JP2022009415A - 抗炎症性ペプチドおよびその使用 - Google Patents
抗炎症性ペプチドおよびその使用 Download PDFInfo
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- 239000010452 phosphate Substances 0.000 description 1
- CGIHFIDULQUVJG-UHFFFAOYSA-N phytantriol Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO CGIHFIDULQUVJG-UHFFFAOYSA-N 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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Abstract
Description
エンドウマメゲノムは、70,000を超える異なるタンパク質をコードする。本出願人は、これらのタンパク質のうち7種を同定し、それらの各々は、1つまたは複数の抗炎症性断片を含有する。同様に、イネゲノムによってコードされる60,000種を超えるタンパク質のうち、本出願人は、8種のタンパク質を同定し、それらの各々は、1つまたは複数の抗炎症性断片を含有する。16種の同定されたタンパク質の抗炎症性断片は、LPSによって刺激されたヒト細胞とともにインキュベートされた場合に抗炎症性活性を有し(図1から19)、ヒト細胞生存力問題を引き起こさず(図20)、ヒト細胞に対して毒性ではない(図21)。天然ペプチドが由来する特定の植物タンパク質は、配列番号1~15および353~355に提供されており、特に、配列番号17~69に提供されるタンパク質の領域に由来する。ペプチドが由来する特定のエンドウマメタンパク質は、配列番号1から5、8および9に提供され、ペプチドが由来する特定のイネタンパク質は、配列番号6、7および10から15に提供されている。
FLPQHTD(配列番号332)-配列番号1のエンドウマメタンパク質の断片
GPQQYAEWQINEK(配列番号333)-配列番号7のイネタンパク質の断片
PGQLQSFLLSGN(配列番号334)-配列番号1のエンドウマメタンパク質の断片
PGQLQSFLLSGNQNQQNYLSGF(配列番号335)-配列番号1のエンドウマメタンパク質の断片
PQQYAEWQ(配列番号336)-配列番号7のイネタンパク質の断片
QLQSFLLSGNQNQQNYLSGFSK(配列番号337)-配列番号1のエンドウマメタンパク質の断片
QNQQNYLSGFSK(配列番号338)-配列番号1のエンドウマメタンパク質の断片
QSFLLSGNQNQQ(配列番号339)-配列番号1のエンドウマメタンパク質の断片
QSFLLSGNQ(配列番号340)-配列番号1のエンドウマメタンパク質の断片
RGPQQYA(配列番号341)-配列番号7のイネタンパク質の断片
DALEPDNR(配列番号342)-配列番号354のエンドウマメタンパク質の断片
SEEGYYGEQQQQPGMTR(配列番号343)-配列番号353のイネタンパク質の断片
GYYGEQQQQPGMTR()-配列番号353のイネタンパク質の断片
IDGYDTPVEGR(配列番号345)-配列番号15のイネタンパク質の断片
NGVLRPGQL(配列番号346)-配列番号14のイネタンパク質の断片
RHGEWGPSY(配列番号347)
FWM(配列番号348)-配列番号3のエンドウマメタンパク質の断片
TVFDGVLRPGQL[配列番号349]-配列番号10のイネタンパク質の断片
RLQSQNDQRGEIIHVK[配列番号350]-配列番号10のイネタンパク質の断片
HGPVEMPYTLLYPSSK[配列番号351]-配列番号355のエンドウマメタンパク質の断片
LDALEPDNR[配列番号352]-配列番号354のエンドウマメタンパク質の断片
RGPQQYAEWQINE[配列番号320]-配列番号7のイネタンパク質の断片
- 17から109個のアミノ酸長、
- -6から+4の間の電荷、
- C末端アミノ酸は、アスパラギン酸(D)、フェニルアラニン(F)、メチオニン(M)またはトリプトファン(W)ではない、
- N末端アミノ酸は、アスパラギン酸(D)、ヒスチジン(H)、メチオニン(M)、プロリン(P)またはトリプトファン(W)ではない。
好ましくは、ペプチドは、配列番号1のタンパク質もしくはその相同体の生物活性断片、またはそのタンパク質断片の生物活性変異体を含む。
好ましくは、ペプチドは、配列番号2のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号3のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号4のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号5のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号6のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号7のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号8のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号9のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号10のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号11のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号12またはその相同体のタンパク質の生物活性断片を含む。
好ましくは、ペプチドは、配列番号13のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号14のタンパク質またはその相同体の断片を含む。
好ましくは、ペプチドは、配列番号15のタンパク質またはその相同体の生物活性断片を含む。
好ましくは、ペプチドは、配列番号16のタンパク質またはその相同体の生物活性断片を含む。
>gi|580560623|gb|EVF84961.1|グルタミルエンドペプチダーゼ[黄色ブドウ球菌(staphylococcus aureus)COAS6020]
>gi|580687002|gb|EVH10169.1|グルタミルエンドペプチダーゼ[黄色ブドウ球菌UCIM6080]
>gi|751815683|gb|KIN24957.1|グルタミルエンドペプチダーゼ[黄色ブドウ球菌MRSA_CVM43477]
>gi|781884797|dbj|BAR08486.1|グルタミルエンドペプチダーゼ前駆体[黄色ブドウ球菌亜種オーレウス(aureus)]
>gi|781887762|dbj|BAR11210.1|グルタミルエンドペプチダーゼ前駆体[黄色ブドウ球菌亜種オーレウス]
が含まれる。
本明細書において記載されるすべての刊行物、特許、特許出願およびその他の参考文献は、各個々の刊行物、特許または特許出願が、参照により組み込まれるように具体的に、個々に示され、その内容物が完全に列挙されるかのようにその全文が参照により本明細書に組み込まれる。
文脈によって必要とされない限り、単数形の本明細書における使用は、複数形を含むと読まれるべきである、逆もまた同様。実体に関連して使用される用語「1つの(a)」または「1つの(an)」は、1つまたは複数のその実態を指すように読まれるべきである。そのようなものとして、用語「1つの(a)」(または「1つの(an)」)、「1つまたは複数の」および「少なくとも1つの」は、本明細書において同義的使用される。
>gi|137584|sp|P08438.1|VCL_VICFA RecName:Full=ビシリン;Flags:前駆体[ソラマメ(Vicia faba)]
>gi|22057|emb|CAA68559.1|ビシリン[ソラマメ変種マイナー(minor)]>gi|383931031|gb|AFH56916.1|ビシリン[ソラマメ]
>gi|502105533|ref|XP_004492829.1|PREDICTED:ビシリン様イソ型X1[ヒヨコマメ]ヒヨコマメ
>gi|29539109|emb|CAD87730.1|アレルゲン Len c1.0101[レンズマメ]レンズマメ
が含まれる。
1、2または3つの保存的アミノ酸置換、1、2から3つの非保存的アミノ酸置換、1~2個のアミノ酸付加、1、2または3個のアミノ酸欠失を有する変異体を含む配列番号109(RGPQQYAEWQINEK)の変異体を以下に提供する:
1つの保存的アミノ酸置換:
RGPQQYAEWQINER、RGPQQYAEWQINDK、RGPQQFAEWQINEK、KGPQQYAEWQINEK、RGPEQYAEWQINEK、RGPQEYAEWQINEK、RGPQQYADWQINEK、RGPQQYAEYQINEK(配列番号268から275)
2つの保存的アミノ酸置換:
KGPEQYAEWQINEK、KGPQEYAEWQINEK、KGPQQFAEWQINEK、RGPEQFAEWQINEK、KGPQQYAEWQINER、RGPQQYAEWQINDR、RGPQQYADWQINDK、RGPQQFAEWQINER(配列番号276から283)
3つの保存的アミノ酸置換:
RGPQQYAEWQVNEK、RGPQQFAEWQINEK、KGPQQFAEWQINER、KGPQQFAEWQVNEK、RGPQQFAEWQVNDK、RGPQQYADWQINDR、KGPQQYADWQINDK、RGPQQFADYQINEK(配列番号284から291)
1つの非保存的アミノ酸置換
RGPQQYARWQINEK、RGPQQYAEWQINEE、HGPQQYAEWQINEK、RGPYQYAEWQINEK、RGPQQYMEWQINEK、RGPQQYAEWCINEK、RGPQPYAEWQINEK(配列番号292から298)
2つの非保存的アミノ酸置換
RGGQQYAEWQINED、RGPQQYARWKINEK、RGGQQYAETQINEK、RGPLQYAEWQNNEK、EGPQQYAEWQINED、RGPQQYAEWQINLL、RGPQQGGEWQINEK(配列番号299から305)
3つの非保存的アミノ酸置換
RGPQQYAEWQIGGG、RGPQQKYEWQINEK、RGPQAQYEWQINEK、RPHQQYAEWQINEK、RGPQHHHEWQINEK、RGPPQYAPPQINEK、RGPQCYYEWCINEK、RGPTQYAEGQINEG(配列番号306から313)
1個または2個のアミノ酸付加
RGPQQYAEWQINEKG、RGPQQYAEWQINEKY、RGPQQYAFTEWQINEK、RGPQSQYAEWQINEKPM、RGPQQYAEWQINEKKK、RRRRGPQQYAEWQINEK(配列番号314から319)。
RGPQQYAEWQINE、RGPQQYAEWQIN、RGPQQYAEWQI、GPQQYAEWQINEK、PQQYAEWQINEK、QQYAEWQINEK、QQYAEWQI、PQQYAEWQINE、PQQYAEWQIN、RGPQQYA、EWQINEK(配列番号320から330)
「炎症性障害」とは、ヒトに影響を及ぼし、一般に、1種または複数のサイトカインの調節不全の発現を特徴とする免疫媒介性炎症状態を意味する。炎症性障害の例には、皮膚炎症性障害、関節の炎症性障害、心血管系の炎症性障害、特定の自己免疫疾患、肺および気道の炎症性障害、腸管炎症性障害が含まれる。皮膚の炎症性障害の例には、皮膚炎、例えば、アトピー性皮膚炎および接触皮膚炎、尋常性ざ瘡および乾癬が含まれる。関節の炎症性障害の例には、関節リウマチが含まれる。心血管系の炎症性障害の例は、心血管疾患およびアテローム性動脈硬化症である。自己免疫疾患の例には、1型糖尿病、グレーブス病、ギランバレー病、ループス、乾癬の関節炎および潰瘍性大腸炎が含まれる。肺および気道の炎症性障害の例には、喘息、嚢胞性線維症、COPD、肺気腫および急性呼吸窮迫症候群が含まれる。腸管炎症性障害の例には、大腸炎および炎症性腸疾患が含まれる。その他の炎症性障害には、癌、枯草熱、歯周炎、アレルギー、過敏症、虚血、鬱病、全身性疾患、感染後炎症および気管支炎が含まれる。
リポ多糖(LPS)などのエンドトキシンによる刺激に応じてマクロファージによってTNF-αが分泌される。TNF-αは、全身炎症に関与していると考えられ、TNF-α生成の調節不全は、多数の疾患に関与していると考えられている。Biolegendアッセイは、細胞培養上清、血清または血漿からのヒトTNF-αの正確な定量化のために設計されているサンドイッチELISAキットである。
細胞株を使用するin vitroでの炎症反応に対する、本発明の6種の合成ペプチド、SP1からSP6(配列番号108、109、110、111、85および91)および4種のペプチド組成物の効果を決定した。
合成ペプチドを適した溶媒でまず希釈した。ジメチルスルホキシド(DMSO)を、予測される水溶解度の低いペプチドの最適の溶媒とした。各ウェルにおけるDMSOの最終濃度:SP1(1_155_HR)-0.3%、SP2(1_374_HR)-0%、SP3(E_155_HR)-0.3%、SP4(E_54_HR)-1%、SP5(E_41_HR)-1%、SP6(E_788_HR)-0.3%、陽性対照-0%。細胞をまず、100μΜの各SPを用いて24時間処理し、その後、アラマーブルーアッセイを実施した。ペプチドのいずれを用いても生存力の問題は見られなかった。
ペプチド組成物を、pHを6~7の間に調整することおよび滅菌濾過によって調製した。細胞生存力に対するペプチド組成物の効果を決定した。J774.2マクロファージを、1mg/mlおよび0.5mg/mlの各ペプチド組成物、陽性対照としての細胞死を誘導するための過酸化水素および陰性対照としての非毒性であるとわかっているペプチドを用いて処理した。次いで、アラマーブルーアッセイを実施し、細胞生存が、未処理のもの(100%)のパーセンテージとして図19に示されている。1mg/mlのペプチドを用いた場合、細胞生存が損なわれたので、さらなるアッセイには0.5mg/mlのペプチド組成物を使用した。
TNFαおよびIL-1β分泌に対するDMSOの効果を決定した。1%DMSOは、TNFαのレベルを有意に増大し(図3A.LPSに関して***p<0.001)、これは、TNFαに対するペプチドの効果を分析する場合に考慮した。DMSOおよびIL-1β分泌に関して有意な効果は見られなかった。
THP-1分化したマクロファージを、LPS刺激に先立って本発明のイネペプチド(I_2_HR)の組成物で24時間処理し、未処理細胞と比較した。I_2_HR処理された細胞におけるTNF-α分泌は、未処理細胞に対して92%低減される。100μg/mlおよび500μg/mlの濃度のI_2_HRで、I_2_HRの効力を示す有意な結果が観察される。
エンドウマメタンパク質 1 : P13918 - 1 -
MAATTMKASFPLLMLMGISFLASVCVSSRSDPQNPFIFKSNKFQTLFENENGHIRLLQKFDQRSKIFENLQNYRLLEYKSKPHTIFLPQHTDADYILVVLSGKAILTVLKPDDRNSFNLERGDTIKLPAGTIAYLVNRDDNEELRVLDLAIPVNRPGQLQSFLLSGNQNQQNYLSGFSKNILEASFNTDYEEIEKVLLEEHEKETQHRRSLKDKRQQSQEENVIVKLSRGQIEELSKNAKSTSKKSVSSESEPFNLRSRGPIYSNEFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPHYNSRAIVIVTVNEGKGDFELVGQRNENQQEQRKEDDEEEEQGEEEINKQVQNYKAKLSSGDVFVIPAGHPVAVKASSNLDLLGFGINAENNQRNFLAGDEDNVISQIQRPVKELAFPGSAQEVDRILENQKQSHFADAQPQQRERGSRETRDRLSSV [SEQ ID 1]
