JP2021533091A - 新規なジンセノサイドを含む抗酸化組成物 - Google Patents
新規なジンセノサイドを含む抗酸化組成物 Download PDFInfo
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- JP2021533091A JP2021533091A JP2021502623A JP2021502623A JP2021533091A JP 2021533091 A JP2021533091 A JP 2021533091A JP 2021502623 A JP2021502623 A JP 2021502623A JP 2021502623 A JP2021502623 A JP 2021502623A JP 2021533091 A JP2021533091 A JP 2021533091A
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- Japan
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- composition
- weight
- ginsenoside
- compound
- ginseng
- Prior art date
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- Granted
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- 150000003839 salts Chemical class 0.000 claims abstract description 24
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Abstract
Description
分画
高麗人参の種子(Seeds of Panax ginseng)5.5kgをミキサーで細かく粉砕して粉末状にしてメタノールで抽出後、n−ヘキサン、エチルアセテート、n−ブタノールなどを用いて段階的に分画した。脂質(Lipid)の大部分はn−ヘキサンによって除去され、エチルアセテート分画物に残っている脂質はメタノール:水=1:1(v/v)で懸濁した、これをフリーザーに一晩保管してから上層液だけを取った後、遠心分離機を利用してもう一回除去した。このように前処理が施されたエチルアセテート分画物2.61gとn−ブタノール分画物114.64gをカラム及びHPCCC(High Performance Counter−Current Chromatography)によって下記のように分画した。
n−ブタノール分画物114.64gに対してMPLCにて分画を分けた。このときに用いた溶媒はn−ヘキサン/エチルアセテート=10:1→5:1→1:1→CHCl3/MeOH=10:1→5:1(v/v)であり、流速は50mL/minとした。前記条件を用いて合計12個の下位分画に分けた。各分画をさらにHPCCC、HPLC(High−performance liquid chromatography)、セファデックス(Sephadex)LH−20カラムなどを用いて各分画に含有されている成分を分離した。次いで、NMR(Nuclear magnetic resonance)、UV(Ultraviolet rays)、MS(Mass spectrometry)を用いて構造を同定して16種の化合物を究明した。
前記高麗人参の種子抽出物から分離したジンセノサイドの抗酸化効能を比較するために、DPPH(2,2−diphenyl−1−picrylhydrazyl)抑制効能実験を次のように実施した。
前記高麗人参の種子抽出物から分離したジンセノサイドの抗酸化効能を比較するために、活性酸素種(Reactive oxygen species;ROS)除去効能実験を次のように実施した。
前記試験例1と同じ方法にてDPPH抑制効能を比較しており、本発明の一実施例である新規なジンセノサイドGS#10(高麗人参の種子抽出物から分離)を、本発明の比較例としての紅参の指標成分である3種のジンセノサイド(Rg1、Rg3、Rb1;Sigma)と比較した。このとき、前記各ジンセノサイドの濃度は1、10μMであった。前記本発明の比較例であるジンセノサイドRg3の化学構造は次のとおりである。
前記試験例2と同じ方法にて活性酸素除去能を比較しており、本発明の一実施例である新規なジンセノサイドGS#10(高麗人参の種子抽出物から分離)を、本発明の比較例として紅参の指標成分である3種のジンセノサイド(Rg1、Rg3、Rb1;Sigma)と比較した。このとき、前記各ジンセノサイドの濃度は1、10μMであった。
ジンセノサイドが細胞毒性活性を通じて抗酸化効能に影響を及ぼす可能性を排除するために、CCK(Cell Counting Kit)−8を用いて本発明の実施例である新規なジンセノサイドGS#10の存在時の細胞成長を評価した。実験方法は次のとおりである。
下記の表に記載された組成にて通常の方法に従い柔軟化粧水を製造した。
下記の表に記載された組成にて通常の方法に従い栄養化粧水を製造した。
ジンセノサイドPG−RT8 100mg、ラクトース400mg、とうもろこし澱粉400mg及びステアリン酸マグネシウム2mgを混合した後、通常の錠剤の製造方法に従い打錠して錠剤を製造した。
ジンセノサイドPG−RT8 100mg、ラクトース400mg、とうもろこし澱粉400mg及びステアリン酸マグネシウム2mgを混合した後、通常のカプセル剤の製造方法に従いゼラチンカプセルに充填してカプセル剤を製造した。
ジンセノサイドPG−RT8 50mg、無水結晶ブドウ糖250mg及び澱粉550mgを混合し、流動層造粒機を用いて顆粒に成形した後、分包に充填した。
ジンセノサイドPG−RT8 50mg、ブドウ糖10g、クエン酸0.6g、及び液状オリゴ糖25gを混合した後、精製水300mlを加えて、各瓶に200mlずつ充填する。瓶に充填した後、130℃で4〜5秒間殺菌してドリンク剤を製造した。
ジンセノサイドPG−RT8 50mg、とうもろこしシロップ(corn syrup)1.8g、脱脂牛乳0.5g、大豆レシチン0.5g、バター0.6g、植物性硬化油0.4g、砂糖1.4g、マーガリン0.58g、及び食塩20mgを混合し、キャラメル成形した。
下記の表に記載された組成にて通常の方法に従い注射剤を製造した。
Claims (9)
- (20S,24R)−6−O−β−D−グルコピラノシル(1−>2)−β−D−グルコピラノシド−ダンマル−3−オン−20,24−エポキシ−6a,12b,25−トリオール((20S,24R)−6−O−β−D−glucopyranosyl(1−>2)−β−D−glucopyranoside−dammar−3−one−20,24−epoxy−6a,12b,25−triol)、その薬学的に許容可能な塩、その水和物、又はその溶媒和物を有効成分として含む、抗酸化用組成物。
- 前記有効成分は、高麗人参の種子から抽出したものである、請求項1に記載の組成物。
- 前記有効成分は、DPPH(2,2−diphenyl−1−picrylhydrazyl)活性を抑制するものである、請求項1に記載の組成物。
- 前記有効成分は、活性酸素種(Reactive oxygen species;ROS)を除去するものである、請求項1に記載の組成物。
- 前記有効成分を、組成物の総重量に対して0.0001〜99.9重量%の範囲で含む、請求項1に記載の組成物。
- 当該組成物は、皮膚外用剤組成物である、請求項1に記載の組成物。
- 当該組成物は、化粧料組成物である、請求項1に記載の組成物。
- 当該組成物は、食品組成物である、請求項1に記載の組成物。
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JP2020079233A (ja) * | 2018-10-17 | 2020-05-28 | アモーレパシフィック コーポレーションAmorepacific Corporation | 新規なジンセノサイドを含む組成物 |
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