JP2022093031A - Patch - Google Patents

Abstract

To provide a patch containing a hydrous gel that has shape retentivity and is also less prone to back-staining, and further has adhesive force and a refreshing feel.SOLUTION: A patch contains a hydrous gel and a support. The hydrous gel contains (A) at least one selected from polyacrylic acid and a salt thereof and (B) a hydrous gel crosslinked with a crosslinker. In the crosslinker, the molar ratio between magnesium ions and aluminum ions (magnesium ions/aluminum ions) is 1.9 or more and less than 3.0.SELECTED DRAWING: None

Description

The present invention relates to a patch having a hydrogel.

The patch having a water-containing gel has a three-dimensional three-dimensional structure in which one or more water-soluble polymers having at least one of a carboxyl group, a hydroxyl group and an acetic acid group are crosslinked with a cross-linking agent to retain water. However, when the water content becomes high, the shape-retaining property is lost, and the water-containing gel may ooze out on the back side of the support when the patch is stored. From the above, a patch having a water-containing gel that has both shape retention and suppression of back stain has been desired. In addition, a patch having adhesive strength and a refreshing feeling has been desired.

Japanese Unexamined Patent Publication No. 10-265373 Japanese Unexamined Patent Publication No. 2004-231567

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a patch containing a water-containing gel having both shape retention and back stain suppression, and having adhesive strength and a refreshing feeling.

As a result of diligent studies to achieve the above object, the present inventor has conventionally used cross-linking with trivalent aluminum ions most, but divalent magnesium ions and trivalent aluminum ions have a specific molar ratio. By doing so, it has been found that a patch having a water-containing gel having both shape retention and back stain suppression, adhesive strength and a refreshing feeling can be obtained, and the present invention has been made.

Therefore, the present invention provides the following patch.
1. 1. A patch containing a hydrogel and a support.
The above hydrogel is
It contains a hydrogel in which (A) one or more selected from polyacrylic acid and salts thereof are crosslinked with (B) a cross-linking agent, and the molar ratio of magnesium ions to aluminum ions in the cross-linking agent (magnesium ion / aluminum ion). ) Is 1.9 or more and less than 3.0.
2. 2. Further, (C) the patch according to 1 containing one or more selected from carboxymethyl cellulose and a salt thereof.
3. 3. The patch according to 1 or 2, wherein the support is a knitted cloth.

According to the present invention, it is possible to provide a patch having a water-containing gel having both shape retention and back stain suppression, and having adhesive strength and a refreshing feeling.

Hereinafter, the present invention will be described in detail.
I. Hydrous gel The hydrogel of the present invention is
It contains a hydrogel in which (A) one or more selected from polyacrylic acid and salts thereof are crosslinked with (B) a cross-linking agent, and the molar ratio of magnesium ions to aluminum ions in the cross-linking agent (magnesium ion / aluminum ion). ) Is 1.9 or more and less than 3.0.

[(A) component]
The component (A) of the present invention is a water-soluble polymer having one or more groups selected from a carboxyl group, a hydroxyl group and an acetic acid group, and can be used alone or in combination of two or more. Examples of the component (A) include polyacrylic acid, polyacrylic acid salt and the like.

As the polyacrylic acid salt, those in which 20 to 80 mol% of the carboxy groups in one polymer chain are neutralized can also be used. Examples of the salt include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, and amine salts of polyacrylic acid such as monoethanolamine polyacrylate, diethanolamine polyacrylate, and triethanolamine polyacrylate. , Ammonium salt of polyacrylic acid and the like.

As the component (A), a commercially available product can be used, and examples thereof include the following products.
Carboxyvinyl polymer: Carbopol (trade name: Goodrich Corporation, USA)
Polyacrylic acid: Toagosei Co., Ltd., "Julimer AC-10H", weight average molecular weight: 150,000, neutralization degree: 0 mol%
Polyacrylic acid: Toagosei Co., Ltd., "Julimer SH8", weight average molecular weight: 1 million, neutralization degree: 0 mol%
Polyacrylic acid: Toagosei Co., Ltd., "Julimer AC-10P", weight average molecular weight: 9000, neutralization degree: 0 mol%
Polyacrylic acid: Made by Nippon Shokubai Co., Ltd. "AS-58", weight average molecular weight: 800,000, neutralization degree: 0 mol%
Polyacrylic acid partially neutralized product: Toagosei Co., Ltd., "Aronbis AH-106X", weight average molecular weight: 4.5 million, neutralization degree: 40 mol%
Polyacrylic acid partially neutralized product: Showa Denko KK, "Viscomate NP-800", weight average molecular weight: 5 million, neutralization degree: 35 mol%
Partial neutralization of polyacrylic acid: Sumitomo Seika Chemical Co., Ltd., "Akpana AP-40F", weight average molecular weight: 5 million, neutralization degree: 40 mol%
Na polyacrylic acid: manufactured by Toagosei Co., Ltd., "Aronbis SX", weight average molecular weight: 4.5 million, neutralization degree: 100 mol%
Na polyacrylic acid: Made by Nippon Shokubai Co., Ltd. "FHS", weight average molecular weight: 4 million, neutralization degree: 100 mol%