領域 : 253 to 274 - PFNLRSRGPIYSNEFGKFFEIT [SEQ ID 17 ]
ペプチド : SRGPIYSNEFGK [SEQ ID 71]
領域 : 110 to 126 - KPDDRNSFNLERGDTIK [SEQ ID 18 ]
ペプチド : NSFNLER [SEQ ID 72]
領域 : 134 to 160 - YLVNRDDNEELRVLDLAIPVNRPGQLQ [SEQ ID 19]
ペプチド : VLDLAIPVNR [SEQ ID 73]
ペプチド : DDNEELR [SEQ ID 74]
領域 : 331 to 381 - QEQRKEDDEEEEQGEEEINKQVQNYKAKLSSGDVFVIPAGHPVAVKASSNL [SEQ ID 20]
ペプチド : LSSGDVFVIPAGHPVAVK [SEQ ID 75]
ペプチド : EDDEEEEQGEEEINK [SEQ ID 76]
領域 : 175 to 242 - SGFSKNILEASFNTDYEEIEKVLLEEHEKETQHRRSLKDKRQQSQEENVIVKLSRGQIEELSKNAKST [SEQ ID 21]
ペプチド : NILEASFNTDYEEIEKVLLEEHEKETQHR [SEQ ID 77]
ペプチド : NILEASFNTDYEEIEKVLLEEHEK [SEQ ID 78]
ペプチド : NILEASFNTDYEEIEK [SEQ ID 79]
ペプチド : RQQSQEENVIVK [SEQ ID 80]
ペプチド : QQSQEENVIVK [SEQ ID 81]
ペプチド : LSRGQIEELSK [SEQ ID 82]
ペプチド : GQIEELSK [SEQ ID 83]
ペプチド : VLLEEHEK [SEQ ID 84]
領域 : 35 to 108 - PFIFKSNKFQTLFENENGHIRLLQKFDQRSKIFENLQNYRLLEYKSKPHTIFLPQHTDADYILVVLSGKAILTV [SEQ ID 22]
ペプチド : SKPHTIFLPQHTDADYILVVLSGK [SEQ ID 85]
ペプチド : PHTIFLPQHTDADYILVVLSGK [SEQ ID 86]
ペプチド : SNKFQTLFENENGHIR [SEQ ID 87]
ペプチド : SKIFENLQNYR [SEQ ID 88]
ペプチド : IFENLQNYR [SEQ ID 89]
領域 : 423 to 450 - QEVDRILENQKQSHFADAQPQQRERGSR [SEQ ID 23]
ペプチド : ILENQKQSHFADAQPQQR [SEQ ID 90]
ペプチド PGQLQSFLLSGNQNQQNYLSGFSK [SEQ ID 91]
DRRQELSNENVLVKVSRRQLEELSKNAKSSSRRSVSSESGPFNLRSEDPLYSNNSGKFFELTPEKNQQLQDLDLFVNSVDLKEGSLLLPNYNSRALLVLVLVVNEGKGDFELVGQRNENQGKEN [SEQ ID 2]
領域 : 53 to 87 - NNSGKFFELTPEKNQQLQDLDLFVNSVDLKEGSLL [SEQ ID 24]
ペプチド : FFELTPEKNQQLQDLDLFVNSVDLK [SEQ ID 92]
領域 : 14 to 30 - KVSRRQLEELSKNAKSS [SEQ ID 25]
ペプチド : QLEELSK [SEQ ID 93]
MATKLLALSLSFCFLLLGGCFALREQPEQNECQLERLNALEPDNRIESEGGLIETWNPNNKQFRCAGVALSRATLQHNALRRPYYSNAPQEIFIQQGNGYFGMVFPGCPETFEEPQESEQGEGRRYRDRHQKVNRFREGDIIAVPTGIVFWMYNDQDTPVIAVSLTDIRSSNNQLDQMPRRFYLAGNHEQEFLRYQHQQGGKQEQENEGNNIFSGFKRDFLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIISPPEKQARHQRGSRQEEDEDEDEERQPRHQRGSRQEEEEDEDEERQPRHQRRRGEEEEEDKKERRGSQKGKSRRQGDNGLEETVCTAKLRLNIGPSSSPDIYNPEAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSIIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSDRFSYVAFKTNDRAGIARLAGTSSVINNLPLDVVAATFNLQRNEARQLKSNNPFKFLVPARQSENRASA [SEQ ID 3]
領域 : 267 to 287 - QRGSRQEEDEDEDEERQPRHQ [SEQ ID 26]
ペプチド : QEEDEDEDEER [SEQ ID 94]
領域 : 190 to 222 - QEFLRYQHQQGGKQEQENEGNNIFSGFKRDFLE [SEQ ID 27]
ペプチド : YQHQQGGKQEQENEGNNIFSGFK [SEQ ID 95]
MATTIKSRFPLLLLLGIIFLASVVCVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWRPSYEKQEDEEEKQKYRYQREKEDEEEKQKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRDRRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEKVLLEEQEKDRKRRQQGEETDAIVKVSREQIEELKKLAKSSSKKSLPSEFEPINLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDLFVSCVEINEGALMLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNERNFLSGSDDNVISQIENPVKELTFPGSVQEINRLIKNQKQSHFANAEPEQKEQGSQGKRSPLSSILGTFY [SEQ ID 4]
領域 : 284 to 317 - YNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLV [SEQ ID 28]
ペプチド : GDTIKLPAGTTSYLVNQDDEEDLR [SEQ ID 96]
領域 : 321 to 400 - NGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEKVLLEEQEKDRKRRQQGEETDAIVKVSREQIEELKKLAKSS [SEQ ID 29]
ペプチド : RQQGEETDAIVK [SEQ ID 97]
ペプチド : VLLEEQEKDRK [SEQ ID 98]
ペプチド : NILEASYNTR [SEQ ID 99]
ペプチド : FEAFDLAK [SEQ ID 100]
ペプチド : EQIEELKK [SEQ ID 101]
ペプチド : EQIEELK [SEQ ID 102]
ペプチド : NKNQYLR [SEQ ID 103]
領域 : 503 to 549 - RYEARLSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNERNFLSG [SEQ ID 30]
ペプチド : LSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNER [SEQ ID 104]
領域 : 89 to 112 - HGEWRPSYEKQEDEEEKQKYRYQR [SEQ ID 31]
ペプチド : PSYEKQEDEEEKQK [SEQ ID 105]
領域 : 62 to 80 - PSYEKEEDEEEGQRERGRQ [SEQ ID 32]
ペプチド : EEDEEEGQR [SEQ ID 106]
MAATPIKPLMLLAIAFLASVCVSSRSDQENPFIFKSNRFQTLYENENGHIRLLQKFDKRSKIFENLQNYRLLEYKSKPRTLFLPQYTDADFILVVLSGKATLTVLKSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLTIPVNKPGQLQSFLLSGTQNQPSLLSGFSKNILEAAFNTNYEEIEKVLLEQQEQEPQHRRSLKDRRQEINEENVIVKVSREQIEELSKNAKSSSKKSVSSESGPFNLRSRNPIYSNKFGKFFEITPEKNQQLQDLDIFVNSVDIKEGSLLLPNYNSRAIVIVTVTEGKGDFELVGQRNENQGKENDKEEEQEEETSKQVQLYRAKLSPGDVFVIPAGHPVAINASSDLNLIGFGINAENNERNFLAGEEDNVISQVERPVKELAFPGSSHEVDRLLKNQKQSYFANAQPLQRE [SEQ ID 5]
領域 : 75 to 104 - KSKPRTLFLPQYTDADFILVVLSGKATLTV [SEQ ID 33]
ペプチド : TLFLPQYTDADFILVVLSGK [SEQ ID 107]
MATTTSLLSSCLCALLLAPLFSQGVDAWESRQGASRQCRFDRLQAFEPLRKVRSEAGDTE
YFDERNEQFRCAGVFVIRRVIEPQGLVVPRYSNTPALAYIIQGKGYVGLTFPGCPATHQQ
QFQLFEQRQSDQAHKFRDEHQKIHEFRQGDVVALPASVAHWFYNGGDTPAVVVYVYDIKS
FANQLEPRQKEFLLAGNNQRGQQIFEHSIFQHSGQNIFSGFNTEVLSEALGINTEASKRL
QSQNDQRGDIIRVKHGLQLLKPTLTQRQEEHRQYQQVQYREGQYNGLDENFCTIKARVNI
ENPSRADYYNPRAGRITLLNNQKFPILNLIGMGAARVNLYQNALLSPFWNINAHSVVYII
QGSVRVQVANNQGRSVFNGVLHQGQLLIIPQNHAVIKKAEHNGCQYVAIKTISDPTVSWV
AGKNSILRALPVDVIANAYRISRDEARRLKNNRADEIGPFTPRFPQKSQRGYQFLTEGLS
LIGM [SEQ ID 6]
ペプチド: GYVGLTFPGCPATHQQQFQLFEQR [SEQ ID 108]
MASMSTILPLCLGLLLFFQVSMAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATH
QQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGM
ALPGCPETFQSVRSPFEQEVATAGEAQSSIQKMRDEHQQLHQFHQGDVIAVPAGVAHWLY
NNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAG
FSPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPT
KQLQPTWLRSGGACGQQNVLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPIL
NIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGHIQVVDHRGRSVFDGELHQQQIL
LIPQNFAVVVKARREGFAWVSFKTNHNAVDSQIAGKASILRALPVDVVANAYRLSREDSR
HVKFNRGDEMAVFAPRRGPQQYAEWQINEK [SEQ ID 7]
ペプチド: RGPQQYAEWQINEK [SEQ ID 109]
MATTIKSRFPLLLLLGIIFLASVVSVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEW
RPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEK
QKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRD
RRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNY
RLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTS
YLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEK
VLLEEQEKDRKRRQQGEETDAIVKVS [SEQ ID 8]
ペプチド: LVDLVIPVNGPGKFEAFDLAK [SEQ ID 110]
MATTIKSRFPLLLLLGIIFLASVVSVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEW
RPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEK
QKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRD
RRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNY
RLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTS
YLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEK
VLLEEQEKDRKRRQQGEETDAIVKVS [SEQ ID 9]
ペプチド: KNPQLQDLDIFVNYVEIK [SEQ ID 111]
MASSVFSRFSIYFCVLLLCHGSMAQLFNPSTNPWHSPRQGSFRECRFDRLQAFEPLRKVRSEAGVTEYFDEKNELFQCTGTFVIRRVIQPQGLLVPRYTNIPGVVYIIQGRGSMGLTFPGCPATYQQQFQQFSSQGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNDGDAPIVAVYVYDVNNNANQLEPRQKEFLLAGNNNRAQQQQVYGSSIEQHSGQNIFSGFGVEMLSEALGINAVAAKRLQSQNDQRGEIIHVKNGLQLLKPTLTQQQEQAQAQDQYQQVQYSERQQTSSRWNGLEENFCTIKVRVNIENPSRADSYNPRAGRITSVNSQKFPILNLIQMSATRVNLYQNAILSPFWNVNAHSLVYMIQGRSRVQVVSNFGKTVFDGVLRPGQLLIIPQHYAVLKKAEREGCQYIAIKTNANAFVSHLAGKNSVFRALPVDVVANAYRISREQARSLKNNRGEEHGAFTPRFQQQYYPGLSNESESETSE [SEQ ID 10]
領域 : 138 to 159 - SQSQKFRDEHQKIHQFRQGDIV [SEQ ID 34]
ペプチド : DEHQKIHQFR [SEQ ID 112]
