JP2021533181A5 - - Google Patents
Info
- Publication number
- JP2021533181A5 JP2021533181A5 JP2021518993A JP2021518993A JP2021533181A5 JP 2021533181 A5 JP2021533181 A5 JP 2021533181A5 JP 2021518993 A JP2021518993 A JP 2021518993A JP 2021518993 A JP2021518993 A JP 2021518993A JP 2021533181 A5 JP2021533181 A5 JP 2021533181A5
- Authority
- JP
- Japan
- Prior art keywords
- uchl5
- bifunctional molecule
- target protein
- binding partner
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862684268P | 2018-06-13 | 2018-06-13 | |
| US62/684,268 | 2018-06-13 | ||
| US201962835955P | 2019-04-18 | 2019-04-18 | |
| US62/835,955 | 2019-04-18 | ||
| PCT/EP2019/065479 WO2019238816A1 (en) | 2018-06-13 | 2019-06-13 | Bifunctional molecules for targeting uchl5 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021533181A JP2021533181A (ja) | 2021-12-02 |
| JP2021533181A5 true JP2021533181A5 (enExample) | 2022-06-21 |
Family
ID=67105989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518993A Pending JP2021533181A (ja) | 2018-06-13 | 2019-06-13 | ＵｃｈＬ５を標的化するための二機能性分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210283139A1 (enExample) |
| EP (1) | EP3807263A1 (enExample) |
| JP (1) | JP2021533181A (enExample) |
| KR (1) | KR20210020107A (enExample) |
| CN (1) | CN112585127A (enExample) |
| CA (1) | CA3103205A1 (enExample) |
| WO (1) | WO2019238816A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3164578A1 (en) * | 2020-01-14 | 2021-07-22 | Scott KANNER | Compositions and methods for targeted protein stabilization by redirecting endogenous deubiquitinases |
| GB202102494D0 (en) * | 2021-02-22 | 2021-04-07 | Amphista Therapeurics Ltd | Novel bifunctional molecules for targeted protein degredation |
| PE20240545A1 (es) | 2020-12-18 | 2024-03-19 | Amphista Therapeutics Ltd | Moleculas bifuncionales novedosas para la degradacion de proteinas dirigidas |
| AU2022263269A1 (en) * | 2021-04-09 | 2023-10-19 | President And Fellows Of Harvard College | Bifunctional molecules for selective modification of target substrates |
| IL307863A (en) * | 2021-04-29 | 2023-12-01 | Novartis Ag | Diubiquitinase-directed chimeras and related methods |
| JP2025525347A (ja) | 2022-06-16 | 2025-08-05 | アンフィスタ セラピューティクス リミテッド | 標的タンパク質分解のための新規の二官能性分子 |
| WO2023242598A1 (en) | 2022-06-16 | 2023-12-21 | Amphista Therapeutics Limited | Bifunctional molecules for targeted protein degradation |
| CA3267147A1 (en) | 2022-09-13 | 2024-03-21 | Amphista Therapeutics Limited | COMPOUNDS FOR THE TARGETED DEGRADATION OF A PROTEIN |
| IL319486A (en) | 2022-10-07 | 2025-05-01 | Pfizer | HSD17B13 Inhibitors and/or Retarders |
| JP2025541231A (ja) | 2022-12-16 | 2025-12-18 | ファイザー・インク | ３－フルオロ－４－ヒドロキシベンズアミド含有阻害剤および／または分解剤ならびにそれらの使用 |
| CN121752561A (zh) * | 2023-07-26 | 2026-03-27 | 先声再明医药股份有限公司 | 用于靶蛋白降解的化合物 |
| US20250188030A1 (en) | 2023-12-07 | 2025-06-12 | Pfizer Inc. | Biphenyl and Phenylpyridine Compounds |
| GB202319256D0 (en) | 2023-12-15 | 2024-01-31 | Amphista Therapeutics Ltd | Novel compounds for targeted protein degradation |
| WO2025221154A1 (en) | 2024-04-17 | 2025-10-23 | Captor Therapeutics S.A. | Klhdc2 (kelch domain-containing protein 2) ligase ligands |
| US12624035B2 (en) | 2024-09-06 | 2026-05-12 | Amphista Therapeutics Limited | Compounds for targeted protein degradation |
| WO2026088071A1 (en) | 2024-10-23 | 2026-04-30 | Pfizer Inc. | Substituted fused heteroaryl lactam compounds |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| NZ513639A (en) * | 1999-04-15 | 2004-02-27 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US7208157B2 (en) | 2000-09-08 | 2007-04-24 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| US8003625B2 (en) | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| RU59063U1 (ru) | 2006-05-30 | 2006-12-10 | Государственное образовательное учреждение высшего профессионального образования "Ульяновский государственный технический университет" | Режущий инструмент с многослойным покрытием |
| US8552048B2 (en) | 2006-12-26 | 2013-10-08 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| WO2012040527A2 (en) * | 2010-09-24 | 2012-03-29 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| AU2011338615B2 (en) | 2010-12-07 | 2017-07-27 | Yale University | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
| JP2015508414A (ja) | 2012-01-12 | 2015-03-19 | イエール ユニバーシティ | Ｅ３ユビキチンリガーゼによる標的タンパク質および他のポリペプチドの分解増強のための化合物および方法 |
| EP3148572A4 (en) * | 2014-05-27 | 2017-12-27 | Pharmakea, Inc. | Compositions and methods of delivery of deubiquitinase inhibitors |
| US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| GB201504314D0 (en) | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| AU2016301196B2 (en) | 2015-08-06 | 2022-09-08 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation |
| WO2017024317A2 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| AU2016349781A1 (en) * | 2015-11-02 | 2018-05-10 | Yale University | Proteolysis targeting chimera compounds and methods of preparing and using same |
| GB2554071A (en) * | 2016-09-14 | 2018-03-28 | Univ Dundee | Small molecules |
-
2019
- 2019-06-13 CA CA3103205A patent/CA3103205A1/en active Pending
- 2019-06-13 JP JP2021518993A patent/JP2021533181A/ja active Pending
- 2019-06-13 KR KR1020217000976A patent/KR20210020107A/ko not_active Withdrawn
- 2019-06-13 WO PCT/EP2019/065479 patent/WO2019238816A1/en not_active Ceased
- 2019-06-13 US US17/251,621 patent/US20210283139A1/en not_active Abandoned
- 2019-06-13 EP EP19733977.3A patent/EP3807263A1/en not_active Withdrawn
- 2019-06-13 CN CN201980038871.3A patent/CN112585127A/zh active Pending
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