JP5575944B2 - Colored patch - Google Patents

Description

  The present invention relates to a colored patch and a method for producing the same, and more particularly to a water-containing patch that has no skin dyeability and is uniformly colored and a method for producing the same.

  Conventionally, a hydrogel applied to a poultice has been used as a plaster suitable for cooling an affected area by the heat of vaporization of water and for allowing a drug to be percutaneously absorbed. Recently, it is used as a base material for patches mainly for cooling, such as recovery of fatigue and swelling of arms and legs, cooling of the body during fever, in addition to haptics for anti-inflammatory analgesia. .

  In addition, the water-containing gel of the patch is colored differently depending on the application, sex, efficacy, etc. to increase the discriminating power and commercial value. As such coloring agents, water-soluble acids such as acid dyes are used. Dyes are mainly used.

  However, when a water-soluble dye such as an acid dye is used in a gel having a high water content, there is a problem of staining on the skin (color transfer to the skin). The problem of dyeing on the skin is the development of a coloring patch that uses a water-containing gel with a high water content for the purpose of improving the cooling effect (extending the cooling time) and that can further extend the application time. Tend to become more prominent.

  Thus, there has been a strong demand for the development of a coloring patch having a water-containing gel layer that has a suppressed skin dyeing property and is uniformly colored.

  Under such circumstances, it is an object of the present invention to solve various problems in the prior art and achieve the following objects. That is, an object of the present invention is to provide a colored patch having a uniformly colored water-containing gel layer and a support layer, which has no skin dyeing property, and a method for producing the same.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have added an organic pigment to the hydrogel, or a dispersion in which the organic pigment is dispersed in a dispersion medium, to the hydrogel. It has been found that even a highly water-containing adhesive gel can effectively suppress skin dyeability.

  In addition, legal organic pigments that are usually commercially available (average particle size is usually about several hundred μm) are inferior in dispersibility and are lightly colored with respect to the water-containing gel. By adjusting the particle size so that the average particle size is 50 μm or less and the maximum particle size is 90 μm or less, there is no skin staining and a colored patch having a uniformly colored water-containing gel It was found that can be obtained.

  And from the above knowledge, as a result of further diligent studies by the present inventors, when producing a hydrogel layer containing an organic pigment, the average particle size is 50 μm or less, and the maximum particle size is 90 μm or less. By dispersing an organic pigment in a dispersion medium selected from monohydric alcohols, polyhydric alcohols, fatty acids, fatty acid salts, surfactants and water-absorbing polymer aqueous solutions, and then blending the dispersion into a hydrogel, The present inventors have found that a uniformly colored water-containing gel can be obtained and the above conventional problems can be effectively solved, and the present invention has been made.

  That is, this invention provides the following coloring patch and its manufacturing method in order to solve the said subject.

  The invention of claim 1 is a colored patch comprising a hydrogel layer containing an organic pigment and a support layer.

  The invention according to claim 2 is a colored patch characterized by having an organic pigment-containing hydrogel layer and a support layer obtained by adding a dispersion obtained by dispersing an organic pigment in a dispersion medium to a hydrogel.

  The invention according to claim 3 is the colored patch according to claim 2, wherein the dispersion medium is selected from monohydric alcohol, polyhydric alcohol, fatty acid, fatty acid salt, surfactant and water-absorbing polymer aqueous solution.

  The invention according to claim 4 is the colored patch according to any one of claims 1 to 3, wherein the average particle diameter of the organic pigment is 50 μm or less.

  The invention according to claim 5 is the colored patch according to any one of claims 1 to 4, wherein the maximum particle diameter of the organic pigment is 90 μm or less.

  The invention according to claim 6 is the colored patch according to any one of claims 1 to 5, wherein the organic pigment is an azo compound or a phthalocyanine compound having a particle size distribution shown in Table 1 below.

  The invention of claim 7 has a water content in the hydrogel layer of 40 to 98% by mass and an organic pigment content of 0.00001 to 1% by mass. It is a coloring patch as described.

