JP2022009463A5 - - Google Patents
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- JP2022009463A5 JP2022009463A5 JP2021173867A JP2021173867A JP2022009463A5 JP 2022009463 A5 JP2022009463 A5 JP 2022009463A5 JP 2021173867 A JP2021173867 A JP 2021173867A JP 2021173867 A JP2021173867 A JP 2021173867A JP 2022009463 A5 JP2022009463 A5 JP 2022009463A5
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- JP
- Japan
- Prior art keywords
- composition according
- formula
- complex
- mol
- dota
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000203 mixture Substances 0.000 claims 19
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 5
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 4
- 229910052688 Gadolinium Inorganic materials 0.000 claims 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- FDSYTWVNUJTPMA-UHFFFAOYSA-N 2-[3,9-bis(carboxymethyl)-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]acetic acid Chemical compound C1N(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC2=CC=CC1=N2 FDSYTWVNUJTPMA-UHFFFAOYSA-N 0.000 claims 1
- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 claims 1
- JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 1
- -1 BT-DO3A Chemical compound 0.000 claims 1
- IQUHNCOJRJBMSU-UHFFFAOYSA-N H3HP-DO3A Chemical compound CC(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 IQUHNCOJRJBMSU-UHFFFAOYSA-N 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1900432A FR3091873B1 (fr) | 2019-01-17 | 2019-01-17 | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| FR1900432 | 2019-01-17 | ||
| PCT/EP2020/051153 WO2020148436A1 (fr) | 2019-01-17 | 2020-01-17 | Complexe de gadolinium et d'un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| JP2021541202A JP7071596B2 (ja) | 2019-01-17 | 2020-01-17 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021541202A Division JP7071596B2 (ja) | 2019-01-17 | 2020-01-17 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022009463A JP2022009463A (ja) | 2022-01-14 |
| JP2022009463A5 true JP2022009463A5 (enExample) | 2022-02-28 |
| JP7321230B2 JP7321230B2 (ja) | 2023-08-04 |
Family
ID=67001953
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021541202A Active JP7071596B2 (ja) | 2019-01-17 | 2020-01-17 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
| JP2021173867A Active JP7321230B2 (ja) | 2019-01-17 | 2021-10-25 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021541202A Active JP7071596B2 (ja) | 2019-01-17 | 2020-01-17 | ジアステレオ異性的に濃縮されたｐｃｔａから誘導されたガドリニウム及びキレート配位子の錯体並びに調製及び精製プロセス |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US11590246B2 (enExample) |
| EP (2) | EP3902800B1 (enExample) |
| JP (2) | JP7071596B2 (enExample) |
| KR (2) | KR102438394B1 (enExample) |
| CN (3) | CN113735854B (enExample) |
| AR (1) | AR117835A1 (enExample) |
| AU (1) | AU2020208794B2 (enExample) |
| BR (1) | BR112021014006B1 (enExample) |
| CA (1) | CA3126268C (enExample) |
| CL (1) | CL2021001868A1 (enExample) |
| CO (1) | CO2021009261A2 (enExample) |
| DK (2) | DK3943493T3 (enExample) |
| ES (2) | ES2930136T3 (enExample) |
| FI (1) | FI3943493T3 (enExample) |
| FR (1) | FR3091873B1 (enExample) |
| HR (2) | HRP20221402T1 (enExample) |
| HU (2) | HUE062554T2 (enExample) |
| IL (1) | IL284884B2 (enExample) |
| MA (2) | MA54626A (enExample) |
| MX (1) | MX2021008651A (enExample) |
| PH (1) | PH12021551725A1 (enExample) |
| PL (2) | PL3902800T3 (enExample) |
| PT (2) | PT3902800T (enExample) |
| RS (1) | RS64334B1 (enExample) |
| SG (1) | SG11202107779SA (enExample) |
| TW (1) | TWI811518B (enExample) |
| WO (1) | WO2020148436A1 (enExample) |
| ZA (1) | ZA202104994B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10973934B2 (en) | 2018-08-06 | 2021-04-13 | Bracco Imaging S.P.A. | Gadolinium bearing PCTA-based contrast agents |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US20230339945A1 (en) * | 2020-07-17 | 2023-10-26 | Guerbet | Method for preparing a chelating ligand derived from pcta |
| WO2022072947A1 (en) * | 2020-10-02 | 2022-04-07 | Eagle Harbor Technologies, Inc. | Ion current droop compensation |
| CN119698423A (zh) * | 2022-09-01 | 2025-03-25 | 泰瑞诺科有限公司 | 新型化合物以及包含其的mri造影剂 |
| KR102845061B1 (ko) * | 2022-09-01 | 2025-08-13 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
