JPH05148111A - Sustained release antimicrobial formulation for plastic - Google Patents

Abstract

PURPOSE:To obtain a sustained release antimicrobial agent effective for inhibiting the growth of mold and other microorganisms on the surface of plastics and accompanying discoloration and emission of foul smell by including Sanaizol 100(R) and SK-612(R) in a zeolite. CONSTITUTION:The objective sustained release antimicrobial agent for plastics can be produced by mixing a zeolite with a solution of Sanaizol 100 [2-(4- thiazolyl)benzimidazole] and SK-612(R) (zinc 2-pyridinethiol-1-oxide), thereby including these compounds in the zeolite. The zeolite is preferably an X-type synthetic zeolite having a pore diameter of 13Angstrom . The sustained release antimicrobial preparation is extremely excellent in moderate bleeding property and sustained releasability. It is stable even at the molding temperature of the plastics to enable sufficient exhibition of the antimicrobial activity.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antibacterial agent having a sustained release property, which prevents the growth of molds and other microorganisms generated on the surface of plastics, and prevents discoloration and odor associated therewith.

[0002]

2. Description of the Related Art Recently, many plastic products for various purposes are in daily use. For example, most of kitchen appliances, bathroom accessories, home appliances such as air conditioners and refrigerators use plastic materials. These plastics have a problem that the materials themselves are contaminated by the generation of microorganisms or the appearance is impaired. Therefore, the generation of these microorganisms has been prevented by treating with a general bactericide (sodium hypochlorite, oxygen bleach) or simply mixing the antibacterial agent with the resin.

[0003]

The conventional disinfectants (sodium hypochlorite, oxygen-based bleaching agent) are used each time to treat, for example, triangular corners for kitchens, soap stands used in washrooms and baths. Not only is it time-consuming, but its effect is not long-lasting. In addition, in a product in which an antibacterial agent is contained in plastic, the phenomenon of bleeding powder on the plastic surface (bleed) is so severe that the aesthetic appearance of the product is lost and the commercial value is lost. Alternatively, the effect was not obtained due to insufficient bleeding. An object of the present invention is to provide a sustained-release antibacterial preparation for plastics, which is capable of preventing excessive bleeding and having a sustained release property and an excellent effect.

[0004]

Means for Solving the Problems As a result of intensive research aimed at solving the above problems, the present inventor has found that even general-purpose resins such as polyolefins, for which microorganisms are not expected to grow in a short period of time, are contaminated by long-term use. It was found that the conditions for the growth and growth of microorganisms in plastics are related to the factors of temperature and moisture, as well as nutrient sources contained in dirt such as dust. In addition, we searched for substances with antibacterial properties that can be mixed with plastics and that do not affect the physical properties of plastics. 2- (4-thiazolyl) benzimidazole (San-Isol 100) and zinc-2-pyridinethiol-1-oxide (SK-612) is effective, and it was found that there is a synergistic effect when both are used together. Further, they have found that, when this substance is incorporated into zeolite, an antibacterial preparation for plastics, which is extremely excellent in both bleeding and controlled release, can be obtained, and the present invention has been completed. The present invention is a sustained-release antibacterial drug for plastics, which contains San-Isol 100 and SK-612 in zeolite.

The San-Isol 100 and SK-612 of the present invention are mainly used as a fungicidal and anti-algal agent for paints. To include this substance in zeolite, use Sanisol 10
It can be carried out by mixing a solution of 0 and SK-612 with zeolite. The zeolite is San Isol.
4Å, 5Å, 1 considering the molecular size of 100 and SK-612
As a result of examining 3Å X-type zeolite, Y-type zeolite and natural zeolite, X-type zeolite (pore size 13Å) is preferable.