ペプチド : FRDEHQK [SEQ ID 113]
領域 : 336 to 358 - VNSQKFPILNLIQMSATRVNLYQ [SEQ ID 35]
ペプチド : FPILNLIQMSATR [SEQ ID 114]
領域 : 423 to 462 - YIAIKTNANAFVSHLAGKNSVFRALPVDVVANAYRISREQ [SEQ ID 36]
ペプチド : TNANAFVSHLAGK [SEQ ID 115]
ペプチド : ALPVDVVANAYR [SEQ ID 116]
領域 : 175 to 205 - APIVAVYVYDVNNNANQLEPRQKEFLLAGNN [SEQ ID 37]
ペプチド : YVYDVNNNANQLEPRQKEFL [SEQ ID 117]
ペプチド : VYVYDVNNNANQLEPRQKEFL [SEQ ID 118]
領域 : 318 to 334 - ENPSRADSYNPRAGRIT [SEQ ID 38]
ペプチド : ADSYNPR [SEQ ID 119]
領域 : 265 to 296 - GLQLLKPTLTQQQEQAQAQDQYQQVQYSERQQ [SEQ ID 39]
ペプチド : KPTLTQQQEQAQAQDQ [SEQ ID 120]
ペプチド : QAQAQDQYQQVQY [SEQ ID 121]
ペプチド : QAQDQYQQVQY [SEQ ID 122]
領域 : 45 to 62 - CRFDRLQAFEPLRKVRSE [SEQ ID 40]
ペプチド : LQAFEPLR [SEQ ID 123]
領域 : 361 to 408 - ILSPFWNVNAHSLVYMIQGRSRVQVVSNFGKTVFDGVLRPGQLLIIPQ [SEQ ID 41]
ペプチド : SRVQVVSNFGK [SEQ ID 124]
ペプチド : WNVNAHSLVY [SEQ ID 125]
ペプチド : NVNAHSLVY [SEQ ID 126]
ペプチド : IQGRSRVQVVSNFGK [SEQ ID 127]
ペプチド : GKTVFDGVLRPGQL [SEQ ID 128]
ペプチド : FGKTVFDGVLRPGQL [SEQ ID 129]
領域 : 476 to 499 - AFTPRFQQQYYPGLSNESESETSE [SEQ ID 42]
ペプチド : FQQQYYPGLSNESESETSE [SEQ ID 130]
ペプチド : QQYYPGLSN [SEQ ID 131]
ペプチド : QQQYYPGLSN [SEQ ID 132]
MASINRPIVFFTVCLFLLCNGSLAQQLLGQSTSQWQSSRRGSPRECRFDRLQAFEPIRSVRSQAGTTEFFDVSNEQFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPESYQQQFQQSGQAQLTESQSQSQKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDLNNGANQLDPRQRDFLLAGNKRNPQAYRREVEERSQNIFSGFSTELLSEALGVSSQVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQGQVQSRERYQEGQYQQSQYGSGCSNGLDETFCTLRVRQNIDNPNRADTYNPRAGRVTNLNTQNFPILSLVQMSAVKVNLYQNALLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFNGELRRGQLLIIPQHYAVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPNDVLANAYRISREEAQRLKHNRGDEFGAFTPIQYKSYQDVYNAAESS [SEQ ID 11]
領域 : 332 to 362 - PRAGRVTNLNTQNFPILSLVQMSAVKVNLYQ [SEQ ID 43]
ペプチド : VTNLNTQNFPILSLVQMSAVK [SEQ ID 133]
領域 : 375 to 406 - HSVVYITQGRARVQVVNNNGKTVFNGELRRGQ [SEQ ID 44]
ペプチド : ITQGRARVQVVNNNGKTVF [SEQ ID 134]
ペプチド : ITQGRARVQVVNNNGKTVFNGE [SEQ ID 135]
ペプチド : ITQGRARVQVVNNNGKTVFNG [SEQ ID 136]
ペプチド : RVQVVNNNGKTVF [SEQ ID 137]
領域 : 440 to 471 - HIAGKSSIFRALPNDVLANAYRISREEAQRLK [SEQ ID 45]
ペプチド : RALPNDVLANAYRISREE [SEQ ID 138]
ペプチド : SIFRALPNDVLANAYR [SEQ ID 139]
ペプチド : SIFRALPNDVLANAY [SEQ ID 140]
ペプチド : SIFRALPNDVLAN [SEQ ID 141]
ペプチド : SSIFRALPNDVLANAYR [SEQ ID 142]
ペプチド : SIFRALPNDVLANAYRISREE [SEQ ID 143]
ペプチド : SIFRALPND [SEQ ID 144]
領域 : 180 to 208 - VPVVAIYVTDLNNGANQLDPRQRDFLLAG [SEQ ID 46]
ペプチド : IYVTDLNNGANQLDPRQRD [SEQ ID 145]
MASINRPIVFFTVCLFLLCDGSLAQQLLGQSTSQWQSSRRGSPRGCRFDRLQAFEPIRSVRSQAGTTEFFDVSNELFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPETYQQQFQQSGQAQLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDINNGANQLDPRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFSTELLSEAFGISNQVARQLQCQNDQRGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQEGGYQQSQYGSGCPNGLDETFCTMRVRQNIDNPNRADTYNPRAGRVTNLNSQNFPILNLVQMSAVKVNLYQNALLSPFWNINAHSIVYITQGRAQVQVVNNNGKTVFNGELRRGQLLIVPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS [SEQ ID 12]
領域 : 311 to 362 - TFCTMRVRQNIDNPNRADTYNPRAGRVTNLNSQNFPILNLVQMSAVKVNLYQ [SEQ ID 47]
ペプチド : VTNLNSQNFPILNLVQMSAVK [SEQ ID 146]
ペプチド : QNIDNPNR [SEQ ID 147]
ペプチド : ADTYNPR [SEQ ID 148]
ペプチド : NIDNPNRADTYNPRAGRVTNL [SEQ ID 149]
ペプチド : RVRQNIDNPNRADTYNPRAGRVTNL [SEQ ID 150]
領域 : 427 to 499 - YIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS[SEQ ID 48]
ペプチド : TNPNSMVSHIAGKSSIFR [SEQ ID 151]
ペプチド : HNRGDEFGAFTPLQYK [SEQ ID 152]
ペプチド : SYQDVYNVAESS [SEQ ID 153]
ペプチド : ISREEAQR [SEQ ID 154]
ペプチド : SIFRALPTDVLANAYRISREE [SEQ ID 155]
ペプチド : YRISREEAQRLKHNRGDEF [SEQ ID 156]
ペプチド : YRISREEAQRLKHNRGDE [SEQ ID 157]
領域 : 143 to 178 - SQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDG [SEQ ID 49]
ペプチド : FKDEHQKIHR [SEQ ID 158]
ペプチド : QGDVIALPAGVAHW [SEQ ID 159]
領域 : 381 to 409 - TQGRAQVQVVNNNGKTVFNGELRRGQLLI [SEQ ID 50]
ペプチド : TVFNGELRR [SEQ ID 160]
ペプチド : TVFNGELR [SEQ ID 161]
ペプチド : QVQVVNNNGKTVF [SEQ ID 162]
領域 : 101 to 124 - NGASLVYIIQGRGITGPTFPGCPE [SEQ ID 51]
ペプチド : YIIQGRGITGPTF [SEQ ID 163]
ペプチド : VYIIQGRGITGPTF [SEQ ID 164]
領域 : 46 to 66 - CRFDRLQAFEPIRSVRSQAGT [SEQ ID 52]
ペプチド : LQAFEPIRSVR [SEQ ID 165]
領域 : 253 to 292 - QNDQRGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQE [SEQ ID 53]
ペプチド : GLSLLQPYASLQEQEQGQMQSR [SEQ ID 166]
ペプチド : GEIVRVER [SEQ ID 167]
ペプチド : RGLSLLQPYASLQ [SEQ ID 168]
ペプチド : RGLSLLQPYASLQEQ [SEQ ID 169]
ペプチド : RGLSLLQPYASLQEQE [SEQ ID 170]
ペプチド : RGLSLLQPYASLQE [SEQ ID 171]
領域 : 199 to 233 - PRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFST [SEQ ID 54]
ペプチド : RNPQAYR [SEQ ID 172]
ペプチド : FLLAGNKRNPQAY [SEQ ID 173]
ペプチド : EVEEWSQNIF [SEQ ID 174]
ペプチド : LAGNKRNPQAYR [SEQ ID 175]
ペプチド : FLLAGNKRNPQA [SEQ ID 176]
MASNKVVFSVLLLAVVSVLAATATMAEYHHQDQVVYTPGPLCQPGMGYPMYPLPRCRALVKRQCVGRGTAAAAEQVRRDCCRQLAAVDDSWCRCEAISHMLGGIYRELGAPDVGHPMSEVFRGCRRGDLERAAASLPAFCNVDIPNGGGGVCYWLARSGY [SEQ ID 13]
領域 : 102 to 124 - GGIYRELGAPDVGHPMSEVFRGC [SEQ ID 55]
ペプチド : ELGAPDVGHPMSE [SEQ ID 177]
MATIAFSRLSIYFCVLLLCHGSMAQLFGPNVNPWHNPRQGGFRECRFDRLQAFEPLRRVRSEAGVTEYFDEKNEQFQCTGTFVIRRVIEPQGLLVPRYSNTPGMVYIIQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDAPVVALYVFDLNNNANQLEPRQKEFLLAGNNNREQQMYGRSIEQHSGQNIFSGFNNELLSEALGVNALVAKRLQGQNDQRGEIIRVKNGLKLLRPAFAQQQEQAQQQEQAQAQYQVQYSEEQQPSTRCNGLDENFCTIKARLNIENPSHADTYNPRAGRITRLNSQKFPILNLVQLSATRVNLYQNAILSPFWNVNAHSLVYIVQGHARVQVVSNLGKTVFNGVLRPGQLLIIPQHYVVLKKAEHEGCQYISFKTNANSMVSHLAGKNSIFRAMPVDVIANAYRISREQARSLKNNRGEELGAFTPRYQQQTYPGFSNESENEALE [SEQ ID 14]
領域 : 372 to 397 - HSLVYIVQGHARVQVVSNLGKTVFNG [SEQ ID 56]
ペプチド : IVQGHARVQVVSNLGK [SEQ ID 178]
ペプチド : IVQGHARVQVVSNL [SEQ ID 179]
ペプチド : IVQGHARVQVVSN [SEQ ID 180]
領域 : 464 to 486 - ARSLKNNRGEELGAFTPRYQQQT [SEQ ID 57]
ペプチド : NNRGEELGAFTPR [SEQ ID 181]
ペプチド : GEELGAFTPR [SEQ ID 182]
領域 : 337 to 359 - LNSQKFPILNLVQLSATRVNLYQ [SEQ ID 58]
ペプチド : FPILNLVQLSATR [SEQ ID 183]
領域 : 210 to 293 - QMYGRSIEQHSGQNIFSGFNNELLSEALGVNALVAKRLQGQNDQRGEIIRVKNGLKLLRPAFAQQQEQAQQQEQAQAQYQVQYS [SEQ ID 59]
ペプチド : SIEQHSGQNIFSGFNNELLSEALGVNALVAK [SEQ ID 184]
ペプチド : LQGQNDQR [SEQ ID 185]
ペプチド : SGFNNELLSEALGVNALVAK [SEQ ID 186]
ペプチド : PAFAQQQEQAQQQEQAQAQY [SEQ ID 187]
ペプチド : VAKRLQGQNDQRGEI [SEQ ID 188]
ペプチド : ALVAKRLQGQNDQRGEI [SEQ ID 189]
ペプチド : LQGQNDQRGEIIR [SEQ ID 190]
領域 : 24 to 47 - AQLFGPNVNPWHNPRQGGFRECRF [SEQ ID 60]
ペプチド : PNVNPWHNPRQGGF [SEQ ID 191]
領域 : 164 to 186 - GVAHWFYNEGDAPVVALYVFDLN [SEQ ID 61]
ペプチド : FYNEGDAPVVALY [SEQ ID 192]
ペプチド : FYNEGDAPVV [SEQ ID 193]
ペプチド : FYNEGDAPVVAL [SEQ ID 194]
ペプチド : FYNEGDAPVVA [SEQ ID 195]
領域 : 424 to 463 - YISFKTNANSMVSHLAGKNSIFRAMPVDVIANAYRISREQ [SEQ ID 62]
ペプチド : TNANSMVSHLAGK [SEQ ID 196]
ペプチド : AMPVDVIANAYR [SEQ ID 197]
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDATSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFIDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLCQAALEAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLASYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAFEDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQEDVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKFNAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVKKVAATLKRAIKVVGTPAYEEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAAP [SEQ ID 15]