  The invention according to claim 8 is an organic pigment having an average particle size of 50 μm or less and a maximum particle size of 90 μm or less, comprising a monohydric alcohol, a polyhydric alcohol, a fatty acid, a fatty acid salt, a surfactant, and a water-absorbing polymer. A method for producing a colored patch, comprising: dispersing in a dispersion medium selected from an aqueous solution, adding the dispersion to a hydrogel, and spreading the organic pigment-containing hydrogel on a support.

  According to the present invention, the above-described problems can be solved and the object can be achieved, and an organic pigment is added to the hydrogel or a dispersion obtained by dispersing the organic pigment in a dispersion medium is added to the hydrogel. By adding, it is possible to obtain a colored patch having a water-containing gel layer and a support layer that are uniformly colored and have no skin dyeing property.

Hereinafter, the present invention will be described in more detail.
The colored patch of the present invention has a water-containing colored gel layer and a support layer containing an organic pigment, or contains an organic pigment-containing water-containing solution obtained by adding a dispersion liquid in which an organic pigment is dispersed in a dispersion medium to a water-containing gel. It is characterized by having a gel layer and a support layer, whereby a patch having a water-containing gel that is uniformly colored and has no skin dyeing property is obtained.

--Hydrogel layer--
<Organic pigment>
The organic pigment contained in the hydrated gel layer has an average particle size of 50 μm or less, preferably 30 μm or less, more preferably 20 μm or less, and even more preferably 10 μm or less. In this case, the lower limit of the average particle diameter is not particularly limited, but is preferably 0.05 μm or more, more preferably 0.1 μm or more, and further preferably 1 μm or more. The average particle diameter is measured by an infrared scattering method.
If the average particle diameter of the organic pigment is too large, the color of the hydrous gel may become light and a uniform colored gel layer may not be obtained.

The maximum particle diameter of the organic pigment is 90 μm or less, preferably 70 μm or less, more preferably 50 μm or less, and still more preferably 20 μm or less. The maximum particle size is measured by a particle gauge method (grindometer method).
If the maximum particle size of the organic pigment is too large, a uniform colored hydrous gel layer may not be obtained.

The organic pigment preferably has a particle size distribution (infrared scattering method) shown in Table 2 below.

  The organic pigment having the average particle size, the maximum particle size and the particle size distribution as described above can be obtained by adjusting the particle size by pulverizing a commercially available legal organic pigment. In this case, pulverization and dispersion include wet pulverization with a dispersion medium using a ball mill, speed mill, etc., dry pulverization using a pin mill, etc., and kneading dispersion using a Henschel mixer or a kneader. Is desirable.

As the organic pigment, an azo compound or a phthalocyanine compound is preferable.
Specifically, blue 404, yellow 205, yellow 401, orange 203, orange 204, orange 401, red 201, red 202, red 203, red 204, red 205, red No. 206, Red No. 207, Red No. 208, Red No. 219, Red No. 220, Red No. 221, Red No. 228, Red No. 404, Red No. 405, etc. These are used alone or in combination of two or more. Can be used in appropriate combination. Among these, blue 404, yellow 205, orange 203, red 201, red 202 and the like are preferable.

The content of the organic pigment in the hydrogel layer of the present invention is preferably 0.00001 to 1% by mass, more preferably 0.0001 to 0.1% by mass, more preferably 0.001 to 0.05% by mass. It is.
If the content of the organic pigment is too small, the water-containing gel may be insufficiently colored. On the other hand, if the content is too large, the water-containing gel may be softened or separated by the dispersion medium.

  From the viewpoint of obtaining a uniform water-containing colored gel, it is preferable to pre-disperse the organic pigment in a suitable dispersion medium and then add the dispersion to the water-containing gel. Although it does not restrict | limit especially as a preliminary | backup dispersion medium, What is chosen from monohydric alcohol, a polyhydric alcohol, a fatty acid, a fatty acid salt, surfactant, and a water-absorbing polymer aqueous solution is preferable.

