JP2021525265A5 - - Google Patents

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Publication number
JP2021525265A5
JP2021525265A5 JP2020565857A JP2020565857A JP2021525265A5 JP 2021525265 A5 JP2021525265 A5 JP 2021525265A5 JP 2020565857 A JP2020565857 A JP 2020565857A JP 2020565857 A JP2020565857 A JP 2020565857A JP 2021525265 A5 JP2021525265 A5 JP 2021525265A5
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JP
Japan
Prior art keywords
formula
group
alkyl
methyl
composite according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020565857A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021525265A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2019/063423 external-priority patent/WO2019224340A1/en
Publication of JP2021525265A publication Critical patent/JP2021525265A/ja
Publication of JP2021525265A5 publication Critical patent/JP2021525265A5/ja
Pending legal-status Critical Current

Links

JP2020565857A 2018-05-25 2019-05-24 ピロロベンゾジアゼピン複合体 Pending JP2021525265A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862676407P 2018-05-25 2018-05-25
US62/676,407 2018-05-25
PCT/EP2019/063423 WO2019224340A1 (en) 2018-05-25 2019-05-24 Pyrrolobenzodiazepine conjugates

Publications (2)

Publication Number Publication Date
JP2021525265A JP2021525265A (ja) 2021-09-24
JP2021525265A5 true JP2021525265A5 (enExample) 2022-05-31

Family

ID=66677112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020565857A Pending JP2021525265A (ja) 2018-05-25 2019-05-24 ピロロベンゾジアゼピン複合体

Country Status (5)

Country Link
US (1) US20210283141A1 (enExample)
EP (1) EP3801630A1 (enExample)
JP (1) JP2021525265A (enExample)
CN (1) CN112203696A (enExample)
WO (1) WO2019224340A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3895209A4 (en) 2018-12-12 2021-12-22 Heraeus Materials Singapore Pte. Ltd. METHOD FOR ELECTRICALLY CONNECTING CONTACT SURFACES OF ELECTRONIC COMPONENTS
GB202105186D0 (en) 2021-04-12 2021-05-26 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB202105187D0 (en) 2021-04-12 2021-05-26 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP4548932A1 (en) 2022-06-30 2025-05-07 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58180487A (ja) 1982-04-16 1983-10-21 Kyowa Hakko Kogyo Co Ltd 抗生物質ｄｃ−８１およびその製造法
DE69925133T2 (de) 1998-08-27 2006-01-19 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
WO2005085251A1 (en) 2004-03-01 2005-09-15 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
US7612062B2 (en) 2005-04-21 2009-11-03 Spirogen Limited Pyrrolobenzodiazepines
RS52060B (sr) 2006-01-25 2012-04-30 Sanofi Citotoksični agensi koji sadrže nove derivate tomaimicina
CN104758281A (zh) * 2007-04-23 2015-07-08 西佳技术公司 用于治疗和预防正痘病毒感染和相关疾病的化合物、组合物和方法
SI2528625T1 (sl) 2010-04-15 2013-11-29 Spirogen Sarl Pirolobenzodiazepini in njihovi konjugati
WO2012064733A2 (en) 2010-11-09 2012-05-18 Medimmune, Llc Antibody scaffold for homogenous conjugation
RS57694B1 (sr) * 2012-10-12 2018-11-30 Adc Therapeutics Sa Pirolobenzodiazepin - anti-psma konjugati antitela
MX338711B (es) * 2012-10-12 2016-04-28 Medimmune Ltd Pirrolobenzodiazepinas y conjugados de las mismas.
CN105189507A (zh) * 2012-12-21 2015-12-23 斯皮罗根有限公司 吡咯并苯并二氮杂卓及其结合物
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201506389D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
RU2018124319A (ru) * 2015-12-04 2020-01-09 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Новые антитела к клаудину и способы их применения
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
AR111963A1 (es) * 2017-05-26 2019-09-04 Univ California Método y moléculas

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