The effect of the antibacterial agent of the present invention will be described.
Anti-fungal and anti-bacterial test of San-Isol 100 and SK-612 used in the present invention Test sample Sun-Isol 100, SK-612 test method Mixing a predetermined concentration of the test sample in polypropylene resin, molding this test piece, For the mold resistance test,
NaNO ₃ 2.0 g, KH ₂ PO ₄ 0.7 g, K ₂ HPO ₄ 0.3 g,
_{MgSO 4 · 7H 2 O 0.5g,} KCl 0.5g, FeSO 4 · 7H 2 O 0.01
g, glucose 30g, agar 20g, distilled water 1000ml on the medium, Aspergillus niger, Penicillium funiclos
um, Cladosoporium cladosporioides, Trichoderma vir
After inoculating a mixed spore suspension of 5 kinds of ide and Chaetomium globosum and culturing at 28 ± 2 ℃ for 4 weeks, the growth of hyphae on the test piece was observed. 0, if not visible to the naked eye 1,25% or less 2,25 to 50% 3, 50 to 100% 4, whole surface 5
Evaluate as (ISO 846 1978 (E) B Method)
Tested. In addition, the bacterial resistance test was performed using Escherichia coli (IFO) prepared by adjusting the viable cell count to 1.0 × 10 ⁶ cells / ml.
3806) Peptone 1.0g inoculated with test solution, sodium chloride 0.5g, meat extract 0.3g, agar 15g, TTC reagent 0.1
g, place on 1,000 ml of distilled water on the medium, cover the test piece with the same medium, and incubate at 28 ± 2 ℃ for 48 hours, then observe the growth of E. coli on the test piece The test was carried out by evaluating the case where it was observed as + and the case where it was not observed (referred to as TTC thin film method). The results are shown in [Table 1].

[0007]

[Table 1] As described above, it is clear that the mixture of San-Isol 100 and SK-612 has excellent antifungal and anti-bacterial properties even when added to plastics.
When 612 is used in an amount of 0.3% or more, and when each of them is used in an amount of 0.05% or more, a preferable effect is obtained.

Next, a test for antifungal and antibacterial properties and sustained-release properties of the sustained-release antibacterial formulation for plastics of the present invention The sustained-release antibacterial formulation for plastics of the present invention in which zeolite is incorporated with Sanaisol 100 and SK-612 The antifungal and antibacterial properties of the above were tested by the same test method as above [Table 2]
Indicate.

[0009]

[Table 2] * 1: The concentration of San-Isol 100 in the resin is 0.3% * 2: The concentration of San-Isol 100 and SK-612 in the resin is 0.05% or more, respectively. It is clear that the sustained-release antibacterial preparation for plastics of the invention has antifungal and antibacterial properties.

Dissolution Test of Sustained Release Antibacterial Formulation for Plastics of the Present Invention San-Isol 100 alone and an inclusion composition in which 1.0% of zeolite inclusion of San-Isol 100 was added to polypropylene had a concentration of 0.1 in the resin of San-Isol 100. %, The elution concentration of San-Isol 100 for 98 days was measured. The results are shown in [Fig. 1]. As is clear from FIG. 1, it is clear that the elution amount of Sanaisol 100 entrapped with zeolite is small and released on average.

[0011]

Example: Propylene glycol monomethyl ether 2
20 g of San-Isol 100 and 20 g of SK-612 were dissolved in 000 g and 2400 g of dimethylformamide, and zeolite was dissolved in this.
Add 200g, stir for 2.5 hours, concentrate, 120 ℃, 1mmH
The mixture was heated under reduced pressure for 3 hours and dried under reduced pressure to obtain a sustained-release antibacterial preparation for plastics of the present invention having a total amount of 10%.

[0012]

INDUSTRIAL APPLICABILITY When the sustained-release antibacterial preparation for plastics of the present invention is used for plastics, it has an effect on both microorganisms such as bacteria and fungi, and has an appropriate bleeding property for plastics, and has a plastic molding temperature. However, it is an extremely useful invention as a sustained release antibacterial preparation for plastics, which is stable and can sufficiently exhibit the antibacterial activity of the active ingredient of the present bactericide.

[Brief description of drawings]

FIG. 1 is a drawing showing the sustained release property of an antibacterial agent of the present invention to a polypropylene resin.

[Explanation of symbols]

-○-○-San-Isol 100, 1.0% added- △-△-San-Isol 100 + zeolite, 1.0% added (San-Isol 100 concentration 0.1%)

Claims (2)

[Claims] 1. A sustained-release antibacterial preparation for plastics, characterized by comprising 2- (4-thiazolyl) benzimidazole and zinc-2-pyridinethiol-1-oxide in zeolite. 2. The sustained-release antibacterial preparation for plastics according to claim 1, wherein the zeolite is an X-type synthetic zeolite having a pore size of 13Å.