JP2022025769A - Patch - Google Patents

Abstract

To provide a colored patch having a hydrous gel layer that has reduced tendency to dye the skin and yet is colored uniformly.SOLUTION: A patch has a hydrous gel layer, and a support layer. The hydrous gel layer contains (A) an iron oxide-based inorganic pigment with an average particle size of 50 μm or less, (B) at least one selected from a polyacrylic acid and a salt thereof, (C) a cellulose derivative, and (D) a polyvalent metal ion. The (A) component is dispersed in a dispersion medium, and the hydrous gel layer has a pH of 6 or less at 25°C.SELECTED DRAWING: None

Description

The present invention relates to a patch having a hydrogel layer containing an iron oxide-based inorganic pigment and a support layer.

Conventionally, a hydrogel applied to a compress has been used as a suitable plaster for cooling the affected area by the heat of vaporization of water and for percutaneously absorbing the drug. Recently, in addition to a poultice for anti-inflammatory analgesia, it is also used as a base for patches whose main purpose is cooling, such as recovery from tiredness and swelling of arms and legs, and cooling of the body during fever. ..

In addition, the water-containing gel of the patch is colored differently according to the use, sex, efficacy, etc. to enhance the discriminating power and commercial value, and such a colorant includes water-soluble acid dyes and the like. Dyes are mainly used.

However, when a water-soluble dye such as an acid dye is used for a gel having a high water content, a problem of dyeing on the skin (color transfer to the skin) occurs. For this problem of dyeing on the skin, a water-containing gel having a high water content is used for the purpose of improving the cooling effect (extending the cooling time), and it is desired to develop a colored patch capable of further extending the sticking time. It tends to be more prominent because it is.

As described above, it has been strongly desired to develop a colored patch having a water-containing gel layer in which the skin-staining property is suppressed and is uniformly colored.

Japanese Unexamined Patent Publication No. 2013-107911

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a colored patch having a water-containing gel layer that is uniformly colored while suppressing skin dyeability.

As a result of diligent studies to achieve the above object, the present inventor has made an iron oxide-based patch having a hydrogel layer and a support layer in which the hydrogel layer has a specific average particle size of 50 μm or less. It has been found that the above-mentioned problems can be solved by blending a dispersion liquid in which an inorganic pigment is dispersed in a dispersion medium and setting the pH to 6 or less, which led to the present invention.

Therefore, the present invention provides the following patch.
1. 1. A patch having a water-containing gel layer and a support layer.
The water-containing gel layer
(A) Iron oxide-based inorganic pigment having an average particle size of 50 μm or less,
(B) One or more selected from polyacrylic acid and its salts,
A patch containing (C) a cellulose derivative and (D) a polyvalent metal ion, wherein the component (A) is dispersed in a dispersion medium, and the pH of the hydrous gel layer at 25 ° C. is 6 or less.
2. 2. The patch according to 1 above, wherein the iron oxide-based inorganic pigment (A) has an average particle size of 0.005 to 10 μm and a maximum particle size of 50 μm or less.
3. 3. The patch according to 1 or 2, wherein the dispersion medium is one or more selected from polyhydric alcohols, fatty acids, fatty acid salts and surfactants.
4. The patch according to any one of 1 to 3, wherein the water-containing gel layer has a water content of 40 to 90% by mass.

According to the present invention, it is possible to provide a colored patch having a water-containing gel layer that is uniformly colored while suppressing skin dyeability.

Hereinafter, the present invention will be described in detail.
I. Hydrous gel layer The hydrogel layer is (A) an iron oxide-based inorganic pigment having an average particle size of 50 μm or less.
(B) One or more selected from polyacrylic acid and its salts,
It contains (C) a cellulose derivative and (D) a polyvalent metal ion, and the component (A) is dispersed in a dispersion medium, and the pH of the hydrogel layer at 25 ° C. is 6 or less.

[(A) component]
The component (A) of the present invention is an iron oxide-based inorganic pigment having an average particle size of 50 μm or less, and can be used alone or in combination of two or more. The hydrogel layer can be colored by blending the component (A). Examples of the iron oxide-based inorganic pigment include iron sesquioxide, iron hydroxide, γ-iron oxide, yellow iron sesquioxide, and black iron oxide. Iron sesquioxide, yellow iron sesquioxide, and black iron oxide are preferred.

