08 CN CN201780082633.3A patent/CN110249050B/zh active Active
- 2017-11-08 US US16/348,054 patent/US20190264199A1/en not_active Abandoned
- 2017-11-08 EP EP17817014.8A patent/EP3538653B1/en active Active
- 2017-11-08 IL IL266318A patent/IL266318B2/en unknown
- 2017-11-08 JP JP2019523655A patent/JP2020503846A/ja active Pending
- 2017-11-08 WO PCT/GB2017/053360 patent/WO2018087539A1/en not_active Ceased
-
2021
- 2021-11-29 US US17/536,889 patent/US20220073907A1/en not_active Abandoned
-
2022
- 2022-08-10 JP JP2022128528A patent/JP2022180348A/ja active Pending
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