領域 : 571 to 608 - KGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAA [SEQ ID 63]
ペプチド : NWENVLLGLGVAGSAPGIEGDEIAPLAK [SEQ ID 198]
ペプチド : NVLLGLGVAGSAPGIEGDE [SEQ ID 199]
ペプチド : NWENVLLGLGVAGSAPGIEGDEIAPLAK [SEQ ID 200]
領域 : 458 to 488 - RAVVKFNAPLAHLIMAGADVLAVPSRFEPCG [SEQ ID 64]
ペプチド : FNAPLAHLIMAGADVLAVPSR [SEQ ID 201]
ペプチド : FNAPLAHLIM [SEQ ID 202]
ペプチド : FNAPLAHLIMAGADVLAVPSR [SEQ ID 203]
領域 : 545 to 566 - KRAIKVVGTPAYEEMVRNCMNQ [SEQ ID 65]
ペプチド : VVGTPAYEEMVR [SEQ ID 204]
領域 : 93 to 147 - APWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRY [SEQ ID 66]
ペプチド : TGGLGDVLGGLPPAMAANGHR [SEQ ID 205]
ペプチド : YDQYKDAWDTSVVAEIK [SEQ ID 206]
ペプチド : DAWDTSVVAEIK [SEQ ID 207]
ペプチド : VMVISPR [SEQ ID 208]
領域 : 305 to 413 - INWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQK [SEQ ID 67]
ペプチド : LTGITGIVNGMDVSEWDPSKDK [SEQ ID 209]
ペプチド : VLTVSPYYAEELISGIAR [SEQ ID 210]
ペプチド : EALQAEAGLPVDRK [SEQ ID 211]
ペプチド : YDATTAIEAK [SEQ ID 212]
ペプチド : IPLIAFIGR [SEQ ID 213]
ペプチド : AGILEADR [SEQ ID 214]
ペプチド : IPLIAFIGR [SEQ ID 215]
領域 : 158 to 202 - RGVDRVFIDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLC [SEQ ID 68]
ペプチド : VFIDHPSFLEK [SEQ ID 216]
ペプチド : GPDTGVDYKDNQM [SEQ ID 217]
ペプチド : IYGPDTGVDYKDNQMR [SEQ ID 218]
ペプチド : IYGPDTGVDYK [SEQ ID 219]
領域 : 206 to 226 - LEAPRILNLNNNPYFKGTYGE [SEQ ID 69]
ペプチド : ILNLNNNPYFK [SEQ ID 220]
ペプチド : KNPQLQDLDI [SEQ ID 356]
タンパク質 P07730
ペプチド : GQSTSQWQSSR [SEQ ID 357]
ペプチド : QSTSQWQSSR [SEQ ID 358]
タンパク質 P07728
ペプチド : QSTSQWQSSR (also in P07730) [SEQ ID 359]
タンパク質 P13918
ペプチド : EEEEQGEEEINK [SEQ ID 360]
タンパク質 P14323
ペプチド : PSTNPWHSPR [SEQ ID 361]
ペプチド : AQAQDQYQQVQYSE [SEQ ID 362]
ペプチド : SEAGVTEYFDEKNELFQCTGTFVIRR [SEQ ID 363]
ペプチド : QAQAQDQYQQVQYSE [SEQ ID 363]
ペプチド : GSMGLTFPGCPAT (also in P14614) [SEQ ID 365]
ペプチド : GSMGLTFPGCPATY (also in P14614) [SEQ ID 366]
タンパク質 P14614
ペプチド : LGAFTPRY [SEQ ID 367]
ペプチド : LGAFTPRYQQ [SEQ ID 368]
ペプチド : ALGVNALVAKRLQGQN [SEQ ID 369]
ペプチド : LGAFTPRYQ [SEQ ID 370]
ペプチド : GSMGLTFPGCPAT (also in P14323) [SEQ ID 371]
ペプチド : GSMGLTFPGCPATY (also in P14323) [SEQ ID 372]
タンパク質 P15838
ペプチド : SNNPFKFLVPARQS [SEQ ID 373]
タンパク質 Q6K508
ペプチド : CAGVFVIRR [SEQ ID 374]
タンパク質 Q6K7K6
ペプチド : GSPLQSPRGF [SEQ ID 375]
ペプチド : RSSWQQQSY [SEQ ID 376]
ペプチド : SFGGSPLQSPR [SEQ ID 377]
ペプチド : YLPTKQLQPTW [SEQ ID 378]
ペプチド : GKPRSSWQQQ [SEQ ID 379]
ペプチド : FGGSPLQSPRG [SEQ ID 380]
タンパク質 Q9M3X6
ペプチド : LNLLGFGINAENNE [SEQ ID 381]
LRGFSK [381]
GALMLPHYN
GALMLPHYNSR
VFDGVLRPG
LQSQND
LQSQNDQRGEI
QSQNDQRGEIIHVK
RGEIIHVK
RLQSQNDQ
RLQSQNDQRG [SEQ ID 390]
RLQSQNDQRGEIIH
MPMP
PMPL
LEPDNR
GIARLAGTSSVIN
RSQNIF
PNSM
GHPM
HPMS
FLPQHTD [SEQ ID 400]
EWQINEK
GPQQYAEWQINEK
PQQYAEWQ
RGPQQYA
HNPR
WHN
WDP
HPSF
PGQLQSFLLSGNQNQQNYLSGF
QLQSFLLSGNQNQQNYLSGFSK [SEQ ID 410]
QSFLLSGNQNQQ
PGQLQSFLLSGN
QSFLLSGNQ
QNQQNYLSGFSK
YLRGFS
PVEMPTLLYPS
RGPQQYAEWQINE [SEQ ID 417]
TVFDGVLRPGQL
LDALEPDNR
RLQSQNDQRGEIIHVK [SEQ ID 420]
VLDLAIPVNRPGQL
HGPVEMPYTLLYPSSK [SEQ ID 422]
GYYGEQQQQPGMTR [SEQ ID 423] タンパク質 : P29835 - 5 - イネ
SEEGYYGEQQQQPGMTR [SEQ ID 424] タンパク質 : P29835 - 5 - イネ
MASKVVFFAAALMAAMVAISGAQLSESEMRFRDRQCQREVQDSPLDACRQVLDRQLTGRERFQPMFRRPGALGLRMQCCQQLQDVSRECRCAAIRRMVRSYEESMPMPLEQGWSSSSSEYYGGEGSSSEQGYYGEGSSEEGYYGEQQQQPGMTRVRLTRARQYAAQLPSMCRVEPQQCSIFAAGQY [SEQ ID 353]
タンパク質 : P02857 - 1 - エンドウマメ
MAKLLALSLSFCFLLLGGCFALREQPQQNECQLERLDALEPDNRIESEGGLIETWNPNNKQFRCAGVALSRATLQRNALRRPYYSNAPQEIFIQQGNGYFGMVFPGCPETFEEPQESEQGEGRRYRDRHQKVNRFREGDIIAVPTGIVFWMYNDQDTPVIAVSLTDIRSSNNQLDQMPRRFYLAGNHEQEFLQYQHQQGGKQEQENEGNNIFSGFKRDYLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIISPPEKQARHQRGSRQEEDEDEEKQPRHQRGSRQEEEEDEDEERQPRHQRRRGEEEEEDKKERGGSQKGKSRRQGDNGLEETVCTAKLRLNIGPSSSPDIYNPEAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSIIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSDRFSYVAFKTNDRAGIARLAGTSSVINNLPLDVVAATFNLQRNEARQLKSNNPFKFLVPARESENRASA [SEQ ID 354]
タンパク質 : P09918 - 14 - Pisum sativum
MFSGVTGILNRGHKIKGTVVLMRKNVLDINSLTTVGGVIGQGFDILGSTVDNLTAFLGRSVSLQLISATKPDATGKGKLGKATFLEGIISSLPTLGAGQSAFKIHFEWDDDMGIPGAFYIKNFMQTEFFLVSLTLDDIPNHGSIYFVCNSWIYNAKHHKIDRIFFANQTYLPSETPAPLVHYREEELNNLRGDGTGERKEWERIYDYDVYNDLGNPDSGENHARPVLGGSETYPYPRRGRTGRKPTRKDPNSESRSDYVYLPRDEAFGHLKSSDFLTYGLKAVSQNVVPALESVFFDLNFTPNEFDSFDEVHGLYEGGIKLPTNILSQISPLPVLKEIFRTDGENTLKYPPPKVIQVSRSGWMTDEEFAREMLAGVNPNVICCLQEFPPRSKLDSQIYGDHTSKISKEHLEPNLEGLTVEEAIQNKKLFLLDHHDSIMPYLRRINSTSTKAYATRTILFLNNNQNLKPLAIELSLPHPQGDEHGAVSYVYQPALEGVESSIWLLAKAYVIVNDSCYHQLVSHWLNTHAVVEPFVIATNRHLSCLHPIYKLLYPHYRDTMNINSLARLSLVNDGGIIEKTFLWGRYSMEMSSKVYKNWVFTEQALPADLIKRGMAIEDPSSPCGVKLVVEDYPYAVDGLEIWAIIKTWVQDYVSLYYTSDEKLRQDSELQAWWKELVEVGHGDKKNEPWWPKMQTREDLIEVCSIVIWTASALHAAVNFGQYSYGGLILNRPTLSRRFMPEKGSAEFEELVKSPQKAYLKTITPKFQTLIDLSVIEILSRHASDELYLGERDNPNWTSDKRALEAFKKFGNKLAEIEKKLTQRNNDEKLRNRHGPVEMPYTLLYPSSKEGLTFRGIPNSISI [SEQ ID 355]
細菌タンパク質 1 : P0C1U8 - 5 -
MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA [SEQ ID 16]
領域 : 92 to 117 - YIQVEAPTGTFIASGVVVGKDTLLTN [SEQ ID 70]
ペプチド : APTGTFIASGVVVGKD [SEQ ID 221]
>gi|137584|sp|P08438.1|VCL_VICFA RecName: Full=Vicilin; Flags: Precursor [Vicia faba] >gi|22057|emb|CAA68559.1| vicilin [Vicia faba var. minor] >gi|383931031|gb|AFH56916.1| vicilin [Vicia faba]
MAATTLKDSFPLLTLLGIAFLASVCLSSRSDQDNPFVFESNRFQTLFENENGHIRLLQKFDQHSKLLENLQNYRLLEYKSKPHTIFLPQQTDADFILVVLSGKAILTVLLPNDRNSFSLERGDTIKLPAGTIGYLVNRDDEEDLRVLDLVIPVNRPGEPQSFLLSGNQNQPSILSGFSKNILEASFNTDYKEIEKVLLEEHGKEKYHRRGLKDRRQRGQEENVIVKISRKQIEELNKNAKSSSKKSTSSESEPFNLRSREPIYSNKFGKFFEITPKRNPQLQDLNIFVNYVEINEGSLLLPHYNSRAIVIVTVNEGKGDFELVGQRNENQQGLREEYDEEKEQGEEEIRKQVQNYKAKLSPGDVLVIPAGYPVAIKASSNLNLVGFGINAENNQRYFLAGEEDNVISQIHKPVKELAFPGSAQEVDTLLENQKQSHFANAQPRERERGSQEIKDHLYSILGSF [SEQ ID 222]
>gi|502105533|ref|XP_004492829.1| PREDICTED: vicilin-like isoform X1 [Cicer arietinum] ChickPea
MAIKARFPLLVLLGIVFLASVCAKSDKENPFFFKSNNCQTLFENENGHVRLLQRFDKRSQLFENLQNYRLMEYNSKPHTLFLPQHNDADFILVVLRGRAILTVLNPNDRNTFKLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNRPGQFQSFSLSGNENQQSYFQGFSKKILEASFNSDYEEIERVLLEEQEQKPEQRRGHKGRQQSQETDVIVKISREQIEELSKNAKSNCKKSVSSESEPFNLRSRSPIYSNRFGNFFEITPEKNPQLKDLDIFVNSVEIKEGSLLLPHFNSRATVILVVNEGKGEVELVGLRNENEQENKKEDEEEEEDRNVQVQRFQSKLSSGDVVVIPASHPFSINASSDLFLLGFGINAQNNQRNFLAGEEDNVISQIQRPVKEVAFPGSAEEVDRLLKNQRQSHFANAQPQQKRKGSQRIRSPF [SEQ ID 223]
>gi|29539109|emb|CAD87730.1| allergen Len c 1.0101 [Lens culinaris] Lentil
SRSDQENPFIFKSNRFQTIYENENGHIRLLQRFDKRSKIFENLQNYRLLEYKSKPHTIFLPQFTDADFILVVLSGKAILTVLNSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNRPGQLQSFLLSGTQNQPSFLSGFSKNILEAAFNTEYEEIEKVLLEEQEQKSQHRRSLRDKRQEITNEDVIVKVSREQIEELSKNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPNYNSRAIVIVTVNEGKGDFELVGQRNENQQEQREENDEEEGQEEETTKQVQRYRARLSPGDVLVIPAGHPVAINASSDLNLIGFGINAKNNQRNFLAGEEDNVISQIQRPVKELAFPGSSREVDRLLTNQKQSHFANAQPLQIE [SEQ ID 224]
>gi|29539111|emb|CAD87731.1| allergen Len c 1.0102 [Lens culinaris]