The average particle size of the iron oxide-based inorganic pigment is 50 μm or less from the viewpoint of uniform coloring, preferably 0.005 to 10 μm, more preferably 0.01 to 5 μm, still more preferably 0.1 to 1 μm. The maximum particle size is preferably 50 μm or less, more preferably 10 μm or less, still more preferably 1 μm or less. The maximum particle size is measured by the grain gauge method, and the average particle size is measured by the infrared scattering method.

The content of the component (A) is preferably 0.001% by mass or more in the water-containing gel layer from the viewpoint of coloring of the water-containing gel layer, and preferably 0.21% by mass or less from the viewpoint of shape retention of the water-containing gel layer. , 0.002 to 0.1% by mass, more preferably 0.002 to 0.01% by mass.

It is preferable that the component (A) is dispersed in a dispersion medium in advance and the obtained dispersion is added to the water-containing gel from the viewpoint of obtaining a uniform water-containing colored gel. The dispersion medium is not particularly limited, but is preferably selected from monohydric alcohols, polyhydric alcohols, fatty acids, fatty acid salts, surfactants and aqueous solutions of superabsorbent polymers. Of these, polyhydric alcohols, fatty acids, fatty acid salts and surfactants are preferred. The monohydric alcohol, polyhydric alcohol, fatty acid or salt thereof, surfactant and superabsorbent polymer aqueous solution are not particularly limited, and the polyhydric alcohol, fatty acid or salt thereof, surfactant and the like, which are exemplified in the water-containing gel described later, are used. The same as the water-absorbent polymer aqueous solution can be used. Among these, glycerin, POE (20) sorbitan monooleate, ethylene glycol, POE-hardened castor oil, ethanol, PEG1000 and the like are suitable.

The content of the dispersion medium is preferably 1 to 20% by mass, more preferably 6 to 16% by mass in the hydrogel layer.

[(B) component]
The component (B) of the present invention is one or more selected from polyacrylic acid and salts thereof, and can be used alone or in combination of two or more. As the polyacrylic acid, any of linear and branched chains can be used. It is preferable to use a polyacrylic acid having a molecular weight of 10,000 to 10 million, and polyacrylic acid having a weight average molecular weight of 10,000 to less than 500,000, 500,000 to less than 2 million, and an average molecular weight of 2 million to 4 million is used. Combining more than seeds is suitable because it improves the usability. In addition to the polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as Carbopol (trade name: Goodrich Corporation, USA) can also be preferably used.

Examples of the polyacrylic acid salt include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, triethanolamine polyacrylate and the like. Examples thereof include an amine salt of polyacrylic acid and an ammonium salt of polyacrylic acid.

The compounding ratio of polyacrylic acid and polyacrylic acid salt (polyacrylic acid: polyacrylic acid salt, mass ratio) is preferably 1: 0.1 to 1:10, more preferably 1: 1 to 1: 9. Polyacrylic acid or a salt may be partially neutralized so that the polyacrylic acid salt has the above ratio.

The content of the component (B) can be appropriately selected depending on the degree of polymerization thereof, but is preferably 1% by mass or more in the water-containing gel layer from the viewpoint of adhesive strength, and 20% by mass or less from the viewpoint of the viscosity of the water-containing gel. Is preferable, and 3 to 15% by mass is more preferable.

[(C) component]
The component (C) of the present invention is a cellulose derivative, and can be used alone or in combination of two or more. Examples of the cell roll derivative include sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose and salts thereof, and among them, carboxymethyl cellulose and its salt are preferable.

The component (C) has a 1% by mass aqueous solution viscosity at 25 ° C. of 2,000 mPa · s or less, preferably 1,000 to 2,000 mPa · s of sodium carboxymethyl cellulose, or a 1% by mass aqueous solution viscosity at 25 ° C. A cellulose derivative containing 2,500 mPa · s or more, preferably 2,500 to 4,500 mPa · s of sodium carboxymethyl cellulose is preferable, and a 1% by mass aqueous solution viscosity at 25 ° C. is 2,000 mPa · s or less. It is more preferable to use sodium carboxymethyl cellulose having a viscosity of 1% by mass aqueous solution at 25 ° C. of 2,500 mPa · s or more at a blending mass ratio of 1/3 to 3/1.

The content of the component (C) can be appropriately selected depending on the degree of polymerization thereof, but is preferably 1% by mass or more in the hydrogel layer from the viewpoint of shape retention, and 20% by mass or less from the viewpoint of adhesive strength. It is preferable, 3 to 15% by mass is more preferable.

