JP2022130623A5 - - Google Patents
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- Publication number
- JP2022130623A5 JP2022130623A5 JP2022105405A JP2022105405A JP2022130623A5 JP 2022130623 A5 JP2022130623 A5 JP 2022130623A5 JP 2022105405 A JP2022105405 A JP 2022105405A JP 2022105405 A JP2022105405 A JP 2022105405A JP 2022130623 A5 JP2022130623 A5 JP 2022130623A5
- Authority
- JP
- Japan
- Prior art keywords
- adjuvant
- vaccine composition
- domain
- protein
- mic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002671 adjuvant Substances 0.000 claims 54
- 229960005486 vaccine Drugs 0.000 claims 44
- 239000002105 nanoparticle Substances 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 10
- 239000011707 mineral Substances 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004127 Cytokines Human genes 0.000 claims 6
- 108090000695 Cytokines Proteins 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 6
- 102000037865 fusion proteins Human genes 0.000 claims 6
- 230000002068 genetic effect Effects 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 101710157275 Ferritin subunit Proteins 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 5
- 108020003285 Isocitrate lyase Proteins 0.000 claims 4
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims 4
- 239000010445 mica Substances 0.000 claims 4
- 229910052618 mica group Inorganic materials 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 230000002018 overexpression Effects 0.000 claims 3
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 229940029575 guanosine Drugs 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000003308 immunostimulating effect Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- 238000011285 therapeutic regimen Methods 0.000 claims 2
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 101150042997 21 gene Proteins 0.000 claims 1
- VGGGPCQERPFHOB-MCIONIFRSA-N Bestatin Chemical compound CC(C)C[C@H](C(O)=O)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1 VGGGPCQERPFHOB-MCIONIFRSA-N 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 101710146739 Enterotoxin Proteins 0.000 claims 1
- 108050000784 Ferritin Proteins 0.000 claims 1
- 102000008857 Ferritin Human genes 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241000590002 Helicobacter pylori Species 0.000 claims 1
- 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims 1
- 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 229940009859 aluminum phosphate Drugs 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- SIEYLFHKZGLBNX-UHFFFAOYSA-N bupivacaine hydrochloride (anhydrous) Chemical compound [Cl-].CCCC[NH+]1CCCCC1C(=O)NC1=C(C)C=CC=C1C SIEYLFHKZGLBNX-UHFFFAOYSA-N 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000000147 enterotoxin Substances 0.000 claims 1
- 231100000655 enterotoxin Toxicity 0.000 claims 1
- 108700014844 flt3 ligand Proteins 0.000 claims 1
- 229940037467 helicobacter pylori Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 229960001614 levamisole Drugs 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 229940106885 marcaine Drugs 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 229950009811 ubenimex Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024167997A JP2024177207A (ja) | 2015-12-04 | 2024-09-27 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562263377P | 2015-12-04 | 2015-12-04 | |
| US62/263,377 | 2015-12-04 | ||
| US201662422454P | 2016-11-15 | 2016-11-15 | |
| US62/422,454 | 2016-11-15 | ||
| PCT/US2016/064969 WO2017096374A1 (en) | 2015-12-04 | 2016-12-05 | Vaccination with mica/b alpha 3 domain for the treatment of cancer |
| JP2018528691A JP7099956B2 (ja) | 2015-12-04 | 2016-12-05 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528691A Division JP7099956B2 (ja) | 2015-12-04 | 2016-12-05 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024167997A Division JP2024177207A (ja) | 2015-12-04 | 2024-09-27 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022130623A JP2022130623A (ja) | 2022-09-06 |
| JP2022130623A5 true JP2022130623A5 (enExample) | 2023-01-04 |
| JP7564842B2 JP7564842B2 (ja) | 2024-10-09 |
Family
ID=57590885
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528691A Active JP7099956B2 (ja) | 2015-12-04 | 2016-12-05 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
| JP2022105405A Active JP7564842B2 (ja) | 2015-12-04 | 2022-06-30 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
| JP2024167997A Pending JP2024177207A (ja) | 2015-12-04 | 2024-09-27 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528691A Active JP7099956B2 (ja) | 2015-12-04 | 2016-12-05 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024167997A Pending JP2024177207A (ja) | 2015-12-04 | 2024-09-27 | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10993971B2 (enExample) |
| EP (1) | EP3383426A1 (enExample) |
| JP (3) | JP7099956B2 (enExample) |
| KR (1) | KR20180088458A (enExample) |
| CN (1) | CN108770343A (enExample) |
| AU (3) | AU2016362597C1 (enExample) |
| BR (1) | BR112018010705A8 (enExample) |
| CA (1) | CA3005910A1 (enExample) |
| CL (3) | CL2018001470A1 (enExample) |
| CO (1) | CO2018006642A2 (enExample) |
| CR (2) | CR20180350A (enExample) |
| CU (2) | CU20210061A7 (enExample) |
| EA (1) | EA201891287A1 (enExample) |
| IL (1) | IL259490A (enExample) |