SRSDQENPFIFKSNRFQTIYENENGHIRLLQKFDKRSKIFENLQNYRLLEYKSKPHTLFLPQYTDADFILVVLSGKAVLTVLNSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNNPGQLESFLLSGTQNQPSFLSGFNKSILEAAFNTDYEEIEKVLLEDQEQEPQHRRSLRDRRQEINKENVIVKVSREQIKELSKNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPNYNSRAIVIVTVNEGKGYFELVGQRNENQREENDDEEEQEEETSTQVQRYRAKLSPGDVFVVPAGHPVAINASSDLNLIGFGINAKNNQRNFLAGEEDNVISQIQRPVKELAFPGSSREVDRLLTNQKQSHFANAQPLQIE [SEQ ID 225]
>gi|1297072|emb|CAA96514.1| vicilin precursor [Vicia narbonensis]
MAAITMKVSFPLLMLLGISFLASVCVSSRSDQENPFIFKSNKFQTLFENDNGHIRLLQKFDERSKILENLQNYRLLEYKSKPRTIFLPQQTNADFILVVLSGKAILTVLKPDDRNSFNLERGDTIKLPAGTIAYLVNKDDNEDLRVLDLAIPVNGPDQLQSFLLSGSENQQSILSGFSKSVLEASFNTGYEEIEKVLLEEREKETQHRRSLRDKRQHSQDEDVIVKLSRGQIEELSRNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDVLVNSVEIKEGSLLLPHYNSRAIVIVTVNDGKGDFEIVGQRNENRQGQRKEDDEEEEQGDENTNTQVQNYKAKLSRGDVFVIPAGHPVSIKASSNLDLLGFGINAKNNQRNFLAGEEDNVISQIDRPVKELAFPGSAQEVDRLLENQKQSHFANAQPQQRERGSHETRDHLSSILDAF [SEQ ID 226]
>gi|28629838|gb|AAO45103.1| beta-conglycinin alpha' subunit [Glycine max]
QYGHVRVLQRFNKRSQQLQNLRDYRILEFNSKPNTLLLPHHADADYLIVILNGTAILTLVNNDDRDSYNLQSGDALRVPAGTTYYVVNPDNDENLRMITLAIPVNKPGRFESFFLSSTQAQQSYLQGFSKNILEASYDTKFEEINKVLFGREEGQQQGEERLQESVIVEISKKQIRELSKHAKSSSRKTISSEDKPFNLRSRDPIYSNKLGKLFEITPEKNPQLRDLDVFLSVVDMNEGALFLPHFNSKAIVVLVINEGEANIELVGIKEQQQRQQQEEQPLEVRKYRAELSEQDIFVIPAGYPVVVNATSDLNFFAFGINAENNQRNFLAGSKDNVISQIPSQVQELAFPGSAKDIENLIKSQSESYFVDAQPQQKEEGNKGRKGPLSSILRAFY [SEQ ID 227]
>gi|483449|emb|CAA83677.1| legumin A [Vicia sativa]
MAKLLALSLSFCFLLFSSCFALREQSQQNECQLERINALEPDNRIESEGGLIETWNPNNRQFRCARVALSRATLQRNALRRPYYSNAPQEIYIQQGNGYFGMVFPGCPETHEEPQQSEQGEGRRYRDSHQKVNRFREGDIIAVPTGIAFWMYNDQDTPVIAISLTDTGSSNNQLDQMPRRFYLAGNQEQEFLRYQHQQGGKQEQDNDGNNIFSGFKRDFLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIIAPPERQARHERGSRQEEDEDEKEERQPSHHKSRRDEDEDDKEKRHSQKGQSRRQGDNGLEETVCTAKLRANIGSSPSPDIYNPQAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSVIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSERFTYVAFKTDDRASIARLAGTSSVIDDLPLDVVAATFNMQRNEARQLKSNNPFKFLVPPRQSEMRASA [SEQ ID 228]
>gi|657379551|gb|KEH23931.1| legumin A2 [Medicago truncatula]
MAKLLALSLSLCFLLFSGCFAIREHQPHQKQQPQQNECQLEQLNALEPDNRIESEGGIIETWNPNNRQFRCAGVALSRCTLQRNSLRRPFYSNAPQEIFIQQGSGYFGMVFPGCPETFEEPQESEQRESRRIRESEQGESRRIRESEQGEGRRFRDSHQKVNRFREGDLIAVPTGTVFWMYNDQDTPVIAVSLIDTGSFQNQLDEMPRRFYLAGNQEQEFLQYQQQQVRGRGEQRRGREQQENEGGNIFSGFKRDFLEDALNVNRHIVDRLQGRNEDEEKGAIVKVRGGLSFVTPPERQSRHQGGSIIEEDEDEEDEWRRPHHQKSRRGEEEERPCRRGQKCERSNGLEETICTARLRQNIGSSSSPDIYNPEAGRIKTVTSFDLPALRWLRLSAEHGTLHRNAMFVPHYNLNANSAIYALRGRARLQVVNCNGNTVFDGELEAGRVLIVPQNFAVAAKSMSDRFQYVSFKTNDNAAIARLAGTQSTLSGVPMDVLAATYNMDRNEARQLKNNNLYKFLVPPRESERRAAA [SEQ ID 229]
>gi|206712292|emb|CAR78996.1| legumin storage Protein 5 [Lotus japonicus]
MAYKLFALSLSFCFLLFGGCFAIRQQSQQQNECQLERLNALKPDNRIESEAGYIETWNPTNNQFRCAGVALSRCTLRRNGLKRPSYSNAPQEIFIQQGSGIFGMIFPGCPETVEEPFESDQQGRRDRHQKVNRFREGDVIAVPPGVVFWMYNEEETPVIAVSLIDTGSYLNQLDQMPRRFYLSGNQEQEFLQYQRQEVRGREEENQGGNIFSGFGGEFLEDALNIDRNIVHKLQGRDEEQDKGAIVRVKGGLSVITPPERQSHRRGSEEEEDEEEDRPSRHQSRGGSRRNGLEETICTVRLRMNIGKSSSPDIFNPQAGRIKTATGFDFPALRFLKLSAEHGSLNRNAMVVPHYNLNANSIIYALRGRAWIQVVNCKGNRIFDGELEEGQVLIVPQNFVVAARSMSDKFNYVAFKTNDMPTMAKLAGATSEIQAMPLEVIQNAFNLEREQAKQVKFNNRFNFLVPPREQSQRRASA [SEQ ID 230]
>gi|164512526|emb|CAP06312.1| cvc [Pisum abyssinicum]
MATTVESRFPLLLFPGIIFLASVCVTYANYDEGSETRVPGQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEEKEVQPGRERWEREEDEEQVDEEWRGSQRRQDPEERARLRHREERTKRDRRHKREGEEEERSSESQEQRNPFLFKSNKFLTLFENENGHIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTIKIPAGTTSYLVNQDDEEDLRVVDFVIPVNRPGKFEAFGLSENKNQYLRGFSKNILEASLNTKYETIEKVLLEEQEKKPQQLRDRKRRQQGGERDAIIKVSREQIEELRKLAKSSSKKSLPSEFEPFNLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDILVSCVEINKGALMLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAISASSNLNLLGFGTNAENNQRNFLSGSDDN [SEQ ID 231]
>gi|164512538|emb|CAP06318.1| cvc [Lathyrus annuus]
MATTIKSRFPLLLLLGIIFLASVCVTWANYDEGSEPRVPGQRERGRQEGEKEEKRHGEWRPSYEEEYDEGLEPKVPGKRERGRQEGEKEEKRHEEWRPSYEKEEDEEEKQKYNYQREKKEHKEVQPGRERWERKQDEKQVEEDEEPGEEQWRGSKRHEDPEERARLRHREEKTKSYVEDNEETSSKEGRNPFLFKSNKFLTLFENENGHIRRLQRFDERSDIFENLQNYRLVEYRAKPHTMFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTVKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKFEAFGLSANKNQYLRGFSKNILEASLNTKYETIEKVLLEERRDQKGRQQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSESEPLNLRSQNPKYSNKFGKFFEITPQKKYPQLQDLDVSISCVEINKGALLLPHYNSRSIGILLVNEGKGNLELVGFKNEQQRQRENEETNKKLQRYEARLSSGDVVVIPEGHPVAISASSNLNLLGFGINAANNQRNFLTGSDDN [SEQ ID 232]
>gi|164512558|emb|CAP06328.1| cvc [Vicia villosa]
MATTIKSRFPVLLLLGIIFLTSVCVTYANYDEGREPSVPGQRERGRQEGEKEEKRHGEWRPSEEDEEEKYKYEEGRVPGQRERGRQEGEKEEKRHGKWRPSEEEDEEEKYRYEEGSEPRGPGQRETGRQEGEKEKQRPEREPSYEKEEDEEEKQKYQYHREKKEQREVRPGRERFERHEDEEQWRGIQRHEDPEERARERYRAEIAKRQVEEEREERDIPHEREQRNPFLFKSNKFQTLFQNENGYIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLIIVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKVESFLLSGNKNQYLRGFSKNILEASFNTNYETIERVLLEEQDKESQQSIGQKRRSQRQETNALVKVSREQLEDLKRLAKSSSQEGLSSQFEPINLRSQNPKYSNKFGKVFEITPEKKYPQLQDLDLFVSSVDIKEGALMLPHYNSRAIVVLLVNEGRGNLELVGLKNEQQEQREKEDEQQERNNQVQRYEARLSPGDVVIIPAGHPVAVRASSDLNLLAFGINAENNQRNFLAGSDDN [SEQ ID 233]
>gi|357507721|ref|XP_003624149.1| Provicilin [Medicago truncatula] >gi|87162569|gb|ABD28364.1| Cupin, RmlC-type [Medicago truncatula] >gi|355499164|gb|AES80367.1| vicilin 47 kDa protein [Medicago truncatula]
MAIKAPFQLLMLLGIFFLASVCVSSRDDRHDQENPFFFNANHFQTLFENENGHIRLLQRFDKRSKIFENLQNYRLLEYHSKPHTLFLPQHNDADFILAVLSGKAILTVLNPDNRNSFNLERGDTIKLPAGSIAYLANRDDNEDLRVLDLAIPVNRPGKFQSFSLSGSQNQQSFFSGFSKNILEAAFNANYEEIERVLIEEHEQEPQHRRGLRKDRRQQSQDSNVIVKVSREQIEELSRHAKSSSRRSGSSESAPFNLRSREPIYSNEFGNFFEITPEKNPQLKDLDILVNYAEIREGSLLLPHFNSRATVIVVVDEGKGEFELVGQRNENQQEQREEDEQQEEERSQQVQRYRARLSPGDVYVIPAGHPTVVSASSDLSLLGFGINAENNERNFLAGEEDNVISQIERPVKEVAFPGSAQDVESLLKNQRQSYFANAQPQQREREEGRSQRQRELISSILGVF [SEQ ID 234]
>gi|164512560|emb|CAP06329.1| convicilin [Vicia peregrina]
MATTFKSRFSLLLLLGIIFLAFVCVTCANYDEGSEPRVPGQRERGRQEGEKEEQSRERHPQREPSREKEEDEEEKQKYDEGTEPRVPGQRERGRQEGEKEEQRRERHPGQREPSQEEDEEREESDRRQEGSSKSEEQRNPFLFKSNKFLTLFQNGNGHIRLLQRFDKRSDLFENLQNYRLLEYRAKPHTIFLPQHIDADLILVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYPLNQDDEEDLRVVDLAISVNRPGKVESFNLSGNKNQYLRGFSENILEASFNTKYETIEKVLLEEQDKESQQPRGQRLQRQETNALVKVSREQVEELKRLARTSSKKGVSSEFEPFNLRSHGPKYSNKFGKFFEITPEKKYPQLQDLDISVSSVEINEGALFLPHYNSRAIVVVLVDEGKGNLELVGFKNEQQEQREKEDEQEERNKQVQRYEAKLSPGDVVIIPAGHPVAVSASSNLNLLGFGINAENNQRNFLTGSDDN [SEQ ID 235]
>gi|164512562|emb|CAP06330.1| convicilin [Vicia lutea]
MATTIKLRFPLLLLLGVILLASVCVTCANYDEGSEPRVPGRPEGEKEEKHRGKLRPSYEKEEDEGEKQRYHYEKKEQKEAQPRREKKEQKEEEKQVEEESRESQRYEDPGERARERYRAEIIKRQVEKEREERDRRHQREGEEEEGSSKSRNPFLFKSNNFLTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNNRNSYNLKRGDTIKLPAGTTSYLLNSDDEEDLRMVDLAISVNRPGKVESFNLSGNKNQYLRGFSKNILEASFNTKYETIEKVLLEEQDKESQQSIGQKRISQRQETNALVKVSREQIEEPKRLARSSSRKGVSSEFEPINLRSQRPKYSNKFGKFYEISPEKKYPQLQDLDVSVSSVEINEGALLLPHYNSRAIVTVLVNEGKGNLELIGFQNEQQGQREKEDEQQHERNKQVQRYDARLSSGDVVIIPAGHPVAVSASSNLDLLGFGINAENSQRNFLTGSDDN [SEQ ID 236]
>gi|573919041|ref|XP_006647142.1| PREDICTED: glutelin type-B 4-like [Oryza brachyantha]