  Examples of the monohydric alcohol include methanol, ethanol, propanol, isopropanol, and butanol.

The polyhydric alcohol, fatty acid or salt thereof, surfactant and water-absorbing polymer aqueous solution are not particularly limited, and polyhydric alcohol, fatty acid or salt thereof, surfactant and water-absorbing polymer exemplified in the hydrous gel described later. The same molecular aqueous solution can be used.
Among these, glycerin, POE (20) sorbitan monooleate, ethylene glycol, POE hydrogenated castor oil, ethanol, PEG1000, and the like are preferable.

<Water-containing gel>
The water-containing gel of the colored patch of the present invention is not particularly limited and can be appropriately selected according to the purpose. However, a crosslinking agent such as a polyvalent metal salt in a matrix containing a water-soluble polymer compound. Furthermore, a water-containing gel obtained by adding a crosslinking regulator and gelling is preferable.
In this case, the water content in the hydrogel layer is 40 to 98% by mass, preferably 60 to 98%, more preferably 70 to 95% by mass. If the water content is too small, the cooling effect for a long time may not be obtained. On the other hand, if the content is too large, the shape retention as an adhesive substrate may not be maintained.

  Examples of the water-soluble polymer compound include gelatin, polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene oxide, sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, methylcellulose, sodium alginate, xanthan gum, arabic. Examples thereof include gum, tragacanth gum, karaya gum, and maleic anhydride copolymer. These can be used individually by 1 type or in combination of 2 or more types.

In the present invention, it is particularly desirable to use polyacrylic acid and / or polyacrylate and sodium carboxymethylcellulose mixed with the above-described other polymer compound.
As the polyacrylic acid, either linear or branched can be used. It is preferable to use those having a molecular weight of 10,000 to 10,000,000, particularly two types of polyacrylic acids having a weight average molecular weight of 10,000 to less than 500,000, 500,000 to less than 2,000,000, and 2,000,000 to 4,000,000. Combining the above is preferable because the usability is improved. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as carbopol (trade name: manufactured by Goodrich, USA) can also be suitably used.

  Examples of the polyacrylate include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, and triethanolamine polyacrylate. 1 type (s) or 2 or more types, such as polyacrylic acid amine salt, polyacrylic acid ammonium salt, etc. can be used conveniently.

  In this case, the blending ratio (mass ratio) of polyacrylic acid and polyacrylate is preferably 1: 0.1 to 1:10, more preferably 1: 1 to 1: 9. It is also possible to use a material in which the polyacrylate is partially neutralized to have the above ratio.

The blending amount of the water-soluble polymer compound can be appropriately selected according to the type of polymer compound to be selected and the degree of polymerization thereof, but is usually 1 to 40% by mass, preferably 3 to 30% by mass of the entire hydrogel. More preferably, it is about 5 to 20% by mass.
If the blending amount of the water-soluble polymer compound is too small, sufficient cohesive force may not be obtained. On the other hand, if it is too much, the viscosity becomes too high and the productivity may be lowered.

  Examples of the crosslinking agent include a polyvalent metal salt that releases a polyvalent metal ion that metal-crosslinks the water-soluble polymer compound. As such a polyvalent metal salt, the type is not particularly limited as long as the system gels when added to a matrix containing a water-soluble polymer compound. It can be selected and used. For example, magnesium compounds, calcium compounds, zinc compounds, cadmium compounds, aluminum compounds, titanium compounds, tin compounds, iron compounds, chromium compounds, manganese compounds, cobalt compounds, nickel compounds, etc. can be used. If it is applied to the skin and the safety to the skin is taken into consideration, it is particularly preferable to use an aluminum compound, a magnesium compound, a calcium compound or the like.