| WO2026027591A1 (en) | 2024-07-31 | 2026-02-05 | Bracco Imaging Spa | Synthesis of an intermediate of a gadolinium-based contrast agent |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| DE4001655A1 (de) | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| JPH04154729A (ja) | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
| IT1292128B1 (it) | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| EP0992245A1 (en) | 1998-09-16 | 2000-04-12 | Goldham Bioglan Pharma GmbH | Radio-contrast agents |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| US20090208421A1 (en) * | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| US8119817B2 (en) * | 2009-09-29 | 2012-02-21 | Degussa-Huels Ag | Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline |
| EP2786768A1 (en) * | 2013-04-04 | 2014-10-08 | Agfa Healthcare | Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide |
| CA2909919C (fr) * | 2013-04-26 | 2022-07-12 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
| CN104188957B (zh) * | 2014-05-28 | 2017-04-26 | 中国中医科学院西苑医院 | 一种防治再狭窄的药物及其制备和使用方法 |
| SG11201909240SA (en) * | 2017-04-28 | 2019-11-28 | Otsuka Pharma Factory Inc | Method for manufacturing diastereomer of citric acid derivative |
| US10973934B2 (en) * | 2018-08-06 | 2021-04-13 | Bracco Imaging S.P.A. | Gadolinium bearing PCTA-based contrast agents |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| FR3091872B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
-
2019
- 2019-01-17 FR FR1900432A patent/FR3091873B1/fr active Active
-
2020
- 2020-01-17 HU HUE21190088A patent/HUE062554T2/hu unknown
- 2020-01-17 TW TW109101779A patent/TWI811518B/zh active
- 2020-01-17 SG SG11202107779SA patent/SG11202107779SA/en unknown
- 2020-01-17 ES ES20701709T patent/ES2930136T3/es active Active
- 2020-01-17 ES ES21190088T patent/ES2950118T3/es active Active
- 2020-01-17 HR HRP20221402TT patent/HRP20221402T1/hr unknown
- 2020-01-17 KR KR1020217025766A patent/KR102438394B1/ko active Active
- 2020-01-17 KR KR1020217036451A patent/KR102502862B1/ko active Active
- 2020-01-17 PT PT207017096T patent/PT3902800T/pt unknown
- 2020-01-17 MA MA054626A patent/MA54626A/fr unknown
- 2020-01-17 PL PL20701709.6T patent/PL3902800T3/pl unknown
- 2020-01-17 AR ARP200100125A patent/AR117835A1/es unknown
- 2020-01-17 PL PL21190088.1T patent/PL3943493T3/pl unknown
- 2020-01-17 EP EP20701709.6A patent/EP3902800B1/fr active Active
- 2020-01-17 US US17/423,638 patent/US11590246B2/en active Active
- 2020-01-17 CN CN202111049738.3A patent/CN113735854B/zh active Active
- 2020-01-17 DK DK21190088.1T patent/DK3943493T3/da active
- 2020-01-17 MX MX2021008651A patent/MX2021008651A/es unknown
- 2020-01-17 WO PCT/EP2020/051153 patent/WO2020148436A1/fr not_active Ceased
- 2020-01-17 MA MA055389A patent/MA55389A/fr unknown
- 2020-01-17 HU HUE20701709A patent/HUE060343T2/hu unknown
- 2020-01-17 BR BR112021014006-9A patent/BR112021014006B1/pt active IP Right Grant
- 2020-01-17 JP JP2021541202A patent/JP7071596B2/ja active Active
- 2020-01-17 DK DK20701709.6T patent/DK3902800T3/da active
- 2020-01-17 HR HRP20230678TT patent/HRP20230678T1/hr unknown
- 2020-01-17 IL IL284884A patent/IL284884B2/en unknown
- 2020-01-17 CN CN202411689939.3A patent/CN119552163A/zh active Pending
- 2020-01-17 CA CA3126268A patent/CA3126268C/fr active Active
- 2020-01-17 CN CN202080009625.8A patent/CN113646308B/zh active Active
- 2020-01-17 PT PT211900881T patent/PT3943493T/pt unknown
- 2020-01-17 EP EP21190088.1A patent/EP3943493B1/fr active Active
- 2020-01-17 AU AU2020208794A patent/AU2020208794B2/en active Active
- 2020-01-17 FI FIEP21190088.1T patent/FI3943493T3/fi active
- 2020-01-17 PH PH1/2021/551725A patent/PH12021551725A1/en unknown
- 2020-01-17 RS RS20230530A patent/RS64334B1/sr unknown
-
2021
- 2021-07-14 CL CL2021001868A patent/CL2021001868A1/es unknown
- 2021-07-15 CO CONC2021/0009261A patent/CO2021009261A2/es unknown
- 2021-07-15 ZA ZA2021/04994A patent/ZA202104994B/en unknown
- 2021-10-25 JP JP2021173867A patent/JP7321230B2/ja active Active
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2023
- 2023-01-16 US US18/154,894 patent/US12064487B2/en active Active
-
2024
- 2024-07-09 US US18/766,792 patent/US20240358863A1/en active Pending
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