[(D) component]
The component (D) of the present invention is a polyvalent metal ion, and can be used alone or in combination of two or more. Examples of polyvalent metal ions include magnesium ions such as potassium myoban, ammonium myoban, and iron myoban, which release magnesium ions and aluminum ions in an aqueous solution, aluminum hydroxide, aluminum sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, and aluminum oxide. , Aluminum silicate, Aluminum metasilicate, Magnesium hydroxide, Magnesium carbonate, Magnesium sulfate, Magnesium acetate, Magnesium silicate, Magnesium oxide, Magnesium hydroxide alumina, Magnesium aluminometasilicate, Magnesium aluminate silicate, Synthetic hydrotal Examples thereof include water-soluble compounds such as sites and compound salts containing these metals, sparingly water-soluble compounds, and antioxidants containing aluminum and magnesium. Among them, potassium myoban, aluminum hydroxide, aluminum glycinate, magnesium hydroxide, magnesium hydroxide alumina, magnesium aluminometasilicate, magnesium aluminometasilicate, and synthetic hydrotalcite are preferable, and aluminum glycinate and synthetic hydrotalcite are preferable. More preferred.

The content of the component (D) is preferably 0.001% by mass or more in the hydrogel layer from the viewpoint of shape retention, preferably 10% by mass or less, and 0.01 to 5% by mass from the viewpoint of adhesive strength. More preferred.

The water content of the hydrogel layer is preferably 40% by mass or more in the hydrogel layer from the viewpoint of cooling power, preferably 90% by mass or less, and more preferably 65 to 85% by mass from the viewpoint of shape retention.

The pH of the water-containing gel layer at 25 ° C. is 6 or less, preferably 3.5 to 5.5, and more preferably 4.0 to 5.0, from the viewpoint of adhesive strength. If the pH is too high, the adhesive strength may deteriorate. If the pH of the hydrogel layer is acidic, the inorganic pigment may be affected by the acid. However, (A) a dispersion liquid in which an iron oxide-based inorganic pigment is dispersed in a dispersion medium is applied to the hydrogel layer. By adding the mixture, it is not affected by pH, and even in a highly water-containing water-containing gel layer, skin staining by pigments can be effectively suppressed.

[Arbitrary ingredient]
In the water-containing gel layer of the present invention, an appropriate amount of an arbitrary component can be appropriately added to the normal water-containing gel layer as long as the effects of the present invention are not impaired. The optional component can be used alone or in combination of two or more. Examples of the optional component include the following.

Examples of the water-soluble polymer compound other than the above components (B) and (C) include gelatin, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, sodium alginate, xanthan gum, arabic gum, tragant gum, karaya gum, and maleic anhydride copolymer. And so on.

Examples of monohydric alcohols, polyhydric alcohols, fatty acids, fatty acid salts, surfactants and superabsorbent polymer aqueous solutions that are also used as dispersion media are as follows. The content includes those used as a dispersion medium.

Examples of the monohydric alcohol include methanol, ethanol, propanol, isopropanol, butanol and the like.

Examples of the polyhydric alcohol include glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3-propanediol, and 1,4-butanediol. , Martinol, xylitol and the like.

When the polyhydric alcohol is blended, the content thereof is preferably 50% by mass or less, more preferably 0 to 20% by mass in the hydrogel layer. If the blending amount of the polyhydric alcohol exceeds 50% by mass, the cohesive force of the aqueous pressure-sensitive adhesive base is lowered, and the water-based pressure-sensitive adhesive base may remain on the adherend at the time of peeling.

Examples of fatty acids and fatty acid salts include lauric acid, myristic acid, stearic acid, oleic acid, isostearic acid, behenic acid, and salts thereof.

Examples of the surfactant include a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant.

Specific examples of the nonionic surfactant include polyglycerin fatty acid esters (eg, diglycerin monostearate, etc.) of (fatty acid residues, alkyl groups having 8 to 22 carbon atoms, preferably 10 to 18), and polyoxyethylene. Glycerin fatty acid ester (eg, polyoxyethylene glyceryl (POE10) monoolate, etc.), polyoxyethylene fatty acid ester, polyoxyalkylene alkyl ether (eg, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl) Ether, etc.), polyoxyethylene alkylphenyl ether, polyhydric alcohol fatty acid partial ester (eg, glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, etc.), polyoxyethylene polyhydric alcohol fatty acid partial ester (eg, polyoxyethylene). Glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, etc.), polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, polyoxyethylene polyoxypropylene glycol, polyoxyethylene Examples thereof include alkylphenyl ether, fatty acid diethanolamide, polyoxyethylene alkylamine, ethanolamine fatty acid partial ester, and alkylamine oxide.

