JP2021530487A - Ｅｐ４阻害剤およびその合成 - Google Patents

Ｅｐ４阻害剤およびその合成 Download PDF

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Publication number
JP2021530487A
JP2021530487A JP2021500587A JP2021500587A JP2021530487A JP 2021530487 A JP2021530487 A JP 2021530487A JP 2021500587 A JP2021500587 A JP 2021500587A JP 2021500587 A JP2021500587 A JP 2021500587A JP 2021530487 A JP2021530487 A JP 2021530487A
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Japan
Prior art keywords
pharmaceutically acceptable
compound
acceptable salt
cancer
compounds
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JP2021500587A
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English (en)
Japanese (ja)
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JP2021530487A5 (https=
JPWO2020014445A5 (https=
Inventor
マーク マンフレディ，
ジェフリー エクセディ，
アルフレッド シー． カストロ，
祥征 奥村
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Askat Inc
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Askat Inc
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Publication date
Application filed by Askat Inc filed Critical Askat Inc
Publication of JP2021530487A publication Critical patent/JP2021530487A/ja
Publication of JP2021530487A5 publication Critical patent/JP2021530487A5/ja
Publication of JPWO2020014445A5 publication Critical patent/JPWO2020014445A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/63—N-sulfonylisoureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021500587A 2018-07-11 2019-07-11 Ｅｐ４阻害剤およびその合成 Pending JP2021530487A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862696440P 2018-07-11 2018-07-11
US62/696,440 2018-07-11
US201862737250P 2018-09-27 2018-09-27
US62/737,250 2018-09-27
US201962834525P 2019-04-16 2019-04-16
US62/834,525 2019-04-16
PCT/US2019/041351 WO2020014445A1 (en) 2018-07-11 2019-07-11 Ep4 inhibitors and synthesis thereof

Publications (3)

Publication Number Publication Date
JP2021530487A true JP2021530487A (ja) 2021-11-11
JP2021530487A5 JP2021530487A5 (https=) 2022-07-20
JPWO2020014445A5 JPWO2020014445A5 (https=) 2022-07-20

Family

ID=69141735

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021500587A Pending JP2021530487A (ja) 2018-07-11 2019-07-11 Ｅｐ４阻害剤およびその合成

Country Status (7)

Country Link
US (2) US20210300921A1 (https=)
EP (1) EP3820469A4 (https=)
JP (1) JP2021530487A (https=)
CN (1) CN113301896A (https=)
CA (1) CA3107023A1 (https=)
IL (1) IL280051B2 (https=)
WO (1) WO2020014445A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973834B2 (en) 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
US11254675B2 (en) * 2019-08-12 2022-02-22 Cadila Healthcare Limited Process for preparation of grapiprant
CN110386941A (zh) * 2019-08-15 2019-10-29 上海邦耀生物科技有限公司 Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗
CN115697317A (zh) * 2020-04-08 2023-02-03 株式会社AskAt Ep4受体拮抗剂用于治疗肝癌、黑色素瘤、淋巴瘤和白血病的应用
TWI877433B (zh) * 2020-11-30 2025-03-21 大陸商杭州阿諾生物醫藥科技有限公司 用於治療ｐｉｋ３ｃａ突變癌症的組合療法
CN117377471A (zh) * 2021-05-28 2024-01-09 凯复(苏州)生物医药有限公司 治疗肿瘤的联合疗法
US20240343725A1 (en) * 2021-08-01 2024-10-17 Zenfold Sustainable Technologies Private Limited A process for the preparation of grapiprant and its intermediates
CN117466888A (zh) * 2023-10-30 2024-01-30 西北农林科技大学 一种1h-咪唑并[4,5-c]吡啶化合物的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006249089A (ja) * 2005-03-11 2006-09-21 Pfizer Inc 結晶形態のイミダゾール誘導体
JP2007504210A (ja) * 2003-09-03 2007-03-01 ファイザー株式会社 プロスタグランジンｅ２拮抗薬としてのフェニルまたはピリジルアミド化合物
JP2007533723A (ja) * 2004-04-20 2007-11-22 ファイザー・プロダクツ・インク α２δリガンドを含む組合せ
JP2016501241A (ja) * 2012-12-06 2016-01-18 バイエル・ファルマ・アクティエンゲゼルシャフト Ｅｐ４アンタゴニストとしての新規ベンゾイミダゾール誘導体
JP2017507161A (ja) * 2014-03-06 2017-03-16 アラタナ セラピューティクス、 インコーポレイテッド グラピプラントの結晶型
WO2018084230A1 (en) * 2016-11-04 2018-05-11 Askat Inc. Use of ep4 receptor antagonists for the treatment of nash-associated liver cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2001000224A (es) * 2000-10-19 2002-06-13 Pfizer Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos.
EP3431085B1 (en) * 2009-04-22 2023-10-11 AskAt Inc. Selective ep4 receptor antagonistic substance for treatment of cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007504210A (ja) * 2003-09-03 2007-03-01 ファイザー株式会社 プロスタグランジンｅ２拮抗薬としてのフェニルまたはピリジルアミド化合物
JP2007533723A (ja) * 2004-04-20 2007-11-22 ファイザー・プロダクツ・インク α２δリガンドを含む組合せ
JP2006249089A (ja) * 2005-03-11 2006-09-21 Pfizer Inc 結晶形態のイミダゾール誘導体
JP2016501241A (ja) * 2012-12-06 2016-01-18 バイエル・ファルマ・アクティエンゲゼルシャフト Ｅｐ４アンタゴニストとしての新規ベンゾイミダゾール誘導体
JP2017507161A (ja) * 2014-03-06 2017-03-16 アラタナ セラピューティクス、 インコーポレイテッド グラピプラントの結晶型
WO2018084230A1 (en) * 2016-11-04 2018-05-11 Askat Inc. Use of ep4 receptor antagonists for the treatment of nash-associated liver cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
医薬審発第１２１６００１号, JPN6023030362, 2002, ISSN: 0005283793 *

Also Published As

Publication number Publication date
US20240254120A1 (en) 2024-08-01
IL280051A (en) 2021-03-01
CA3107023A1 (en) 2020-01-16
US20210300921A1 (en) 2021-09-30
IL280051B1 (en) 2023-11-01
EP3820469A4 (en) 2022-04-13
CN113301896A (zh) 2021-08-24
EP3820469A1 (en) 2021-05-19
WO2020014445A1 (en) 2020-01-16
IL280051B2 (en) 2024-03-01

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