|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
WO1995013365A1
(en)
|
1993-11-09 |
1995-05-18 |
Targeted Genetics Corporation |
Generation of high titers of recombinant aav vectors
|
|
PT728214E
(pt)
|
1993-11-09 |
2004-11-30 |
Ohio Med College |
Linhas celulares estaveis capazes de expressar o gene de replicacao do virus adeno-associado
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
CA2207927A1
(en)
|
1994-12-06 |
1996-06-13 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
FR2737730B1
(fr)
|
1995-08-10 |
1997-09-05 |
Pasteur Merieux Serums Vacc |
Procede de purification de virus par chromatographie
|
|
WO1997008298A1
(en)
|
1995-08-30 |
1997-03-06 |
Genzyme Corporation |
Chromatographic purification of adenovirus and aav
|
|
US6632670B1
(en)
|
1995-09-08 |
2003-10-14 |
Genzyme Corporation |
AAV vectors for gene therapy
|
|
US5795872A
(en)
|
1995-09-19 |
1998-08-18 |
Pharmadigm, Inc. |
DNA construct for immunization
|
|
US5910434A
(en)
|
1995-12-15 |
1999-06-08 |
Systemix, Inc. |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
|
|
JP2001500497A
(ja)
|
1996-09-06 |
2001-01-16 |
トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスに指図される遺伝子治療の方法
|
|
US5965542A
(en)
|
1997-03-18 |
1999-10-12 |
Inex Pharmaceuticals Corp. |
Use of temperature to control the size of cationic liposome/plasmid DNA complexes
|
|
JP4119607B2
(ja)
|
1997-08-15 |
2008-07-16 |
チッソ株式会社 |
多分散性プロピレン重合体およびその製造方法
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
DK1009808T3
(da)
|
1997-09-05 |
2013-01-21 |
Genzyme Corp |
Fremgangsmåder til generering af hjælper-frie præparater af rekombinante aav-vektorer med høj titer
|
|
US6410328B1
(en)
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
|
CA2321837C
(en)
|
1998-02-03 |
2011-08-16 |
Inex Pharmaceuticals Corporation |
Systemic delivery of serum stable plasmid lipid particles for cancer therapy
|
|
JPH11318467A
(ja)
|
1998-05-08 |
1999-11-24 |
Japan Science & Technology Corp |
短縮型ジストロフィン
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6211140B1
(en)
|
1999-07-26 |
2001-04-03 |
The Procter & Gamble Company |
Cationic charge boosting systems
|
|
US7056502B2
(en)
|
2000-04-28 |
2006-06-06 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
|
|
ES2330615T3
(es)
|
2000-04-28 |
2009-12-14 |
Asklepios Biopharmaceutical, Inc. |
Secuencias de adn que codifican para minigenes de distrofina y metodos de uso de las mismas.
|
|
ATE373095T1
(de)
|
2000-07-14 |
2007-09-15 |
Univ Michigan |
Mutierte muskelspezifische enhancer
|
|
EP1366160B1
(en)
|
2000-10-06 |
2008-07-09 |
The Regents Of The University Of Michigan |
Mini-dystrophin nucleic acid and peptide sequences
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20060194265A1
(en)
|
2001-10-23 |
2006-08-31 |
Morris David W |
Novel therapeutic targets in cancer
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
EP1519714B1
(en)
|
2002-06-28 |
2010-10-20 |
Protiva Biotherapeutics Inc. |
Method and apparatus for producing liposomes
|
|
CA2532228C
(en)
|
2003-07-16 |
2017-02-14 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
US6927663B2
(en)
|
2003-07-23 |
2005-08-09 |
Cardiac Pacemakers, Inc. |
Flyback transformer wire attach method to printed circuit board
|
|
EP1664316B1
(en)
|
2003-09-15 |
2012-08-29 |
Protiva Biotherapeutics Inc. |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
|
CA2554818A1
(en)
|
2004-02-09 |
2005-08-25 |
Thomas Jefferson University |
Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
|
|
US20070053845A1
(en)
|
2004-03-02 |
2007-03-08 |
Shiladitya Sengupta |
Nanocell drug delivery system
|
|
JP4764426B2
(ja)
|
2004-06-07 |
2011-09-07 |
プロチバ バイオセラピューティクス インコーポレイティッド |
カチオン性脂質および使用方法
|
|
CA2569664C
(en)
|
2004-06-07 |
2013-07-16 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
US20080044393A1
(en)
|
2004-07-16 |
2008-02-21 |
White Robert L |
Retinal dystrophin transgene and methods of use thereof
|
|
CN101267805A
(zh)
|
2005-07-27 |
2008-09-17 |
普洛体维生物治疗公司 |
制造脂质体的系统和方法