As the component (A), polyacrylic acid and sodium polyacrylate having a weight average molecular weight of 10,000 to 10 million are preferable, and the weight average molecular weight is 10,000 or more and less than 500,000, 500,000 or more and less than 2 million, and 2 million. It is preferable to combine two or more kinds of polyacrylic acid having a weight average molecular weight of -7 million and a salt thereof. The weight average molecular weight means the weight average molecular weight measured by gel permeation chromatography (GPC) (polyacrylic acid conversion).

The content of the component (A) is preferably 1 to 15% by mass, more preferably 5 to 12% by mass in the gel composition from the viewpoint of shape retention and adhesive strength.

[(B) component]
The component (B) of the present invention is a cross-linking agent and can be used alone or in combination of two or more. Of these, those that release magnesium ions and aluminum ions in an aqueous solution are preferable. Specifically, any of the aluminum compound and the magnesium compound can be preferably used. For example, myobans such as potassium myoban, ammonium myoban, iron myoban, aluminum hydroxide, aluminum sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum silicate, aluminum metasilicate, magnesium hydroxide, magnesium carbonate. , Magnesium sulfate, Magnesium acetate, Magnesium silicate, Magnesium oxide, Alumina hydroxide magnesium hydroxide, Magnesium aluminometasilicate, Magnesium aluminate silicate, Synthetic hydrotalcite, Water-soluble compounds such as compound salts containing these metals, Water-soluble Acidic agents containing compounds, aluminum and magnesium can be mentioned. Among them, potassium myoban, aluminum hydroxide, aluminum glycinate, magnesium hydroxide, magnesium hydroxide alumina, magnesium aluminometasilicate, magnesium aluminometasilicate, and synthetic hydrotalcite are preferable, and aluminum glycinate and synthetic hydrotalcite are preferable. More preferred. Commercially available products include dihydroxyaluminum aminoacetate: "Glycinal" manufactured by Kyowa Chemical Industry Co., Ltd., synthetic hydrotalsite: "Alcamac SH" manufactured by Kyowa Chemical Industry Co., Ltd., magnesium hydroxide alumina: Kyowa Chemical Industry Co., Ltd. "Sanarumin" manufactured by Sanalmin, magnesium aluminometasilicate: "Neucillin" manufactured by Fuji Chemical Industry Co., Ltd. can be used.

The molar ratio of magnesium ions to aluminum ions (magnesium ion / aluminum ion) in the cross-linking agent is 1.9 or more and less than 3.0, preferably 2.0 to 2.5. The ion ratio in the cross-linking agent is adjusted by the molar ratio in each cross-linking agent to be blended.

The hydrogel of the present invention is a hydrogel in which the above component (A) is crosslinked with (B) a cross-linking agent, and when another polymer compound is further blended, a hydrogel having a good usability can be obtained. Examples of other polymer compounds include (C) carboxymethyl cellulose and salts thereof.

The degree of etherification of sodium carboxymethyl cellulose is preferably 0.5 or more. The viscosity of the 1% by mass aqueous solution at 25 ° C. is preferably 100 to 4,000 mPa · s, more preferably 1,500 to 3,000 mPa · s. The more linear the concentration and viscosity of the aqueous solution of carboxymethyl cellulose, the more uniform the substituent distribution, but in order to increase the effect, it is preferable to use a non-uniform one. The ratio of the viscosity of the 5% by mass aqueous solution at 25 ° C. to the viscosity of the 1% by mass aqueous solution at 25 ° C. is preferably 400 to 3,000, more preferably 450 to 2,000. For example, sodium carboxymethyl cellulose: CMC1380 (Daicel FineChem Co., Ltd.), CMC1390 (same as above), CMC2280 (same as above) can be used. The viscosity is a value measured by a BH type viscometer (rotor: No. 2, rotation speed: 20 rpm) manufactured by Tokyo Keiki Co., Ltd.