MATTTFSRFSIYFCVLLLCHGSMAQLFSPTLNPWHSSRRGGSRDCRFDRLQAFEPLRRVRSEAGVTEYFDERNEQFQCTGTFVIRRVIEPQGLLVPRYTNTPGVVYIMQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDTPVVALYVFDINNSANQLEPRQKDFLLAGNNNREQQVYGRSIEKHSGQNIFSGFNHELLSEALGISTLAAKRLQGQNDHRGEIIRVRNGLQLLKPTFTQQQEQAQSQYQVQYSEKQQESTRCNGLDENFCTINARLNIENPSRADTYNPRAGRITHLNNQKFPILNLVQMSATRVNLYQNAILSPYWNVNAHSLVYMVQGHARVQVVSNLGKTVFNSVLRPGQLLIIPQHYVVLKKAEREGCQYIAFKTNANSIVSQLAGKNSILRAMPVDVVANAYRISREQARDLKNNRGEELGAFTPKFEQQSYPGLSNESESEASE [SEQ ID 237]
>gi|2764800|emb|CAA54153.1| 12s globulin [Avena sativa]
MATTSFPSVLFYSCIFLLYNGSMAQLFGQSFTPWQSSRQGGLKGCKFDRLQAFEPLRQVRSQAGVTEYFDEQNEQFRCTGVFVIRRVIEPQGLLLPQYHNAPGLVYILQGRGYTGLTFPGCPATFQQQFQPFDQAQDQSQSHLKDEHQRVHRFKQGDVIALPAGIVHWGYNDGDAPVVAIYVFDVNNNANQLEPRQKEFLLAGNNKEDQQFGQNIFSGFNIQLLSEALGISQQAAQRIQSQKEQRGEIIRVTQALQFLKPTMSQQELVEHQAYQPIQSQEGQSTQYQVGQSTQYQEGQSTQYQAGQSQDRSFNGLEENFCSLEARQNIGNPKRADTHNPRAGRITRLHGQNFPILNLVQMSATRVNLYQNAILSPFWNINAHSVVYMIQGHAQVQVVNNNGQTVFNDRLRQGQLLIVPQHYVVLKKAEREGCQYISFKTNPNSMVSHIAGKSSILRALPVDVLANAYRISRQEARNLKNNRGQESGVFTPKFTQTSFQPYPEGEDESSLTNKASE [SEQ ID 238]
>gi|357130026|ref|XP_003566659.1| PREDICTED: 12S seed storage globulin 1-like [Brachypodium distachyon] >gi|357130028|ref|XP_003566660.1| PREDICTED: 12S seed storage globulin 1-like [Brachypodium distachyon]
MAHTSFSSVLSYFCIFLLFHGSMAQVPGQGSTWQSPRQGGSRECSFDRLQTIEPLTQVRSQAGLTEYFDEQNEQFRCAGVSVIRRVIEPRGLLLPRYHNTPGLVYILEGSGFVGLAFPGCPETFLEQFQQSRQTQSTLGQSQCQSQSQKLGDVHQRVHQFTQGDVVALPAGVAHWFYNGGDAPVVAVYVFDVNNNANQLEPRQKEFLLAGNYNGVLQSGRNILNGLNAQLLSQAFGINEQTSRIIQNQNDGRGEIVRVEYGLQFLTPVVTQQQQKQPFLPIEPQEGQSSRNGLEENFCSLEPRQNIEDPNRADTYNPRAGSIARLNGQNFPILNLVQMSATRVNLQKNAIVSPFWNINAHSVVYVIQGQASVQVVNNQGRNVFNGLLRRGQLLIIPQNYVVLKKAESEGYQYIAFKTNANSMVSHIAGKNSILRALPVDVIANAYRISRQEAQNLKNNRGEEIGVLTPNFPQSSCQSYPIGDVDSSSTPKAQE [SEQ ID 239]
>gi|222622792|gb|EEE56924.1| hypothetical protein OsJ_06602 [Oryza sativa Japonica Group]
MAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATHQQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGMALPGCPETFQSVRSPFEQEVATAGEAQSSIQKMRDEHQQLHQFHQGDVIAVPAGVAHWLYNNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAGFSPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPTKQLQPTWLRSGGACGQQNVLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPILNIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGHIQVVDHRGRSVFDGELHQQQILLIPQNFAVVVKARREGFAWVSFKTNHNAVDSQIAGKASILRALPVDVVANAYRLSREDSRHVKFNRGDEMAVFAPRRGPQQYAEWQINEK [SEQ ID 240]
>gi|218190679|gb|EEC73106.1| hypothetical protein OsI_07091 [Oryza sativa Indica Group]
MAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATHQQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGMALPGCPETFQSVRSPFEQEVATAGEAQSSMQKMRDEHQQLHQFHQGDVIAVPAGVAHWLYNNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAGFNPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPTKQLQPTWSRSGGACGQQNGLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPILNIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGRIQVVDHRGRSVFDGELHQQQILLIPQNFAVVVKARREGFAWVSFKTNHNAVDSQIAGKASILRALPVDVVANAYRLSREDSRRVKFNRGDEMAVFAPRRGPQQYAEWQINEK [SEQ ID 241]
>gi|573922051|ref|XP_006648611.1| PREDICTED: glutelin type-A 1-like [Oryza brachyantha]
MVDMSIVVPVCLTIFLLSQVCIAQVSFDGSPLYSSRGFRGGSASQQQCRFEHLAALEVTHQEKSEAGSIEYYNTEARDEFRCARVSARRLVIESRGLVLPVYANAHKLLYIVQGRGVFGMALPGCPETFQSVRSAFEMATGDAESSTRKLRDEHQKIHQFRQGDVIAVPPGVAHWLYNNGDSPVVAFSVIDFGNNANQLDPKPREFFLAGKPWGWQQVQYSYQSEQQSKHQNIFAGFNPDLLAEALSVSRQTAMRLQELNDQRGAIIRVEQGLQLALDPSFQAEQEQEEQPQEYLSSQQQQPTWSQRSGACVQNNGLDEIMCAFKVSKNINSAQSTDIFNPRGGRITRANSQNFPVLNIIQMSATRTVLQNNALLTPHWTVNAHTVMYVTAGQGRIQVVDHRGRTVFDGELRQQQILLIPQNFAVAVKARHEGFSWVSFKTSHNAIDSQIAGKGSILRALPVDVLAKAYMLSREESRTLKYNRADETLVFAPRPEIQLYAESEK [SEQ ID 242]
>gi|164512534|emb|CAP06316.1| cvc [Pisum fulvum]
MATTTKSRFPLLLLLGIIFLASVVCVTYANYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEQKEVQPGRERWEREEDEEHVDEEWRGSQRHEDPEERARLRYREERTKRDRRHQREGEEEERSSESQERRNPFLFKSNKFQTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNARNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLSKNKNQYLRGFSKNILEASYNTKYETIEKVLLEEQEKTDAIVKVSREQIEELRKHAKSSSKKIFPSEFEPINLRNHKPEYSNKFGKLFEITPEKKYPQLQDLDIFVSCVEINEGALMLPHYNSRAIVVLLVNEGKGNLELLGLENEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAITASSNLNLLAFGINAENNQRNFLSGSDDN [SEQ ID 243]
>gi|164512526|emb|CAP06312.1| cvc [Pisum abyssinicum]
MATTVESRFPLLLFPGIIFLASVCVTYANYDEGSETRVPGQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEEKEVQPGRERWEREEDEEQVDEEWRGSQRRQDPEERARLRHREERTKRDRRHKREGEEEERSSESQEQRNPFLFKSNKFLTLFENENGHIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTIKIPAGTTSYLVNQDDEEDLRVVDFVIPVNRPGKFEAFGLSENKNQYLRGFSKNILEASLNTKYETIEKVLLEEQEKKPQQLRDRKRRQQGGERDAIIKVSREQIEELRKLAKSSSKKSLPSEFEPFNLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDILVSCVEINKGALMLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAISASSNLNLLGFGTNAENNQRNFLSGSDDN [SEQ ID 244]
>gi|164512558|emb|CAP06328.1| cvc [Vicia villosa]
MATTIKSRFPVLLLLGIIFLTSVCVTYANYDEGREPSVPGQRERGRQEGEKEEKRHGEWRPSEEDEEEKYKYEEGRVPGQRERGRQEGEKEEKRHGKWRPSEEEDEEEKYRYEEGSEPRGPGQRETGRQEGEKEKQRPEREPSYEKEEDEEEKQKYQYHREKKEQREVRPGRERFERHEDEEQWRGIQRHEDPEERARERYRAEIAKRQVEEEREERDIPHEREQRNPFLFKSNKFQTLFQNENGYIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLIIVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKVESFLLSGNKNQYLRGFSKNILEASFNTNYETIERVLLEEQDKESQQSIGQKRRSQRQETNALVKVSREQLEDLKRLAKSSSQEGLSSQFEPINLRSQNPKYSNKFGKVFEITPEKKYPQLQDLDLFVSSVDIKEGALMLPHYNSRAIVVLLVNEGRGNLELVGLKNEQQEQREKEDEQQERNNQVQRYEARLSPGDVVIIPAGHPVAVRASSDLNLLAFGINAENNQRNFLAGSDDN [SEQ ID 245]
>gi|164512536|emb|CAP06317.1| cvc [Lathyrus hirsutus]
MAIIIKSRFPLLLLLGIIFLASVCATWANYDEGSEPRVPGQRERGRQEGEKAEKSHEKWRPSYEEEYDEGSEPRVPGKRERGRQEGEKEEKRHGEWRPSHEEEYDEGSEPRVPTHGERGRQEGEKEEKRHEEWRPSYEKEEDEEEKEKYKYQREKKEQKEVQPGREKWERKQDEKHVEEDEDQEEEQWRGSKRREDPEERARLRYREERTKSNVEEETEERRNPFLFKSNKFLTLFENENGHIRRLQRFDERSDIFENLQNYRLVEYKAKPHTMFLPQHIDADLIIVVLNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKFEAFGLSANKNQYLRGFSKNILEAFLNTKYETIEKVLLEEQERRDRKGRQQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSESEPINLRSQNPKYSNKFGKLFEITPEKKYPQLQDLDVSISCVEINEGAPLLPHYNSRAIVLLLVNEGKGNLELVGFKNEQQRQRENEERNKKVQRYEARLSPGDVVVIPAGHPVAISASLNLNLVGFGVNAENNQRNFLTGSDDN [SEQ ID 246]
>gi|164512542|emb|CAP06320.1| cvc [Lathyrus cicera]
MATIIKSRFPLLLLLGIIFLASVCVTLANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSHEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEEEKQKYQYEREKEEQKEVQPGRERWERKEDEEKEEDQWRGSQRHEDPEERARLRYRKERTKKYVEEDTEETSSESQGRRNPFLFKSNKFLTLFENENGYIRRLQRFDERSDIFENLQNYRLVEYRAKPHTIFLPQHIDADLILVILNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNEDDEEDLRVVDLVIPVNRPGKFEAFDLNQYLGGFSKSVLEASLNTKYETIEKVLLEEQQKQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSELEPVNLRSHSPKYSNKFGKFFEITPEKKYPQLQDLDVSISCVEINEGALLLPHYNSRAIVVVLVNEGKGNLELLGVQNEDEQQERKERNKEVQRYEARLSPGDVVIIPSGHPVAVSASSNLNLLGFGINAENNQRNFLSGSDDN [SEQ ID 247]
>gi|164512544|emb|CAP06321.1| convicilin [Lathyrus sativus]
