JP2021529176A5 - - Google Patents
Info
- Publication number
- JP2021529176A5 JP2021529176A5 JP2020571580A JP2020571580A JP2021529176A5 JP 2021529176 A5 JP2021529176 A5 JP 2021529176A5 JP 2020571580 A JP2020571580 A JP 2020571580A JP 2020571580 A JP2020571580 A JP 2020571580A JP 2021529176 A5 JP2021529176 A5 JP 2021529176A5
- Authority
- JP
- Japan
- Prior art keywords
- scfv
- cd3zeta
- antibody
- virus
- intracellular region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810636414.1A CN110615843B (zh) | 2018-06-20 | 2018-06-20 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| CN201810636414.1 | 2018-06-20 | ||
| PCT/CN2019/077923 WO2019242339A1 (zh) | 2018-06-20 | 2019-03-13 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529176A JP2021529176A (ja) | 2021-10-28 |
| JP2021529176A5 true JP2021529176A5 (https=) | 2023-05-23 |
| JP7433656B2 JP7433656B2 (ja) | 2024-02-20 |
Family
ID=68920806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020571580A Active JP7433656B2 (ja) | 2018-06-20 | 2019-03-13 | 第３シグナル受容体を含むキメラ抗原受容体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11524034B2 (https=) |
| EP (1) | EP3812401A4 (https=) |
| JP (1) | JP7433656B2 (https=) |
| KR (1) | KR102853978B1 (https=) |
| CN (3) | CN110615843B (https=) |
| WO (1) | WO2019242339A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
| CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| WO2021207150A1 (en) * | 2020-04-06 | 2021-10-14 | Celledit Llc | Genetically modified immune cells expressing a chimeric antigen receptor and having reduced proinflammatory cytokine signaling |
| CN111518219B (zh) * | 2020-05-08 | 2021-06-22 | 浙江大学 | 嵌合性抗原受体及表达其的巨噬细胞、调节巨噬细胞极化的方法和应用 |
| CN112062864A (zh) * | 2020-09-18 | 2020-12-11 | 樊克兴 | 靶向bcma肿瘤抗原受体修饰t细胞的制备方法和应用 |
| CN114853900A (zh) * | 2021-02-03 | 2022-08-05 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| WO2023274355A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海交通大学 | 改造的间充质干细胞和免疫效应细胞联合治疗肿瘤 |
| EP4402160A4 (en) * | 2021-09-17 | 2025-11-19 | Univ Pennsylvania | CHIMERIC ANTIGENIC RECEPTORS COMPRISING AN INTERLEUKIN-9 RECEPTOR SIGNALING DOMAIN |
| AU2022348588A1 (en) | 2021-09-17 | 2024-04-04 | Parker Institute For Cancer Immunotherapy | Switch receptors using il-9 signaling domains |
| KR20250112314A (ko) * | 2022-01-10 | 2025-07-23 | 페노믹 에이아이 | 항-콜라겐 삼중 나선 반복 함유 1(cthrc1) 항체 및 이를 사용하는 방법 |
| CN120225568A (zh) * | 2022-12-27 | 2025-06-27 | 广州瑞风生物科技有限公司 | 一种融合蛋白及其应用 |
| WO2025039159A1 (en) * | 2023-08-21 | 2025-02-27 | Hangzhou Hervor Therapeutics Co., Ltd | Synthetic cytokine signaling system, preparation method, and uses thereof |
| CN117402231B (zh) * | 2023-12-14 | 2024-04-09 | 南方医科大学南方医院 | 一种自发传递il-21信号的受体及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2832569A1 (en) * | 2011-04-08 | 2012-10-11 | Baylor College Of Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| MX370148B (es) * | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| CN106279434B (zh) * | 2014-02-24 | 2020-07-03 | 西比曼生物科技（上海）有限公司 | 工程化cd20靶向性的nkt细胞及其制备方法和应用 |
| WO2016127257A1 (en) * | 2015-02-12 | 2016-08-18 | University Health Network | Chimeric antigen receptors |
| WO2016134284A1 (en) | 2015-02-19 | 2016-08-25 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| IL315940A (en) * | 2015-07-28 | 2024-11-01 | Univ Pennsylvania | Altered monocytes/macrophages expressing chimeric antigen receptors and their uses |
| GB201514875D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| GB201518816D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| ES2891578T3 (es) * | 2016-04-01 | 2022-01-28 | Kite Pharma Inc | Antígeno quimérico y receptores de células T y métodos de uso |
| CN105949317B (zh) * | 2016-04-12 | 2019-07-02 | 上海优卡迪生物医药科技有限公司 | 抗cd20嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用 |
| CN105777911B (zh) * | 2016-04-12 | 2019-07-02 | 上海优卡迪生物医药科技有限公司 | 抗bcma嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用 |
| WO2017184901A1 (en) * | 2016-04-20 | 2017-10-26 | Fred Hutchinson Cancer Research Center | Immunomodulatory il2r fusion proteins and uses thereof |
| CN106397608A (zh) * | 2016-10-19 | 2017-02-15 | 中国医学科学院血液病医院（血液学研究所） | Cd20特异性嵌合抗原受体及其应用 |
| MA46862A (fr) | 2016-11-17 | 2019-09-25 | Bluebird Bio Inc | Convertisseur de signaux tgf béta |
| WO2018103734A1 (zh) * | 2016-12-09 | 2018-06-14 | 北京中捭生物科技有限公司 | 嵌合抗原受体及其用途和制备方法 |
| CN107058234B (zh) * | 2017-05-12 | 2019-09-13 | 常州市第一人民医院 | Car.il-33-t及其制备与应用 |
| CN107245106B (zh) * | 2017-07-18 | 2020-06-12 | 深圳市免疫基因治疗研究院 | 一种基于cd10的嵌合抗原受体及其应用 |
| CN107400168B (zh) * | 2017-07-18 | 2020-02-07 | 深圳市免疫基因治疗研究院 | 一种基于cd117的嵌合抗原受体及其应用 |
| CN107384870A (zh) * | 2017-07-31 | 2017-11-24 | 时力生物科技（北京）有限公司 | 一种靶向pd‑l1嵌合抗原受体修饰的t淋巴细胞及其制备方法和应用 |
| CN110615843B (zh) * | 2018-06-20 | 2023-05-09 | 上海隆耀生物科技有限公司 | 一种包含第三信号受体的嵌合抗原受体及其应用 |
-
2018
- 2018-06-20 CN CN201810636414.1A patent/CN110615843B/zh active Active
-
2019
- 2019-03-13 WO PCT/CN2019/077923 patent/WO2019242339A1/zh not_active Ceased
- 2019-03-13 EP EP19823459.3A patent/EP3812401A4/en active Pending
- 2019-03-13 JP JP2020571580A patent/JP7433656B2/ja active Active
- 2019-03-13 KR KR1020217001094A patent/KR102853978B1/ko active Active
- 2019-03-13 CN CN202210196195.6A patent/CN114516922A/zh active Pending
- 2019-03-13 CN CN201980041282.0A patent/CN112673025B/zh active Active
-
2020
- 2020-12-18 US US17/127,283 patent/US11524034B2/en active Active
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