The content of the component (C) is preferably 1% by mass or more in the gel composition from the viewpoint of suppressing back stains, preferably 8% by mass or less from the viewpoint of adhesive strength, and 2.5 to 5.5% by mass. More preferred.

The water content in the hydrogel composition is preferably 65 to 80% by mass, more preferably 69 to 75% by mass.

The hydrogel of the present invention may contain an appropriate amount of components other than the above, either alone or in combination of two or more, as long as the effects of the present invention are not impaired. For example, a surfactant, a filler, a cellulose derivative other than the component (C), a water-soluble polymer compound other than the components (A) and (C), a superabsorbent polymer compound other than the component (A), and a polyhydric alcohol. , Oil content, moisturizing agent, antioxidant, ultraviolet absorbing / scattering agent, preservative, fragrance and the like can be blended.

As the surfactant, a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant can be used, and these can be used alone or in combination of two or more. .. When a surfactant is blended, the amount thereof is about 0 to 5% by mass in the hydrogel.

Specific examples of the nonionic surfactant include polyglycerin fatty acid esters (eg, diglycerin monostearate, etc.) of (fatty acid residues, alkyl groups having 8 to 22 carbon atoms, preferably 10 to 18), and polyoxyethylene. Glycerin fatty acid ester (eg, polyoxyethylene glyceryl (POE10) monooleate, etc.), polyoxyethylene fatty acid ester, polyoxyalkylene alkyl ether (eg, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl) Ether, etc.), polyoxyethylene alkylphenyl ether, polyhydric alcohol fatty acid partial ester (eg, glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, etc.), polyoxyethylene polyvalent alcohol fatty acid partial ester (eg, polyoxyethylene glycerin fatty acid). Ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, etc.), polyoxyethylene castor oil, polyglycerin fatty acid ester, polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkylphenyl ether, fatty acid diethanolamide, poly Examples thereof include oxyethylene alkylamine, ethanolamine fatty acid partial ester, and alkylamine oxide.

Among these nonionic surfactants, POE (25) lauryl ether, citrus fatty acid ester, sorbitan monooleate, sorbitan monolaurate, sorbitan palm oil fatty acid, sorbitan monostearate, glyceryl monooleate, glyceryl laurate, coconut oil fatty acid Glyceryl, polyethylene glycol monolaurate, polyethylene glycol monooleate, glyceryl myristate, decaglyceryl monooleate, diglyceryl diolate, hexaglyceryl monolaurate, propylene glycol monostearate, POE (20) sorbitan monooleate (polysorbate 80) , POE (60) sorbit tetraolate, POE (40) monostearate, POE (10) oleyl ether, POE (10) nonylphenyl ether, POE (50) hardened castor oil, POE (5) oleic acid amide, oleic acid Diethanolamide, diethanolamide lauric acid and the like are more preferable. In the above notation, for example, "POE (25)" indicates a structure to which 25 mol of ethylene oxide is added.

The most preferable nonionic surfactants are polyoxyethylene alkyl ethers having 12 to 18 carbon atoms of an alkyl group, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene hydrogenated castor oil.

Anionic surfactants include higher fatty acid salts, alkyl ether carboxylates, polyoxyethylene alkyl ether carboxylates, alkyl sulfates, polyoxyethylene alkyl sulfates, alkyl isothianate salts, alkylbenzene sulfonates, and alkyl phosphates. Examples thereof include salts and polyoxyethylene alkyl phosphates, and examples of these salts are preferably sodium salts, potassium salts, organic amine salts and the like, and those having an alkyl group and an alkenyl group having 8 to 22 carbon atoms, particularly 10 to 18 carbon atoms. Is more preferable.

Among these, sodium oleate, sodium laurate, sodium myristate, sodium cetyl sulfate, sodium cetostearyl sulfate, sodium oleyl sulfate, polyoxyethylene lauryl ether sodium sulfate, sodium lauryl sulfate, sodium dioctyl sulfosuccinate, coconut oil fatty acid. Sodium hydrolyzed collagen, sodium glycyrrhizinate, sodium glycyrrhetinate, triPOE (10) alkyl ether sodium phosphate and potassium salts thereof, diethanolamine salt, triethanolamine salt, sodium N-acylmethyltaurine and the like are more preferable.