|
|
WO2007095387A2
(en)
|
2006-02-17 |
2007-08-23 |
Dharmacon, Inc. |
Compositions and methods for inhibiting gene silencing by rna interference
|
|
US9149564B2
(en)
|
2006-06-23 |
2015-10-06 |
The Regents Of The University Of California |
Articles comprising large-surface-area bio-compatible materials and methods for making and using them
|
|
CN101711164B
(zh)
|
2007-01-18 |
2014-06-04 |
密苏里-哥伦比亚大学 |
可修复肌纤维膜中的神经元型一氧化氮合酶的合成小/微-抗肌萎缩蛋白基因
|
|
EP2182969B1
(en)
|
2007-07-31 |
2016-11-16 |
The Board of Regents of The University of Texas System |
A micro-rna family that modulates fibrosis and uses thereof
|
|
ES2639852T3
(es)
|
2007-10-26 |
2017-10-30 |
Academisch Ziekenhuis Leiden |
Medios y métodos para contrarrestar los trastornos musculares
|
|
WO2009086558A1
(en)
|
2008-01-02 |
2009-07-09 |
Tekmira Pharmaceuticals Corporation |
Improved compositions and methods for the delivery of nucleic acids
|
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
|
US8236557B2
(en)
|
2008-05-28 |
2012-08-07 |
University Of Missouri-Columbia |
Hybrid-AAV vectors to deliver large gene expression cassette
|
|
CN111808084A
(zh)
|
2008-11-10 |
2020-10-23 |
阿布特斯生物制药公司 |
用于递送治疗剂的新型脂质和组合物
|
|
WO2010071454A1
(en)
|
2008-12-17 |
2010-06-24 |
Auckland Uniservices Limited |
Adeno-associated viral vectors and uses thereof
|
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011000107A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
|
WO2011004395A1
(en)
|
2009-07-06 |
2011-01-13 |
Intas Biopharmaceuticals Limited |
Microemulsion formulation for biologicals
|
|
WO2011066651A1
(en)
|
2009-12-01 |
2011-06-09 |
Protiva Biotherapeutics, Inc. |
Snalp formulations containing antioxidants
|
|
EP3296398A1
(en)
|
2009-12-07 |
2018-03-21 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
|
EP3494963A1
(en)
|
2009-12-18 |
2019-06-12 |
The University of British Columbia |
Methods and compositions for delivery of nucleic acids
|
|
CA2800497C
(en)
|
2010-05-10 |
2019-03-12 |
The Regents Of The University Of California |
Methods for preparing ratiometric combinatorial nanoparticules
|
|
US20130123338A1
(en)
|
2010-05-12 |
2013-05-16 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
KR20190039347A
(ko)
|
2010-06-03 |
2019-04-10 |
알닐람 파마슈티칼스 인코포레이티드 |
활성제의 전달을 위한 생분해성 지질
|
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
CA2824526C
(en)
|
2011-01-11 |
2020-07-07 |
Alnylam Pharmaceuticals, Inc. |
Pegylated lipids and their use for drug delivery
|
|
US8691750B2
(en)
|
2011-05-17 |
2014-04-08 |
Axolabs Gmbh |
Lipids and compositions for intracellular delivery of biologically active compounds
|
|
WO2013016126A1
(en)
|
2011-07-22 |
2013-01-31 |
The General Hospital Corporation |
Therapeutic nanoparticles and methods of use thereof
|
|
WO2013016058A1
(en)
|
2011-07-22 |
2013-01-31 |
Merck Sharp & Dohme Corp. |
Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
|
|
EP2736539B1
(en)
|
2011-07-25 |
2017-08-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
EP3456317B1
(en)
|
2011-09-27 |
2025-09-24 |
Alnylam Pharmaceuticals, Inc. |
Di-aliphatic substituted pegylated lipids
|
|
US8762704B2
(en)
|
2011-09-29 |
2014-06-24 |
Apple Inc. |
Customized content for electronic devices
|
|
WO2013075008A1
(en)
|
2011-11-16 |
2013-05-23 |
University Of Florida Research Foundation Inc. |
Aav dual vector systems for gene therapy
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
AU2012347605B2
(en)
|
2011-12-07 |
2017-09-21 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
|
WO2013086354A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
CA3018046A1
(en)
|
2011-12-16 |
2013-06-20 |
Moderna Therapeutics, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
|
WO2013102904A1
(en)
|
2012-01-05 |
2013-07-11 |
Hadasit Medical Research Services & Development Ltd. |
Methods and compositions for gene delivery
|
|
MX367100B
(es)
|
2012-02-17 |
2019-08-05 |
The Children´S Hospital Of Philadelphia |
Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos.