| MX (2) | MX2018006785A (enExample) |
| MY (1) | MY199248A (enExample) |
| NZ (1) | NZ742663A (enExample) |
| PE (2) | PE20181158A1 (enExample) |
| PH (1) | PH12018501170A1 (enExample) |
| RU (2) | RU2021109510A (enExample) |
| SG (1) | SG11201804597TA (enExample) |
| TN (1) | TN2018000187A1 (enExample) |
| WO (1) | WO2017096374A1 (enExample) |
| ZA (1) | ZA202204223B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112584858A (zh) | 2018-04-03 | 2021-03-30 | 赛诺菲 | 抗原性ospa多肽 |
| EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
| JP7614841B2 (ja) | 2018-04-03 | 2025-01-16 | サノフイ | 抗原性呼吸器合胞体ウイルスポリペプチド |
| CN112512566A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性爱泼斯坦-巴尔病毒多肽 |
| EP4110384A4 (en) * | 2020-02-26 | 2024-07-31 | The Wistar Institute of Anatomy and Biology | COMPOSITIONS CONTAINING SELF-ASSEMBLING VACCINES AND METHODS OF USE THEREOF |
| KR102594083B1 (ko) | 2020-07-07 | 2023-10-25 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| CN116396398B (zh) * | 2023-01-16 | 2024-07-16 | 四川大学 | 一种实现铁蛋白纳米颗粒可控自组装的方法以及基于该方法搭建的纳米颗粒抗原展示平台 |
| WO2024222886A1 (zh) | 2023-04-28 | 2024-10-31 | 北京先声祥瑞生物制品股份有限公司 | 一种针对MICA/B靶点的mRNA肿瘤疫苗 |
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| US4709017A (en) | 1985-06-07 | 1987-11-24 | President And Fellows Of Harvard College | Modified toxic vaccines |
| US4950740A (en) | 1987-03-17 | 1990-08-21 | Cetus Corporation | Recombinant diphtheria vaccines |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| US5073627A (en) | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| JP3506431B2 (ja) | 1992-05-06 | 2004-03-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ジフテリア毒素受容体結合領域 |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| US6455673B1 (en) | 1994-06-08 | 2002-09-24 | President And Fellows Of Harvard College | Multi-mutant diphtheria toxin vaccines |
| US5917017A (en) | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| ATE348887T1 (de) | 1996-10-31 | 2007-01-15 | Human Genome Sciences Inc | Streptococcus pneumoniae antigene und impfstoffe |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| CA2366152A1 (en) | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Streptococcus pneumoniae vaccine |
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| JP5525689B2 (ja) | 2004-11-02 | 2014-06-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 過剰増殖性障害を処置するための組成物および方法 |
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| EP3116903A2 (en) * | 2014-03-14 | 2017-01-18 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
-
2016
- 2016-12-05 MX MX2018006785A patent/MX2018006785A/es unknown
- 2016-12-05 CR CR20180350A patent/CR20180350A/es unknown
- 2016-12-05 TN TNP/2018/000187A patent/TN2018000187A1/en unknown
- 2016-12-05 PE PE2018001072A patent/PE20181158A1/es unknown
- 2016-12-05 JP JP2018528691A patent/JP7099956B2/ja active Active
- 2016-12-05 CN CN201680080434.4A patent/CN108770343A/zh active Pending
- 2016-12-05 CU CU2021000061A patent/CU20210061A7/es unknown
- 2016-12-05 RU RU2021109510A patent/RU2021109510A/ru unknown
- 2016-12-05 AU AU2016362597A patent/AU2016362597C1/en active Active
- 2016-12-05 NZ NZ742663A patent/NZ742663A/en unknown
- 2016-12-05 BR BR112018010705A patent/BR112018010705A8/pt active Search and Examination
- 2016-12-05 EA EA201891287A patent/EA201891287A1/ru unknown
- 2016-12-05 PE PE2022002801A patent/PE20230495A1/es unknown
- 2016-12-05 SG SG11201804597TA patent/SG11201804597TA/en unknown
- 2016-12-05 KR KR1020187019140A patent/KR20180088458A/ko not_active Ceased
- 2016-12-05 CR CR20230116A patent/CR20230116A/es unknown
- 2016-12-05 US US15/781,448 patent/US10993971B2/en active Active
- 2016-12-05 WO PCT/US2016/064969 patent/WO2017096374A1/en not_active Ceased
- 2016-12-05 CU CU2018000050A patent/CU24609B1/es unknown
- 2016-12-05 CA CA3005910A patent/CA3005910A1/en active Pending
- 2016-12-05 EP EP16816550.4A patent/EP3383426A1/en active Pending
- 2016-12-05 RU RU2018123307A patent/RU2747296C2/ru active
- 2016-12-05 MY MYPI2018000849A patent/MY199248A/en unknown
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2018
- 2018-05-21 IL IL259490A patent/IL259490A/en unknown
- 2018-06-01 PH PH12018501170A patent/PH12018501170A1/en unknown
- 2018-06-01 CL CL2018001470A patent/CL2018001470A1/es unknown
- 2018-06-01 MX MX2022010194A patent/MX2022010194A/es unknown
- 2018-06-27 CO CONC2018/0006642A patent/CO2018006642A2/es unknown
-
2021
- 2021-02-19 US US17/180,183 patent/US20210299186A1/en not_active Abandoned
- 2021-05-13 CL CL2021001256A patent/CL2021001256A1/es unknown
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2022
- 2022-03-21 AU AU2022201940A patent/AU2022201940B2/en active Active
- 2022-04-14 ZA ZA2022/04223A patent/ZA202204223B/en unknown
- 2022-06-30 JP JP2022105405A patent/JP7564842B2/ja active Active
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2023
- 2023-10-26 CL CL2023003217A patent/CL2023003217A1/es unknown
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2024
- 2024-02-19 US US18/581,148 patent/US20250064863A1/en active Pending
- 2024-09-27 JP JP2024167997A patent/JP2024177207A/ja active Pending
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2025
- 2025-08-08 AU AU2025213685A patent/AU2025213685A1/en active Pending
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