Among these nonionic surfactants, POE (25) lauryl ether, sucrose fatty acid ester, sorbitan monooleate, sorbitan monolaurate, sorbitan coconut oil fatty acid, sorbitan monostearate, glyceryl monooleate, glyceryl laurate, palm oil. Fatty acid glyceryl, polyethylene glycol monolaurate, polyethylene glycol monooleate, glyceryl myristate, decaglyceryl monooleate, diglyceryl dioleate, hexaglyceryl monolaurate, propylene glycol monostearate, POE (20) sorbitan monooleate, POE ( 60) Solbit tetraolate, POE (40) monostearate, POE (10) oleyl ether, POE (10) nonylphenyl ether, POE (50) hardened castor oil, POE (5) oleic acid amide, oleic acid diethanolamide, Lauric acid diethanolamide and the like are more preferable. In the above notation, for example, "POE (25)" indicates a structure to which 25 mol of ethylene oxide is added. The most preferable nonionic surfactants are polyoxyethylene alkyl ethers having 12 to 18 carbon atoms of an alkyl group, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene hydrogenated castor oil.

Anionic surfactants include higher fatty acid salts, alkyl ether carboxylates, polyoxyethylene alkyl ether carboxylates, alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl isothianate salts, alkylbenzene sulfonates, and alkyl phosphates. Examples thereof include salts and polyoxyethylene alkyl phosphates. Examples of these salts are sodium salt, potassium salt, organic amine salt and the like, and the alkyl group and alkenyl group preferably have 8 to 22 carbon atoms, and 10 The value of ~ 18 is more preferable.

Among them, sodium oleate, sodium laurate, sodium myristate, sodium cetyl sulfate, sodium cetostearyl sulfate, sodium oleyl sulfate, sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium dioctyl sulfosuccinate, and coconut oil fatty acid hydrolysis. Sodium collagen, sodium glycyrrhizinate, sodium glycyrrhetinate, triPOE (10) alkyl ether sodium phosphate and potassium salts thereof, diethanolamine salt, triethanolamine salt, sodium N-acylmethyltaurine and the like are more preferable.

Specific examples of the cationic surfactant include primary to tertiary fatty amine salts, quaternary ammonium salts, urea condensates of polyethylene polyamine fatty acid amides, and urea condensates of polyethylene polyamine fatty amides. Examples thereof include stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, stearyltrimethylammonium saccharin, lauryltrimethylammonium saccharin, benzalconium chloride, laurylpyridinium chloride, cetylpyridinium chloride, laurylpyridinium chloride, and the like. Examples thereof include alkyldiaminoethylglycine hydrochloride.

Specific examples of the amphoteric surfactant include amino acids, sulfoamino acids, quaternized betaine, sulfobetaine, imidazolinium betaine and the like, and more specifically, lauryldimethylaminoacetate betaine and coconut oil. Examples thereof include alkyl betaine, coconut oil fatty acid amide propyl betaine, coconut oil fatty acid hydrolyzed collagen, diethyl sebacate, and lecithin. When a surfactant is blended, its content is about 0 to 5% by mass in the hydrogel layer.

Examples of the superabsorbent polymer compound include an ionic superabsorbent polymer compound such as a partially neutralized product of crosslinked polyacrylic acid, a modified polyalkylene oxide, an N-vinylacetamide crosslinked product, and a nonionic crosslinked product such as an acrylamide crosslinked product. Examples include superabsorbent polymers. Of these, preferred are nonionic superabsorbent polymers. Since the nonionic high water-absorbing polymer compound has a higher water absorption capacity for an aqueous solution having a high ionic concentration than that of an ionic one, a preparation having a high ionic concentration (for example, gel cosmetics, pharmaceuticals, poultices, etc.) ) It is possible to stably hold a large amount of water.

As such a super absorbent polymer compound, more specifically, Sunwet IM-100.
0 (Sanyo Kasei, water absorption capacity 800 times), Sun Fresh AT-35 (Sanyo Kasei, water absorption capacity 800)
Double), aqua cork (Sumitomo Seika: water absorption capacity 30 times) and other commercially available products can be mentioned.

When the superabsorbent polymer compound is blended, the content thereof is not particularly limited, but is preferably 0.1 to 30% by mass, more preferably 0.5 to 15% by mass in the hydrogel layer.

