JP2022088078A - Antibacterial particles, mold/bacteria extermination method using antibacterial particles, and antibacterial product for clothing and dwelling using antibacterial particles - Google Patents

Abstract

To provide antibacterial particles for sustained release of a safe anti-fungal/insect pest component into a space for a long term.SOLUTION: Antibacterial particles of the invention are formed by imbedding a thermofusion resin and antibacterial medicine in porous particles such as cellulose, in which weight of the antibacterial medicine with respect to total weight of the porous particles, the thermofusion resin, and the antibacterial medicine is 10% or greater and less than 40%. In the invention, a volatilization amount of the antibacterial medicine can be controlled, and by selecting the antibacterial medicine, specific molds or bacteria are exterminated.SELECTED DRAWING: Figure 1

Description

The present invention relates to antibacterial particles, molds using antibacterial particles, a method for controlling bacteria, clothes using antibacterial particles, and antibacterial products for residential use.

Various control products are commercially available against molds and bacteria that propagate in clothing and homes. Some of them have antifungal and insect repellent components that have an adverse effect on the human body and pets and have an unpleasant odor, and there is a demand for safe and comfortable use. In addition, volatile chemicals may be used as a method to spread the antifungal component evenly in spaces such as clothes cases, chests of drawers, and closets, but the effect does not last long due to the rapid volatilization of the chemicals, and frequent replacement work occurs. There was a problem such as (Patent Document 1).

Patent Document 2 describes a method of volatilizing an antifungal agent by an apparatus to fill a room. However, there is a problem in handleability because a ventilation mechanism for filling the fungicide is required and ventilation is required after the fungicide is treated.

Further, various inorganic antibacterial agents made of fine powder obtained by adsorbing a metal having a bactericidal / antibacterial effect, for example, silver, copper, zinc or the like on an inorganic carrier such as zeolite, are known. However, since all of these inorganic carriers are fine powders, they are difficult to handle, and the elution rate depends only on the metal-supporting force of the inorganic carrier, so that they are insufficient in terms of sustained release (Patent Document 3).

JP-A-2015-224214 Japanese Unexamined Patent Publication No. 2017-333240 Japanese Unexamined Patent Publication No. 2006-8672

An object of the present invention is to obtain antibacterial particles in which a safe fungal and insect repellent component is continuously released into a space for a long period of time.

In order to solve the above-mentioned problems, it is a porous particle in which a heat-meltable resin and an antibacterial agent are embedded according to one aspect of the present invention, and the antibacterial agent is cinnamaldehyde, linalool, carbachlor, 1-octene. It is selected from at least one of -3-ol and citral, and is characterized in that the weight of the antibacterial agent is 10% or more and less than 40% with respect to the total weight of the porous particles, the heat-meltable resin and the antibacterial agent. ..

Further, the antibacterial particles according to one aspect of the present invention are characterized in that the volatile amount of the antibacterial agent from the antibacterial particles at 25 ° C. is 20 mg or more per 1 g of the antibacterial particles.

Further, the antibacterial particles according to one aspect of the present invention, wherein the porous particles are cellulose, and a method for controlling mold and bacteria using the antibacterial particles according to one aspect of the present invention. And molds of the genus Aspergillu, Cladosporium, Penicillium, and Staphylococcus, Escheri.
It is characterized by being a method for controlling bacteria of the genus chia.

Further, it is an antibacterial product for clothes and houses according to one aspect of the present invention, and is characterized in that it is enclosed in a container / packaging material made of a material through which a drug using the antibacterial particles can pass.

According to the present invention, it is possible to obtain antibacterial particles having good antibacterial properties and capable of sustained release of a safe antifungal and insect repellent component into a space for a long period of time.

It is sectional drawing which shows the antibacterial particle which concerns on embodiment of this invention.

Hereinafter, the antibacterial particles of the embodiment of the present invention will be described with reference to the drawings. Here, the drawings are schematic, and the sizes, ratios, etc. are different from the actual ones. Further, each embodiment shown below exemplifies a configuration for embodying the technical idea of the present invention, and the technical idea of the present invention includes the following materials, shapes, structures, and the like. It is not specific to the thing. The technical idea of the present invention may be modified in various ways within the technical scope specified by the claims described in the claims.

As shown in FIG. 1, the antibacterial particles 4 of the present invention are formed by embedding a heat-meltable resin 2 and an antibacterial agent 3 in the porous particles 1 to adjust the embedding amount of the antibacterial agent. Therefore, the amount of volatilization of the antibacterial agent can be controlled, and by appropriately selecting the antibacterial agent, specific molds and bacteria can be controlled.