MATIIKSRFPLLLLLGIIFLASVCVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSSEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEEEKQKYQYEREKKEQKEVEPGRERWERKEDEEKEEDQWRGSQRHEDPEERARLRYRKERTKKYVEEDTEETSSESQGRRNPFLFKSNKFLTLFENENGYIRRLQRFDERSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVILNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNEDDEEDLRVVDLVIPVNRPGKFEAFDLNQYLGGFSKSVLKASLNTKYETIEKVLLEEQQKQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSELEPVNLRSHSPKYSNKFGKFFEITPEKKYPQLQDLDVSISCVEINEGALLLPHYNSRAIVVLLVNEGKGNLELLGVQDEDEQQERKKRNKEVQRYEARLSPSDVVIIPAGHPVAVSASSNLNLLGFGINAENNERNFLSGSDDN [SEQ ID 248]
>gi|573918992|ref|XP_006647120.1| PREDICTED: glutelin type-B 2-like [Oryza brachyantha]
MATTVFSRFSTYFCVLLLCHGSMAQLFNPSTNPWHNPRQGSSRECRFDRLQPFEPLRKVRSEAGVTEYFDEKNELFQCTGTFVIRRVIQPQGLLVPRYTNAPGLVYIIQGRGSIGLTFPGCPATYQQQFQQFLPQEQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNDGDAPVVAVYVYDVKNSANQLEPRQREFLLGGNNMRAQQVYGSSAEQHSRQNIFSGFGVEILSEALGISTVTTKRLQSQNDQRGEIIHVKNGLQFLKPTLTQQQEQAQAQYQEVQYSEQQQTSSRWNGLDENFCTIKARMNIENTSRADTYNPRAGRTTSLNSQKFPILNLVQMSATRVNLYQNAILSTFWNVNAHSLVYTIQGRARVQVVSNFGKTVFDGELRPGQLLIIPQHYVVLKKAQREGFRYIAIKTNANAFVSQLVGKNSVFRSLPVDVIANVYRISREQARSLKNNRGEEHGAFAPRSQQQSYPGFSNQSESETSE [SEQ ID 249]
>gi|573919041|ref|XP_006647142.1| PREDICTED: glutelin type-B 4-like [Oryza brachyantha]
MATTTFSRFSIYFCVLLLCHGSMAQLFSPTLNPWHSSRRGGSRDCRFDRLQAFEPLRRVRSEAGVTEYFDERNEQFQCTGTFVIRRVIEPQGLLVPRYTNTPGVVYIMQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDTPVVALYVFDINNSANQLEPRQKDFLLAGNNNREQQVYGRSIEKHSGQNIFSGFNHELLSEALGISTLAAKRLQGQNDHRGEIIRVRNGLQLLKPTFTQQQEQAQSQYQVQYSEKQQESTRCNGLDENFCTINARLNIENPSRADTYNPRAGRITHLNNQKFPILNLVQMSATRVNLYQNAILSPYWNVNAHSLVYMVQGHARVQVVSNLGKTVFNSVLRPGQLLIIPQHYVVLKKAEREGCQYIAFKTNANSIVSQLAGKNSILRAMPVDVVANAYRISREQARDLKNNRGEELGAFTPKFEQQSYPGLSNESESEASE [SEQ ID 250]
>gi|109894635|gb|ABG47337.1| glutelin precursor [Zizania latifolia]
MNMATINGPTIFFTVCLFLLCHGSLAQLLGQSTSQWQSSHRGSSRQCRFDRLQAFEPVRSVRSQAGTTEFFDASNELFQCAGVSIVRRIIEPRGLLLPQYTNGATIMYIIQGRGITGQTFPGCPESYQQQFQQSMQAQLTGSQSQSQKFKDEHQKINRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVIDINNAANQLDPRQRDFLLAGNMRSPQAYRREVENQSQNIFSGFSAELLSEALGISTGVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQKQEQPRERYQVTQHQQSQYGGGCSNGLDETFCAMRIWQNIDNPNLADTYNPRAGRVTNLNSQKFPILNLIQMSAVKVNLYQNALLSPFWNINSHSVVYVTQGCARVQVVNNNGKTVFNGELRRGQLLIIPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIVGKSSIFRALPTDVLANAYRISREDAQRLKHNRGDELGAFTPLQYKSYQDVSSVAASS [SEQ ID 251]
>gi|531874314|gb|AGT59174.1| glutelin, partial [Oryza sativa Indica Group]
CRFDRLQAFEPIRSVRSQAGTTEFFDVSNEQFQCTGVSAVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPESYQQQFQQSGQAQLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDLNNGANQLDPRQRDFLLAGNKRNPQAYRREVEERSQNIFSGFSTELLSEALGVSSQVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQGQVQSRERYQEGQYQQSQYGSGCSNGLDETFCTMKVRQNIDNPNRADTYNPRAGRVTNLNTQNFPILNLVQMSAVKVNLYQNALLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFNGELRRGQLLIIPQHYAVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPNDVLANAYRISREEAQRLKHNRGDEFGAFTPIQYKSYQDVYNAAESS [SEQ ID 252]
>gi|109894635|gb|ABG47337.1| glutelin precursor [Zizania latifolia]
MNMATINGPTIFFTVCLFLLCHGSLAQLLGQSTSQWQSSHRGSSRQCRFDRLQAFEPVRSVRSQAGTTEFFDASNELFQCAGVSIVRRIIEPRGLLLPQYTNGATIMYIIQGRGITGQTFPGCPESYQQQFQQSMQAQLTGSQSQSQKFKDEHQKINRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVIDINNAANQLDPRQRDFLLAGNMRSPQAYRREVENQSQNIFSGFSAELLSEALGISTGVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQKQEQPRERYQVTQHQQSQYGGGCSNGLDETFCAMRIWQNIDNPNLADTYNPRAGRVTNLNSQKFPILNLIQMSAVKVNLYQNALLSPFWNINSHSVVYVTQGCARVQVVNNNGKTVFNGELRRGQLLIIPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIVGKSSIFRALPTDVLANAYRISREDAQRLKHNRGDELGAFTPLQYKSYQDVSSVAASS [SEQ ID 253]
>gi|472867|emb|CAA52764.1| 11S globulin [Avena sativa]
MATTSFPSMLFYFCIFLLFHGSMAQLFGQSSTPWQSSRQGGLRGCRFDRLQAFEPLRQVRSQAGITEYFDEQNEQFRCTGVSVIRRVIEPQGLVLPQYHNAPALVYILQGRGFTGLTFPGCPATFQQQFQPFDQSQFAQGQRQSQTIKDEHQRVQRFKQGDVVALPAGIVHWCYNDGDAPIVAIYVFDVNNNANQLEPRQKEFLLAGNNKREQQSGNNIFSGLSVQLLSEALGISQQAAQRIQSQNDQRGEIIRVSQGLQFLKPIVSQQVPGEQQVYQPIQTQEGQATQYQVGQSTQYQVGKSTPYQGGQSSQYQAGQSWDQSFNGLEENFCSLEARKNIENPQHADTYNPRAGRITRLNSKNFPILNIVQMSATRVNLYQNAILSPFWNINAHSVIYMIQGHARVQVVNNNGQTVFNDILRRGQLLIVPQHFVVLKKAEREGCQYISFKTNPNSMVSHIAGKSSILRALPIDVLANAYRISRQEARNLKNNRGEEFGAFTPKLTQKGFQSYQDIEEGSSSPVRASE [SEQ ID 254]
>gi|225959|prf||1404367A glutelin
MASTNRPIVFFTVCLFLLCDGSLAQQLLGQSTSQWQSSRRGSPRGCRFDRLQAFEPIRSVRSQAGTTEFFDVSNELFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPETYQQQFQQSGQAGLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDCEVPVVAIYVTDINNGANQLDPRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFSTELLSEAFGISNQVARQLQCQNDQKGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQEGGYQQSQYGSGCPNGLDETFCVNKVRQNIDNPNRADTYNPRAGRVTNLSQNFPILNLVQMSAVKVNLYQNTDTWISMGQEENALLSPFWNINAHSIVYITQGRAQVQVLRRGQLLIVPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS [SEQ ID 255]
>gi|573943558|ref|XP_006654150.1| PREDICTED: glutelin type-A 3-like [Oryza brachyantha]
MKSSIVFSTICLVLLCHGSLAQLLSQSTSQWQSSRRGSPRQCRFDQLQAFEPIRTVRSQAGVTEFYDVSNELFQCTGVSVVRRVIEPRGLLLPHYSNGATLVYIIQGRGITGPTFPGCPETYQQQFQQSGEAQPFEGQSHKFRDEHQKIHRFRQGDVVALPAGVAHWCYNDGEVPIVAIYVTDIYNSANQLDPRHRDFFLAGNNKVAQQLYRSEARENSKNIFGGFSVELLSEALGISRGVARQLQCQNDQRGEIVRVEHGLALLQPYASVQEQQQEQVQSRDYEQTQYQQKQPQGSCSNGLDETFCTMRLRQNIDNPNLADTYNPKAGRITYLNGQKFPILNLVQMSAVKVNLYQNAVLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFDGELRQGQLLIIPQHHVVLKKAQREGCSYIALKTNPNSIVSHIAGKNSIFRALPGDVVTNAYRISREEAKRIKHNRGDESGVFAPSHAYRSYQDMSVAA [SEQ ID 256]
>gi|721641733|ref|XP_010231907.1| PREDICTED: 12S seed storage globulin 1-like [Brachypodium distachyon]
MAHTSFSSFLSYFCLFLLFHGSMAQVLGQVSTWQSSRQGGSRDCSFDRLQAIEPVTQVRSQAGLTEYFDEQNEQFRCAGVFVIRRVIEPRGLLLPRYHNTPGLVYILQGNGFVGLTFPGCPETFREQFQQFRQTQSTLGQSQCQSQKLGDVHQRVHQFTQGDVVALPTGVAHWIYNGGDAPVVIVYVFDVNNNANQLEPRQKEFLLGGNYNGVLQYGQNIFSGFNAQLLSQAFGINEQTSQRIQNQNDGRGDIIRVDNGLQFLKPVVTQQQPEQPFMPIQHQTGQSSRNGLEENFCSLEPRQNIEDPNRADTYNPRAGSITRLNGQNFPILNLVQMSATRVNLQKNAILSPFWNINAHSVVYVIQGHALVQVVNNQGHNVFNGLLHRGQLLIIPQNYVVLKKAESEGYQYIAFKTNANSMVSHIAGKNSILRALPVDVIANAYRISRQEAQNLKNNRGEETGVLTPNFSQSTCQSYQTEDVQSLRPMSHWSE [SEQ ID 257]
>gi|169244463|gb|ACA50505.1| seed allergenic protein RAG2 [Oryza sativa Japonica Group]
MASNKVVFSALLLIIVSVLAATATMADHHKDQVVYSLGERCQPGMGYPMYSLPRCRAVVKRQCVGHGAPGGAVDEQLRQDCCRQLAAVDDSWCRCSALNHMVGGIYRELGATDVGHPMAXVFPGCRRGDLERAAASLPAFCNVDIPNGTGGVCYWLGYPRTPRTGH [SEQ ID 258]
>gi|5777592|emb|CAA44001.1| low molecular weight globulin [Oryza sativa]
MASNKVVFSALLLIIVSVLRRDGTMADHHKDQVVYSLGERCQPGMGYPMYSLPRCRAVVKRQCVGHGAPGAVDEQLRQDCCRQLAAVDDSWCRCSALNHMVGGIYRELGATDVGHPMAEVFPGCRRGDLERAAASLPAFCNVDIPNGTGGVCYWLGYPRTPRTGH [SEQ ID 259]
>gi|115471175|ref|NP_001059186.1| Os07g0214600 [Oryza sativa Japonica Group] >gi|23616954|dbj|BAC20657.1| allergen RA16 [Oryza sativa Japonica Group] >gi|113610722|dbj|BAF21100.1| Os07g0214600 [Oryza sativa Japonica Group] >gi|125557687|gb|EAZ03223.1| hypothetical protein OsI_25372 [Oryza sativa Indica Group]
MASNKVVISALLVVVVSVLAATTTMADHHQEQVVYTPGQLCQPGIGYPTYPLPRCRAFVKRQCVAPGTVDEQVRRGCCRQLAAIDSSWCRCDALNHMLRIIYRESGAADAGHPMAEVFRGCRRGDIERAAASLPAFCNVDIPNGVGGVCYWLPGTGY [SEQ ID 260]