As the organic pigment, an azo compound or a phthalocyanine compound is preferable. Specifically, blue 404, yellow 205, yellow 401, orange 203, orange 204, orange 401, red 201, red 202, red 203, red 204, red 205, red. Examples thereof include No. 206, No. 207, No. 208, No. 219, No. 220, No. 221 of Red, No. 228 of Red, No. 404 of Red, and No. 405 of Red. When the organic pigment is blended, the content thereof is preferably 0.0001 to 0.001% by mass in the hydrogel layer.

Examples of the filler include kaolin, bentonite, montmorillonite, smectite, zinc oxide, titanium oxide, silicic acid anhydride and the like. When the filler is blended, the content thereof is about 0 to 10% by mass in the hydrogel layer.
Examples of oils include vegetable oils and fats such as paraffin oil, olive oil, cacao oil, palm oil, camellia oil, palm oil, wood wax, jojoba oil, grapeseed oil, and avocado oil; and animal oils and fats such as mink oil and egg yolk oil. Rows such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystallin wax, selecin wax, paraffin wax, vaseline; lauric acid, myristic acid, stearic acid, olein Natural and synthetic fatty acids such as acids, isostearic acid and behenic acid; natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, Esters such as octyldodecyl oleate and cholesterol oleate can be exemplified.

Examples of the moisturizer include amino acids, NMF components such as sodium pyrrolidone carboxylate, and water-soluble polymer substances such as hyaluronic acid, collagen, mucopolysaccharide, and chondroitin sulfate.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and salts thereof.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, titanium oxide, kaolin, talc and the like.

Examples of the preservative include parabens such as methylparaben, propylparaben and butylparaben, quaternary cations such as benzalkonium chloride and benzethonium chloride, sorbic acid and benzoic acid.

The active ingredient is not particularly limited, and those used as the active ingredient of a normal patch can be used. Specifically, the following can be used.
[Non-steroidal anti-inflammatory drug]
Salicylic acid and its salts, salicylic acid derivatives such as aspirin, acetaminophen, aminopyrine, antipyrine, oxyphenbutazone, sulpyrine, indomethacin, diclofenac sodium, ibprofen, slindac, naproxen, ketoprofen, etofenamate, salicylamide, triethanolamine salicylamide. Tyrate, flufenamic acid and its salts and derivatives thereof, meclophenamic acid and its salts and its derivatives, corhitin, bufexamac, ibfenac, loxoprofen, fenoprofen, diflunisar, alcrophenac, phenylbutazone, mephenamic acid and its salts and theirs. Derivatives, phenoprofen, bendazac, pyroxicum, flurubiprofen, salicylamide, ketoprofen, sprofen, fervinac and the like can be mentioned.

[Steroidal anti-inflammatory agent]
Amsinoid, prednisolone valerate, diflucortisone valerate, betamethasone valerate, betamethasone acetate, dexamethasone acetate, betamethasone dipropionate, dexamethasone, triamcinolone acetonide, lylcinonide, hydrocortisone, fluocinolone pivalate, fluocinolone, fluocinolone acetonide. Examples thereof include otometron, fluocinolone acetide, prednisolone, clobetazole propionate, bechrometasone propionate, betamethasone, methylprednisolone, methylprednisolone acetate, hydrocortisone butyrate and the like.
[Muscle relaxant]
Diazepam and the like can be mentioned.
[Antemetic]
Examples include chlorpromazine.
[Psoriasis remedy]
Examples include methoxsalen.
[Skin softener or skin palliative]
Examples include hydroquinone, urea, heparin, chondroitin sulfate and the like.
[Other medicinal ingredients]
Examples thereof include diphenhydramine, dibucaine, procaine, lidocaine, glycyrrhetinic acid and derivatives thereof.
[Enzyme preparation]
Examples thereof include trypsin, papain, protease, lysoteam, streptokinase, plasmin, urokinase, hyaluronidase, α-chymotrypsin, seratiopeptidase, bromelain, semi-alkali peptidase and the like.
[Refreshing agent]
Menthol derivatives such as camphor, thymol, borneol, menthol, N-ethyl-p-menthane-carboxyamide, p-menthane-3,8-diol, l-isopulegol, l-mentylglyceryl ether, peppermint oil, spirantol, etc. Can be mentioned.
[Vitamins]
Examples include pantothenic acid, panthenol, vitamin A (retinol palmitate, etc.), vitamin E (d-α-tocopherol acetate), vitamin K, vitamin C, B vitamins, vitamin F, vitamin P, etc. Grantor]
Examples thereof include capsaicin, vanillyl amide nonyl acid, vanillyl ether nonyl acid and the like.
[Crude drugs]
Examples thereof include crude drug powder such as Oobaku, crude drug soft extract such as Togarashi extract, crude drug dried extract such as dried Oobaku extract, crude drug flow extract such as Senburi style extract, and crude drug tincture such as Arnica tincture.
[Plant extract]
Anise, Angelica, Rest Incense, Immortelle, Chamomile, Garlic, Cardamon, Galvanum, Caraway, Carrot Seed, Guaacwood, Grapefruit, Cypress, Sandalwood, Cedarwood, Juniper, Star Anise, Sage, Geranium, Celoli, Thyme, Taragon, TVon, star anise, frankincense, violet, pine, parsley, birch, patchouli, hyssop, fennel, black pepper, bodaiju flower, anise, marigold, lavender, yarrow, lemon, lemongrass, rose, rosemary, laurel, shimotsukegiku, peach , Essential oils or extracts such as star anise, eucalyptus, yuzu, lavender and the like.
[Seaweed extract]
Seaweed, Ogonori, Gelidiaceae, Mirin, Comb, Ainuwakame, Hondawara, Hibamata, Funori, Hitoegusa, Mill, Ushikenori, Suginori, Kaginori, Ibaranori, Nagamatsumo, Moduku Examples thereof include extracts of seaweeds belonging to the family, Daviria, Lessonia and Dalus, and among these, extracts of seaweeds belonging to the family Durbilia are preferable.