  In this case, any of aluminum compounds, magnesium compounds and calcium compounds can be suitably used. Specifically, alums such as potassium alum, ammonium alum, and iron alum, aluminum hydroxide, aluminum sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum silicate, aluminum metasilicate, calcium hydroxide , Calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate, magnesium hydroxide, magnesium carbonate, magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, magnesium hydroxide aluminate, aluminate metasilicate Magnesium, magnesium aluminate silicate, synthetic hydrotalcite, water soluble compounds such as double salts containing these metals, 1 of poorly water soluble compounds Or may be used two or more. An antacid containing aluminum and magnesium can also be blended as a polyvalent metal salt.

  In addition, the compounding quantity of a crosslinking agent is 0.005-3 mass% with respect to the whole water-containing gel, Preferably it is about 0.03-1 mass%.

  Examples of the crosslinking regulator include polycarboxylic acids (salts) such as EDTA-Na, citric acid, malic acid, tartaric acid, succinic acid, and disodium edetate.

  The hydrous gel of the present invention may optionally contain other gel base components as necessary. For example, a surfactant, a filler, a superabsorbent polymer compound, a polyhydric alcohol, an oil component, a humectant, an antioxidant, an ultraviolet absorber / scatterer, an antiseptic, an active ingredient, a fragrance and the like can be blended.

As the surfactant, nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants can be used, and these may be used alone or in combination of two or more. it can.
In addition, the compounding quantity of surfactant is about 0-5 mass% with respect to the whole water-containing gel.

  Specific examples of the nonionic surfactant include (glyceryl fatty acid esters of fatty acid residues and alkyl groups having 8 to 22 carbon atoms, preferably 10 to 18) (for example, diglycerin monostearate), polyoxy Ethylene glycerin fatty acid ester (eg, polyoxyethylene glyceryl (POE10) monooleate), polyoxyethylene fatty acid ester, polyoxyalkylene alkyl ether (eg, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether) Etc.), polyoxyethylene alkylphenyl ether, polyhydric alcohol fatty acid partial ester (eg glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fat) Acid esters), polyoxyethylene polyhydric alcohol fatty acid partial esters (eg, polyoxyethylene glycerin fatty acid esters, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, etc.), polyoxyethylene castor oil, polyglycerin fatty acid esters, Examples include polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkylphenyl ether, fatty acid diethanolamide, polyoxyethylene alkylamine, ethanolamine fatty acid partial ester, and alkylamine oxide.

Among these nonionic surfactants, POE (25) lauryl ether, sucrose fatty acid ester, sorbitan monooleate, sorbitan monolaurate, sorbitan palm oil fatty acid sorbitan, sorbitan monostearate, glyceryl monooleate, glyceryl laurate, coconut oil fatty acid Glyceryl, polyethylene glycol monolaurate, polyethylene glycol monooleate, glyceryl myristate, decaglyceryl monooleate, diglyceryldiolate, hexaglyceryl monolaurate, propylene glycol monostearate, POE (20) sorbitan monooleate, POE (60 ) Sorbit tetraoleate, POE (40) monostearate, POE (10) oleyl ether, POE (10) nonyl phenyl ether, P E (50) hardened castor oil, POE (5) oleic acid amide, oleic acid diethanol amide, etc. lauric acid diethanolamide is preferable. In the above notation, for example, “POE (25)” indicates a structure in which 25 mol of ethylene oxide is added.
Most preferred nonionic surfactants are polyoxyethylene alkyl ethers having 12 to 18 carbon atoms in the alkyl group, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene hydrogenated castor oil.

  Examples of the anionic surfactant include higher fatty acid salts, alkyl ether carboxylates, polyoxyethylene alkyl ether carboxylates, alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl isothiocyanates, alkyl benzene sulfonates, alkyls Examples thereof include phosphates, polyoxyethylene alkyl phosphates, and the like. These salts are preferably sodium salts, potassium salts, organic amine salts and the like, and those having an alkyl group or an alkenyl group having 8 to 22 or 10 to 18 carbon atoms. Is preferred.

