JP2021529777A - 進行非小細胞肺癌の治療のための標的ＴＧＦ−β阻害による組み合わせ療法 - Google Patents

進行非小細胞肺癌の治療のための標的ＴＧＦ−β阻害による組み合わせ療法 Download PDF

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JP2021529777A
JP2021529777A JP2020573342A JP2020573342A JP2021529777A JP 2021529777 A JP2021529777 A JP 2021529777A JP 2020573342 A JP2020573342 A JP 2020573342A JP 2020573342 A JP2020573342 A JP 2020573342A JP 2021529777 A JP2021529777 A JP 2021529777A
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seq
protein
polypeptide
nsclc
tgfβ
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JP2021529777A5 (https=
JPWO2020009992A5 (https=
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デュサール，イザベル
グレンガ，イタリア
ヴァグマイスター，ユリア
カーンデルワル，アカシュ
クリステンセン，オラフ
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メルク パテント ゲーエムベーハー
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    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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JP2020573342A 2018-07-02 2019-07-01 進行非小細胞肺癌の治療のための標的ＴＧＦ−β阻害による組み合わせ療法 Pending JP2021529777A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862693042P 2018-07-02 2018-07-02
US62/693,042 2018-07-02
US201962801014P 2019-02-04 2019-02-04
US62/801,014 2019-02-04
PCT/US2019/040129 WO2020009992A1 (en) 2018-07-02 2019-07-01 Combination therapy with targeted tgf-b inhibition for treatment of advanced non-small cell lung cancer

Publications (3)

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JP2021529777A true JP2021529777A (ja) 2021-11-04
JP2021529777A5 JP2021529777A5 (https=) 2022-07-08
JPWO2020009992A5 JPWO2020009992A5 (https=) 2022-07-08

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JP2020573342A Pending JP2021529777A (ja) 2018-07-02 2019-07-01 進行非小細胞肺癌の治療のための標的ＴＧＦ−β阻害による組み合わせ療法

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US (1) US20210115145A1 (https=)
EP (1) EP3817740A4 (https=)
JP (1) JP2021529777A (https=)
KR (1) KR20210028219A (https=)
CN (1) CN112638374A (https=)
AU (1) AU2019299318A1 (https=)
BR (1) BR112020026902A2 (https=)
CA (1) CA3105360A1 (https=)
IL (1) IL279862A (https=)
MX (1) MX2021000110A (https=)
SG (1) SG11202013190YA (https=)
TW (1) TW202019405A (https=)
WO (1) WO2020009992A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230365653A1 (en) * 2020-07-24 2023-11-16 Mabwell (shanghai) Bioscience Co., Ltd. Tgf-beta rii mutant and fusion protein thereof
CN114573701A (zh) * 2020-12-02 2022-06-03 上海华奥泰生物药业股份有限公司 抗PD-L1/TGF-β双功能抗体及其用途
WO2022171121A1 (zh) * 2021-02-10 2022-08-18 同润生物医药(上海)有限公司 治疗肿瘤的方法和组合

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2017506217A (ja) * 2014-02-10 2017-03-02 メルク パテント ゲーエムベーハー 標的ＴＧＦβ阻害
US20180118832A1 (en) * 2016-08-12 2018-05-03 Merck Patent Gmbh Combination therapy for cancer

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Publication number Priority date Publication date Assignee Title
US20130110045A1 (en) * 2011-10-31 2013-05-02 Ming-Yuan Wu Single use intravenous therapy administering device with needle safety covers
CN109640988A (zh) * 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
WO2018129331A1 (en) * 2017-01-07 2018-07-12 Merck Patent Gmbh Dosing regimens and dosage forms for targeted tgf-b inhibition
EP3806842A4 (en) * 2018-06-13 2022-03-16 Merck Patent GmbH Treatment of stage iii nsclc and mitigation of pathological conditions associated with the treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017506217A (ja) * 2014-02-10 2017-03-02 メルク パテント ゲーエムベーハー 標的ＴＧＦβ阻害
US20180118832A1 (en) * 2016-08-12 2018-05-03 Merck Patent Gmbh Combination therapy for cancer

Non-Patent Citations (4)

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Title
CANCER RES. (2017) VOL.77, ISSUE 13 SUPPL., ABSTRACT 611, <HTTPS://AACRJOURNALS.ORG/CANCERRES/ARTICL, JPN6023009221, ISSN: 0005285637 *
J. CLIN. ONCOL., vol. vol.36, no.15 suppl., JPN6023035453, June 2018 (2018-06-01), pages 2566, ISSN: 0005285640 *
J. IMMUNOTHER. CANCER (2017) VOL.5, SUPPL.2, 86, P.7-8(O14), JPN6023009219, ISSN: 0005285639 *
ONCOIMMUNOLOGY (2017) VOL.6, NO.10, E1349589, P.1-16, JPN6023009220, ISSN: 0005285638 *

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Publication number Publication date
CA3105360A1 (en) 2020-01-09
KR20210028219A (ko) 2021-03-11
WO2020009992A8 (en) 2020-08-13
CN112638374A (zh) 2021-04-09
US20210115145A1 (en) 2021-04-22
MX2021000110A (es) 2021-03-09
IL279862A (en) 2021-03-01
SG11202013190YA (en) 2021-01-28
AU2019299318A1 (en) 2021-01-21
TW202019405A (zh) 2020-06-01
BR112020026902A2 (pt) 2021-03-30
EP3817740A1 (en) 2021-05-12
EP3817740A4 (en) 2022-04-13
WO2020009992A1 (en) 2020-01-09

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