When the above-mentioned active ingredient is blended in the hydrogel of the present invention, if the substance is listed in the Japanese Pharmacopoeia or the appropriate amount for use is determined by other documents, etc., it is blended according to the appropriate amount for use. Is preferable. In particular, the blending amount of the substance for which the appropriate amount for use is not defined is preferably about 0.0001 to 10% by mass.

As the fragrance, natural vegetable fragrances, compounded fragrance components, synthetic fragrance components and the like can be used, and these can be arbitrarily combined to mask the base odor and the chemical odor, or to add fragrance.

Examples of the natural vegetable fragrance include uikyo oil, castor oil, peppermint oil, peppermint oil, daiuikyo oil, keihi oil, butterfly oil, chimian oil, televisionn oil, henoposi oil, yamadin oil, eucalyptus oil, lavender oil, and lemon. Examples thereof include oil, orange oil, touka oil, bergamot oil, rose oil, citronella oil, lemongrass oil, cypress oil, geranium oil and the like.

Examples of the compounded fragrance component include limonene, terpinolene, camphen, citronellol, geraniol, nerol, linalool, menthol, borneol, terpinelol, citronellal, citral, menthon, carbomenton, camphor, citronellic acid, cineole, curcumen, farnesol and neroli. Dole, hinokiic acid, santalic acid and the like are suitable.

In addition, as synthetic fragrance components, for example, "Synthetic fragrance chemistry and product knowledge" by Motokazu Indo, published by The Chemical Daily in 1996, 1969 MONTCAIR, N.C. J. The fragrances described in "Perfume and Flavor Chemicals" by STEFFEN ARCTANDER can be used.

II. Support layer The support layer is not particularly limited, and those used for the support layer of a normal patch can be used. Examples of such materials include woven fabrics such as paper, thick weave, thread weave, gauze, cole heaven, and flannel, flat knitting, rubber knitting, tuck knitting, knitted fabric by a manufacturing method such as double knitting, and spun lace. Woven fabrics, knits, plastic films, plastic films / fiber laminated sheets, plastic films / hydrophilic resin laminated sheets and the like produced by a manufacturing method such as spun bond, thermal bond, chemical bond and needle punch can be used.
Examples of the material of the non-woven fabric include polyester fiber, polyethylene fiber, polyamide fiber, polyurethane fiber, rayon, hemp and the like.
When a plastic film is used, materials such as polyethylene, polypropylene, polyethylene terephthalate, polyester, nylon, and polyurethane can be used. The film thickness of the resin film is not particularly limited, and is usually about 5 to 100 μm.

III. Patching agent In the patching agent of the present invention, (A) an iron oxide-based inorganic pigment having an average particle size of 50 μm or less is dispersed in a dispersion medium, and then this dispersion is selected from (B) polyacrylic acid and a salt thereof. It is added to a hydrogel containing (C) a cellulose derivative and (D) a polyvalent metal ion, and the hydrogel containing the component (A) is spread on a support and cut into an appropriate size. It can be manufactured by doing so.