Specific examples of the cationic surfactant include primary to tertiary fatty amine salts, quaternary ammonium salts, urea condensates of polyethylene polyamine fatty acid amides, and urea condensates of polyethylene polyamine fatty amides. Examples thereof include stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, stearyltrimethylammonium saccharin, lauryltrimethylammonium saccharin, benzalconium chloride, laurylpyridinium chloride, cetylpyridinium chloride, laurylpyridinium chloride, and the like. Examples thereof include alkyldiaminoethylglycine hydrochloride.

Specific examples of the amphoteric surfactant include amino acids, sulfoamino acids, quaternized betaine, sulfobetaine, and imidazolinium betaine, and more specifically, lauryldimethylaminoacetate betaine and coconut oil. Examples thereof include alkyl betaine, coconut oil fatty acid amide propyl betaine, coconut oil fatty acid hydrolyzed collagen, diethyl sebacate, and lecithin.

Examples of the filler include kaolin, bentonite, montmorillonite, smectite, zinc oxide, titanium oxide, silicic acid anhydride and the like. When the filler is blended, the amount thereof is about 0 to 10% by mass in the hydrogel.

Examples of the cell roll derivative other than the component (C) include hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose and salts thereof.

Examples of the water-soluble polymer compound other than the above components (A) and (C) include gelatin, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, sodium alginate, xanthan gum, arabic gum, tragant gum, karaya gum, and maleic anhydride copolymer. And so on.

As the superabsorbent polymer compound other than the component (A), a water-insoluble nonionic superabsorbent polymer compound is preferable. Since the water-insoluble nonionic superabsorbent polymer compound has a higher water absorption capacity for an aqueous solution having a high ionic concentration than that of an ionic one, a preparation having a high ionic concentration (for example, gel cosmetics, pharmaceuticals, etc.) , Pap agent, etc.) can stably retain a large amount of water. Examples of the nonionic water-absorbent polymer compound include a modified polyalkylene oxide, an N-vinylacetamide crosslinked product, and an acrylamide crosslinked product.

As such water-insoluble nonionic superabsorbent polymer compounds, more specifically, Sunwet IM-1000 (SANYO CHEMICAL INDUSTRIES, water absorption capacity 800 times), Sunfresh AT-35 (SANYO CHEMICAL INDUSTRIES, water absorption capacity 800 times). Commercial products such as Aquacork (Sumitomo Seika: water absorption capacity 30 times), Aquaric CA (Nippon Shokubai, water absorption capacity 400 times) can be mentioned.

When a water-insoluble nonionic superabsorbent polymer compound is blended, the amount thereof is preferably 0.1 to 30% by mass, more preferably 0.5 to 15% by mass in the hydrogel.

Examples of the polyhydric alcohol include glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3-propanediol, and 1,4-butanediol. , Martinol, xylitol, etc. may be used alone or in combination of two or more. When the polyhydric alcohol is blended, the amount thereof is preferably 50% by mass or less, more preferably 0 to 20% by mass in the hydrogel. If the blending amount of the polyhydric alcohol exceeds 50% by mass, the cohesive force of the aqueous pressure-sensitive adhesive base is lowered, and the water-based pressure-sensitive adhesive base may remain on the adherend at the time of peeling.

Examples of oils include vegetable oils such as paraffin oil, olive oil, cacao oil, palm oil, camellia oil, palm oil, wood wax, jojoba oil, grape seed oil, and avocado oil; and animal oils and fats such as mink oil and egg yolk oil. Rows such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystallin wax, selecin wax, paraffin wax, vaseline; lauric acid, myristic acid, stearic acid, olein Natural and synthetic fatty acids such as acids, isostearic acid and behenic acid; natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, Examples of esters such as octyldodecyl oleate and cholesterol oleate can be exemplified.

The dye is not particularly limited, and those conventionally used for the pressure-sensitive adhesive layer (plaster) can be appropriately selected depending on the purpose. Specific examples of the dyes include Red No. 2, Red No. 3, Red No. 102, Red No. 104, Red No. 105, Red No. 106, Red No. 201, Red No. 202, Red No. 203, Red No. 204, and Red No. 205. , Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 404, Red 405, Red 501 , Red 502, Red 503, Red 504, Red 505, Red 506, Yellow 4, Yellow 5, Yellow 201, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 204, Yellow 205, Yellow 401, Yellow 402, Yellow 403 (1), Yellow 404, Yellow 405, Yellow 406, Yellow 407, Green 3, Green 201 , Green 202, Green 204, Green 205, Green 401, Green 402, Blue 1, Blue 2, Blue 201, Blue 202, Blue 203, Blue 204, Blue 205, Blue 401, Blue 403, Blue 404, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Brown 201 , Purple No. 201, Purple No. 401, Black No. 401 and the like. When the dye is blended, the amount thereof is preferably 0.00005 to 0.1% by mass, more preferably 0.0001 to 0.01% by mass in the hydrogel. If the blending amount is too small, the effect of the blending may not be sufficiently obtained, and if the blending amount is too large, the color tone may become too strong. When blending a dye, the dye is dissolved in water, oil, alcohol, etc. and then kneaded with other components so that the dye does not have shades or spots when the hydrogel is spread on the surface of the support. It is preferable to do so.