  Among these, sodium oleate, sodium laurate, sodium myristate, cetyl sulfate, sodium cetostearyl sulfate, sodium oleyl sulfate, sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium dioctyl sulfate sulfosuccinate, coconut oil fatty acid Hydrolyzed collagen sodium, sodium glycyrrhizinate, sodium glycyrrhetinate, triPOE (10) alkyl ether sodium phosphate and potassium salts thereof, diethanolamine salt, triethanolamine salt, sodium N-acylmethyltaurate and the like are more preferable.

  Specific examples of the cationic surfactant include primary to tertiary fatty amine salts, quaternary ammonium salts, polyethylene polyamine fatty acid amide urea condensate salts, and polyethylene polyamine fatty amide urea condensates. And more specifically, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, stearyltrimethylammonium saccharin, lauryltrimethylammonium saccharin, benzalkonium chloride, laurylpyridinium chloride, cetylpyridinium chloride, and laurylpyridinium chloride. And alkyldiaminoethylglycine hydrochloride.

Specific examples of the amphoteric surfactant include amino acids, sulfoamino acids,
Quaternized betaine, sulfobetaine, imidazolinium betaine and the like can be mentioned. More specifically, lauryldimethylaminoacetic acid betaine, coconut oil alkylbetaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid hydrolyzed collagen, sebacic acid Examples include diethyl and lecithin.

Examples of the filler include kaolin, bentonite, montmorillonite, smectite, zinc oxide, titanium oxide, and silicic anhydride, and these can be used alone or in combination of two or more.
In addition, the compounding quantity of a filler is about 0-10 mass% with respect to the whole water-containing gel.

  Examples of the superabsorbent polymer compound include nonionic superabsorbent polymer compounds such as partially neutralized products of crosslinked polyacrylic acid, modified polyalkylene oxides, N-vinylacetamide crosslinked products, and acrylamide crosslinked products. Highly water-absorbing polymer compounds. Among these, preferred are nonionic highly water-absorbing polymer compounds. Nonionic highly water-absorbing polymer compounds have a higher water-absorbing capacity for aqueous liquids with higher ionic concentrations than ionic ones, so formulations with high ionic concentrations (eg gel cosmetics, pharmaceuticals, poultices, etc.) It is possible to stably hold a large amount of water.

  More specifically, as such a highly water-absorbing polymer compound, Sunwet IM-1000 (Sanyo Kasei, water absorption capacity 800 times), Sun Fresh AT-35 (Sanyo Kasei, water absorption capacity 800 times), Aqua Coke ( Sumitomo Seika: Water absorption capacity 30 times), Noniolex NA-010 (water absorption capacity 50 times), Noniolex NA-150 (water absorption capacity 50 times), Noniolex NA-500 (water absorption capacity 50 times) (Showa Denko) Can be mentioned.

  In addition, although the compounding quantity of a superabsorbent polymer compound is not restrict | limited in particular, it is 0.1-30 mass% with respect to the whole water-containing gel, More preferably, it is 0.5-15 mass%.

  Examples of the polyhydric alcohol include glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3-propanediol, and 1,4-butane. One or more of diol, maltitol, xylitol and the like can be used.

In addition, the compounding quantity of a polyhydric alcohol is 50 mass% or less with respect to the whole water-containing gel, Preferably it is 0-20 mass%.
When the blending amount of the polyhydric alcohol exceeds 50% by mass, the cohesive force of the aqueous adhesive base decreases, and the aqueous adhesive base may remain on the adherend during peeling.

  Examples of the oil include vegetable oils such as castor oil, olive oil, cacao oil, palm oil, straw oil, coconut oil, tree wax, jojoba oil, grape seed oil, avocado oil; animal oils such as mink oil and egg yolk oil Waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petrolatum; lauric acid, myristic acid, stearic acid, Natural and synthetic fatty acids such as oleic acid, isostearic acid, behenic acid; natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyl decanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, myristic acid Kuchirudodeshiru, octyldodecyl oleate, and the like can be exemplified esters such cholesterol oleate.

