JP2021529559A - グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 - Google Patents

グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 Download PDF

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JP2021529559A
JP2021529559A JP2021522932A JP2021522932A JP2021529559A JP 2021529559 A JP2021529559 A JP 2021529559A JP 2021522932 A JP2021522932 A JP 2021522932A JP 2021522932 A JP2021522932 A JP 2021522932A JP 2021529559 A JP2021529559 A JP 2021529559A
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cells
polypeptide
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immune cell
glucose
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マクギネス キャスリーン
エッテンバーグ セス
バロン ルーク
フレイ マイケル
ウィルソン チャールズ
モッツ グレゴリー
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ソティオ，リミティド ライアビリティ カンパニー
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JP2021522932A 2018-07-03 2019-07-02 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用 Pending JP2021529559A (ja)

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JP2024076738A JP2024102286A (ja) 2018-07-03 2024-05-09 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用

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US201862693677P 2018-07-03 2018-07-03
US201862693668P 2018-07-03 2018-07-03
US62/693,677 2018-07-03
US62/693,668 2018-07-03
US201862713369P 2018-08-01 2018-08-01
US62/713,369 2018-08-01
US201862756698P 2018-11-07 2018-11-07
US201862756664P 2018-11-07 2018-11-07
US62/756,664 2018-11-07
US62/756,698 2018-11-07
PCT/US2019/040346 WO2020010110A1 (en) 2018-07-03 2019-07-02 Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof

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JP2024076738A Pending JP2024102286A (ja) 2018-07-03 2024-05-09 グルコース輸入を向上させるトランス代謝分子と組み合わせたキメラ受容体及びその治療的使用

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JP7685726B1 (ja) * 2024-01-09 2025-05-30 国立研究開発法人国立がん研究センター サバイバーｔ細胞、サバイバーｔ細胞集団および医薬組成物
WO2025150523A1 (ja) * 2024-01-09 2025-07-17 国立研究開発法人国立がん研究センター オンデマンドにグルコース取り込み能が強化されたｔ細胞、細胞集団およびそれを含む医薬組成物

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WO2020037066A1 (en) 2018-08-14 2020-02-20 Unum Therapeutics Inc. Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
WO2021154218A1 (en) * 2020-01-28 2021-08-05 Nantkwest, Inc. Chimeric antigen receptor-modified nk-92 cells targeting egfr super-family receptors
EP4178974A4 (en) * 2020-07-09 2024-10-30 The Board of Trustees of the Leland Stanford Junior University IMMUNE CELLS WITH INCREASED GLYCOLYTIC FLOW
WO2022140361A1 (en) * 2020-12-22 2022-06-30 Ludwig Institute For Cancer Research Ltd Genetically engineered lymphocytes for adoptive cell therapy
US20240108652A1 (en) * 2021-02-18 2024-04-04 University Of Florida Research Foundation, Incorporated Enhancing metabolic fitness of t cells to treat cancer
US20240197881A1 (en) * 2021-04-23 2024-06-20 Sorrento Therapeutics, Inc. Dimeric Antigen Receptors (DARs) that Bind GD2
MX2024004009A (es) * 2021-09-27 2024-06-19 Sotio Biotech Inc Polipéptidos receptores quiméricos en combinación con moléculas transmetabólicas que redirigen metabolitos de glucosa fuera de la vía de la glucólisis y usos terapéuticos de estos.
EP4429676A4 (en) * 2021-11-08 2025-08-20 Memorial Sloan Kettering Cancer Center IMMUNE CELLS EXPRESSING GLUCOSE TRANSPORTER 5 (GLUT5) AND COMPOSITIONS AND METHODS COMPRISING SAME
CA3237201A1 (en) 2021-11-16 2023-05-25 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients
GB202118201D0 (en) 2021-12-15 2022-01-26 King S College London Engineered immune cell
US20250382382A1 (en) * 2022-03-08 2025-12-18 Synthekine, Inc. Orthogonal gpc3 chimeric antigen receptor t cells
CN115678856A (zh) * 2022-06-09 2023-02-03 郑州大学第一附属医院 一种肿瘤杀伤细胞及其应用
WO2024040207A1 (en) 2022-08-19 2024-02-22 Sotio Biotech Inc. Genetically engineered natural killer (nk) cells with chimeric receptor polypeptides in combination with trans metabolism molecules and therapeutic uses thereof
US20260053924A1 (en) 2022-08-19 2026-02-26 Sotio Biotech Inc. Genetically engineered immune cells with chimeric receptor polypeptides in combination with multiple trans metabolism molecules and therapeutic uses thereof
WO2024215987A1 (en) 2023-04-14 2024-10-17 Sotio Biotech Inc. IMMUNE CELLS FOR TREATING CANCER IN COMBINATION WITH IL-15/IL-15Rα CONJUGATES
EP4694916A1 (en) 2023-04-14 2026-02-18 SOTIO Biotech Inc. Engineered immune cells for treating cancer in combination with il-2/il-15 receptor ?? agonists

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