Examples of the moisturizing agent include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol and dipropylene glycol; NMF components such as amino acids and sodium pyrrolidone carboxylate; hyaluronic acid. , Collagen, mucopolysaccharide, water-soluble polymer substance such as chondroitin sulfate can be exemplified.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and salts thereof.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, titanium oxide, kaolin, talc and the like.

Examples of the preservative include parabens such as methylparaben, propylparaben and butylparaben, quaternary cations such as benzalkonium chloride and benzethonium chloride, sorbic acid and benzoic acid.

The active ingredient is not particularly limited, and those used as the active ingredient of a normal patch can be used. Specifically, the following can be used.
[Non-steroidal anti-inflammatory drug]
Salicylic acid and its salts, salicylic acid derivatives such as aspirin, acetaminophen, aminopyrine, antipyrine, oxyphenbutazone, sulpyrine, indomethacin, diclophenac sodium, ibuprofen, slindac, naproxen, ketoprofen, etofenamate, salicylamide, triethanolamine salicy Tyrate, flufenamic acid and its salts and their derivatives, meclophenamic acid and its salts and its derivatives, corhitin, bufexamac, ibuphenac, loxoprofen, fenbufen, diflunisar, alcrophenac, phenylbutazone, mephenamic acid and its salts and theirs. Examples thereof include derivatives, phenoprofen, bendazac, pyroxycam, flurubiprofen, salicyphopen, etdrac and the like.
[Steroidal anti-inflammatory agent]
Amsinoid, prednisolone valerate, diflucortone valerate, betamethasone valerate, betamethasone acetate, dexamethasone acetate, betamethasone dipropionate, dexamethasone, triamcinolone acetonide, lylcinonide, hydrocortisone, flumethasone pivalate, fluosinoneide, fluosinolone. Examples thereof include otometron, fludroxycortide, prednisolone, clobetazole propionate, bechrometasone propionate, betamethasone, methylprednisolone, methylprednisolone acetate, hydrocortisone butyrate and the like.
[Muscle relaxant]
Diazepam and the like can be mentioned.
[Antemetic]
Examples include chlorpromazine.
[Psoriasis remedy]
Examples include methoxsalen.
[Skin softener or skin palliative]
Examples include hydroquinone, urea, heparin, chondroitin sulfate and the like.
[Other medicinal ingredients]
Examples thereof include indomethacin, glycol salicylate, methyl salicylate, ketoprofen, flurbiprofen, ibuprofen, sprofen, loxoprofen, saltprofen, pyroxicum, felbinac, diphenhydramine, dibucaine, prokine, lidocaine, vitamin E derivative, glycyrrhetinic acid or derivatives thereof. These can be used alone or in combination of two or more.
[Enzyme preparation]
Examples thereof include trypsin, papain, protease, lysoteam, streptokinase, plasmin, urokinase, hyaluronidase, α-chymotrypsin, seratiopeptidase, bromelain, semi-alkali peptidase and the like.
[Refreshing agent]
Camphor, thymol, borneol, menthol, N-ethyl-p-menthane-carboxyamide, p-menthane-3,8-diol, l-isopulegol, l-menthol glyceryl ether and other menthol derivatives, peppermint oil, spirantol, etc. Can be mentioned.
[Vitamins]
Examples include pantothenic acid, pantenol, vitamin A (retinol palmitate, etc.), vitamin E (d-α-tocopherol acetate), vitamin K, vitamin C, B vitamins, vitamin F, vitamin P, etc. Grantor]
Examples thereof include capsaicin, vanillyl amide nonyl acid, vanillyl ether nonyl acid and the like.
[Crude drugs]
Examples thereof include crude drug powder such as Oobaku, crude drug soft extract such as Togarashi extract, crude drug dried extract such as dried Oobaku extract, crude drug flow extract such as Senburi style extract, and crude drug tincture such as Arnica tincture.
[Plant extract]
Anise, Angelica, Rest Incense, Immortelle, Chamomile, Garlic, Cardamon, Galvanum, Caraway, Carrot Seed, Guaacwood, Grapefruit, Cypress, Sandalwood, Cedarwood, Juniper, Staranis, Sage, Geranium, Celoli, Thyme, Taragon, TVon, touhi, frankincense, violet, pine, parsley, birch, patchouli, hissop, fennel, black pepper, bodaiju flower, anise, marigold, lavender, yarrow, lemon, lemongrass, rose, rosemary, laurel, shimotsukegiku, peach , Essential oils or extracts of thyme, eucalyptus, yuzu, lavender and the like.
[Seaweed extract]
Seaweed, Ogonori, Gelidiaceae, Mirin, Comb, Ainuwakame, Hondawara, Hibamata, Funori, Hitoegusa, Mill, Ushikenori, Suginori, Kaginori, Ibaranori, Nagamatsumo, Moduku Examples thereof include extracts of seaweeds belonging to the family, Daviria, Lessonia and Dalus, and among these, extracts of seaweeds belonging to the family Durbilia are preferable.