  Examples of the humectant include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, and dipropylene glycol; NMF components such as amino acids and sodium pyrrolidonecarboxylate; Examples thereof include water-soluble polymer substances such as acid, collagen, mucopolysaccharide, and chondroitin sulfate.

  Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and salts thereof.

  Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycynamate, titanium oxide, kaolin, and talc.

  Examples of the preservative include parabens such as methyl paraben, propyl paraben and butyl paraben, quaternary cations such as benzalkonium chloride and benzethonium chloride, sorbic acid, and benzoic acid.

The active ingredient is not particularly limited, and those used for the active ingredient of ordinary patches can be used. Specifically, the following can be used.
[Nonsteroidal anti-inflammatory agents]
Salicylic acid and its salts, salicylic acid derivatives such as aspirin, acetaminophen, aminopyrine, antipyrine, oxyphenbutazone, sulpyrine, indomethacin, diclofenac sodium, ibuprofen, sulindac, naproxen, ketoprofen, etofenamate, salicylamide, triethanolamine Tyrate, flufenamic acid and its salts and derivatives, meclofenamic acid and its salts and derivatives, colchicine, bufexamac, ibufenac, loxoprofen, fenbufen, diflunisal, alclofenac, phenylbutazone, mefenamic acid and its salts and its Derivatives, fenoprofen, bendazac, piroxicam, flurbiprofen, zaltoprofen, etodolac It is.

[Steroid anti-inflammatory agent]
Amsinoids, prednisolone valerate, diflucortron valerate, betamethasone valerate, betamethasone acetate, dexamethasone acetate, betamethasone dipropionate, dexamethasone, triamcinolone acetonide, rilcinonide, hydrocortisone, flumethasone pivalate, fluocinonide, fluocinolone acetonide, fluocinolone acetonide Examples include otometron, fludroxycortide, prednisolone, clobetasol propionate, beclomethasone propionate, betamethasone, methylprednisolone, methylprednisolone acetate, hydrocortisone butyrate and the like.
[Muscle relaxant]
Examples include diazepam.
[Antiemetic]
Examples include chlorpromazine.
[Psoriasis treatment agent]
And methoxalene.
[Emulsifier or emollient]
Examples include hydroquinone, urea, heparin, and chondroitin sulfate.
[Other medicinal ingredients]
Indomethacin, glycol salicylate, methyl salicylate, ketoprofen, flurbiprofen, ibuprofen, suprofen, loxoprofen, zaltoprofen, piroxicam, felbinac, diphenhydramine, dibucaine, procaine, lidocaine, vitamin E derivatives, glycyrrhetinic acid or derivatives thereof, etc. These can be used individually by 1 type or in combination of 2 or more types as appropriate.
[Enzyme preparation]
Examples include trypsin, papain, protease, lysozyme, streptokinase, plasmin, urokinase, hyaluronidase, α-chymotrypsin, seratiothiopeptidase, bromelain, semi-alkaline peptidase and the like.
[Cooling agent]
Menthol derivatives such as camphor, thymol, borneol, menthol, N-ethyl-p-menthane-carboxamide, p-menthane-3,8-diol, l-isopulegol, l-menthylglyceryl ether, peppermint, peppermint oil, spirantol, etc. Can be mentioned.
[Vitamins]
Examples include pantothenic acid, panthenol, vitamin A (such as retinol palmitate), vitamin E (d-α-tocopherol acetate), vitamin K, vitamin C, vitamin B group, vitamin F, vitamin P, etc. Giving agent]
Capsaicin, nonyl acid vanillyl amide, nonyl acid vanillyl ether and the like can be mentioned.
(Herbal medicine)
Examples include herbal powders such as pistol, herbal soft extracts such as pepper extract, dry herbal extracts such as dried dry extract, herbal extracts such as assembly extract, and herbal tinctures such as arnica tincture.
[Plant extract]
Anise, Angelica, Benzo, Immortelle, Chamomile, Garlic, Cardamom, Galvanam, Caraway, Carrot Seed, Guacwood, Grapefruit, Cypress, Sandalwood, Cedarwood, Juniper, Star Anise, Sage, Geranium, Celery, Thyme, Tarragon, Turpentine, spruce, frankincense, violet, pine, parsley, birch, patchouli, hyssop, fennel, black pepper, bodaiju flower, myrrh, marigold, lavender, yarrow, lemon, lemongrass, rose, rosemary, laurel, shimotsukegiku, peach , Essential oils or extracts such as cornflower, eucalyptus, yuzu, lavender and the like.
[Seaweed extract]
Blue-tailedaceae, scorpionaceae, proboscisaceae, milinaceae, kombudiaceae, ainuwakame, hondaidae, hibamata, funori, euphoridae, milaceae, oxenaceae, cedaraceae, scorpionaceae, nymphalidae, nagamatsuri Extracts of seaweeds belonging to the family, Dalbiridae, Lessoniaceae and Dulceae are mentioned, and among these, seaweed extracts belonging to the Dalbiridae are preferred.