>gi|115445309|ref|NP_001046434.1| Os02g0248800 [Oryza sativa Japonica Group] >gi|37993738|gb|AAR06952.1| glutelin type-B [Oryza sativa Japonica Group] >gi|47497729|dbj|BAD19794.1| glutelin type-B [Oryza sativa Japonica Group] >gi|113535965|dbj|BAF08348.1| Os02g0248800 [Oryza sativa Japonica Group] >gi|215768942|dbj|BAH01171.1| unnamed protein product [Oryza sativa Japonica Group] >gi|284431772|gb|ADB84627.1| glutelin [Oryza sativa Japonica Group]
MTISVFSRFSIYFCVLLLCNGSMAQLFDPATNQWQTHRQGSFRECRFERLQAFEPLQNVRSEAGVTEYFDETNELFQCTGTFVIRRVIQPQGLLIPRYANTPGMVYIIQGRGSMGLTFPGCPATYQQQSQQFLFQGESQSQKFIDEHQKIHQFRQGDIVVLPTGVAHWFYNDGDTPVVALYVYDINNSANQLEPRHREFLLAGKNNRVQQVYGRSIQQHSGQNIFNGFSVEPLSEALNINTVTTKRLQSQNDQRGEIIHVKNGLQLLKPTLTQRQEQEQAQYQEVQYSEKPQTSSRWNGLEENLCTIKTRLNIENPSRADSYDPRAGRITSLDSQKFPILNIIQMSATRVNLYQNAILTPFWNVNAHSLMYVIRGRARVQVVSNFGKTVFDGVLRPEQLLIIPQNYVVLKKAQHEGCQYIAINTNANAFVSHLAGVDSVFHALPVDVIANAYCISREEARRLKNNRGDEYGPFPPRLQQQIYPEFSNESKGETSE [SEQ ID 261]
>gi|428674402|gb|AFZ41188.1| glutelin, partial [Oryza sativa Japonica Group]
LLCHGSMAQIFSLGINPWQNPRQGGSRECRFDRLQAFEPLRKVRHEAGVTEYFDEKNEQFQCTGTLVIRRIIEPQGLLLPRYSNTPGLVYIIQGTGVLGLTFPGCPATYQKQFRHFGLEGGSQRQGKKLRDENQKIHQFRQGDVVALPSGIPHWFYNEGDTPVVALFVFDVNNNANQLEPRQKEFLLAGNNIEQQVSNPSINKHSGQNIFNGFNTKLLSEALGVNIEVTRRLQSQNDRRGDIIRVKNGLRLIKPTITQQQEQTQDQYQQIQYHREQRSTSKYNGLDENFCAIRARLNIENPNHADTYNPRAGRITNLNSQKFSILNLVQMSATRVNLYQNAILSPFWNINAHSLVYTIQGRARVQVVSNHGKAVFNGVLRPGQLLIIPQNYVVMKKAELEGFQFIAFKTNPNAMVNHIAGKNSVLRAMPVDVIANAYRISRQEARSLKNNRGEEIGAFTPRYQQQKIHQEYSNPNESETQ [SEQ ID 262]
>gi|226510|prf||1515394A seed storage globulin
MATTRFPSLLFYSCIFLLCNGSMAQLFGQSFTPWQSSRQGGLRGCRFDRLQAFEPLRQVRSQAGITEYFDEQNEQFRCAGVSVIRRVIEPQGLLLPQYHNAPGLVYILQGRGFTGLTFPGCPATFQQQFQPFDQARFAQGQSKSQNLKDEHQRVHHIKQGDVVALPAGIVHWCYNDGDAPIVAVYVFDVNNNANQLEPRQKEFLLAGNNKREQQFGQNIFSGFSVQLLSEALGISQQAAQKIQSQNDQRGEIIRVSQGLQFLKPFVSQQGPVEHQAYQPIQSQQEQSTQYQVGQSPQYQEGQSTQYQSGQSWDQSFNGLEENFCSLEARQNIENPKRADTYNPRAGRITHLNSKNFPTLNLVQMSATRVNLYQNAILSPYWNINAHSVMHMIQGRARVQVVNNHGQTVFNDILRRGQLLIIPQHYVVLKKAEREGCQYISFKTTPNSMVSYIAGKTSILRALPVDVLANAYRISRQESQNLKNNRGEEFGAFTPKFAQTGSQSYQDEGESSSTEKASE [SEQ ID 263]
>gi|83375868|gb|ABC17777.1| waxy [Oryza rufipogon]
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDATSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFVDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLCQAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLASYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAFEDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQEDVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKFNAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVKKVAATLKRAIKVVGTPAYEEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAAP [SEQ ID 264]
>gi|297614332|gb|ADI48504.1| glycogen synthetase [Oryza officinalis]
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDASSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVISPRHDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFIDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLCQAALEAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLPSYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAFEDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILESDRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYIAAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQENVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKFNAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVQKVATTLKRAIKIVGTPAYNEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGVEGEEIAPLAKENVAAP [SEQ ID 265]
>gi|389620054|gb|AFK93486.1| granule-bound starch synthase [Hordeum vulgare subsp. vulgare]
MAALATSQLATSGTVLGVTDRFRRPGFQGLRPRNPADAALGMRTIGASAAPKQSRKAHRGSRRCLSVVVRATGSGMNLVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVVSPRYDQYKDAWDTSVISEIKVADEYERVRFFHCYKRGVDRVFIDHPWFLEKVRGKTKEKIYGPDAGTDYEDNQQRFSLLCQAALEAPRILNLNNNPYFSGPYGEDVVFVCNDWHTGLLACYLKSNYQSNGIYRTAKVAFCIHNISYQGRFSFDDFAQLNLPDRFKSSFDFIDGYDKPVEGRKINWMKAGILQADKVLTVSPYYAEELISDEARGCELDNIMRLTGITGIVNGMDVSEWDPTKDKFLAVNYDITTALEAKALNKEALQAEVGLPVDRKVPLVAFIGRLEEQKGPDVMIAAIPEILKEEDVQIILLGTGKKKFEKLLKSMEEKFPGKVRAVVRFNAPLAHQMMAGADLLAVTSRFEPCGLIQLQGMRYGTPCVCASTGGLVDTIVEGKTGFHMGRLSVDCNVVEPADVKKVATTLKRAVKVVGTPAYQEMVKNCMIQDLSWKGPAKNWEDVLLELGVEGSEPGIVGEEIAPLAMENVAAP [SEQ ID 266]
>gi|446599182|ref|WP_000676528.1| glutamyl endopeptidase [Staphylococcus aureus] >gi|253729369|gb|EES98098.1| trypsin [Staphylococcus aureus subsp. aureus TCH130] >gi|341844549|gb|EGS85761.1| glutamyl endopeptidase [Staphylococcus aureus subsp. aureus 21259] >gi|537390486|gb|AGU61109.1| Glutamyl endopeptidase precursor [Staphylococcus aureus subsp. aureus CN1] >gi|564714561|gb|ETD14665.1| glutamyl endopeptidase [Staphylococcus aureus subsp. aureus KPL1845] >gi|577466329|gb|EUG79766.1| glutamyl endopeptidase [Staphylococcus aureus M0139] >gi|580560623|gb|EVF84961.1| glutamyl endopeptidase [Staphylococcus aureus COAS6020] >gi|580687002|gb|EVH10169.1| glutamyl endopeptidase [Staphylococcus aureus UCIM6080] >gi|751815683|gb|KIN24957.1| glutamyl endopeptidase [Staphylococcus aureus MRSA_CVM43477] >gi|781884797|dbj|BAR08486.1| glutamyl endopeptidase precursor [Staphylococcus aureus subsp. aureus] >gi|781887762|dbj|BAR11210.1| glutamyl endopeptidase precursor [Staphylococcus aureus subsp. aureus]
MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQSQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA [SEQ ID 267]
Claims (12)
- 配列番号344のアミノ酸配列からなるペプチド。
- 請求項1に記載のペプチドと比較して1個のアミノ酸の変更を有し、そのアミノ酸の変更が、アミノ酸の挿入、付加、欠失および置換から選択される請求項1に記載のペプチドの抗炎症性変異体。
- 配列番号344のアミノ酸配列の化学的に修飾されたペプチド、または配列番号344と比較して1個のアミノ酸の変更を有する配列番号344の抗炎症性変異体であって、前記アミノ酸の変更がアミノ酸の挿入、付加、欠失および置換から選択される抗炎症性変異体であり、
前記化学的に修飾されたペプチド、または前記抗炎症性変異体が、アミノ基、アルギニン残基のグアニジン基、カルボキシル基またはスルフヒドリル基の修飾から選択される側鎖への修飾、N-末端保護基、C-末端保護基または側鎖保護基から選択される保護基の組込み、および、ペプチド合成の間での、ノルロイシン、4-アミノ酪酸、4-アミノ-3-ヒドロキシ-5-フェニルペンタン酸、6-アミノヘキサン酸、t-ブチルグリシン、ノルバリン、フェニルグリシン、オルニチン、サルコシン、4-アミノ-3-ヒドロキシ-6-メチルヘプタン酸、2-チエニルアラニンおよび/またはアミノ酸のD-異性体から選択される非天然アミノ酸および/またはそれらの誘導体の組込みによって化学的に修飾される、前記化学的に修飾されたペプチドまたは抗炎症性変異体。 - ポリエチレングリコールホモポリマーまたはコポリマー、PEGのモノメチル置換ポリマー(mPEG)およびポリオキシエチレングリセロール(POG)から選択される分子量を増加する化合物、ポリアミノ酸、または抗体分子から選択される結合パートナーと、コンジュゲートされた、連結された、または融合された、請求項1に記載のペプチド、または請求項2に記載の抗炎症性変異体、または請求項3に記載の化学的に修飾されたペプチドを含むコンジュゲート。
- 請求項1に記載の1または複数のペプチド、請求項2に記載の抗炎症性変異体、請求項3に記載の化学的に修飾されたペプチド、または請求項4に記載のコンジュゲートを含む組成物。
- 配列番号344のアミノ酸配列からなるペプチドを含む、請求項5に記載の組成物。
- 粉末である、請求項5または6のいずれかに記載の組成物。
- 請求項5から7のいずれか1項に記載の組成物を含む、食物または飲料、栄養補助食品、パーソナルケア組成物、または医薬組成物。
- 局所組成物の形態の請求項8に記載のパーソナルケア組成物。
- クリーム、ローション、ゲル、ハイドロゲル、軟膏または血清から選択される、請求項9に記載のパーソナルケア組成物。
- 哺乳動物における炎症または炎症性障害の治療または予防のための方法における使用のための、請求項1に記載のペプチド、請求項2に記載の抗炎症性変異体、請求項3に記載の化学的に修飾されたペプチド、請求項4に記載のコンジュゲート、請求項5~7のいずれか1項に記載の組成物、請求項9に記載のパーソナルケア組成物、または請求項8に記載の医薬組成物。
- 炎症性障害が、皮膚の炎症性障害、関節の炎症性障害、心血管系の炎症性障害、肺または気道の炎症性障害および腸の炎症性障害から選択される請求項11に記載の使用のための、請求項1に記載のペプチド、請求項2に記載の抗炎症性変異体、請求項3に記載の化学的に修飾されたペプチ、請求項4に記載のコンジュゲート、請求項5~7のいずれか1項に記載の組成物、請求項9に記載のパーソナルケア組成物、または請求項8に記載の医薬組成物。
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