The patch of the present invention can be widely used for the face, body, feet, etc., and can also be used for dry, cracked and rough skin (heels, etc.). Further, the patch of the present invention is a colored patch and has a water-containing gel layer that is uniformly colored without color unevenness. As shown in Examples described later, no color transfer occurs on the skin even after application for 8 hours or more.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. Unless otherwise specified in the following examples, "%" in the composition indicates mass%, and the ratio indicates mass ratio.

[Examples, comparative examples]
Purified water was placed in a Henschel mixer according to the composition shown in Table 1, each component was added, and the mixture was stirred for 10 minutes (100 rpm) to prepare a hydrogel. A pigment previously dispersed in a dispersion medium was added to this hydrous gel, and the mixture was stirred at 100 rpm for 15 minutes to obtain a colored hydrous gel. The particle size of the pigment was measured by the following method. For those blended as a dispersion, the amount of the component is described, and the amount of the dispersion medium is not described in the table.
The obtained colored hydrogel was spread on a support (polyester knit) by 0.1 g / cm ² and then cut into 10 cm × 14 cm to prepare a colored patch having a hydrogel layer.

The characteristics of each of the obtained colored patches were evaluated by the following methods. The results are also shown in the table.
Furthermore, even if the support is manufactured in place of polyester non-woven fabric, urethane foam film, urethane film, polyester film, polyester film / polyester non-woven fabric, polyester film / polyester knit, urethane film / polyester non-woven fabric, urethane film / polyester knit, the book A good colored patch of the invention was obtained.

<pH of hydrogel layer>
It was measured directly at 25 ° C. using a flat glass electrode.

<Pigment particle size measurement>
The maximum particle size was measured with a particle gauge.
<Pigment particle size measurement>
The average particle size was measured by wet measurement using a particle size distribution measuring device by an infrared scattering method and ethanol as a dispersion medium. The maximum particle size and average particle size of the inorganic pigments used in the examples are shown in the table.

<Colorability of patch (water-containing gel layer) (no color unevenness)>
By visual evaluation, the presence or absence of color unevenness of each patch (moisture-containing gel layer) was confirmed according to the following criteria.
Evaluation criteria ◎: Uniform coloring ○: Slight color unevenness △: Slight color unevenness ×: Significant color unevenness

<No color transfer to the skin>
The color transfer to the skin after applying each patch to the calf for 8 hours under the conditions of room temperature and 50% RH was evaluated by 10 panelists according to the following criteria.
Evaluation criteria ○: No color transfer △: Slight color transfer ×: Color transfer

<Shape retention>
The residual amount of the water-containing gel layer on the skin when the colored patch was applied to the back of the hand and peeled off after 20 minutes was evaluated by the area.
⊚: No remaining water-containing gel layer ○: The remaining area of the water-containing gel layer on the skin is less than 5% of the pasted area Δ: The remaining area of the water-containing gel layer on the skin is 5% or more and less than 20% of the pasted area. ×: The remaining area of the hydrogel layer on the skin is 20% or more of the pasted area.

<Adhesive strength>
The colored patch was applied to the calf and evaluated by the area peeled off after 4 hours.
⊚: No plaster residue ○: The peeled area is less than 10% of the pharmaceutical area Δ: The peeled area is 10% or more and less than 50% of the pharmaceutical area ×: The peeled area is 50% or more of the pharmaceutical area

<No pain when peeling>
Evaluate the pain when the colored patch is applied and peeled off after 4 hours.
◎: I do not feel pain ○: I feel a little pain △: I feel a lot of pain ×: I feel a lot of pain

<Cooling power>
The colored patch was applied, and 30 minutes later, the temperature of the application site was measured by thermography and evaluated by the difference from the skin temperature around the application.
⊚: Temperature difference is 4 ° C or more Δ: Temperature difference is 2 ° C or more and less than 4 ° C ×: Temperature difference is less than 2 ° C