|
|
DE102012007232B4
(de)
|
2012-04-07 |
2014-03-13 |
Susanne Weller |
Verfahren zur Herstellung von rotierenden elektrischen Maschinen
|
|
WO2014008334A1
(en)
|
2012-07-06 |
2014-01-09 |
Alnylam Pharmaceuticals, Inc. |
Stable non-aggregating nucleic acid lipid particle formulations
|
|
US9624282B2
(en)
|
2012-11-26 |
2017-04-18 |
The Curators Of The University Of Missouri |
Microdystrophin peptides and methods for treating muscular dystrophy using the same
|
|
MX388221B
(es)
|
2013-04-20 |
2025-03-19 |
Res Institute At Nationwide Children´S Hospital |
ADMINISTRACIÓN DE VIRUS ADENO-ASOCIADO RECOMBINANTE DE CONSTRUCCIONES DE POLINUCLÉOTIDOS U7snRNA DIRIGIDA AL EXÓN 2.
|
|
JP2015092462A
(ja)
|
2013-09-30 |
2015-05-14 |
Tdk株式会社 |
正極及びそれを用いたリチウムイオン二次電池
|
|
GB201400598D0
(en)
|
2014-01-14 |
2014-03-05 |
Univ Glasgow |
Materials and methods for modulation of tendon healing
|
|
PL3097197T3
(pl)
|
2014-01-21 |
2021-06-28 |
Vrije Universiteit Brussel |
Mięśniowo-specyficzne elementy regulatorowe kwasów nukleinowych oraz sposoby i ich zastosowanie
|
|
WO2015141521A1
(ja)
|
2014-03-21 |
2015-09-24 |
株式会社日立国際電気 |
基板処理装置、半導体装置の製造方法及び記録媒体
|
|
WO2015157306A1
(en)
|
2014-04-09 |
2015-10-15 |
University Of Houston |
Therapeutic mirnas for treating heart and skeletal muscle diseases
|
|
WO2015161255A1
(en)
|
2014-04-18 |
2015-10-22 |
Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno |
Methods for enhancing or decreasing the levels of mir124 and mir29 in subjects with muscular dystrophy
|
|
HUE060907T2
(hu)
|
2014-06-25 |
2023-04-28 |
Acuitas Therapeutics Inc |
Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére
|
|
EP2960336A1
(en)
|
2014-06-27 |
2015-12-30 |
Genethon |
Efficient systemic treatment of dystrophic muscle pathologies
|
|
CA2957661A1
(en)
|
2014-08-09 |
2016-02-18 |
Kevin FLANIGAN |
Methods and materials for activating an internal ribosome entry site in exon 5 of the dmd gene
|
|
JP6197169B2
(ja)
|
2014-09-29 |
2017-09-20 |
東芝メモリ株式会社 |
半導体装置の製造方法
|
|
JP6832280B2
(ja)
|
2015-01-16 |
2021-02-24 |
ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ |
新規のマイクロジストロフィンおよび使用の関連する方法
|
|
GB201507842D0
(en)
|
2015-05-07 |
2015-06-17 |
New Royal Holloway & Bedford |
Production of large-sized microdystrophins in an AAV-based vector configuration
|
|
PT3313829T
(pt)
|
2015-06-29 |
2024-07-08 |
Acuitas Therapeutics Inc |
Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos
|
|
IL258005B2
(en)
|
2015-09-17 |
2025-01-01 |
Res Inst Nationwide Childrens Hospital |
Methods and materials for gene therapy for beta-4,1-N-acetylgalactosaminyltransferase 2
|
|
HRP20230209T1
(hr)
|
2015-10-28 |
2023-04-14 |
Acuitas Therapeutics Inc. |
Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
|
|
ES3034857T3
(en)
|
2015-11-12 |
2025-08-25 |
The Res Institute At Nationwide Childrens Hospital |
Methods of treating muscular dystrophy
|
|
WO2017117528A1
(en)
|
2015-12-30 |
2017-07-06 |
Acuitas Therapeutics, Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