  When the active ingredient is blended in the water-containing gel of the present invention, if the substance is listed in the Japanese Pharmacopeia or the appropriate amount of use is determined by other literature, etc., it is blended according to the appropriate amount of use. It is preferable. In particular, the blending amount of a substance for which an appropriate amount is not determined is preferably about 0.0001 to 10% by mass.

  As said fragrance | flavor, a natural vegetable fragrance | flavor, a mixing | blending fragrance | flavor component, a synthetic | combination fragrance | flavor component, etc. can be used, These can be combined arbitrarily and masking of a base odor or a chemical | medical odor can be carried out.

  Examples of the natural plant fragrances include fennel oil, castor oil, mint oil, mint mint oil, dai fennel oil, cinnamon oil, clove oil, chimian oil, turpentine oil, henoposi oil, yamadine oil, eucalyptus oil, lavender oil, lemon Oil, orange oil, touka oil, bergamot oil, rose oil, citronella oil, lemongrass oil, camphor oil, geranium oil and the like.

  Examples of the blended perfume ingredients include limonene, terpinolene, camphene, citronellol, geraniol, nerol, linalool, menthol, borneol, terpineol, citronellal, citral, menthone, carbomenton, camphor, citronellic acid, cineol, curcumen, farnesol, neroli Doles, hinokic acid, santalic acid and the like are preferred.

  Other synthetic fragrance ingredients include, for example, “Initiative fragrance chemistry and product knowledge” published by Motoichi Into, 1996 published by Chemical Industry Daily, 1969 MONTCLAIR, N. J. et al. The fragrance | flavor as described in "Perfume and Flavor Chemicals" by Stefan Arctander (Perfume and Flavor Chemicals) etc. can be used.

--Support layer--
The support layer is not particularly limited, and those used for the support layer of ordinary patches can be used. Such materials include, for example, woven fabrics such as paper, thick weave, yarn weave, gauze, corten, and flannel, flat knitting, rubber knitting, tuck knitting, knitted fabric by a method such as double stitching, spun lace, Nonwoven fabrics, knits, plastic films, plastic film / fiber laminate sheets, plastic film / hydrophilic resin laminate sheets, etc. produced by a method such as spun bond, thermal bond, chemical bond, needle punch, etc. can be used.
Examples of the nonwoven material include polyester fiber, polyethylene fiber, polyamide fiber, polyurethane fiber, rayon, hemp and the like.
When a plastic film is used, materials such as polyethylene, polypropylene, polyethylene terephthalate, polyester, nylon, and polyurethane can be used.
In addition, the film thickness of the resin film is not particularly limited, and is usually about 5 to 100 μm.