The raw materials used in the above example are shown below. Unless otherwise specified, the amount of each component in the table is a net conversion amount.
Yellow iron sesquioxide: manufactured by Ami Kasei Co., Ltd., "Pharmaceuticals Regulation Yellow steride iron dioxide"
Iron sesquioxide: "Pharmaceutical rule iron sesquioxide" manufactured by Ami Kasei Co., Ltd.
Black iron oxide: "Yakuzoi Black Iron Oxide" manufactured by Ami Kasei Co., Ltd.
Polyacrylic acid 1: Toagosei Co., Ltd., "Julimer AC-10H", mass average molecular weight: 150,000, neutralization degree: 0 mol%
Polyacrylic acid 2: Made by Toagosei Co., Ltd., "Julimer SH8", mass average molecular weight: 1 million, neutralization degree: 0 mol%
Polyacrylic acid partially neutralized product: Toagosei Co., Ltd., "Aronbis AH-106X", mass average molecular weight: 4.5 million, neutralization degree: 40 mol%
Sodium polyacrylate: manufactured by Toagosei Co., Ltd., "Aronbis SX", mass average molecular weight: 4.5 million, neutralization degree: 100 mol%
Sodium Carboxymethyl Cellulose A: "CMC1380" manufactured by Daicel FineChem Co., Ltd.
Sodium Carboxymethyl Cellulose B: "CMC1390" manufactured by Daicel FineChem Co., Ltd.
Synthetic hydrotalcite: "Alcamac SH" manufactured by Kyowa Chemical Industry Co., Ltd.
Concentrated glycerin: Made by Sakamoto Pharmaceutical Co., Ltd., "Japanese Pharmacopoeia concentrated glycerin"
Polyalkylene oxide-based water-absorbent resin: "Aquacork TWB-P" manufactured by Sumitomo Seika Chemical Co., Ltd.
Dihydroxyaluminum aminoacetate: "Glycinal" manufactured by Kyowa Chemical Industry Co., Ltd.
Disodium edetate: "Sodium edetate" manufactured by Chubu Kirest Co., Ltd.
Methyl paraoxybenzoate: "Methyl paraoxybenzoate" manufactured by Ueno Fine Chemicals Industry Co., Ltd.
Propyl paraoxybenzoate: "Propyl paraoxybenzoate" manufactured by Ueno Fine Chemicals Industry Co., Ltd.
Polysorbate 80: "TO-10MV" manufactured by Nikko Chemicals Co., Ltd.
Tartaric acid: "Tartaric acid" manufactured by Iwata Chemical Industry Co., Ltd.
Sodium metaphosphate: "Sodium metaphosphate" manufactured by Taihei Kagaku Sangyo Co., Ltd.
Castor oil: "Castor oil" manufactured by Kosakai Pharmaceutical Co., Ltd.
l-Menthol: "l-Menthol" manufactured by Takasago International Corporation
Lavender oil: "Lavender oil" manufactured by Takasago International Corporation
Hack Haku Oil: "Hack Haku Oil" manufactured by Takasago International Corporation
Eucalyptus oil: "Eucalyptus oil" manufactured by Takasago International Corporation
Rosemary oil: "Rosemary oil" manufactured by Takasago International Corporation
Sage oil: "Sage oil" manufactured by Vemanfis Fragrance Co., Ltd.
Orange oil: "Orange oil" manufactured by Takasago International Corporation
Lemon oil: "Lemon oil" manufactured by Takasago International Corporation
Blue No. 1: "Blue No. 1" manufactured by Ryomi Kasei Co., Ltd.
Blue No. 404: "Blue No. 404" manufactured by Ami Kasei Co., Ltd.
Purified water: "Purified water (distilled)" manufactured by Kyoei Pharmaceutical Co., Ltd.
Fragrances: Fragrances a to d described in paragraphs [0065] to [0071] of JP-A-2002-128658, A to E described in JP-A-2003-73249, or Japanese Patent Application No. 2019-023940 [0016]. It is appropriately selected from 1 to 4 described in [0023].

Claims (4)

A patch having a water-containing gel layer and a support layer.
The water-containing gel layer
(A) Iron oxide-based inorganic pigment having an average particle size of 50 μm or less,
(B) One or more selected from polyacrylic acid and its salts,
A patch containing (C) a cellulose derivative and (D) a polyvalent metal ion, wherein the component (A) is dispersed in a dispersion medium, and the pH of the hydrous gel layer at 25 ° C. is 6 or less. The patch according to claim 1, wherein the iron oxide-based inorganic pigment (A) has an average particle size of 0.005 to 10 μm and a maximum particle size of 50 μm or less. The patch according to claim 1 or 2, wherein the dispersion medium is at least one selected from polyhydric alcohols, fatty acids, fatty acid salts and surfactants. The patch according to any one of claims 1 to 3, wherein the water-containing gel layer has a water content of 40 to 90% by mass.