PT3902800T - Complexo de gadolínio e um ligando quelante derivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação - Google Patents

Complexo de gadolínio e um ligando quelante derivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação

Info

Publication number
PT3902800T
PT3902800T PT207017096T PT20701709T PT3902800T PT 3902800 T PT3902800 T PT 3902800T PT 207017096 T PT207017096 T PT 207017096T PT 20701709 T PT20701709 T PT 20701709T PT 3902800 T PT3902800 T PT 3902800T
Authority
PT
Portugal
Prior art keywords
cheling
pcta
ligand
purification
derivative
Prior art date
Application number
PT207017096T
Other languages
English (en)
Portuguese (pt)
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of PT3902800T publication Critical patent/PT3902800T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT207017096T 2019-01-17 2020-01-17 Complexo de gadolínio e um ligando quelante derivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação PT3902800T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1900432A FR3091873B1 (fr) 2019-01-17 2019-01-17 Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification

Publications (1)

Publication Number Publication Date
PT3902800T true PT3902800T (pt) 2022-11-16

Family

ID=67001953

Family Applications (2)

Application Number Title Priority Date Filing Date
PT207017096T PT3902800T (pt) 2019-01-17 2020-01-17 Complexo de gadolínio e um ligando quelante derivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação
PT211900881T PT3943493T (pt) 2019-01-17 2020-01-17 Complexo de gadolínio e um ligano quelante dirivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT211900881T PT3943493T (pt) 2019-01-17 2020-01-17 Complexo de gadolínio e um ligano quelante dirivado de pcta diastereoisomericamente enriquecido e processo de preparação e purificação

Country Status (28)

Country Link
US (3) US11590246B2 (enExample)
EP (2) EP3902800B1 (enExample)
JP (2) JP7071596B2 (enExample)
KR (2) KR102438394B1 (enExample)
CN (3) CN113735854B (enExample)
AR (1) AR117835A1 (enExample)
AU (1) AU2020208794B2 (enExample)
BR (1) BR112021014006B1 (enExample)
CA (1) CA3126268C (enExample)
CL (1) CL2021001868A1 (enExample)
CO (1) CO2021009261A2 (enExample)
DK (2) DK3943493T3 (enExample)
ES (2) ES2930136T3 (enExample)
FI (1) FI3943493T3 (enExample)
FR (1) FR3091873B1 (enExample)
HR (2) HRP20221402T1 (enExample)
HU (2) HUE062554T2 (enExample)
IL (1) IL284884B2 (enExample)
MA (2) MA54626A (enExample)
MX (1) MX2021008651A (enExample)
PH (1) PH12021551725A1 (enExample)
PL (2) PL3902800T3 (enExample)
PT (2) PT3902800T (enExample)
RS (1) RS64334B1 (enExample)
SG (1) SG11202107779SA (enExample)
TW (1) TWI811518B (enExample)
WO (1) WO2020148436A1 (enExample)
ZA (1) ZA202104994B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973934B2 (en) 2018-08-06 2021-04-13 Bracco Imaging S.P.A. Gadolinium bearing PCTA-based contrast agents
FR3091872B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
US20230339945A1 (en) * 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
WO2022072947A1 (en) * 2020-10-02 2022-04-07 Eagle Harbor Technologies, Inc. Ion current droop compensation
CN119698423A (zh) * 2022-09-01 2025-03-25 泰瑞诺科有限公司 新型化合物以及包含其的mri造影剂
KR102845061B1 (ko) * 2022-09-01 2025-08-13 주식회사 테라노큐어 신규한 화합물 및 이를 포함하는 mri 조영제
WO2026027591A1 (en) 2024-07-31 2026-02-05 Bracco Imaging Spa Synthesis of an intermediate of a gadolinium-based contrast agent

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
DE4001655A1 (de) 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH04154729A (ja) 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
IT1292128B1 (it) 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
EP0992245A1 (en) 1998-09-16 2000-04-12 Goldham Bioglan Pharma GmbH Radio-contrast agents
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
US8119817B2 (en) * 2009-09-29 2012-02-21 Degussa-Huels Ag Process for separating the diastereomers of RSS-and SSS-N- α [1-carboxy-3-phenylpropyl] lysylproline
EP2786768A1 (en) * 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
CA2909919C (fr) * 2013-04-26 2022-07-12 Guerbet Formulation de produit de contraste et son procede de preparation associe
CN104188957B (zh) * 2014-05-28 2017-04-26 中国中医科学院西苑医院 一种防治再狭窄的药物及其制备和使用方法
SG11201909240SA (en) * 2017-04-28 2019-11-28 Otsuka Pharma Factory Inc Method for manufacturing diastereomer of citric acid derivative
US10973934B2 (en) * 2018-08-06 2021-04-13 Bracco Imaging S.P.A. Gadolinium bearing PCTA-based contrast agents
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese

Also Published As

Publication number Publication date
CN113646308B (zh) 2024-12-13
HUE060343T2 (hu) 2023-02-28
ES2930136T3 (es) 2022-12-07
CA3126268A1 (fr) 2020-07-23
IL284884B2 (en) 2025-09-01
MX2021008651A (es) 2021-10-26
FI3943493T3 (fi) 2023-07-19
PT3943493T (pt) 2023-07-12
IL284884A (en) 2021-08-31
IL284884B1 (en) 2025-05-01
PL3902800T3 (pl) 2022-12-27
ZA202104994B (en) 2023-04-26
JP2022009463A (ja) 2022-01-14
MA55389A (fr) 2022-01-26
US12064487B2 (en) 2024-08-20
US20220062443A1 (en) 2022-03-03
PH12021551725A1 (en) 2022-04-11
EP3943493B1 (fr) 2023-04-19
HRP20221402T1 (hr) 2023-01-06
CN113735854A (zh) 2021-12-03
SG11202107779SA (en) 2021-08-30
AR117835A1 (es) 2021-08-25
FR3091873A1 (fr) 2020-07-24
EP3902800A1 (fr) 2021-11-03
JP7321230B2 (ja) 2023-08-04
AU2020208794B2 (en) 2023-01-12
MA54626A (fr) 2022-04-20
TW202043227A (zh) 2020-12-01
US20230149568A1 (en) 2023-05-18
BR112021014006A2 (pt) 2021-09-21
PL3943493T3 (pl) 2023-08-07
WO2020148436A1 (fr) 2020-07-23
CO2021009261A2 (es) 2021-12-10
BR112021014006B1 (pt) 2023-05-02
CN113646308A (zh) 2021-11-12
TWI811518B (zh) 2023-08-11
JP7071596B2 (ja) 2022-05-19
RS64334B1 (sr) 2023-08-31
CA3126268C (fr) 2024-01-09
AU2020208794A1 (en) 2021-08-05
EP3943493A1 (fr) 2022-01-26
CN119552163A (zh) 2025-03-04
HUE062554T2 (hu) 2023-11-28
US11590246B2 (en) 2023-02-28
KR20210109039A (ko) 2021-09-03
EP3902800B1 (fr) 2022-09-07
US20240358863A1 (en) 2024-10-31
CN113735854B (zh) 2024-05-14
KR102438394B1 (ko) 2022-09-01
HRP20230678T1 (hr) 2023-09-29
FR3091873B1 (fr) 2020-12-25
KR102502862B1 (ko) 2023-02-23
DK3943493T3 (da) 2023-07-24
DK3902800T3 (da) 2022-11-28
CL2021001868A1 (es) 2022-01-21
ES2950118T3 (es) 2023-10-05
JP2022508496A (ja) 2022-01-19
KR20210138134A (ko) 2021-11-18

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