The porous particles 1 have a large number of pores that open on the surface, have a specific surface area of 0.1 m ² / g or more, and are hydrophilic when the heat-meltable resin 2 and the antibacterial agent 3 are hydrophobic substances. It is desirable to have. When a hydrophobic substance is embedded in the pores of hydrophilic porous particles, a slight gap is created at the interface between two phases having different properties. Therefore, the antibacterial agent is gradually released to the outside through this slight gap, so that a sustained release effect can be obtained for a long period of time.

Further, the porous particles 1 are required to have features such as a low melting point, a solid at room temperature, and no chemical reaction with the heat-meltable resin 2 and the antibacterial particles 3. Examples of the porous particles satisfying these include particles made of a resin such as cellulose, ceramics, and polyvinyl alcohol, and particles made of cellulose are preferable from the viewpoint of high chemical stability.

The porous particles 1 made of cellulose have voids for embedding the heat-meltable resin 2 and the antibacterial agent 3, and the porosity with respect to the volume of the particles is preferably 80% to 90%. Further, in order to ensure good workability and handleability, the particle size is preferably 1 mm to 10 mm. If necessary, additives such as colorants, antioxidants, and antistatic agents may be included.

Specific examples include, but are not limited to, Rengo's Viscopearl A, JNC's Cellflow-C-5, Asahi Kasei's Selfia, and Cellos.

The heat-meltable resin 2 melts at a temperature lower than the boiling point of the antibacterial agent 3, is solid at room temperature, and a material compatible with the antibacterial agent is appropriately selected. For example, wax: beeswax, lanolin, petroleum wax, carnauba wax higher fatty acid: palmitic acid, stearic acid, myristic acid, lauric acid and the like are preferably used. By using the heat-meltable resin, there is an effect that the volatilization speed can be suppressed as compared with the antibacterial agent alone. If you want to slow down and gradually volatilize the antibacterial agent,
It is effective to increase the proportion of the heat-meltable resin within the above-mentioned range of 10% or more and less than 40%. If necessary, an emulsifier may be added to facilitate compatibility with the antibacterial agent.

Antibacterial agents 3 include molds such as Aspergillus, Penicillium, Cladosporium and Staphylococcus, HYPERLINK "https://en.wikipedia.org/ wiki / Escherichia "\ o" w: Escherichia "Uses cinnamaldehyde, linalol, carbachlor, 1-octen-3-ol, and citral, which have been confirmed to have antibacterial effects on the genus Escherichia. Since these are components contained in the essential oils of plants used for aromatherapy, they are safe to volatilize in space and there is no concern about unpleasant odors. In particular, cinnamaldehyde has an excellent antibacterial effect even in a small amount and can be preferably used. Further, two or more of the above components may be mixed and used.

Sufficient antibacterial properties can be exhibited by containing the antibacterial agent 3 in an amount of 10% or more and less than 40% with respect to the total weight of the porous particles 1, the heat-meltable resin 2, and the antibacterial agent 3. If it is less than this, the antibacterial property is lowered, the time for the drug to volatilize is short, and a sufficient period of use cannot be guaranteed. If it is contained in an amount of 40% or more, the odor becomes too strong, and the antibacterial agent 3 may flow out from the porous particles 1 to pollute the surroundings.

Regarding sustained release properties, the volatilization amount of the antibacterial agent 3 at 25 ° C. with respect to the weight of the antibacterial particles 4 is preferably 20 mg or more in terms of 1 g of the antibacterial particles. If it is less than 20 mg, the amount of the drug released to the antibacterial target is not sufficiently released and the antibacterial property is lowered.

As a method for producing the antibacterial particles 4, the heat-meltable resin 2 and the antibacterial agent 3 are kneaded while being heated, and the porous particles 1 are added thereto and further kneaded. Since it is a porous particle, the resin and the chemicals are absorbed just by kneading. In general, just by mixing, it becomes a sticky semi-solid state with resin or chemicals, but in this case, since the shape of the beads is maintained independently for each particle, the porous particles 1 It is considered that the heat-meltable resin 2 and the antibacterial agent 3 are embedded in the voids. The antibacterial particles 4 produced in this manner can maintain antibacterial properties for a long time by gradually volatilizing the antibacterial agent from the voids of the porous particles 1.

The obtained antibacterial particles 4 can be installed in various places by enclosing them in a container or packaging made of a material through which the antibacterial agent 3 can pass. For example, antibacterial particles can be enclosed in a non-woven fabric, a paper box, a basket-shaped plastic case, etc., and installed in a closet, a chest of drawers, a geta box, or the like.