ES2977730T3
(es)
|
2016-04-15 |
2024-08-29 |
Res Inst Nationwide Childrens Hospital |
Administración de microARN-29 y micro-distrofina por virus adenoasociado para tratar la distrofia muscular
|
|
LT3442600T
(lt)
*
|
2016-04-15 |
2024-05-27 |
Research Institute At Nationwide Children's Hospital |
Su adeno virusu susijusio viruso vektoriaus iš β-sarkoglikano ir mikro- rnr-29 pristatymas ir raumenų distrofijos gydymas
|
|
CA2971303C
(en)
|
2016-06-21 |
2026-03-03 |
Bamboo Therapeutics, Inc. |
Optimized mini-dystrophin genes and expression cassettes and their use
|
|
JP7676111B2
(ja)
*
|
2017-03-17 |
2025-05-14 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーを治療するための筋肉特異的マイクロジストロフィンのアデノ随伴ウイルスベクター送達
|
|
EP3596112A2
(en)
|
2017-03-17 |
2020-01-22 |
Newcastle University |
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
|
|
CN107369008A
(zh)
|
2017-07-17 |
2017-11-21 |
北京京东金融科技控股有限公司 |
用于提高票据交易安全性的管理方法、装置及系统
|
|
US20200164008A1
(en)
|
2017-07-17 |
2020-05-28 |
Spark Therapeutics, Inc. |
Apheresis methods and uses
|
|
MA50836A
(fr)
|
2017-10-18 |
2020-08-26 |
Res Inst Nationwide Childrens Hospital |
Administration par vecteur à virus adéno-associé de micro-dystrophine spécifique de muscles pour traiter la dystrophie musculaire
|
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
|
AR114350A1
(es)
|
2018-01-31 |
2020-08-26 |
Res Institute At Nationwide ChildrenS Hospital |
Terapia genética para la distrofia muscular de cinturas del tipo 2c
|
|
WO2019177550A1
(en)
|
2018-03-10 |
2019-09-19 |
Koc Universitesi |
Therapeutic nanoparticles containing argonaute for microrna delivery and compositions and methods using same
|
|
US20210139550A1
(en)
|
2018-04-03 |
2021-05-13 |
Curators Of The University Of Missouri |
Hinges 1 and/or 4 modified dystrophins for dystrophinopathy therapy
|
|
US12152242B2
(en)
|
2018-04-23 |
2024-11-26 |
The Curators Of The University Of Missouri |
CRISPR therapy
|
|
MY208145A
(en)
|
2018-06-18 |
2025-04-18 |
Res Inst Nationwide Childrens Hospital |
Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy
|
|
KR20210028162A
(ko)
|
2018-06-29 |
2021-03-11 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
지대근 이영양증 2a형을 치료하기 위한 재조합 아데노 연관 바이러스 생성물 및 방법
|
|
CA3116576A1
(en)
|
2018-10-18 |
2020-04-23 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
WO2020123645A1
(en)
|
2018-12-12 |
2020-06-18 |
Solid Biosciences Inc. |
Combination therapy for treating muscular dystrophy
|
|
AU2020229340A1
(en)
|
2019-02-26 |
2021-09-16 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of B-sarcoglycan and the treatment of muscular dystrophy
|
|
RS65421B1
(sr)
|
2019-08-21 |
2024-05-31 |
Res Inst Nationwide Childrens Hospital |
Isporuka adeno-asociranog virusnog vektora alfa-sarkoglikana i lečenje mišićne distrofije
|
|
US12391745B2
(en)
|
2020-06-15 |
2025-08-19 |
Sarepta Therapeutics, Inc. |
Adeno-associated virus antibodies and fragments thereof
|