When the above-mentioned active ingredient is blended in the hydrogel of the present invention, if the substance is listed in the Japanese Pharmacopoeia or the appropriate amount for use is determined by other documents, etc., it is blended according to the appropriate amount for use. Is preferable. In particular, the blending amount of the substance for which the appropriate amount for use is not defined is preferably about 0.0001 to 10% by mass.

As the fragrance, natural vegetable fragrances, compounded fragrance components, synthetic fragrance components and the like can be used, and these can be arbitrarily combined to mask the base odor and the chemical odor, or to add fragrance.
Examples of the natural vegetable fragrance include uikyo oil, castor oil, peppermint oil, peppermint oil, daiuikyo oil, keihi oil, butterfly oil, chimian oil, televisionn oil, henoposi oil, yamadin oil, eucalyptus oil, lavender oil, and lemon. Examples thereof include oil, orange oil, touka oil, bergamot oil, rose oil, citronella oil, lemongrass oil, cypress oil, geranium oil and the like.
Examples of the compounded fragrance component include limonene, terpinolene, camphen, citronellol, geraniol, nerol, linalool, menthol, borneol, terpinelol, citronellal, citral, menthon, carbomenton, camphor, citronellic acid, cineole, curcumen, farnesol and neroli. Dole, linalool, santalic acid and the like are suitable.
Other examples of synthetic fragrance components include, for example, "Synthetic fragrance chemistry and product knowledge" by Motokazu Indo, published by The Chemical Daily in 1996, 1969 MONTCAIR, N.C. J. The fragrances described in "Perfume and Flavor Chemicals" by STEFFEN ARCTANDER can be used.

II. Support The support is not particularly limited, and those used for the support layer of a normal patch can be used. Examples of such materials include woven fabrics such as paper, thick weave, thread weave, gauze, cole heaven, and flannel, flat knitting, rubber knitting, tuck knitting, knitted fabric by a manufacturing method such as double knitting, and spun lace. Woven fabrics, knits, plastic films, plastic films / fiber laminated sheets, plastic films / hydrophilic resin laminated sheets and the like produced by a manufacturing method such as spun bond, thermal bond, chemical bond and needle punch can be used. In particular, when a knitted cloth is used, it follows the movement of the skin and is difficult to peel off. The film thickness of the plastic film is not particularly limited, and is usually about 5 to 100 μm.

Examples of the material include polyester fiber, polyethylene fiber, polyamide fiber, polyurethane fiber, rayon, hemp and the like. When a plastic film is used, materials such as polyethylene, polypropylene, polyethylene terephthalate, polyester, nylon, and polyurethane can be used.

The basis weight of the support is preferably 80 g / m ² or more from the viewpoint of suppressing back stains, preferably 200 g / m ² or less, and more preferably 90 to 180 g / m ² from the viewpoint of followability.

The patch of the present invention can be widely used for the face, body, feet, etc., and can also be used for dry, cracked and rough skin (heels, etc.). As one embodiment of the present invention, a release liner is further provided on the back surface of the surface of the support of the plaster layer in contact with the base cloth, and the patch of the present embodiment is a support (base cloth) and a water-containing gel. Layers and release liners are laminated in this order.