[Example 1]
52 g of stearic acid as the heat-meltable resin 2 and antibacterial so that the weight of the antibacterial agent 3 (hereinafter referred to as the agent content) is 20% with respect to the total weight of the porous particles 1, the heat-meltable resin 2, and the antibacterial agent 3. As the sex agent 3, 38 g of cinnamaldehyde was kneaded while heating at 70 ° C. until stearic acid was melted. Next, 100 g of Rengo-made Viscopearl A (particle diameter 2 mm type) was added as the porous particles 1 and kneaded until the viscopearl absorbed stearic acid and cinnamaldehyde and became non-sticky to obtain antibacterial particles 4.

(Evaluation of antibacterial properties)
Ingest 50 μl of Aspergillus niger spore solution (10 ^6.2 cfu / ml) into a potato dextrose agar medium in a 50 mm petri dish, and place 0.1 g of the antibacterial particles obtained above on the lid side of the petri dish. The culture was carried out at 25 ° C. for 15 hours. As a control, a petri dish to be cultured without antibacterial particles was also prepared. After culturing, the medium cut into thin slices was placed on a slide glass and observed with an optical microscope.

[Example 2]
Antibacterial particles were obtained in the same manner as in Example 1 except that 38 g of linalool was used as the antibacterial agent 3.

[Example 3]
Antibacterial particles were obtained in the same manner as in Example 1 except that 38 g of carvacrol was used as the antibacterial agent 3.

[Example 4]
Antibacterial particles were obtained in the same manner as in Example 1 except that 38 g of 1-octen-3-ol was used as the antibacterial agent 3.

[Example 5]
Antibacterial particles were obtained in the same manner as in Example 1 except that 38 g of citral was used as the antibacterial agent 3.

[Example 6]
Antibacterial particles were obtained in the same manner as in Example 1 except that 40 g of stearic acid was used as the heat-meltable resin 2 and 60 g of cinnamaldehyde was used as the antibacterial agent so that the drug content 3 was 30%.

[Comparative Example 1]
Antibacterial particles were obtained in the same manner as in Example 1 except that 10 g of stearic acid was used as the heat-meltable resin 2 and 90 g of cinnamaldehyde was used as the antibacterial agent so that the drug content 3 was 45%.

[Comparative Example 2]
Antibacterial particles were obtained in the same manner as in Example 1 except that 52 g of stearic acid was used as the heat-meltable resin 2 and 8 g of cinnamaldehyde was used as the antibacterial agent so that the drug content was 5%.

"Spore germination rate%" obtained by dividing the number of spore germinations of Examples 1 to 6 and Comparative Examples 1 and 2 by the number of control spores, and the hyphal length of Examples 1 to 6 and Comparative Examples 1 and 2 was the control hyphal length. Table 1 shows the “hyphal growth rate%” divided by.

0.02 g of antibacterial particles of Examples 1 to 6 and Comparative Examples 1 and 2 were measured and the volatile amount of the antibacterial agent at 25 ° C. was measured by gas chromatography and converted into the volatile amount per 1 g of antibacterial particles. Is shown in Table 2.

According to the results in Table 1, the spore germination rate and the hyphal growth rate were suppressed in each of the examples as compared with Comparative Example 2, and it can be said that they have good antibacterial properties. Further, according to the results in Table 2, it can be said that the antibacterial agent has a good sustained release property because the volatilization amount of the antibacterial agent per 1 g of the antibacterial particles is 20 mg or more.

1 Porous particles 2 Heat-meltable resin 3 Antibacterial agent 4 Antibacterial particles

Claims (5)

It is an antibacterial particle composed of porous particles embedding a heat-meltable resin and an antibacterial agent, and the antibacterial agent is from at least one of cinnamaldehyde, linalool, carbachlor, 1-octen-3-ol, and citral. An antibacterial particle selected, wherein the weight of the antibacterial agent is 10% or more and less than 40% with respect to the total weight of the porous particles, the heat-meltable resin, and the antibacterial agent. It is an antibacterial particle composed of porous particles in which a heat-meltable resin and an antibacterial agent are embedded, and the volatile amount of the antibacterial agent from the antibacterial particles at 25 ° C. is 20 mg or more per 1 g of the antibacterial particles. The antibacterial particle according to claim 1. The antibacterial particles according to claim 1 or 2, wherein the antibacterial particles are composed of porous particles in which a heat-meltable resin and an antibacterial agent are embedded, and the porous particles are cellulose. A method for controlling molds and bacteria using the antibacterial particles, which comprises controlling molds of the genus Aspergillu, Cladosporium, Penicillium, and bacteria of the genus Staphylococcus and the genus Escherichia. The method for controlling mold and bacteria described in any of the above. The clothing or residential antibacterial product according to any one of claims 1 to 3, wherein the antibacterial particles are enclosed in a container / packaging material made of a material through which an antibacterial agent can pass.

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