<Coloring patch>
The patch of the present invention comprises an organic pigment having an average particle size of 50 μm or less and a maximum particle size of 90 μm or less, a monohydric alcohol, a polyhydric alcohol, a fatty acid, a fatty acid salt, a surfactant, and a water-absorbing polymer. After being dispersed in a dispersion medium selected from an aqueous solution, the dispersion can be added to a hydrated gel, and the organic pigment-containing hydrated gel can be spread on a support and cut into an appropriate size. .

The colored patch of the present invention can be widely used for face, body, foot and the like, and can also be used for rough skin (such as heels) cracked by drying.
In addition, the colored patch of the present invention has a water-containing gel layer that is uniformly colored with no color unevenness, and as shown in the examples described later, even if it is applied for 8 hours or more, color transfer occurs on the skin. There is no.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated further more concretely, this invention is not limited at all by these examples.

[Examples 1 to 1 5 , Reference Example 16 and Comparative Example 1]
Purified water was put into a Henschel mixer according to the composition shown in Tables 3 to 5, and each component was added, and stirred for 10 minutes (100 rpm) to prepare a hydrogel. To this water-containing gel, a pigment previously dispersed in a dispersion medium was added and stirred at 100 rpm for 15 minutes to obtain a colored water-containing gel. The particle size of the pigment was measured by the following method.
The obtained colored hydrous gel was spread on a support (polyester knit) by 0.1 g / cm ² , and then cut to 10 × 14 cm , and colored patches of Examples 1 to 15, Reference Example 16 and Comparative Example 1 An agent was produced.

Various properties of the obtained colored patches were evaluated by the following methods. The results are also shown in Tables 3-5. In addition, all of the organic pigments of Examples 1 to 16 satisfied the particle size distribution shown in Table 3 above.
Furthermore, even if the support is manufactured in place of polyester nonwoven fabric, foamed urethane film, urethane film, polyester film, polyester film / polyester nonwoven fabric, polyester film / polyester knit, urethane film / polyester nonwoven fabric, urethane film / polyester knit, A good colored patch of the invention was obtained.

<Pigment particle size measurement>
The maximum particle size was measured with a particle gauge.
The average particle diameter was measured by wet measurement using ethanol as a dispersion medium using a particle size distribution measuring instrument by an infrared scattering method.

<Colorability of patches (plasters)>
By visual evaluation, the presence or absence of color unevenness of each patch was confirmed according to the following criteria.
Evaluation standard ◎: Colored uniformly ○: Slightly uneven color △: Slightly uneven color ×: Remarkably uneven color

<Color transfer>
Ten panelists evaluated the color transfer to the skin after applying each patch to the leg for 8 hours under the conditions of room temperature and 50% RH according to the following criteria.
Evaluation criteria ○: No color transfer △: Slight color transfer ×: Color transfer

Claims (5)

It has an organic pigment-containing hydrogel layer and a support layer obtained by adding a dispersion in which an organic pigment is dispersed in a dispersion medium to a hydrous gel, and the content of the organic pigment in the organic pigment-containing hydrogel layer is 0 .00 from 2% to 0.21% by weight,
A colored patch, wherein the organic pigment has an average particle size of 50 μm or less and a maximum particle size of 65 μm or less.   2. The colored patch according to claim 1, wherein the organic pigment has an average particle size of 1 μm to 20 μm and a maximum particle size of 50 μm or less.   The colored patch according to any one of claims 1 to 2, wherein the dispersion medium is at least one selected from monohydric alcohols, polyhydric alcohols, fatty acids, fatty acid salts, surfactants and water-absorbing polymer aqueous solutions. The colored patch according to any one of claims 1 and 3, wherein the organic pigment has a particle size distribution shown in Table 1 below.
  The colored patch according to any one of claims 1 to 4, wherein the water content in the hydrogel layer is 40% by mass to 98% by mass.