JP2021529325A - 伝導度センサを含む流体チャネルおよびその使用方法 - Google Patents
伝導度センサを含む流体チャネルおよびその使用方法 Download PDFInfo
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Abstract
Description
本出願は、開示が参照により本明細書に組込まれている2018年7月6日出願の米国仮特許出願第62/694,621号、2018年7月6日出願の米国仮特許出願第62/694,594号および2018年7月6日出願の米国仮特許出願第62/694,599号の利益を共に主張する2019年9月1日出願の米国特許出願第16/120,224号および2018年9月1日出願の米国特許出願第16/120,225号の利益を主張するものである。
Claims (20)
- 少なくとも1つの流体チャネルと;
流体アクチュエータと;
前記流体チャネル内部に配置された分析センサと;
前記流体チャネル内部に配置された伝導度センサと;
イントロデューサと;
を含む第1の部分、および、
少なくとも1つの材料を封入する少なくとも1つのウェル;
を含む第2の部分、
を含むデバイスにおいて、
前記第1または第2の部分のうちの一方が他方との関係において移動可能であり、前記イントロデューサが、前記少なくとも1つのウェルから前記材料の少なくとも一部分を得、それを前記流体チャネルに送出するように構成されており、前記流体アクチュエータが、前記流体チャネル内の前記材料の少なくとも一部分を移動させるように構成されている、デバイス。 - 前記分析センサが共振器センサである、請求項1に記載のデバイス。
- 前記共振センサがバルク音響波(BAW)センサである、請求項2に記載のデバイス。
- 前記伝導度センサが前記分析センサの上流側に位置設定されている、請求項1から3のいずれか一つに記載のデバイス。
- 前記伝導度センサが2つの電極を含む、請求項1ないし3のいずれか1項に記載のデバイス。
- 前記2つの電極が金を含む、請求項5に記載のデバイス。
- 少なくとも1つの流体チャネルと;
流体アクチュエータと;
前記流体チャネル内部に配置された分析センサと;
前記流体チャネル内部に配置された伝導度センサと;
イントロデューサと;
を含む第1の部分、および、
少なくとも1つの材料を封入する少なくとも1つのウェル;
を含む第2の部分、
を含むシステムであって、
前記第1または第2の部分のうちの一方が他方との関係において移動可能であり、前記イントロデューサが、前記少なくとも1つのウェルから前記材料の少なくとも一部分を得、それを前記流体チャネルに送出するように構成されており、前記流体アクチュエータが、前記流体チャネル内の前記材料の少なくとも一部分を移動させるように構成されているシステムの、
使用方法において、
前記伝導度センサの抵抗を監視するステップと;
前記流体チャネル内部で液体を移動させるステップと;
前記伝導度センサの前記抵抗の変化を監視するステップと;
を含む方法。 - 前記流体チャネル内部で液体を移動させるステップが、前記流体チャネル内の液体の流れを開始させるステップを含む、請求項7に記載の方法。
- 前記伝導度センサの前記抵抗の変化を監視するステップが、前記伝導度センサの前記抵抗の低下を監視するステップを含む、請求項7または8のいずれか1項に記載の方法。
- 前記抵抗の前記低下がひとたび監視された時点で前記流体チャネル内の前記液体の前記流れを停止するステップをさらに含む、請求項9に記載の方法。
- 前記流体チャネル内で前記液体を移動させる前記ステップが第1の流速を有し、前記抵抗の低下が第2の流速で監視された後に前記流体チャネル内の前記流体の前記流れを逆転させるステップがさらに含まれ、前記第2の流速が前記第1の流速よりも低い、請求項10に記載の方法。
- 流体の前記流れがひとたび停止された時点で前記流体チャネルを通気するステップをさらに含む、請求項10に記載の方法。
- 少なくとも1つの流体チャネルと;
流体アクチュエータと;
前記流体チャネルの内部に配置された分析センサと;
前記流体チャネル内部に配置された伝導度センサと;
イントロデューサと;
を含む第1の部分、および、
少なくとも1つの材料を封入する少なくとも1つのウェル;
を含む第2の部分、
を含むシステムであって、
前記第1または第2の部分のうちの一方が他方との関係において移動可能であり、前記イントロデューサが、前記少なくとも1つのウェルから前記材料の少なくとも一部分を得、それを前記流体チャネルに送出するように構成されており、前記流体アクチュエータが、前記流体チャネル内の前記材料の少なくとも一部分を移動させるように構成されているシステム、
の利用方法において、
前記伝導度センサにおける抵抗を監視するステップと;
前記流体チャネル内部の流体の流れを開始させるステップであって、ここで前記流れが1つの流速を有しているステップと;
前記抵抗が実質的に恒常な値に維持された時間を決定するステップと;
前記抵抗が実質的に恒常な値に維持された前記時間と前記液体の前記流速に少なくとも基づいて、前記流体チャネルの少なくとも一部分の中の流体の体積を決定するステップと;
を含む方法。 - 前記流体チャネル内部の圧力を監視するステップをさらに含む、請求項13に記載の方法。
- 前記流体体積を決定するステップが同様に、前記流体チャネル内部の圧力データに基づいている、請求項14に記載の方法。
- 前記流体体積を第2の流体の公知の体積に加えるステップをさらに含む、請求項13ないし15のいずれか1項に記載の方法。
- 前記監視ステップを反復するステップ、第2の液体の流れを開始させるステップ、前記時間を決定する前記ステップを反復するステップ、および前記抵抗が実質的に恒常な値に維持された前記時間と前記第2の液体の前記流速に少なくとも基づいて前記第2の液体の前記体積を決定するステップをさらに含む、請求項13ないし15のいずれか1項に記載の方法。
- 前記第2の液体が前記第1の液体と組合わされる、請求項17に記載の方法。
- 前記チャネルの幾何形状、前記チャネル内の圧力、前記流体の流速、流体抵抗、流体が移動させられた時間またはそれらの何らかの組合せを推定するステップをさらに含む、請求項18に記載の方法。
- 第2の液体の前記公知の体積に対して前記第1の液体の2アリコートが添加されるように前記抵抗を監視するステップ、前記流体の流れを開始させるステップおよび前記体積を決定するステップを少なくとも一回反復するステップをさらに含む、請求項16に記載の方法。
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