[Production method]
The method for producing the patch of the present invention is not particularly limited, and a known method can be adopted. For example, the above-mentioned components (A) to (C), water and an arbitrary component are mixed to obtain a hydrogel. The obtained hydrogel is sandwiched between a support and, if necessary, a plastic film using a roll, and then pressed with a pressure roll to remove a part of the plaster layer surface, and the score knife and Cut into a predetermined shape with a guillotine cutter.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. Unless otherwise specified in the following examples, "%" in the composition indicates mass%, and the ratio indicates mass ratio.

[Examples, comparative examples]
According to the composition shown in Table 1, a water-soluble component other than the polymer compound was added to purified water with stirring to prepare a preliminary solution 1.
The lipophilic component was dissolved in polysorbate 80 to prepare a preliminary solution 2.
The pigment was dispersed in glycerin to prepare small pigments.
Further, powdered sodium carboxymethyl cellulose and a partially neutralized polyacrylic acid are added to glycerin and stirred (with a hand mixer at 2,000 to 3,000 rpm for 5 minutes) to uniformly disperse them. -Dissolved to prepare pre-dispersion 1.
Next, the pre-dissolved product 2, the pigment accessory, purified water, and if necessary, the polyalkylene oxide-based water-absorbent resin are added to the pre-dissolved product 1, stirred (with a Henschel mixer at 300 rpm for 2 minutes), and kneaded. I got the thing 1.
Pre-dispersion 1, polyacrylic acid, and purified water were added to the kneaded product 1 and stirred (with a Henschel mixer at 300 rpm for about 2 minutes) to obtain the kneaded product 2.
Further, powdered dihydroxyaluminum aminoacetate and synthetic hydrotalcite were added to glycerin and uniformly dispersed to prepare a preliminary dispersion 2.
The pre-dispersion 2 was added to the kneaded product 2 and stirred (with a Henschel mixer at 300 rpm for about 2 minutes) to obtain a water-containing pressure-sensitive adhesive composition.
After forming a water-containing pressure-sensitive adhesive layer (plaster) on the support by spreading the obtained water-containing pressure-sensitive adhesive composition so as to be sandwiched between a support and a liner film so as to have a predetermined amount. , Cut to the specified size. The obtained patch was placed in an inner bag (paper 64 g / m ² / PE 15 μm / AL 7 μm / EMAA 20 μm) and sealed by heat sealing to prevent drying.
The obtained patch was evaluated as follows. The results are also shown in the table.

[Suppression of back stain]
Immediately after spreading, a stainless steel plate of the same size as the formulation and a mass of 250 g was placed on the release film side of the patch and allowed to stand at a temperature of 25 ° C. for 12 hours or more in a state where the outside air was blocked. After standing, the stainless steel plate was removed, and the patch was placed on the plain paper fixed to the stainless steel plate so that the support touched the plain paper, and the adhesive was gradually inclined. The tilt angle when the patch slipped off was measured to determine the effect of suppressing back dyeing. The results are shown by the following evaluation criteria.
<Evaluation criteria>
⊚: Sliding angle is less than 40 degrees ○: Sliding angle is 40 degrees or more and less than 60 degrees ×: Sliding angle is 60 degrees or more

[Shape retention]
Nine healthy panelists were asked to apply the patch to the back of their hands, and after 20 minutes, the ratio of the amount of hydrogel remaining on the skin when peeled off was evaluated, the average value was calculated, and the evaluation was performed using the following evaluation criteria. ..
<Evaluation criteria>
⊚: Remaining water-containing gel is 0 to less than 10% ○: Remaining water-containing gel is 10% or more and less than 30% ×: Remaining water-containing gel is 30% or more and 100%

[Speed of refreshing feeling]
The calves of five healthy panelists were asked to apply the patch, and the refreshing sensation after 5 minutes was sensory-evaluated according to the following criteria, and the average value was calculated. Pass 4 points or more.
<Criteria>
5: Very refreshing 4: Very refreshing 3: Slightly refreshing 2: Slightly refreshing 1: Slightly refreshing 0: No refreshing

[Adhesive force]
Using the ball rolling device used in JIS Z 0237, the inclination angle was 30 °, the approach length was 100 mm, and the measurement surface was 50 mm. The size of the ball made of the material specified by JIS G 4805 is 31 types in total from 1/16 to 1 of the "ball call" of JIS B 1501, and the value 32 times the "ball call" is the ball number. It was called and used as an index of adhesive strength. A test piece was attached to a predetermined position on the inclined plate of the ball rolling device with the adhesive side facing up, and balls of each size were set at the gate. When the gate is slowly opened and the ball is rolled, the largest ball that stops completely (the ball does not move for 5 seconds or more) is found in the measuring section, and the ball number at that time is used as an index of adhesive strength. And said. The ball tack value of 20 or more was regarded as acceptable.

