JP2021536478A5 - - Google Patents
Info
- Publication number
- JP2021536478A5 JP2021536478A5 JP2021512749A JP2021512749A JP2021536478A5 JP 2021536478 A5 JP2021536478 A5 JP 2021536478A5 JP 2021512749 A JP2021512749 A JP 2021512749A JP 2021512749 A JP2021512749 A JP 2021512749A JP 2021536478 A5 JP2021536478 A5 JP 2021536478A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- human
- antibody
- variable
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024168973A JP2024177226A (ja) | 2018-09-06 | 2024-09-27 | 対合していない可変ドメインを含む抗原結合分子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1814529.2A GB2576914A (en) | 2018-09-06 | 2018-09-06 | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
| GB1814529.2 | 2018-09-06 | ||
| PCT/EP2019/073767 WO2020049128A1 (en) | 2018-09-06 | 2019-09-05 | Antigen-binding molecules comprising unpaired variable domains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024168973A Division JP2024177226A (ja) | 2018-09-06 | 2024-09-27 | 対合していない可変ドメインを含む抗原結合分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021536478A JP2021536478A (ja) | 2021-12-27 |
| JP2021536478A5 true JP2021536478A5 (https=) | 2022-09-13 |
Family
ID=63921217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512749A Pending JP2021536478A (ja) | 2018-09-06 | 2019-09-05 | 対合していない可変ドメインを含む抗原結合分子 |
| JP2024168973A Pending JP2024177226A (ja) | 2018-09-06 | 2024-09-27 | 対合していない可変ドメインを含む抗原結合分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024168973A Pending JP2024177226A (ja) | 2018-09-06 | 2024-09-27 | 対合していない可変ドメインを含む抗原結合分子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12473378B2 (https=) |
| EP (1) | EP3846620A1 (https=) |
| JP (2) | JP2021536478A (https=) |
| GB (1) | GB2576914A (https=) |
| WO (1) | WO2020049128A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
| EP4512243A1 (en) | 2023-08-21 | 2025-02-26 | Kymab Limited | Binding molecules |
| CN117587070B (zh) * | 2024-01-19 | 2024-04-30 | 北京仁源欣生生物科技有限公司 | 一种经遗传修饰的非人哺乳动物的制备方法及应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| EP2319301B1 (en) | 2001-11-30 | 2017-09-06 | Amgen Fremont Inc. | Transgenic animals bearing human Ig lambda light chain genes |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| KR101151957B1 (ko) | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| WO2007022477A2 (en) * | 2005-08-17 | 2007-02-22 | Multicell Immunotherapeutics, Inc. | Methods and compositions to generate and control the effector profile of t cells |
| GB0601513D0 (en) * | 2006-01-25 | 2006-03-08 | Univ Erasmus Medical Ct | Binding molecules 3 |
| MX2008010561A (es) * | 2006-02-15 | 2009-03-02 | Imclone Systems Inc | Anticuerpos funcionales. |
| PT1999154E (pt) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Domínios proteicos heterodiméricos modificados |
| US20090148905A1 (en) | 2007-11-30 | 2009-06-11 | Claire Ashman | Antigen-binding constructs |
| EP2669298A3 (en) | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
| DK3622815T3 (da) * | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| ES2724975T3 (es) | 2009-12-10 | 2019-09-18 | Regeneron Pharma | Ratones que producen anticuerpos de cadena pesada |
| US9527926B2 (en) | 2010-05-14 | 2016-12-27 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| EP2658869B1 (en) * | 2010-12-30 | 2019-06-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigen binding formats for use in therapeutic treatments or diagnostic assays |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US9248181B2 (en) | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| WO2013176754A1 (en) * | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US20150203591A1 (en) | 2012-08-02 | 2015-07-23 | Regeneron Pharmaceuticals, Inc. | Mutivalent antigen-binding proteins |
| US9631191B2 (en) * | 2012-12-04 | 2017-04-25 | Alexey Gennadievich Zdanovsky | System for production of antibodies and their derivatives |
| WO2014102100A1 (en) * | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within an immunoglobulin domain |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| WO2018038469A1 (ko) * | 2016-08-20 | 2018-03-01 | (주)아이벤트러스 | 목적하는 이중특이성 항체의 선택적 생산 확인 방법 |
| IL322083A (en) | 2016-08-24 | 2025-09-01 | Teneobio Inc | Non-human transgenic animals that produce modified heavy chain antibodies only |
| EP3625250B1 (en) | 2017-07-21 | 2021-04-14 | Trianni, Inc. | Single chain vh and heavy chain antibodies |
| EP3746470A1 (en) * | 2018-01-31 | 2020-12-09 | F. Hoffmann-La Roche AG | Stabilized immunoglobulin domains |
| GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
-
2018
- 2018-09-06 GB GB1814529.2A patent/GB2576914A/en not_active Withdrawn
-
2019
- 2019-09-05 JP JP2021512749A patent/JP2021536478A/ja active Pending
- 2019-09-05 US US17/274,103 patent/US12473378B2/en active Active
- 2019-09-05 EP EP19765467.6A patent/EP3846620A1/en active Pending
- 2019-09-05 WO PCT/EP2019/073767 patent/WO2020049128A1/en not_active Ceased
-
2024
- 2024-09-27 JP JP2024168973A patent/JP2024177226A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7662516B2 (ja) | Ｐｄ－１標的化ｉｌ－１５／ｉｌ－１５ｒアルファｆｃ融合タンパク質およびその組み合わせ療法での使用 | |
| CA2972833C (en) | Anti-pd-1 monoclonal antibodies and obtaining method thereof | |
| JP7061235B2 (ja) | 抗ｃｌｄ１８ａ２ナノ抗体及びその応用 | |
| KR102624023B1 (ko) | 결합-촉발된 전사 스위치 및 이들의 이용 방법 | |
| JP2019525771A5 (https=) | ||
| JP2022512684A5 (https=) | ||
| RU2022102624A (ru) | Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков | |
| WO2017166804A1 (zh) | 抗pd-1的单克隆抗体 | |
| JP2019525738A5 (https=) | ||
| JP2017529067A5 (https=) | ||
| CA2797981A1 (en) | Heterodimeric proteins and methods for producing and purifying them | |
| JP2012514997A5 (https=) | ||
| CA3089419A1 (en) | Therapeutic molecules that bind to lag3 and pd1 | |
| US20230212293A1 (en) | Pd-1 agonist multimeric binding molecules | |
| RU2018104703A (ru) | Опухолеспецифичное антитело против egfr и его применение | |
| CN111848809A (zh) | 靶向Claudin18.2的CAR分子、其修饰的免疫细胞及用途 | |
| JP2021536478A5 (https=) | ||
| AU2019372184A1 (en) | Novel antagonistic anti TNFR2 antibody molecules | |
| CN114391021A (zh) | TGF-β受体和使用方法 | |
| CN112442126A (zh) | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 | |
| TW202334204A (zh) | 條件性活化之抗原結合多肽複合物及其使用方法 | |
| JP2021505663A5 (https=) | ||
| CN115996952A (zh) | 对hla-g和另一种抗原具有结合特异性的双特异性免疫细胞接合子 | |
| KR20230124656A (ko) | 전립선암 키메라 항원 수용체 | |
| CN117343182B (zh) | 抗人tigit抗体或其功能性片段及其应用 |