JP2021525738A - 複素環誘導体及びその使用 - Google Patents
複素環誘導体及びその使用 Download PDFInfo
- Publication number
- JP2021525738A JP2021525738A JP2020566706A JP2020566706A JP2021525738A JP 2021525738 A JP2021525738 A JP 2021525738A JP 2020566706 A JP2020566706 A JP 2020566706A JP 2020566706 A JP2020566706 A JP 2020566706A JP 2021525738 A JP2021525738 A JP 2021525738A
- Authority
- JP
- Japan
- Prior art keywords
- pyrazine
- pyrido
- bromo
- mmol
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *c(cc1N(C2)C3=NC2=O)cnc1N=C3N1CC(CCC2)N2CC1 Chemical compound *c(cc1N(C2)C3=NC2=O)cnc1N=C3N1CC(CCC2)N2CC1 0.000 description 1
- LXKHRWSUVGRSGS-UHFFFAOYSA-N CN(CC1)CCN1C1=Nc(ncc(Br)c2)c2N(C(N)=O)C1=N Chemical compound CN(CC1)CCN1C1=Nc(ncc(Br)c2)c2N(C(N)=O)C1=N LXKHRWSUVGRSGS-UHFFFAOYSA-N 0.000 description 1
- YHXOULSAORZYSW-UHFFFAOYSA-N CNC(C1)CN1C1=Nc(ccc(Br)c2)c2N(C2)C1=NC2=O Chemical compound CNC(C1)CN1C1=Nc(ccc(Br)c2)c2N(C2)C1=NC2=O YHXOULSAORZYSW-UHFFFAOYSA-N 0.000 description 1
- ZELPPFUKNQILQT-UHFFFAOYSA-N CNC(C1)CN1C1=Nc(ncc(Br)c2)c2N(C2)C1=NC2=O Chemical compound CNC(C1)CN1C1=Nc(ncc(Br)c2)c2N(C2)C1=NC2=O ZELPPFUKNQILQT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20180062254 | 2018-05-31 | ||
| KR10-2018-0062254 | 2018-05-31 | ||
| PCT/KR2019/006553 WO2019231270A1 (en) | 2018-05-31 | 2019-05-31 | Heterocyclic derivatives and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021525738A true JP2021525738A (ja) | 2021-09-27 |
| JPWO2019231270A5 JPWO2019231270A5 (https=) | 2022-04-04 |
| JP2021525738A5 JP2021525738A5 (https=) | 2022-04-04 |
Family
ID=68698381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020566706A Withdrawn JP2021525738A (ja) | 2018-05-31 | 2019-05-31 | 複素環誘導体及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20210198259A1 (https=) |
| EP (1) | EP3807282A4 (https=) |
| JP (1) | JP2021525738A (https=) |
| KR (1) | KR102344295B1 (https=) |
| CN (1) | CN112204032A (https=) |
| AU (1) | AU2019279421A1 (https=) |
| BR (1) | BR112020023946A2 (https=) |
| CA (1) | CA3098825A1 (https=) |
| MX (1) | MX2020011955A (https=) |
| SG (1) | SG11202010985TA (https=) |
| TW (1) | TW202021969A (https=) |
| WO (1) | WO2019231270A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| IL298760A (en) | 2020-06-05 | 2023-02-01 | Kinnate Biopharma Inc | Fibroblast growth factor receptor kinase inhibitors |
| EP4067357A1 (en) * | 2021-03-30 | 2022-10-05 | JW Pharmaceutical Corporation | Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine hydrogen sulfate monohydrate |
| CN113929634A (zh) * | 2021-11-22 | 2022-01-14 | 山西永津集团有限公司 | 一种2,3-二溴喹喔啉的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE358395B (https=) * | 1967-09-27 | 1973-07-30 | Siegfried Ag | |
| BRPI0407926A (pt) * | 2003-03-27 | 2006-02-21 | Pfizer Prod Inc | 4-amino[1,2,4]triazol[4,3-a]quinoxalinas substituìdas |
| TW201024297A (en) * | 2008-09-10 | 2010-07-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| TW201204727A (en) * | 2010-03-10 | 2012-02-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| TW201206936A (en) * | 2010-07-19 | 2012-02-16 | Alcon Res Ltd | Methods and compositions for the treatment of allergy |
| TWI551600B (zh) * | 2011-09-30 | 2016-10-01 | Ｃ＆Ｃ新藥研究所 | 新穎雜環衍生物及其用途 |
| CA2904364A1 (en) * | 2013-03-15 | 2014-09-25 | Epigenetix, Inc. | Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors |
| JP2018537450A (ja) * | 2015-11-16 | 2018-12-20 | ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダＦｕｎｄａｃｉｏｎ Ｐａｒａ Ｌａ Ｉｎｖｅｓｔｉｇａｓｉｏｎ Ｍｅｄｉｃａ Ａｐｌｉｃａｄａ | Ｄｎａメチルトランスフェラーゼ阻害剤としての新規化合物 |
| JP7212612B2 (ja) * | 2016-07-28 | 2023-01-25 | プロメガ コーポレイション | セレンテラジン類縁体 |
-
2019
- 2019-05-30 TW TW108118749A patent/TW202021969A/zh unknown
- 2019-05-31 JP JP2020566706A patent/JP2021525738A/ja not_active Withdrawn
- 2019-05-31 US US17/057,753 patent/US20210198259A1/en not_active Abandoned
- 2019-05-31 AU AU2019279421A patent/AU2019279421A1/en not_active Abandoned
- 2019-05-31 CA CA3098825A patent/CA3098825A1/en active Pending
- 2019-05-31 MX MX2020011955A patent/MX2020011955A/es unknown
- 2019-05-31 SG SG11202010985TA patent/SG11202010985TA/en unknown
- 2019-05-31 EP EP19810281.6A patent/EP3807282A4/en not_active Withdrawn
- 2019-05-31 CN CN201980035540.4A patent/CN112204032A/zh active Pending
- 2019-05-31 BR BR112020023946-1A patent/BR112020023946A2/pt not_active Application Discontinuation
- 2019-05-31 WO PCT/KR2019/006553 patent/WO2019231270A1/en not_active Ceased
- 2019-05-31 KR KR1020190064284A patent/KR102344295B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20210198259A1 (en) | 2021-07-01 |
| TW202021969A (zh) | 2020-06-16 |
| BR112020023946A2 (pt) | 2021-02-23 |
| EP3807282A1 (en) | 2021-04-21 |
| MX2020011955A (es) | 2021-01-15 |
| CN112204032A (zh) | 2021-01-08 |
| SG11202010985TA (en) | 2020-12-30 |
| CA3098825A1 (en) | 2019-12-05 |
| WO2019231270A1 (en) | 2019-12-05 |
| EP3807282A4 (en) | 2022-03-02 |
| KR20190137013A (ko) | 2019-12-10 |
| AU2019279421A1 (en) | 2020-12-03 |
| KR102344295B1 (ko) | 2021-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20220323 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220323 |
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| A761 | Written withdrawal of application |
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