A hydrogel having the following formulation was prepared in the same manner as in the above-mentioned example, and a patch was obtained. The same effect as in the examples was confirmed.

The raw materials used in the above example are shown below. Unless otherwise specified, the amount of each component in the table is a net conversion amount.
Polyacrylic acid 1: Toagosei Co., Ltd., "Julimer AC-10H", weight average molecular weight: 150,000, neutralization degree: 0 mol%
Polyacrylic acid 2: Made by Toagosei Co., Ltd., "Julimer SH8", weight average molecular weight: 1 million, neutralization degree: 0 mol%
Partial neutralization of polyacrylic acid: Toagosei Co., Ltd., "Aronbis AH-106X", weight average molecular weight: 4.5 million, neutralization degree: 40 mol%
Na polyacrylic acid: manufactured by Toagosei Co., Ltd., "Aronbis SX", weight average molecular weight: 4.5 million, neutralization degree: 100 mol%
Modified polyalkylene oxide-based water-absorbent resin: "Aquacork TWB-P" manufactured by Sumitomo Seika Chemical Co., Ltd.
Glycerin: "Nippon Pharmacopoeia Glycerin" manufactured by Sakamoto Pharmaceutical Co., Ltd.
Sodium Carboxymethyl Cellulose A: "CMC1380" manufactured by Daicel FineChem Co., Ltd .; viscosity of 1% by mass aqueous solution; 1,524 mPa · s, viscosity of 5% by mass aqueous solution: 952 Pa · s, viscosity ratio 625
Sodium Carboxymethyl Cellulose B: "CMC1390" manufactured by Daicel FineChem Co., Ltd., viscosity of 1% by mass aqueous solution; 3,080 mPa · s, viscosity of 5% by mass aqueous solution; 1,400 Pa · s, viscosity ratio 466
Dihydroxyaluminum aminoacetate: "Glycinal" manufactured by Kyowa Chemical Industry Co., Ltd.
Synthetic hydrotalcite: "Alcamac SH" manufactured by Kyowa Chemical Industry Co., Ltd.
Sodium metaphosphate: Taihei Kagaku Co., Ltd., "Sodium metaphosphate"
Disodium edetate: "Sodium edetate" manufactured by Chubu Kirest Co., Ltd.
Methyl paraoxybenzoate: "Methyl paraoxybenzoate" manufactured by Ueno Fine Chemicals Industry Co., Ltd.
Propyl paraoxybenzoate: "Propyl paraoxybenzoate" manufactured by Ueno Fine Chemicals Industry Co., Ltd.
Polysorbate 80: "TO-10MV" manufactured by Nikko Chemicals Co., Ltd.
Tartaric acid: "Tartaric acid" manufactured by Iwata Chemical Industry Co., Ltd.
l-Menthol: "l-Menthol" manufactured by Takasago International Corporation
Hack Haku Oil: "Hack Haku Oil" manufactured by Takasago International Corporation
Lavender oil: "Lavender oil" manufactured by Takasago International Corporation
Eucalyptus oil: "Eucalyptus oil" manufactured by Takasago International Corporation
Orange oil: "Orange oil" manufactured by Takasago International Corporation
Lemon oil: "Lemon oil" manufactured by Takasago International Corporation
Rosemary oil: "Rosemary oil" manufactured by Takasago International Corporation
Sage oil: "Sage oil" manufactured by Vemanfis Fragrance Co., Ltd.
Castor oil: "Castor oil" manufactured by Kosakai Pharmaceutical Co., Ltd.
Red No. 226: "Red No. 226" manufactured by Ami Kasei Co., Ltd.
Purified water: "Purified water (distillation)" manufactured by Kyoei Pharmaceutical Co., Ltd.

Claims (3)

A patch containing a hydrogel and a support.
The above hydrogel is
It contains a hydrogel in which (A) one or more selected from polyacrylic acid and salts thereof are crosslinked with (B) a cross-linking agent, and the molar ratio of magnesium ions to aluminum ions in the cross-linking agent (magnesium ion / aluminum ion). ) Is 1.9 or more and less than 3.0. The patch according to claim 1, further comprising (C) one or more selected from carboxymethyl cellulose and a salt thereof. The patch according to claim 1 or 2, wherein the support is a knitted fabric.